Effects of the NADPH Oxidase p22phox C242T Polymorphism on Endurance Exercise Performance and Oxidative DNA Damage in Response to Aerobic Exercise Training
![]() |
Paik, Il-Young
(Exercise Physiology Laboratory, Department of Physical Education, Yonsei University)
Jin, Chan-Ho (Exercise Physiology Laboratory, Department of Physical Education, Yonsei University) Jin, Hwa-Eun (Exercise Physiology Laboratory, Department of Physical Education, Yonsei University) Kim, Young-Il (Exercise Physiology Laboratory, Department of Physical Education, Yonsei University) Cho, Su-Youn (Exercise Physiology Laboratory, Department of Physical Education, Yonsei University) Roh, Hee-Tae (Exercise Physiology Laboratory, Department of Physical Education, Yonsei University) Suh, Ah-Ram (Department of Golf, College of Art and Sports Sciences, Hoseo University) Suh, Sang-Hoon (Exercise Physiology Laboratory, Department of Physical Education, Yonsei University) |
1 | Bejma, J., and Ji, L.L. (1999). Aging and acute exercise enhance free radical generation in rat skeletal muscle. J. Appl. Physiol. 87, 465-470 DOI |
2 | Cave, A.C., Brewer, A.C., Narayanapanicker, A., Ray, R., Grieve, D.J., Walker, S., and Shah, A.M. (2006). NADPH oxidases in cardiovascular health and disease. Antioxid Redox Signal. 8, 691-728 DOI ScienceOn |
3 | Davies, K.J., Packer, L., and Brooks, G.A. (1981). Biochemical adaptation of mitochondria, muscle, and whole-animal respiration to endurance training. Arch. Biochem. Biophys. 209, 539-554 DOI ScienceOn |
4 | Dinauer, M.C., Pierce, E.A., Bruns, G.A., Curnutte, J.T., and Orkin, S.H. (1990). Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease. J. Clin. Invest. 86, 1729-1737 DOI ScienceOn |
5 | Tanimura, Y., Shimizu, K., Tanabe, K., Otsuki, T., Yamauchi, R., Matsubara, Y., Iemitsu, M., Maeda, S., and Ajisaka, R. (2008). Exercise-induced oxidative DNA damage and lymphocytopenia in sedentary young males. Med. Sci. Sports Exerc. 40, 1455-1462 DOI ScienceOn |
6 | Toskulkao, C., and Glinsukon, T. (1996). Endurance exercise and muscle damage: relationship to lipid peroxidation and scavenging enzymes in short and long distance runners. Jpn. J. Phys. Fitness Sports Med. 45, 63-70 DOI |
7 | Whaley, M.H., Brubaker, P.H., Otto, R.M., and Armstrong, L.E. (2006). ACSM's Guidelines for Exercise Testing and PrescriptionI 7th eds., (Philadelphia, USA: Lippincott Williams and Wilkins) |
8 | Wierzba, T.H., Olek, R.A., Fedeli, D., and Falcioni, G. (2006). Lymphocyte DNA damage in rats challenged with a single bout of strenuous exercise. J. Physiol. Pharmacol. 57, 115-131 |
9 | Taivassalo, T., and Haller, R.G. (2005). Exercise and training in mitochondrial myopathies. Med. Sci. Sports Exerc. 37, 2094-2101 DOI ScienceOn |
10 | Griendling, K.K., Sorescu, D., and Ushio-Fukai, M. (2000). NAD(P)H oxidase: role in cardiovascular biology and disease. Circ. Res. 86, 494-501 DOI PUBMED ScienceOn |
11 | Shin, Y.A., Lee, J.H., Song, W., and Jun, T.W. (2008). Exercise training improves the antioxidant enzyme activity with no changes of telomere length. Mech. Ageing Dev. 129, 254-260 DOI ScienceOn |
12 | Adams, V., Linke, A., Krankel, N., Erbs, S., Gielen, S., Mobius- Winkler, S., Gummert, J.F., Mohr, F.W., Schuler, G., and Hambrecht, R. (2005). Impact of regular physical activity on the NAD(P)H oxidase and angiotensin receptor system in patients with coronary artery disease. Circulation 111, 555-562 DOI ScienceOn |
