• Tuberculosis and Respiratory Diseases
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• v.50 no.1
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• pp.52-66
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• 2001

Background : NF-${\kappa}B$ is the most important transcriptional factor in IL-8 gene expression. Triptolide is a new compound that recently has been shown to inhibit NF-${\kappa}B$ activation. The purpose of this study is to investigate how triptolide inhibits NF-${\kappa}B$-dependent IL-8 gene transcription in lung epithelial cells and to pilot the potential for the clinical application of triptolide in inflammatory lung diseases. Methods : A549 cells were used and triptolide was provided from Pharmagenesis Company (Palo Alto, CA). In order to examine NF-${\kappa}B$-dependent IL-8 transcriptional activity, we established stable A549 IL-8-NF-${\kappa}B$-luc. cells and performed luciferase assays. IL-8 gene expression was measured by RT-PCR and ELISA. A Western blot was done for the study of $I{\kappa}B{\alpha}$ degradation and an electromobility shift assay was done to analyze NF-${\kappa}B$ DNA binding. p65 specific transactivation was analyzed by a cotransfection study using a Gal4-p65 fusion protein expression system. To investigate the involvement of transcriptional coactivators, we perfomed a transfection study with CBP and SRC-1 expression vectors. Results : We observed that triptolide significantly suppresses NF-${\kappa}B$-dependent IL-8 transcriptional activity induced by IL-$1{\beta}$ and PMA. RT-PCR showed that triptolide represses both IL-$1{\beta}$ and PMA-induced IL-8 mRNA expression and ELISA confirmed this triptolide-mediated IL-8 suppression at the protein level. However, triptolide did not affect $I{\kappa}B{\alpha}$ degradation and NF-$_{\kappa}B$ DNA binding. In a p65-specific transactivation study, triptolide significantly suppressed Gal4-p65T Al and Gal4-p65T A2 activity suggesting that triptolide inhibits NF-${\kappa}B$ activation by inhibiting p65 transactivation. However, this triptolide-mediated inhibition of p65 transactivation was not rescued by the overexpression of CBP or SRC-1, thereby excluding the role of transcriptional coactivators. Conclusions : Triptolide is a new compound that inhibits NF-${\kappa}B$-dependent IL-8 transcriptional activation by inhibiting p65 transactivation, but not by an $I{\kappa}B{\alpha}$-dependent mechanism. This suggests that triptolide may have a therapeutic potential for inflammatory lung diseases.

• Bulletin of the Korean Chemical Society
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• v.32 no.3
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• pp.841-846
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• 2011

New green host materials, 9-phenyl-3-(4-(1-phenyl-1H-benzo[d] imidazol-2-yl)phenyl)-9H-carbazole (3a) and 9-(naphthyl-2-yl)-3-(4-(1-phenyl-1H-benzo[d]imidazol-2-yl)phenyl)-9H-carbazole (3b), have been designed and synthesized by attaching the electron transporting benzimidazole moiety to the hole transporting carbazole unit. These compounds have similar HOMO, LUMO levels and band-gap characteristics compared with CBP (4,4'-di(N-carbazolyl)biphenyl). The fabricated green phosphorescent OLED with this 3a host shows much better device performances compared to CBP-based one. The current and power efficiency is enhanced at least by 60 percent at a given constant luminance of 1000 cd/$m^2$.

• Journal of Broadcast Engineering
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• v.15 no.5
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• pp.653-664
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• 2010

Generally existing video codec employs entropy coding to deal with residual signals with considering temporal and spatial properties. Scalable Video Coding(SVC) which is extension of H.264/AVC has three technical concepts for removing redundancies between inter-layers. In spite of using novel prediction method between inter-layers in SVC, it is still using same entropy coding method to residual signals. According to the studies, the residual obtained by inter-layer prediction technique has different features of residual signal acquired by spatial or temporal prediction technique. In this paper, we propose an efficient entropy coding method which codes the residual signal obtained by inter-layer prediction with regarding its features adequately. We re-designed the Coded Block Pattern(CBP) table suitably for inter-layer texture prediction. The experiments show that the proposed method can further reduce the BD-Bitrate up to average 2.20% in 4CIF and 1.14% in CIF resolution compared to the existing JSVM 9.18.

• Microbiology and Biotechnology Letters
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• v.22 no.1
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• pp.37-44
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• 1994

The homology among the genes coding for degradation of bipheny(BP) and 4-chlorobiphenyl(4CB) was comparatively analyzed by Southern hybridization in several BP/4CB degrading bacterial strains. As the hybridization results of their genomic DNAs with pcbABCD as the DNA probe, the group of Pseudomonas sp. DJ-12. P08 and P27 strain was separated by the group of P20 and P1242 strains. The P. pseudoalcaligenes KF707 showed the hybidization signal which was homologous to the group of DJ-12, but they had different restriction endonuclease sites. The pcbAB genes in pCUl recombinant plasmid from Pseudomonas sp. DJ-12 appeared to be homologous to pchAB genes in pKTF20 cloned from P. pseudoalcaligenes KF707, but the C genes in both strains were not homologous. The bphABC in pKTF20 showed the signals homologous to the cbp ACB in pAW6194 cloned from P. putida OU83, but homologous signal was not found botween the pcbABCD genes in pCUl and the cbpADCB genes in pAW6194 recombbinant plasmid.

