• 한국정보과학회논문지:시스템및이론
• /
• 제31권11호
• /
• pp.643-657
• /
• 2004

Chordal Ring 구조의 CC-NUMA 시스템은 그 구조적 특징 때문에 지역 노드와 원격 노드사이의 트랜잭션 전송을 위해 지나가는 링크의 수가 많게 된다. 그러나, 이러한 트랜잭션이 코달 링보다 링 링크로 몰리는 경향은 링 링크의 트래픽 증가와 응답 지연 시간의 증가를 유발하게 되면서 Chordal Ring 구조의 CC-NUMA 시스템의 성능을 하락시킨다. 이러한 문제론 극복하기 위해서 본 논문에서는 원격 캐쉬를 교체할 경우에 지역 노드와 원격 노드사이에 데이타 전송을 위하여 지나가는 총 링크 수와 링 링크의 수를 고려한 새로운 원격 캐쉬 교체 정책을 제안한다. 본 논문에서 제안하는 원격 캐쉬 교체 정책은 Chordal Ring 구조의 CC-NUMA 시스템의 특징을 반영하였기 때문에 링크간의 데이타를 적절히 분산시킬 수 있는 정책이라 사료된다.

• 한국발생생물학회지:발생과생식
• /
• 제22권4호
• /
• pp.341-350
• /
• 2018

Chemokines is a small protein that plays a major role in inflammatory reactions and viral infections as a chemotactic factor of cytokines involved in innate immunity. Most of the chemokines belong to the chemokine groups CC and CXC. To investigate the immune system of the olive flounder (Paralichthys olivaceus), an expression pattern specifically induced in the early developmental stages of analysis is examined using qRT-PCR. We also examined tissue-specific expression of both CC and CXC chemokine in healthy olive flounder samples. CC and CXC chemokine shows increased expression after immune-related organs are formed compared to expression during early development. CC chemokine was more highly expressed in the fin, but CXC chemokine showed higher expression in the gills, spleen, intestines, and stomach. Spatial and temporal expression analysis of CC and CXC chemokine were performed following viral hemorrhagic septicemia virus (VHSV) infection. CC chemokine showed high expression in the gills, which are respiratory organs, whereas CXC chemokine was more highly expressed in the kidneys, an immune-related organ. These results suggest that CC and CXC chemokine play an important role in the immune response of the olive flounder, and may be used as basic data for the immunological activity and gene analysis of it as well as other fish.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권2호
• /
• pp.701-705
• /
• 2013

Polymorphisms in XPG are considered to contribute to the clinical outcome of patients receiving platinum drug chemotherapy. We aimed to investigate the role of five potential SNPs of XPG gene on the response to platinum-based chemotherapy in advanced Chinese NSCLC patients. A total of 451 patients with newly diagnosed and histopathologically confirmed primary NSCLC were consecutively collected. XPG rs2296147, rs4150261, rs17655, rs1047768 and rs2094258 were genotyped by the Taqman real-time polymerase chain reaction (PCR). In our study, we found patients carrying rs1057768 TT genotype had a significantly lower treatment response when compared with the CC genotype (OR=0.38, 95% CI=0.18-0.78). Patients carrying rs1047768 TT genotype showed a significantly short median PFS (11.2 months) and OS (13.6 months) than CC genotype, and the hazard ratios (HR) for PFS and OS were 2.06 (1.01-4.50) and 2.29 (1.21-2.49), respectively. Moreover, we found a significant decreased risk of death from NSCLC among patients carrying the rs2296147 TT genotype when compared with the CC genotype, the HR (95% CI) for OS being 0.50 (0.27-0.95). In conclusion, our study found that polymorphisms in rs1047768 C/T and rs2296147 C/T are associated with response to platinum-based chemotherapy in advanced NSCLC, and XPG polymorphisms could be predictive of prognosis.

• Restorative Dentistry and Endodontics
• /
• 제48권2호
• /
• pp.12.1-12.11
• /
• 2023

Objectives: The present study evaluated the pulp response of human mandibular incisors subjected to in-office dental bleaching using gels with medium or high concentrations of hydrogen peroxide (HP). Materials and Methods: The following groups were compared: 35% HP (HP35; n = 5) or 20% HP (HP20; n = 4). In the control group (CONT; n = 2), no dental bleaching was performed. The color change (CC) was registered at baseline and after 2 days using the Vita Classical shade guide. Tooth sensitivity (TS) was also recorded for 2 days post-bleaching. The teeth were extracted 2 days after the clinical procedure and subjected to histological analysis. The CC and overall scores for histological evaluation were evaluated by the Kruskal-Wallis and Mann-Whitney tests. The percentage of patients with TS was evaluated by the Fisher exact test (α = 0.05). Results: The CC and TS of the HP35 group were significantly higher than those of the CONT group (p < 0.05) and the HP20 group showed an intermediate response, without significant differences from either the HP35 or CONT group (p > 0.05). In both experimental groups, the coronal pulp tissue exhibited partial necrosis associated with tertiary dentin deposition. Overall, the subjacent pulp tissue exhibited a mild inflammatory response. Conclusions: In-office bleaching therapies using bleaching gels with 20% or 35% HP caused similar pulp damage to the mandibular incisors, characterized by partial necrosis, tertiary dentin deposition, and mild inflammation.

