• Toxicological Research
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• 제9권2호
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• pp.167-175
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• 1993

Protective effects of dithiol malonate derivatives (DMDs), YH-100, YH-150 and YH-439 on carbon tetrachloride-induced hepatotoxicity were investigated in primary rat hepatocytes culture. Treatment of DMDs to hepatocytes culture did not affect total cytochrome P-450 content and ECOD and AHH activities. Protein and RNA synthesis was also similar to control. Meanwhile, DMDs significantly decreased LDH release and in vitro lipid peroxidation induced by $CCI_4$. Accumulation of cellular triglyceride and decreased secretion of VLDL from liver cells by $CCI_4$ treatment were also significantly protected.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2012년도 춘계학술발표대회
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• pp.946-949
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• 2012

일반적으로 낸드플래시는 Matlab이나 간단한 프로그램 언어를 통하여 분석하는 경우가 많았다. 그 이유는 많은 데이터와 공정마다 변하는 데이터 format 그리고 여러 가지 분석방법의 다양성이 그 이유이다. 그 때문에 분석시간과 분석의 정형화가 이루어지지 않았다. 본 논문의 낸드플래시의 분석을 정형화 하였고, DB를 이용하여 많은 양의 테스트데이터를 관리 하였다. 또한 여러 종류의 테스트데이터 format에 대하여 범용 적으로 사용할 수 있도록 제작 하였다. 제작된 분석기는 낸드플래시의 CCI특성 및 EW cycle과 retention에 대한 stress resistance를 분석할 수 있다. 객체지향 으로 설계가 되어 추후 유지 보수를 용이하게 설계하였다.

• 한국정보과학회논문지:소프트웨어및응용
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• 제30권5_6호
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• pp.389-397
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• 2003

소프트웨어 개발의 독립성과 품질 및 생산성의 향상을 위한 재사용 기술로 컴포넌트 기반 개발(component-based development) 방법론이 사용되기 시작했다. 개발될 컴포넌트 기반 시스템의 품질 향상을 위해, 개별 컴포넌트에 대한 개발 주기의 초기 단계에 적용 가능한 컴포넌트 메트릭스에 대한 연구가 필요하다. 따라서, 본 논문에서는 컴포넌트 분석단계의 정보를 사용하여, 컴포넌트 인터페이스 복잡도(CCI)와 컴포넌트 인터페이스 응집 결여도(LCC)를 측정한다. 컴포넌트 인터페이스 복잡도는 인터페이스를 이해, 변경, 관리, 사용하기 위한 어려움을 나타낸다 할 수 있고, 컴포넌트 인터페이스 응집 결여도는 컴포넌트가 독립된 기능 단위로 내부 구성요소들이 얼마나 강하게 연관되었는지를 나타낸다 할 수 있다. 이는 시스템 개발 주기의 초기 분석 단계에서, 독립된 기능 단위로 복잡도가 낮으며 응집도가 높은 컴포넌트를 예측 가능함으로써, 최종적으로는 시스템의 품질 향상을 기대할 수 있다.

• 한국한의학연구원논문집
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• 제14권1호
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• pp.137-143
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• 2008

In this research, as a method for verifying the efficacy of Ssangwhatang and fungus-fermentated Ssangwhatang, a comparative study on the liver protection effect was conducted using animal experiments by inducing the liver toxicity with the $CC_{l4}$ treatment. Inducing the liver damage resulted in the increase in the serum AST and ALP activity, and one day administration of the test material($CCI_4$: 0.5 ml/kg/day) caused 520 IU/L of the ASP activity leading to 29% enhancement in comparison with the normal group and 93% and 81% reductions in the fungus-fermentated Ssangwhatang-administered groups, BFST1 and BFST2, respectively. ALT is 42 IU/L for the normal group and 99 IU/L for the negative control group leading to 135% enhancement. 15 ml/kg/day and 30 ml/kg/day administrations of fungus-fermented Ssangwhatang(BFST) resulted in 51% and 45% decreases in the ALT concentration, respectively. One day administration of 30 ml/kg Ssangwhatang and fungus-fermentated Ssangwhatang caused the LDH in the plasma to tend to decrease. $CCI_4$(1.0 ml/kg/day) administered at the 0th and 4th days led to the observation of the tendency toward the decrease in AST, ALT, and LDH contents. The results indicate that the function of Ssangwhatang is partly reinforced under the fungus-fermentated Ssangwhatang performed in order to verify the efficacy of Ssangwhatang' s effect on the recovery from fatigues.