• International Commerce and Information Review
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• v.10 no.4
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• pp.395-416
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• 2008

The advance information for oceangoing cargoes destined to th United States enable CBP to evaluate the potential risk of smuggling WMD and to facilitate the prompt release of legitimate cargo following its arrival in the Unites States. On January 1, 2008, CBP promulgate regulations, also known as 10+2 rule, to require the electronic transmission of additional data elements for improved high-risk targeting, including appropriate security elements of entry data for cargo destined to the United States by vessel prior to loading of such cargo on vessels at foreign seaports. The potential impact to an importer's international supply chain will be as follows ; Firstly, importers will take incremental supply chain costs and filing costs. Secondly, anticipate delay in shipment of containerized cargo. Thirdly, importers could be charged fines if they fail to file and file inaccurate or missing data. Companies exporting to the United States should be interested in 10+2 rule, analyze their current processes and procedures to ensure that they are prepared to handle the additional filing requirements of 10+2 rule. And they should focus on how 10+2 impacts their supply chain in terms of costs and sourcing. They will be necessary to revise service legal agreements with their forwarders, customs brokers or carriers in order to meet filing requirements of 10+2 rule.

• Journal of the Korean Applied Science and Technology
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• v.32 no.1
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• pp.1-6
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• 2015

We investigated green phosphorescent organic light-emitting diodes with stepwise doping to improve efficiency roll-off and operational lifetime by efficient distribution of triplet excitons. The host material which was 4,4,N,N'-dicarbazolebiphenyl (CBP) of bipolar characteristic that can control the carrier in emitting layer (EML). When the EML devided into four parts with different doping concentration, each devices shows various efficiency roll-off and lifetime enhancement. The distribution of the carrier and excitons in the EML can be confirmed by using stepwise doping structure. The properties of device C exhibited luminous efficiency of 51.10 cd/A, external quantum efficiency of 14.88%, respectively. Lifetime has increased 73.70% compared to the reference device.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.47 no.3
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• pp.32-43
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• 2010

This paper presents deblocking filter for low-complexity video decoder. Baseline profile of the H.264/AVC used for mobile devices such as mobile phones has two times higher compression performance than the MPEG-4 Visual but it has a problem of serious complexity as using 1/4-pel interpolation filter, adaptive entropy model and deblocking filter. This paper presents low-complexity deblocking filter for decreasing complexity of decoder with preserving the coding efficiency of the H.264/AVC. In this paper, the proposed low-complexity deblocking filter decreased 49% of branch instruction than conventional approach as calculating value of BS by using the CBP. In addition, a range of filtering of strong filter applied in intra macroblock boundaries was limited to two pixels. According to the experimental results, the proposed low-complexity deblocking filter decreased -0.02% of the BDBitrate comparison with baseline profile of the H.264/AVC, decreased 42% of the complexity of deblocking filter, and decreased 8.96% of the complexity of decoder.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.42 no.1
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• pp.1-7
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• 2005

We propose an effective Landsat TM image compression method using the classified bidirectional prediction (CBP), the classified KLT and the SPIHT. The SPIHT is used to exploit the spatial redundancy of feature bands selected in the visible range and the infrared range separately. Regions of the prediction bands are classified into three classes in the wavelet domain, and then the CBP is performed to exploit the spectral redundancy. Residual bands that consist of difference values between the original band and the predicted band are decorrelated by the spectral KLT Finally, the three dimensional (3-D) SPIHT is used to encode the decorrelated coefficients. Experiment results show that the proposed method reconstructs higher quality Landsat TM image than conventional methods at the same bit rate.

• Environmental and Resource Economics Review
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• v.30 no.1
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• pp.107-128
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• 2021

It has been recognized that implementing the marginal price mechanism to CBP is not acceptable due to the lack of revenue of the marginal generators. This study shows that it is not the problem of marginal price mechanism but the structural problems originated by the suspension of restructuring, the technical limits of RSC program and inaccuracy of the generation cost estimation method. This study explains the method to calculate the cost function in operating modes of the CC generators and proposes the modeling for the CC generators in RSC program. To implementing the cost function in operating modes could give an opportunity to change the price setting mechanism from average to marginal cost. The price setting mechanism based on the marginal cost will be one of the main points to provide the right price signals and to introduce a real-time and A/S markets to prepare the energy transition era.

• Korean Journal of Food Science and Technology
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• v.20 no.1
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• pp.95-99
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• 1988

The changes of texture, composition of cell wall polysaccharides, polygalacturonase (PG) activity and soaking effect during preserving of persimmon at various tempoeratures were estimated for the purpose of investigating the softening characteristics of persimmon fruit. The softening of persimmon was most promoted at $25^{\circ}C$, where in the higher temperature, at $45^{\circ}C$ it was inhibited. During softening adhesiveness increased, cohesiveness and gumminess decreased. This phenomenon was obvious at $25^{\circ}C$. By soaking in water at $50^{\circ}C,\;70^{\circ}C$ for 30 minutes PG activity and softening was inhibited. Ionically associated pectin (IAP) and covalently bounded pectin (CBP) fractionated from crude cell wall of fresh persimmon were respectively degraded about 60% by PG curde enzyme of softened persimmon. And the degraded ratio of polysaccharides composed of pentose and hexose was very similar to that of polyuronide.