• The Korean Journal of Physiology and Pharmacology
• /
• 제20권3호
• /
• pp.253-259
• /
• 2016

Previously, we found that KTH-13 isolated from the butanol fraction of Cordyceps bassiana (Cb-BF) displayed anti-cancer activity. To improve its antiproliferative activity and production yield, we employed a total synthetic approach and derivatized KTH-13 to obtain chemical analogs. In this study, one KTH-13 derivative, 4-(tert-butyl)-2,6-bis(1-phenylethyl)phenol (KTH-13-t-Bu), was selected to test its anti-cancer activity. KTH-13-t-Bu diminished the proliferation of C6 glioma, MDA-MB-231, LoVo, and HCT-15 cells. KTH-13-t-Bu induced morphological changes in C6 glioma cells in a dose-dependent manner. KTH-13-t-Bu also increased the level of early apoptotic cells stained with annexin V-FITC. Furthermore, KTH-13-t-Bu increased the levels of cleaved caspase-3 and -9. In contrast, KTH-13-t-Bu upregulated the levels of pro- and cleaved forms of caspase-3, -8, and -9 and Bcl- 2. Phospho-STAT3, phospho-Src, and phospho-AKT levels were also diminished by KTH13-t-Bu treatment. Therefore, these results strongly suggest that KTH-13-t-Bu can be considered a novel anti-cancer drug displaying pro-apoptotic activity.

• 한국해양공학회지
• /
• 제20권4호
• /
• pp.76-82
• /
• 2006

The large-eddy simulation(LES) technique, based an a message passing interface method(MPI), was applied to investigate the turbulent flaw phenomena around a ship. The Smagorinski model was used in the present LES simulation to simulate the turbulent flaw around a ship. The SPMD(sidsngle program multiple data) technique was used for parallelization of the program using MPI. All computations were performed an a 24-node PC cluster parallel machine, composed of 2.6 GHz CPU, which had been installed in the Advanced Ship Engineering Research Center(ASERC). Numerical simulations were performed for the Wigley hull, and the Series 60 hull(CB=0.6) using 1/4-, 1/2-, 1- and 2-million grid systems and the computational results had been compared to the experimental ones.

• 정보처리학회논문지:소프트웨어 및 데이터공학
• /
• 제9권12호
• /
• pp.431-438
• /
• 2020

본 논문에서는 입술 윤곽선을 검출하기 위한 다중 문턱치 기반의 검출방법을 제안하였다. 기존의 연구 중 Spyridonos 등이 제안한 방법은 입력영상을 RGB로부터 YIQ 좌표계로 변환하여 Q 성분만을 이용하여 Q 영상을 얻는다. Q 영상으로부터 변화 점 검출을 통하여 입술 모양의 좌우 끝점을 얻어낸다. 좌우 끝점에 대한 수직 좌표의 평균값을 이용하여 Q 영상을 상하로 분리하고, 상하 영역 각각에 대하여 별도로 Q값을 대상으로 문턱치를 적용하여 후보 윤곽선을 추출한다. 추출된 후보 윤곽선에 특징치 거리를 이용하여 최적의 문턱치를 찾고, 해당하는 윤곽선을 최종 입술 윤곽선으로 결정한다. 이 때 사용되는 특징치 거리 D는 후보 윤곽선 상의 점들을 기준으로 주변 영역에 대한 차이의 절대값을 이용하여 계산한다. 기존연구의 문제점은 세 가지인데, 첫째는 입술 끝점 추출 과정에서 피부영역의 과다한 참여로 입술 끝점의 추출의 정확도가 감소하고, 따라서 후속되는 상/하 영역 분리에도 영향을 미친다. 둘째는 YIQ 칼라 좌표계를 사용하였는데, 다양한 칼라 좌표계에 대한 분석이 미비하므로 추가적인 분석이 필요하다. 세 째, 최적 윤곽선의 선택 시 적용하는 거리 값 파라미터의 계산 과정에서, 문턱치를 적용하여 구한 해당 윤곽선 주변의 데이터들에 의한 변화분을 계산하여 변화가 가장 큰 윤곽선을 입술 후보로 채택하는데, 변화분의 최대치를 기준으로 하기 때문에 검출된 입술영역이 기준보다 축소되는 문제점이 있다. 첫 번째 문제점을 해결하기 위하여 피부영역의 계산과정 참여를 줄여서 성능을 30%정도 향상시켰다. 두 번째는 YIQ 외에 HSV, CIELUV, YCrCb 등의 칼라 좌표계에 대한 성능테스트를 거쳐 기존연구 방법이 칼라좌표계에 대한 의존성이 없음을 확인하였다. 세 번째는 윤곽선 주변의 변화분 검토 시, 윤곽선 포인트 당 변화분의 평균값 대신에 변화분의 총량을 적용하여 46% 성능개선 효과를 얻었다. 이상의 내용을 모두 적용하여 제안한 통합방법은 기존연구 대비 2배의 성능향상과 안정성을 확보할 수 있었다.