• Journal of Microbiology and Biotechnology
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• 제27권1호
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• pp.26-35
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• 2017

The hydrolysis of proteins constitutes an invaluable tool, granting access to a variety of peptide fragments with potentially interesting biological properties. Therefore, a hemoglobin (Hb) hydrolysate of Crocodylus siamensis was generated by digestion under acidic conditions. The antibacterial and antioxidant activities of the Hb hydrolysate were assessed in comparison with intact Hb. A disc diffusion assay revealed that the Hb hydrolysate exhibited antibacterial activity against eight strains of gram-positive bacteria and showed a higher efficacy than intact Hb. Moreover, the antioxidant activity of intact Hb and its hydrolysate was evaluated using ABTS and DPPH radical scavenging assays. The Hb hydrolysate exhibited free radical scavenging rates of 6-32%, whereas intact Hb showed a slightly higher activity. In addition, non-toxicity to human erythrocytes was observed after treatment with quantities of Hb hydrolysate up to $10{\mu}g$. Moreover, active fragmented Hb (P3) was obtained after purifying the Hb hydrolysate by reversed-phase HPLC. Scanning electron microscopy demonstrated the induction of bacterial cell membrane abnormalities after exposure to P3. Antibacterial and antioxidant activities play crucial roles for supporting the wound healing activity. Consequently, an in vivo mice excisional skin wound healing assay was carried out to investigate the effects of intact Hb treatment on wound healing in more detail. The results clearly demonstrate that intact Hb is capable of promoting 75% wound closure within 6 days. These findings imply that intact Hb of C. siamensis and its acid hydrolysate may serve as valuable precursors for food supplementary products benefitting human health.

• 보건행정학회지
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• 제30권3호
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• pp.418-429
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• 2020

Background: This study aims to analyze the cost and the length of stay (LOS) of acute myocardial infarction (AMI) patients with coronary artery stenting according to the characteristics of individuals and institutions. Methods: The data was collected from Korean National Health Insurance Service's customized database in 2010 and 2015. Chi-square test, t-test, analysis of variance, and multilevel analysis were performed. Results: The intraclass correlation coefficients for cost were 7.02% in 2010, 5.61% in 2015 and for LOS were 3.17%, 1.40%, respectively. The average costs were 9,067,000 won in 2010 and 9,889,000 won in 2015 (p<0.0001). However, the cost in 2015 was lower than the cost applying increased fee. The costs increased in aged 50-59 years, 60-69 years, and aged ≥70 years versus in aged under 49 years. The cost was higher in Charlson comorbidity index (CCI) 3 to 4 and ≥5 than in CCI 0. The costs were lower in male, medical aid recipients, metropolises, and local hospitals in other regions in 2010. LOS decreased from 8.1 days in 2010 to 7.4 days in 2015. It decreased in male, high income group, and the group of admission via emergency room. However, it increased in higher ages and medical aid recipients, and it also increased when CCI rose. The Internal Herfindahl Index was related to LOS in 2010. Conclusion: The variation of hospital level was small compared to the patient level. Therefore, it is important to implement applicable policies at the patient level in order to reduce cost and LOS of AMI patients.

• 한국건설관리학회논문집
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• 제7권2호
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• pp.53-61
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• 2006

한국의 건설공사비지수는 대한건설협회(이하 건협)가 1994년 이후 발표를 중단한 이후, 2004년 2월부터 정부에서 실적공사비제도와 관련하여 새롭게 공사비지수를 발표하기 시작하였다. 이 공사비지수는 한국은행(이하 한은)의 산업연관표, 생산자물가지수와 건협의 공사부문 시중노임 등 검증된 데이터를 활용하여 개발된 것이다. 기존의 통계자료만을 활용하는 것을 전제로 하였을 경우에는 이와 같은 방법이 유효할 수 있으나, 건설산업의 공사비 특성을 반영하기에는 일정한 한계가 있다. 본 논문에서는 이러한 한계를 극복하기 위하여 공사종류별로 노무비와 자재비의 투입구조를 직접적으로 조사하여, 해당 항목들의 원가변동치를 적용함으로써 건설공사비지수를 산출하는 방법을 도입하고자한다. 본 논문의 범위는 기존통계를 이용한 건설공사비지수의 문제점을 밝히고, 이를 대체할 수 있는 현실적인 대안으로서 직접조사에 의한 공사비지수 개발방법론의 타당성을 확인하는 것으로 한정한다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제9권6호
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• pp.2014-2034
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• 2015

