• 한국임상약학회지
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• 제26권1호
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• pp.53-58
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• 2016

Objective: To estimate the association between ABCG2 C421A polymorphism and response to imatinib in chronic myeloid leukemia. Methods: A systematic review was conducted to evaluate the effect of ABCG2 C421A polymorphism on imatinib response. The databases of PubMed, Embase, Web of science, CINAHL with FullText, and Cochrane Library were searched for all published studies from inception to December 2015. The following terms were used with functions of 'AND' and 'OR': 'chronic myeloid leukemia', 'CML', 'drug transporter', 'ABCG2', 'BCRP', 'polymorphisms', 'SNPs', and 'imatinib'. The studies reporting the association between ABCG2 polymorphism and imatinib response were evaluated. Results: A total of 7 studies were included in the present meta-analysis. The pooled analysis showed that ABCG2 c.421CC genotype was significantly associated with poor response to imatinib under the dominant model (CC vs CA+AA; OR: 0.56; 95% CI: 0.41, 0.77; p = 0.0004). The subgroup analysis of Asian studies demonstrated a significantly lower response in c.421CC genotype than in c.421CA or c.421AA genotype (OR: 0.52; 95% CI: 0.37, 0.73; p = 0.0002). In subgroup analyses of 5 studies, the patients with the c.421CC genotype exhibited higher risk for worse response than the patients with c.421CA or c.421AA genotype (heterozygote codominant model: CC vs. AC; OR: 0.49, 95% CI: 0.33, 0.73; p = 0.0006; homozygote codominant model: CC vs AA; OR: 0.43; 95% CI: 0.25, 0.75, p = 0.003). Conclusion: The ABCG2 c.421CC genotype was significantly associated with poor response to imatinib compared to the c.421CA and c.421AA genotypes in chronic myeloid leukemia, especially in Asian patients.

• 대한본초학회지
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• 제26권4호
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• pp.187-194
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• 2011

Objective : Astragali Radix (AR) and Cinnamomi Cortex (CC) are used to enhance immune response in Asian traditional medicine. Immuno-potentiation of the combination of AR and CC were evaluated on the cellular and humoral immune response using murine macrophage cell line (RAW 264.7) and OVA-immunized mice. Methods : This study was designed to investigate the immuno-potentiative effects of AR, CC, and AR with CC on nitric oxide synthesis in RAW 264.7 cells and proliferation and production levels of Intereukin-2 (IL-2) in mouse splenocytes. In addition, we evaluated the plasma-specific antibody responses and splenocyte proliferation on ovalbumin (OVA)-immunized mice treated with herbal extracts. Results : Combination treatment with AR and CC increased nitric oxide synthesis in RAW 264.7 cells and IL-2 level in splenocytes (p<0.001). Combination of AR and CC significantly enhanced the Concanavalin A- (Con A ; T cell mitogen) and lipopolysaccharide-(LPS ; B cell mitogen) induced splenocyte proliferation on the OVA-immunized mice. Combination of AR and CC also significantly enhanced plasma levels of OVA-specific IgG (p<0.01), IgG1 (p<0.05) and total IgM (p<0.01) compared with the OVA-immunized control group. Conclusion : These results suggest that combination of AR and CC could be used as therapeutic profile on activation of immune response.

• Asian Pacific Journal of Cancer Prevention
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• 제16권5호
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• pp.1873-1880
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• 2015

