• Journal of Biomedical Engineering Research
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• v.19 no.2
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• pp.113-118
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• 1998

By their rapid and periodic actions, the cilia of the human respiratory tract play an important role in clearing inhaled noxious particles. Based on the automated image-processing technique, we studied the method analyzing ciliary beat frequency (CBF) objectively and quantitatively. Microscopic ciliary images were transformed into digitized gray ones through an image-grabber, and from these we extracted signals for CBF. By means of a FFT, maximum peak frequencies were detected as CBFs in each partitioned block for the entire digitized field. With these CBFs, we composed distribution maps visually showing the spatial distribution of CBFs. Through distribution maps of CBF, the whole aspects of CBF changes for cells and the difference of CBF of neighboring cells can be easily measured and detected. Histogram statistics calculated from the user-defined polygonal window can show the local dominant frequency presumed to be the CBF of a cell or a crust the region includes.

• Proceedings of the Korean Information Science Society Conference
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• 2002.04b
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• pp.184-186
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• 2002

기존의 색인 기법들은 차원의 수가 증가할수록 검색 성능이 급격히 저하되는 문제를 지니고 있다. 이문제를 극복하기 위하여 CBF 기법이 제안되었다. 그러나 CBF 기법은 데이터 양이 증가함에 따라 검색 성능이 선형적으로 감소하는 문제가 존재한다. 이를 해결하기 위해 다수의 디스크를 수평 분할 방법을 이용하여 디클러스터링(declustering)을 하는 병렬 CBF 기법이 제안되었다. 본 논문에서는 수평 분할 방법을 이용한 병렬 CBF (Parallel CBF) 기법을 삽입시간, 범위 질의 검색시간, k-최근접 질의 검색시간, 데이터의 편중도 측면에서 성능 평가를 수행한다. 아울러, 병렬 CBF 기법을 기존 CBF 기법과 성능 비교를 수행하며, 이를 통해 병렬 CBF 기법이 기존 CBF 기법보다 우수한 검색 성능을 나타냄을 보인다.

• Proceedings of the Korean Information Science Society Conference
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• 2002.10c
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• pp.250-252
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• 2002

기존의 색인 기법들은 차원의 수가 증가할수록 검색 성능이 급격히 저하되는 문제를 지니고 있으며. 이를 극복하기 위하여 CBF 기법이 제안되었다. 그러나 CBF 기법은 데이터 양이 증가함에 따라 검색성능이 선형적으로 감소하는 문제가 존재한다. 이를 해결하기 위해 다수의 디스크를 수령 분할 방법을 이용하여 디클러스터링(declustering)을 하는 병렬 CBF 기법이 제안되었다. 본 논문에서는 병렬 CBF기법을 여러 대의 리눅스 컴퓨터를 이용한 클러스터 시스템 환경 하에서 구현하고, 삽입시간, 범위 질의 검색시간, k-최근접 질의 검색시간 측면에서 성능 평가를 수행한다. 아울러, 클러스터 시스템 환경 하에서의 병렬 CBF 기법을 기존 CBF 기법과 성능 비교를 수행하며, 이를 통해 병렬 CBF 기법이 기존 CBF 기법보다 우수한 검색 성능을 나타냄을 보인다.

• Proceedings of the Korean Information Science Society Conference
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• 2001.10a
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• pp.70-72
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• 2001

기존의 CBF 기법은 데이타의 차원이 증가함에 따라 검색 성능이 급격히 저하되는 ‘Dimensional Curse’문제를 해결하기 위해 제안되었다. 그러나, 데이타의 양이 증가하고 차원이 증가할수록 검색 성능이 선형적인 감소를 보인다. 따라서, 본 논문에서는 CBF 기법의 성능 향상을 위해 멀티 디스크 환경을 기반으로 하는 병렬 CBF 기법을 제안한다. 제안하는 병렬 CBF 기법은 멀티 디스크 환경하에서 CBF가 지니는 특성을 이용하여 시그니쳐와 특징 벡터 데이타의 수평 분할 방법을 사용한다. 이를 통해, 제안하는 기법은 디스크 개수에 비례하여 선형적인 검색성능 향상을 가져온다.

