• Journal of The Korean Society of Inherited Metabolic disease
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• v.5 no.1
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• pp.9-17
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• 2005

Homocystinuria is a metabolic disorder caused by a deficiency of cystathionine ${\beta}$-synthase (CBS). Patients with homocystinuria show clinical symptoms such as mental retardation, lens dislocation, vascular disease with life-threatening thromboembolisms and skeletal deformities. Generally, the major treatments for CBS deficiency include pharmacologic doses of pyridoxine or dietary restriction of methionine. However, there is no effective treatment for this disease up till today and gene therapy can be an attractive novel approach to treatment of the disease. We investigated whether a recombinant adeno-associated virus could be used as a CBS gene transfer vector to reduce the excessive homocysteine level in the homocystinuria mouse model. Recombinant adeno-associated virus vector encoding the human CBS gene (rAAV-hCBS), driven by EF1-a promoter, was infused into CBS-deficient mice ($CBS^{-/-}$) via intramuscular (IM) and intraperitoneal (IP) injection. IP injection was more efficient than IM injection for prolongation of lives and reduction of plasma homocysteine levels. After 2 weeks of gene transfer by IP injection, serum homocysteine level was significantly decreased in treated mice compared with the age-matched controls and the life span was extended about 1.5 times. Also, increased expression of CBS gene was observed by immunohistochemical staining in livers of treated $CBS^{-/-}$ mice and microvesicular lipid droplets was decreased in cytoplasm of liver. These results demonstrate the possibility and efficacy of gene therapy by AAV gene transfer in homocystinuria mice.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.36 no.6
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• pp.381-389
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• 2023

One of the crucial components in building information modeling (BIM) is data. To systematically manage these data, various research studies have focused on the creation of object breakdown structures and property sets. Specifically, crucial data for managing programs and payments involves work breakdown structures (WBSs) and cost breakdown structures (CBSs), which are indispensable for mapping BIM objects. Achieving this requires disassembling CBS quantities based on 3D objects and WBS. However, this task is highly tedious owing to the large volume of CBS and divergent coding practices employed by different organizations. Manual processes, such as those based on Excel, become nearly impossible for such extensive tasks. In response to the challenge of computing quantities that are difficult to derive from BIM objects, this study presents methods for disassembling length-based quantities, incorporating significant portions of the bill of quantities (BOQs). The proposed approach recommends suitable CBS by leveraging the accumulated history of WBS-CBS mapping databases. Additionally, it establishes a unified CBS code, facilitating the effective operation of CBS databases.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.6
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• pp.2851-2858
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• 2011

The schedule management in construction project have been performed independently by two method, WBS base management and CBS based management, However, the integrated management model is needed according to efficiency of construction project management and introduction of new EVMS system of KOREA government. For this purpose, interworking database system is designed through efficient modeling of WBS based management data and CBS based management data and relation establishment between entities in this paper. WBS based management DB consists of 4 entities and CBS based management DB consists of 3 entity and one of the 4 WBS DB entities is used to play interworking role between WBS and CBS, Also, attributes of all entities are well defined so that data consistency, integrity and newest are guaranteed. The designed interworking database model was realized using Nex-Pert Pro and the efficiency of data interworking was proved.

• Journal of Astronomy and Space Sciences
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• v.20 no.4
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• pp.339-350
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• 2003

Engineering qualification model payload for a communications and broadcasting satellite(CBS) was developed by ETRI from May, 2000 to April, 2003. For. the purpose of functional test and verification of the payload, a real-time hardware-in-the-loop(HITL) CBS simulator(CBSSIM) was also developed. We assumed that the spacecraft platform for the CBSSIM is a geostationary communication satellite using momentum bias three-axis stabilization control technique based on Koreasat. The payload hardware is combined with CBSSIM via Power, Command and Telemetry System(PCTS) of Electrical Ground Support Equipment(EGSE). CBSSIM is connected with PCTS by TCP/IP and the payload is combined with PCTS by MIL-STD-1553B protocol and DC harness. This simulator runs under the PC-based simulation environment with Windows 2000 operating system. The satellite commands from the operators are transferred to the payload or bus subsystem models through the real-time process block in the simulator. Design requirements of the CBSSIM are to operate in real-time and generate telemetry. CBSSIM provides various graphic monitoring interfaces and control functions and supports both pre-launch and after-launch of a communication satellite system. In this paper, the HITL simulator system including CBSSIM, communications payload and PCTS as the medium of interface between CBSSIM and communications payload will be described in aspects of the system architecture, spacecraft models, and simulator operation environment.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.31 no.10
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• pp.97-104
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• 2003

This paper addresses EMC test results for the EQM Communications & Broadcasting Satellite(CBS) Ka-band Payload System. The aim of the EMC test is to verify that the payload system has no effect on the other system and is not affected by the external field. The compliance of EMC system requirements was verified by the analysis and measurement of the emission level from the payload system. The variation of performance by noise injection was measured to inspect the susceptibility of the payload system. The analysis and test results also showed that the electromagnetic interference has no serious effect on the overall payload system performance. It is confirmed that the EQM CBS Ka-band payload system can be operable in the space environment from the EMC performance's viewpoint. It is also obtained that better performance can be acquired by improving waveguide design and integration method.