Background: A recent genome-wide association study (GWAS) on patients with chronic hepatitis C (CHC) treated with peginterferon and ribavirin (pegIFN-${\alpha}$/RBV) identified a single nucleotide polymorphism (SNP) on chromosome 19 (rs12979860) which was strongly associated with a sustained virological response (SVR). The aim of this study was twofold: to study the relationship between IL28B rs12979860 and sustained virological response (SVR) to pegIFN-${\alpha}$/RVB therapy among CHC patients and to detect the rs12979860 polymorphism by high resolution melting curve (HRM) assay as a simple, fast, sensitive, and inexpensive method. Materials and Methods: The study examined outcomes in 100 patients with chronic hepatitis C in 2 provinces of Iran from December 2011 to June 2013. Two methods were applied to detect IL28B polymorphisms: PCR-sequencing as a gold standard method and HRM as a simple, fast, sensitive, and inexpensive method. Results: The frequencies of IL28B rs12979860 CC, CT, and TT alleles in chronic hepatitis C genotype 1a patients were 10% (10/100), 35% (35/100), and 6% (6/100) and in genotype 3a were 13% (13/100), 31% (31/100), and 5% (5/100), respectively. In genotype 3a infected patients, rs12979860 (CC and CT alleles) and in genotype 1a infected patients (CC allele) were significantly associated with a sustained virological response (SVR). The SVR rates for CC, CT and TT (IL28B rs12979860) were 18%, 34% and 4%, respectively. Multiple logistic regression analysis identified two independent factors that were significantly associated with SVR: IL-28B genotype (rs 12979860 CC vs TT and CT; odds ratio [ORs], 7.86 and 4.084, respectively), and HCV subtype 1a (OR, 7.46). In the present study, an association between SVR rates and IL28B polymorphisms was observed. Conclusions: The HRM assay described herein is rapid, inexpensive, sensitive and accurate for detecting rs12979860 alleles in CHC patients. This method can be readily adopted by any molecular diagnostic laboratory with HRM capability and will be clinically beneficial in predicting treatment response in HCV genotype 1 and 3 infected patients. In addition, it was demonstrated that CC and CT alleles in HCV-3a and the CC allele in HCV-1a were significantly associated with response to pegIFN-${\alpha}$/RBV treatment. The present results may help identify subjects for whom the therapy might be successful.

• Clinical and Experimental Reproductive Medicine
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• 제25권2호
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• pp.141-151
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• 1998

Objectives: To determine whether the body weight, body mass index (BMI), and basal serum level of LH, FSH, testosterone (T), dehydroepiandrosterone sulfate (DHEA-S) are related to the ovarian response to clomiphene citrate (CC) in patients with polycystic ovarian syndrome (PCOS). Materials and Method: From January 1996 to June 1997, total 57 patients with PCOS were enrolled in the present study. Women who had other infertility factors were excluded from our study. The ovulation induction using CC was used in all patients. The patients were grouped into 50 mg group, 100 mg group, and 150 mg group according to their daily CC dose. The patients were also grouped to ovulatory and non-ovulatory group. The body weight, BMI, and basal serum level of LH, FSH, T, DHEA-S were measured in all patients on the 2nd or 3rd day of the menstrual cycle. Results were analysed with Student's t-test and Fisher's exact test. Results: The body weight and BMI of the nonovulating group were significantly higher than those of the ovulating group in all groups (50, 100, 150 mg of CC). However, there were no significant differences of the level of LH and FSH between ovulating and nonovulating groups in all CC groups (50, 100, 150 mg). The level of T of nonovulating group was significantly higher in 50 and 100 mg of CC groups, but not in 150 mg group. The level of DHEA-S of the non-ovulating group is significantly higher in 50 mg group, but not in 100 and 150 mg groups. Conclusion: The body weight and BMI could be useful predictors of ovarian response to CC in patients with PCOS, and basal T and DHEA-S also might be useful in cases of low-dose CC treatment.