13 | Davies, K.J., Quintanilha, A.T., Brooks, G.A., and Packer, L. (1982b). Free radicals and tissue damage produced by exercise. Biochem. Biophys. Res. Commun. 107, 1198-1205 DOI ScienceOn |
14 | Niess, A.M., Baumann, M., Roecker, K., Horstmann, T., Mayer, F., and Dickhuth, H.H. (1998). Effects of intensive endurance exercise on DNA damage in leucocytes. J. Sports Med. Phys. Fitness 38, 111-115 |
15 | Hartmann, A., Plappert, U., Raddatz, K., Grunert-Fuchs, M., and Speit, G. (1994). Does physical activity induce DNA damage? Mutagenesis 9, 269-272 DOI ScienceOn |
16 | Jeppesen, T.D., Schwartz, M., Olsen, D.B., Wibrand, F., Krag, T., Duno, M., Hauerslev, S., and Vissing, J. (2006). Aerobic training is safe and improves exercise capacity in patients with mitochondrial myopathy. Brain 129, 3402-3412 DOI ScienceOn |
17 | Park, J.Y., Ferrell, R.E., Park, J.J., Hagberg, J.M., Phares, D.A., Jones, J.M., and Brown, M.D. (2005). NADPH oxidase p22phox gene variants are associated with systemic oxidative stress biomarker responses to exercise training. J. Appl. Physiol. 99, 1905-1911 DOI ScienceOn |
18 | Alessio, H.M. (1993). Exercise-induced oxidative stress. Med. Sci. Sports Exerc. 25, 218-224 PUBMED |
19 | de Garay, A., Levine, L., and Carter, J. (1974). Single gene systems fo blood. In Genetic and Anthropological Studies of Olympic Athletes, Academic Press Inc. pp. 165-187 |
20 | Davies, K.J., Packer, L., and Brooks, G.A. (1982a). Exercise bioenergetics following sprint training. Arch.=Biochem. Biophys. 215, 260-265 DOI ScienceOn |
21 |
Hartmann, A., and Niess, A.M. (2000). Oxidative DNA damage in exercise. In Handbook of Oxidants and Antioxidants in Exercise, C.K. Sen, L. Packer, and O. H |
22 | Miyazaki, H., Oh-ishi, S., Ookawara, T., Kizaki, T., Toshinai, K., Ha, S., Haga, S., Ji, L.L., and Ohno, H. (2001). Strenuous endurance training in humans reduces oxidative stress following exhausting exercise. Eur. J. Appl. Physiol. 84, 1-6 DOI PUBMED |
23 | Finaud, J., Lac, G., and Filaire, E. (2006). Oxidative stress : relationship with exercise and training. Sports Med. 36, 327-358 DOI ScienceOn |
24 | Phillips, S.M., Green, H.J., Tarnopolsky, M.A., Heigenhauser, G.J., and Grant, S.M. (1996). Progressive effect of endurance training on metabolic adaptations in working skeletal muscle. Am. J. Physiol. 270, E265-272 DOI |
25 | Wyche, K.E., Wang, S.S., Griendling, K.K., Dikalov, S.I., Austin, H., Rao, S., Fink, B., Harrison, D.G., and Zafari, A.M. (2004). C242T CYBA polymorphism of the NADPH oxidase is associated with reduced respiratory burst in human neutrophils. Hypertension 43, 1246-1251 DOI ScienceOn |
26 | Collins, A.R., Dusinska, M., Gedik, C.M., and Stetina, R. (1996). Oxidative damage to DNA: do we have a reliable biomarker? Environ. Health Perspect, 104, 465-469 DOI |
27 | Urso, M.L., and Clarkson, P.M. (2003). Oxidative stress, exercise, and antioxidant supplementation. Toxicology 189, 41-54 DOI ScienceOn |
28 | Mastaloudis, A., Yu, T.W., O'Donnell, R.P., Frei, B., Dashwood, R.H., and Traber, M.G. (2004). Endurance exercise results in DNA damage as detected by the comet assay. Free Radic. Biol. Med. PS, 966-975 DOI ScienceOn |
29 | Stanger, O., Renner, W., Khoschsorur, G., Rigler, B., and Wascher, T.C. (2001). NADH/NADPH oxidase p22 phox C242T polymorphism and lipid peroxidation in coronary artery disease. Clin. Physiol. 21, 718-722 DOI ScienceOn |
30 | Singh, N.P., McCoy, M.T., Tice, R.R., and Schneider, E.L. (1988). A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 175, 184-191 DOI ScienceOn |
![]() |