• Proceedings of the Korean Institute Of Construction Engineering and Management
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• autumn
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• pp.401-404
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• 2002

To manage a construction project efficiently, it is essential to ensure the practical usage in construction management. The purpose of this study is to develop a practical model, which will increase the efficiency of management. The followings are the method of this study: (1) Establishing a breakdown structure based on integration of CBS and WBS which is well acquainted (2) Developing and systemizing managerial standards and processes on such activities as calculating and marking progress rates & schedule, summarizing cost by activities level, making out project analysis reports. This study shall contribute to raising the efficiency in construction management after being verified in a pilot project and being developed into construction management system.

• The Journal of the Korea Contents Association
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• v.21 no.8
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• pp.356-366
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• 2021

The high-tech industry, a leader in the national economy, has a larger investment cost compared to general buildings, a shorter construction period, and requires continuous investment. Therefore, accurate construction cost prediction and quick decision-making are important factors for efficient cost and process management. Overseas, the construction information classification system has been standardized since 1980 and has been continuously developed, improving construction productivity by systematically collecting and utilizing project life cycle information. At domestic construction sites, attempts have been made to standardize the classification system of construction information, but it is difficult to achieve continuous standardization and systematization due to the absence of a standardization body and differences in cost and process management methods for each construction company. Particular, in the case of the high-tech industry, the standardization and systematization level of the construction information classification system for high-tech facility construction is very low due to problems such as large scale, numerous types of work, complex construction and security. Therefore, the purpose of this study is to construct a construction information classification system suitable for high-tech facility construction through collection, classification, and analysis of related project data constructed in Korea. Based on the WBS (Work Breakdown Structure) and CBS (Cost Breakdown Structure) classified and analyzed through this study, a code system through hierarchical classification was proposed, and the cost model of buildings by linking WBS and CBS was three-dimensionalized and the utilized method was presented. Through this, an information classification system based on inter-relationships can be developed beyond the one-way tree structure, which is a general construction information classification system, and effects such as shortening of construction period and cost reduction will be maximized.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.40 no.6
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• pp.587-593
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• 2016

Reliability-based design optimization (RBDO) requires a high computational cost owing to its reliability analysis. A surrogate model is introduced to reduce the computational cost in RBDO. The accuracy of the reliability depends on the accuracy of the surrogate model of constraint boundaries in the surrogated-model-based RBDO. In earlier researches, constraint boundary sampling (CBS) was proposed to approximate accurately the boundaries of constraints by locating sample points on the boundaries of constraints. However, because CBS uses sample points on all constraint boundaries, it creates superfluous sample points. In this paper, efficient constraint boundary sampling (ECBS) is proposed to enhance the efficiency of CBS. ECBS uses the statistical information of a kriging surrogate model to locate sample points on or near the RBDO solution. The efficiency of ECBS is verified by mathematical examples.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.29 no.3 s.234
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• pp.387-394
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• 2005

Accurate predictions and simulations of the behavior of space structures based on analytical models become more important. In order to perform analysis to support the design of Ku-band transponder panel for the Communications and Broadcasting Satellite(CBS), mathematical models of the panel were generated in the form of finite element models. Test verification of these models is required before the transponder panel can be certified for launch environments. A modal identification was performed to obtain modal parameters which can be compared with the test results using correlation techniques. This paper approaches the sensor placement from the standpoint of the structural dynamicist who uses the modal parameter obtained during launch environmental test. The models were validated by performing a test-analysis correlation and updating analysis. It was proved that the Ku-band transponder panel satisfies the environmental test requirements.

• Proceedings of the Korea Information Processing Society Conference
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• 2004.11a
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• pp.353-356
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• 2004

일반적으로 컴포넌트 기반의 SW는 바이너리 파일로 구성되어 있다. 즉, 블랙박스 형식이다. 따라서 컴포넌트 테스팅 시에 코드기반의 화이트박스 테스트 기법을 적용하기가 어렵다. 그래서 컴포넌트 테스팅 시에는 소스코드기반이 아닌 명세기반의 테스트를 수행해야 한다. 그러나 컴포넌트 제공자는 고객에게 바이너리 파일과 일부분의 명세만을 제공한다 즉, 컴포넌트 제공자는 컴포넌트 안에서의 테스트 범주와 테스트 메트릭에 대한 정보를 제공하지 않는다. 이에 따라 고객은 컴포넌트의 테스트 적절성, 테스트 커버리지, 그리고 테스트 품질을 이해하는 것이 어렵다. 그리고 효과적인 테스팅을 위해서는 적절한 테스팅 모델이 있어야 한다. 따라서 본 논문에서는 컴포넌트 테스팅을 효율적으로 하기 위하여 컴포넌트 테스팅 모델을 제안하였고, 테스팅을 위한 명세 요소를 식별하였다.