• 한국정보과학회논문지:시스템및이론
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• 제29권9호
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• pp.503-513
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• 2002

CC-NUMA구조에서는 원격 메모리에 대한 접근이 불가피한 구조적인 특성 때문에 상호 연결망이 성능을 좌우하는 큰 변수로 작용한다. 기존에 사용되는 버스는 대역폭의 한계와 물리적 확장성 때문에 대규모의 시스템에는 적합하지 않다. 이를 대체하는 고속의 지점간 링크를 도입한 이중 링 구조는 이러한 버스의 한계를 극복하고는 있지만 많은 노드를 거쳐야 하는 문제로 인해 응답 지연 시간이 증가하는 단점을 안고 있다. 본 논문에서는 요청과 응답 패킷의 지연 시간을 줄이는 방안으로 리피터 노드를 이용한 다중 링을 제안한다. 제안된 시스템은 링과 링 사이의 구조가 대칭형을 이루고 있어 요청을 내보내는 링을 제외한 다른 링의 hop수는 똑같은 수치를 갖고 있으며, 이중 링에 비해 최대의 hop수와 최소의 hop수의 차가 적고 평균 hop수 또한 적어 좋은 성능을 보인다. 본 논문에서는 또한 이러한 구조를 유지하기 위한 리피터 노드의 구조를 제안하며 리피터 노드의 구조와 노드의 확장에 따른 다양한 성능을 확률 구동 시뮬레이터를 사용하여 평가를 수행한다.

• 정보처리학회논문지C
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• 제17C권1호
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• pp.89-98
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• 2010

GEM(Globally Executable MHP) 기반의 MHP(Multimedia Home Platform), OCAP(OpenCable Application Platform), ACAP(Advanced Common Application Platform) 등은 현재 디지털 방송의 대표적인 미들웨어이다. 이러한 미들웨어에 사용된 MPEG-2와 DSM-CC(Digital Storage Media-Command and Control) 프로토콜 표준은 많은 부분이 유사하다는 특징을 가지고 있지만 각 DTV 미들웨어가 필요로 하는 정보와 데이터 구조가 조금씩 차이가 있다. 이는 결과적으로 미들웨어간의 비호환성을 야기한다. 본 논문에서는 다양한 미들웨어 표준을 모두 지원할 수 있는 통합 DTV 미들웨어를 개발하기 위한 노력의 일환으로써, 재구성이 가능한 범용 DSM-CC 아키텍처를 제안한다. 첫째, 모든 GEM 기반의 미들웨어가 공통적으로 필요로 하는 DSM-CC 컴포넌트를 정의하였다. 둘째, 각 미들웨어가 필요로 하는 정보와 데이터 구조를 XML 형태로 정의하여 별도의 수정 없이 정적, 혹은 동적으로 특정 미들웨어에 맞추어 적용할 수 있도록 하였다. 또한, 셋탑박스의 전체적인 성능과 연관성이 높은 어플리케이션 응답시간과 DSM-CC 모듈의 사용빈도를 향상시키기 위해 사용자의 선호도를 고려한 캐시 관리 전략을 제안하고, 제안된 캐시 관리 전략이 응답시간을 줄이는데 효과적임을 실험을 통해서 확인하였다.

• Molecules and Cells
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• 제27권5호
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• pp.557-562
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• 2009

We examined the effects of the NADPH oxidase p22phox C242T polymorphism on endurance exercise performance and oxidative DNA damage in response to acute and chronic exercises. One hundred three subjects were recruited, among which 26 healthy subjects (CC: 12, TC: 12, and TT: 2) were studied during rest, exercise at 85% $VO_2max$, and recovery before and after 8 weeks of treadmill running. Lymphocyte DNA damage increased significantly in response to exercise (p < 0.05). There were no significant differences in plasma MDA, SOD concentrations and lymphocyte DNA damage between CC genotype and T allele group, but significant endurance training differences were observed. Endurance training increased exercise time to exhaustion in both the CC genotype and T allele groups (p < 0.05) but no significant difference was found between groups. The results of the current study with young, healthy, Korean men are interpreted to mean that 1) the majority had the CC genotype of the NADPH oxidase p22phox C242T polymorphism (82.5%: CC, 15.5%: TC, 1.9%: TT), 2) acute exercise increased lymphocyte DNA damage, 3) endurance training significantly increased exercise time to exhaustion, and alleviated lymphocyte DNA damage, and 4) The NADPH oxidase p22phox C242T polymorphism, however, did not alter lymphocyte DNA damage or exercise performance at rest, immediately after exercise, or during recovery.