• Journal of Power Electronics
• /
• 제19권4호
• /
• pp.869-880
• /
• 2019

Due to the inherent feedforward of load current, capacitor current (CC) control shows a fast transient response that makes it suitable for the power supplies used in various portable electronic devices. However, considering the effect of the outer voltage loop, the stable range of the duty-cycle is significantly diminished in CC controlled buck converters. To investigate the stability effect of the outer voltage loop on buck converters, a CC controlled buck converter with a proportion-integral (PI) compensator is taken as an example, and its second-order discrete-time model is established. Based on this model, the instability caused by the duty-cycle is discussed with consideration of the outer voltage loop. Then the dynamical effects of the feedback gain of the PI compensator and the equivalent series resistance (ESR) of the output capacitor on the CC controlled buck converter with a PI compensator are studied. Furthermore, the design-oriented closed-loop stability criterion is derived. Finally, PSIM simulations and experimental results are supplied to verify the theoretical analyses.

• 한국축산식품학회지
• /
• 제43권5호
• /
• pp.889-900
• /
• 2023

In this study, concentration levels of beet powder (BP) and caramel color (CC) were optimized to simulate beef color in meat analogs before and after cooking. The central composite design of response surface methodology (RSM) was used to set the levels of BP and CC, and the CIE L^*, CIE a^*, and CIE b^* were selected as the responses for RSM. After optimization, myoglobin-free beef patties were prepared with three optimized levels of BP and CC. When raw, all the patties had the same color as natural beef; however, CIE L^*, CIE a^*, and CIE b^* were statistically different from those of beef after cooking (p<0.05). Moreover, the use of BP and CC induced "browning" after the cooking process, with no excessive yellow color. Therefore, based on the overall desirability in the color optimization using RSM, the combination of BP (1.32%) and CC (1.08%) with the highest overall desirability can be used to simulate the color change of beef in meat analogs.

• 대한안전경영과학회:학술대회논문집
• /
• 대한안전경영과학회 2009년도 춘계학술대회
• /
• pp.423-427
• /
• 2009

This study proposes the generation mechanism of various design matrix using generalized linear model for design of experiment. Design generation method of GLM analysis, factorial design(FD) with center points, ANOVA design with lack-of-fit test, and response surface design are introduced. In central composite(CC) design, orthogonal blocking and fractional factorial design(FFD) are presented. We compare the design of Box-Benhken(BB) and face-centred central compsite design.

• Journal of Power Electronics
• /
• 제14권2호
• /
• pp.302-314
• /
• 2014

Due to advancements in power electronics and inverter topologies, the current controlled multilevel voltage-source pulse width modulated (PWM) inverter is usually preferred for accurate control, quick response and high dynamic performance. A multilevel topology approach is found to be best suited for overcoming many problems arising from the use of high power converters. This paper presents a comprehensive review and comparative study of several current control (CC) techniques for multilevel inverters with a special emphasis on various approaches of the hysteresis current controller. Since the hysteresis CC technique poses a problem of variable switching frequency, a ramp-comparator controller and a predictive controller to attain constant switching frequency are described along with its quantitative comparison. Furthermore, various methods have been reviewed to achieve hysteresis current control PWM with constant switching frequency operation. This paper complies various guidelines to choose a particular method suitable for application at a given power level, switching frequency and dynamic response.

• 대한의생명과학회지
• /
• 제18권4호
• /
• pp.435-437
• /
• 2012

House dust mite (HDM) is important in the pathogenesis of allergic diseases including asthma and atopic dermatitis. Dermatophagoides pteronissinus (Dp) is one of major HDM allergens. In this study, we investigated that Dp extract (DpE) affects on the chemotactic activity of monocytes isolated from the peripheral blood. DpE inhibited the migration of human monocytes in response to CC chemokines such as MIP-$1{\alpha}$, RANTES, HCC-4, MCP-1, and TARC. DpE did not alter the expression of CC chemokine receptors (CCRs) such as CCR1, CCR2, CCR3, CCR4, and CCR5. These results indicate that DpE blocks the chemotaxis of human monocytes and its mechanism is not involved in alteration of CCR expression. Better understanding of the effect of DpE on monocytes will enable elucidation of the role of Dp in the development of allergic diseases.

• 한국독성학회:학술대회논문집
• /
• 한국독성학회 2002년도 Current Trends in Toxicological Sciences
• /
• pp.137-137
• /
• 2002

Biologically Based Dose-Response (BBDR) models were developed using biomarkers for cancer risk assessment. To establish the relationship among biomarkers, exposure dose and tumor response, biomarkers in the lung, liver, stomach or blood were measured after a single or continuous administration of selected carcinogen (; BaP) in mice or rats.(omitted)