• Korean Journal of Radiology
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• v.20 no.6
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• pp.985-996
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• 2019

Objective: To determine the correlation between cerebral blood flow (CBF) on arterial spin labeling (ASL) MRI and the degree of postoperative revascularization assessed on digital subtraction angiography in children with moyamoya disease (MMD). Materials and Methods: Twenty-one children (9 boys and 12 girls; mean age, 8.4 ± 3.6 years; age range, 3-16 years) with MMD who underwent both pseudocontinuous ASL MRI at 1.5T and catheter angiography before and after superficial temporal artery encephaloduroarteriosynangiosis were included in this retrospective study. The degree of revascularization in the middle cerebral artery (MCA) territory was evaluated on external carotid angiography and was graded on a 3-point scale. On ASL CBF maps, regions of interest were manually drawn over the MCA territory of the operated side at the level of the centrum semi-ovale and over the cerebellum. The normalized CBF (nCBF) was calculated by dividing the CBF of the MCA territory by the CBF of the cerebellum. Changes in nCBFs were calculated by subtracting the preoperative nCBF values from the postoperative nCBF values. The correlation between nCBF changes measured with ASL and the revascularization grade from direct angiography was evaluated. Results: The nCBF value on the operated side increased after the operation (p = 0.001). The higher the degree of revascularization, the greater the nCBF change was: poor revascularization (grade 1), -0.043 ± 0.212; fair revascularization (grade 2), 0.345 ± 0.176; good revascularization (grade 3), 0.453 ± 0.182 (p = 0.005, Jockheere-Terpstra test). The interobserver agreement was excellent for the measured CBF values of the three readers (0.91-0.97). Conclusion: The nCBF values of the MCA territory obtained from ASL MRI increased after the revascularization procedure in children with MMD, and the degree of nCBF change showed a significant correlation with the degree of collateral formation evaluated via catheter angiography.

• Biomedical Science Letters
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• v.11 no.2
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• pp.129-134
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• 2005

Three different deconvolution techniques for quantifying cerebral blood flow (CBF) from whole brain $T2^{\ast}-weighted$ bolus tracking images were implemented (parametric Fourier transform P-FT, parametric single value decomposition P-SVD and nonparametric single value decomposition NP-SVD). The techniques were tested on 206 regions from 38 hyperacute stroke patients. In the P-FT and P-SVD techniques, the tissue and arterial concentration time curves were fit to a gamma variate function and the resulting CBF values correlated very well $(CBF_{P-FT}\;=\;1.02{\cdot}CBF_{p-SVD},\;r^2\;=\;0.96)$. The NP-SVD CBF values correlated well with the P-FT CBF values only when a sufficient number of time series volumes were acquired to minimize tracer time curve truncation $(CBF_{P-FT}\;=\;0.92{\cdot}CBF_{NP-SVD},\;r^2\;=\;0.88)$. The correlation between the fitted CBV and the unfitted CBV values was also maximized in regions with minimal tracer time curve truncation $(CBV_{fit}\;=\;1.00{\cdot}CBV_{ Unfit},\;^r^2\;=\;0.89)$. When a sufficient number of time series volumes could not be acquired (due to scanner limitations) to avoid tracer time curve truncation, the P-FT and P-SVD techniques gave more reliable estimates of CBF than the NP-SVD technique.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.11
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• pp.154-160
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• 1997

By their rapid and periodic actions, the cilia of the human respiratory tract play an important role in clearing inhaled noxious particles. Based on the automated image-processing technique, we studied ciliary beat frequency (CBF) objectively and quantitatively. Microscopic ciliary images were transformed into digitized gray ones through an image-grabber, and from these we extracted signals or CBF. By means of a FFT, maximum peak frequencies were detected as CBFs in each partitioned block or the entire digitized field. With these CBFs, we composed distribution maps visualiy showing the spatial distribution of CBFs. Through distribution maps of CBF, the whole aspects of CBF changes or cells and the difference of CBF of neighboring cells can be easily measured and detected. Histogram statistics calculated from the user-defined polygonal window can show the local dominant frequency presumed to be the CBF of a cell or a crust the region includes.