This paper focuses on solving co-channel interference (CCI) issues arising in the open subscriber group (OSG) mode of heterogeneous networks (HetNets). Considering a general framework consisting of arbitrary number of picocells within a macro cell, where the inter-user interference (IUI) is the main CCI to macro user equipments (UEs), while the the inter-cell interference (ICI) is the major CCI to pico UEs. In this paper, three IA based transceiver design schemes are proposed. For macro cell, we uniformly use block diagonalization (BD) scheme to eliminate the IUI. And for picocells, three IA schemes are proposed to mitigate the ICI. The first scheme, named as zero forcing IA (ZF-IA) scheme, aligns the inter picocell interference onto an arbitrary sub-space of the cross-tier interference using ZF scheme. Considering the channel state information (CSI) of the desired channel of pico UEs, the second scheme, named as optimal desired sub-channel selected IA (ODC-IA) scheme, aligns the inter picocell interference onto a certain sub-space of the cross-tier interference, which guarantees the largest channel gain of the desired signal of pico UEs. The third IA scheme, named as maximum cross-tier interference selected IA (MI-IA) scheme, is designed for the system with less receive antennas. The inter picocell interference is aligned onto the space of the strongest cross-tier interference and only the interference on this space is nullified. The complexity analysis and simulations show that the proposed transceiver design schemes outperform the existing IA schemes in the OSG mode of HetNets, and the MI-IA scheme reduces the requirement of the receive antennas number with lower complexity.

• The Korean Journal of Pain
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• 제25권1호
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• pp.7-15
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• 2012

Background: Neuropathic pain is a chronic pain due to disorder in the peripheral or central nervous system with different pathophysiological mechanisms. Current treatments are not effective. Analgesic drugs combined can reduce pain intensity and side effects. Here, we studied the analgesic effect of nimesulide, nefopam, and morphine with different mechanisms of action alone and in combination with other drugs in chronic constriction injury (CCI) model of neuropathic pain. Methods: Male Wistar rats (n = 8) weighing 150-200 g were divided into 3 different groups: 1- Saline-treated CCI group, 2- Saline-treated sham group, and 3- Drug-treated CCI groups. Nimesulide (1.25, 2.5, and 5 mg/kg), nefopam (10, 20, and 30 mg/kg), and morphine (1, 3, and 5 mg/kg) were injected 30 minutes before surgery and continued daily to day 14 post-ligation. In the combination strategy, a nonanalgesic dose of drugs was used in combination such as nefopam + morphine, nefopam + nimesulide, and nimesulide + morphine. Von Frey filaments for mechanical allodynia and acetone test for cold allodynia were, respectively, used as pain behavioral tests. Experiments were performed on day 0 (before surgery) and days 1, 3, 5, 7,10, and 14 post injury. Results: Nefopam (30 mg/kg) and nimesulide (5 mg/kg) blocked mechanical and thermal allodynia; the analgesic effects of morphine (5 mg/kg) lasted for 7 days. Allodynia was completely inhibited in combination with nonanalgesic doses of nefopam (10 mg/kg), nimesulide (1.25 mg/kg), and morphine (3 mg/kg). Conclusions: It seems that analgesic drugs used in combination, could effectively reduce pain behavior with reduced adverse effects.

• 한국식품영양과학회지
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• 제18권3호
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• pp.273-278
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• 1989

해동피 methanol 추출물을 시료로 mouse의 급성독성실험, 실험적으로 유발시킨 가토의 간장기능 장애에 미치는 영향을 실험하여 다음과 같은 결과를 얻었다. 실험결과 해동피 methanol 추출물의 급성독성 $(LD_{50})=7.3g/kg$으로 무독하였고 $CCI_4$로 손상시킨 가토의 간장기능회복에 있어서는 실험동물체중 kg당 시료 800mg투여군에서 14일째 대조군에 비해 SGPT가 $87.28{\pm}23.03$ unit로 서서히 유의성있게 회복되었다. 시료 800mg/kg투여군에서 alkaline phosphatase 활성도는 2일째부터, 그리고 total bilirubin 측정치는 6일째부터 현저히 회복되는 경향을 보였다. 특히 total cholesterol 측정치는 200mg/kg투여군에서 14일째 $99.36{\pm}12.42mg/d{\ell}$과 800mg/kg투여군에서 10일째 $96.69{\pm}18.40mg/d{\ell}$, 14일째 $80.68{\pm}8.77mg/d{\ell}$로 대조군에 비해 현저한 감소를 보였다.