• 한국정보과학회논문지:시스템및이론
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• 제29권2호
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• pp.105-115
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• 2002

NUMa 구조는 원격 메모리에 대한 접근이 불가피한 구조적 특성 때문에 상호 연결망이 시스템 성능을 좌우하는 큰 변수가 된다. 기존에 대중적으로 사용되던 버스는 물리적 확장성 및 대역폭에서 대규모 시스템을 구성하는데 한계를 보인다. 이를 대체하는 고속의 지점간 링크를 사용한 이중 링구조는 버스가 가지는 확장성 및 대역폭의 한계라는 단점을 개선하였으나, 많은 노드가 연결되는 경우에는 응답 지연시간이 증가하는 문제점을 가지고 있다. 본 논문에서는 스누핑 프로토콜이 적용된 이중 일 구조에서 노드개수 증가에 따른 응답지연시간 증가의 문제점을 보안하기 위해 코달 링 구조로의변화를 제안하고 이 구조에 효과적인 링크 제어기를 설계한다. 또한 확률 구동 시뮬레이터를통해 본 논문을 통해 제시한 코달 링 구조가 시스템의 성능 및 응답시간에 미치는 영향을 알아본다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권11호
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• pp.4659-4664
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• 2015

Background: ABC proteins are one key type of transport superfamilies which undertake majority of drug transport, which affect the osteosarcoma response to chemotherapeutics. Previous studies have suggested the association between ABC polymorphisms and osteosarcoma response. However, the results of previous studies remain controversial. Therefore, we perform a meta-analysis to get a more precise estimation of this association. The association between ABC polymorphisms and osteosarcoma response was assessed by odds ratios (ORs) together with their 95% confidence intervals (CIs). Three polymorphisms of ABC including ABCB1 rs1128503, ABCC3 rs4148416 and ABCC2 rs717620 polymorphism were investigated. Overall, significant association was observed between ABCC3 rs4148416 polymorphism and osteosarcoma response under allele contrast (T vs. C: OR=1.73, 95%CI=1.09-2.74, P=0.019), homozygote comparison (TT vs. CC: OR=2.00, 95%CI=1.25-3.23, P=0.004), recessive genetic model (TT vs. TC/CC: OR=1.80, 95%CI=1.14-2.84, P=0.011) and dominant genetic model (TT/TC vs. CC: OR=1.70, 95%CI=1.20-2.42, P=0.003). Moreover, significant association was also observed in Caucasian population rather than Asian population for ABCB1 rs1128503 polymorphism. We conclude that ABCC3 rs4148416 polymorphism was significantly associated with poor osteosarcoma response and ABCB1 rs1128503 polymorphism was significantly associated with good osteosarcoma response in Caucasian population rather than Asian population.

• 한국컴퓨터정보학회:학술대회논문집
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• 한국컴퓨터정보학회 2011년도 제44차 하계학술발표논문집 19권2호
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• pp.139-142
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• 2011

해외 기술 유출 사고로 인하여 한국 경제에 약 수조원의 피해가 발생하였다. 기업의 기술 유출과 사고 책임 소재를 증명하기 위한 e-Discovery시스템과 기업CERT/CC에 연구가 필요하다. 본 논문에서는 e-Discovery의 개념과 관련법안 및 권고안, 포렌식 수사절차에 대해 연구하고, 국내 e-Discovery 사고 사례와 해외 e-Discovery 사고 사례를 연구한다. e-Discovery가 도입되면 기업 CERT/CC에서 필요한 e-Discovery 시스템을 설계한다. e-Discovery 시스템의 접근과 인증을 위한 사용자인증과 기기 인증에 대한 기술과 암호화 기술을 연구한다. 본 논문 연구를 통하여 e-Discovery 제도의 도입과 포렌식 기술 발전에 기초자료로 활용될 것이다.