• Journal of Acupuncture Research
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• v.28 no.4
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• pp.19-35
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• 2011

Objectives : This study was designed to investigate the effects of acupuncturing $PC_8$ used perpendicular needling method determine the mechanism of action of acupuncturing $PC_8$ by measuring the changes of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal rats. Methods : This study also investigated the effects of acupuncturing $PC_8$ on the change of rCBF in cerebral ischemic rats, and revealed the mechanism of its action. In addition, the effects of acupuncturing $PC_8$ on focal ischemic brain injury was studied in cerebral ischemic rats. Results : 1. Acupuncturing $PC_8$ significantly increase rCBF but decreased MABP in normal rats. 2. Acupuncturing $PC_8$ increased of rCBF was significantly inhibited by pretreatment with indomethacin (1mg/kg, i.p.), an inhibitor of cyclooxygenase in normal rats. 3. Acupuncturing $PC_8$ increased of rCBF was significantly inhibited by pretreatment methylene blue (10 ${\mu}g$/kg, i.p.), an inhibitor of guanylate cyclase in normal rats. 4. Acupuncturing $PC_8$ was significantly improved the rCBF than control group increased unstable in cerebral ischemic rats. 5. Acupuncturing $PC_8$ was not significantly improved the rCBF than control group by pretreatment with indomethacin (1mg/kg, i.p.), an inhibitor of cyclooxygenase in cerebral ischemic rats. 6. Acupuncturing $PC_8$ was significantly increased the rCBF than control group by pretreatment methylene blue ($10{\mu}g$/kg, i.p.), an inhibitor of guanylate cyclase in cerebral ischemic rats. Conclusions : In conclusion, our study suggested that acupuncturing $PC_8$ can increase rCBF in normal state, and improve stability of rCBF in ischemic state. In addition, we suggested that mechanisms related with acupuncturing $PC_8$ was involved in the guanylate cyclase pathway.

• The KIPS Transactions:PartD
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• v.10D no.3
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• pp.459-470
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• 2003

It is required to research on high-dimensional index structures for efficiently retrieving high-dimensional data because an attribute vector in data warehousing and a feature vector in multimedia database have a characteristic of high-dimensional data. For this, many high-dimensional index structures have been proposed, but they have so called ‘dimensional curse’ problem that retrieval performance is extremely decreased as the dimensionality is increased. To solve the problem, the cell-based filtering (CBF) scheme has been proposed. But the CBF scheme show a linear decreasing on performance as the dimensionality. To cope with the problem, it is necessary to make use of parallel processing techniques. In this paper, we propose a parallel CBF scheme which uses a horizontally-partitioned technique as declustering. In order to maximize the retrieval performance of the proposed parallel CBF scheme, we construct our parallel CBF scheme under a SN (Shared Nothing) cluster architecture. In addition, we present a data insertion algorithm, a rage query processing one, and a k-NN query processing one which are suitable for the SN cluster architecture. Finally, we show that our parallel CBF scheme achieves better retrieval performance in proportion to the number of servers in the SN cluster architecture, compared with the conventional CBF scheme.

• Herbal Formula Science
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• v.10 no.1
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• pp.105-112
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• 2002

Yongyanggaktang has been used in oriental medicine as a therapeutic agent for cerebral disease and eclampsia for many years. The purpose of this study was to determine the effect of Yongyanggaktang and its exception of Cornu Saigae Tataricae(羚羊角) in YYG about regional cerebral blood flow(rCBF) in rats. 1. rCBF was increased by Yongyanggaktang in dose dependently. 2. rCBF was increased by exception of Cornu Saigae Tataricae(羚羊角) in YYG at high dosages. 3. rCBF was decreased by Yongyanggaktang pretreated propranolol. 4. L-NNA did not affect rCBF. 5.ODQ did not affect rCBF. Above the results. Yongyanggaktang relates to the symphathetic action.