• 한국학교보건학회지
• /
• 제29권2호
• /
• pp.63-70
• /
• 2016

Purpose: The purpose of this study was to find the factors influencing adolescents' adult media engagement. The study is based on Agnew's General Strain Theory (GST) and a micro-systemic perspective. Methods: The study examined 479 middle school freshmen who participated in the fourth wave of the Korean Children & Youth Panel Survey (KCYPS) conducted by National Youth Policy Institute. Data were analyzed through descriptive statistics, factor analysis, and reliability analysis using SPSS 22.0 Ver. Also, hypothesis testing was performed via covariance-based structure equation modeling (CB-SEM) using Amos 21.0 Ver. Results: Strain factors had positive effects on adolescent depression, and depression had a positive effect on adult media engagement. Also, cell-phone dependency had a positive mediation effect between depression and adult media engagement. Conclusion: The study's result identified the factors affecting adult media engagement. Therefore, we suggest intervention programs considering adolescents' strains, depression and cell-phone dependency to improve their health.

• International Journal of Ocean System Engineering
• /
• 제2권3호
• /
• pp.151-159
• /
• 2012

The characteristics of an impact load and pressure were experimentally investigated. Drop tests were carried out using a modified Wigley with CB = 0.56. The vertical force, pressures, and vertical accelerations were measured. A 6-component load cell was used to measure the forces, piezo-electric sensors were used to capture the impact pressure, and strain-gauge type accelerometers were used to measure the vertical accelerations. A 50-kHz sampling rate was applied to capture the peak values. The repeatability of the measured data was confirmed and the basic characteristics of the impact load and pressure such as the linearity to the falling height were observed for all of the measurements. A simple formula was derived to extract the physical impact load from the measured force based on a simple mass-sensor-mass diagram, which was validated by comparing impact forces with existing data using the mathematical model of Faltinsen and Chezhian (2005). The effects of the elasticity of the model and change in acceleration during the water entry were investigated. It is interesting to observe that the impact loads occurred and reached peak values at the same time duration after water entry for all drop heights.

• Journal of Electrical Engineering and Technology
• /
• 제10권5호
• /
• pp.2046-2051
• /
• 2015

Currently, most high-voltage gas circuit breakers (CBs) include asymmetrical geometries in the shield, the tank, the hot-gas exhaust, and the connection parts for bushings. For this reason, a 3-dimensional (3-D) analysis of the insulation capability is necessary, rather than a 2-D analysis. However, a 3-D analysis has difficulties due to the computational time and complex modeling. This paper presents a 3-D analysis considering the asymmetry in high-voltage gas CBs and a technique to reduce the calculation time. In the proposed technique, the arc plasma requiring the most computational time is first calculated by a 2-D analysis. Then, the results such as pressure, temperature, and velocity are input as a source for the 3-D analysis. This technique is applied to a 145kV self-blast-type CB and the analysis result exhibits good agreement with the experimental result.

• Toxicological Research
• /
• 제30권2호
• /
• pp.65-70
• /
• 2014

Recent episodes of severe air pollution in eastern Asia have been reported in the scientific literature and news media. Therefore, there is growing concern about the systemic effects of air pollution on human health. Along with the other well-known harmful effects of air pollution, recently, several animal models have provided strong evidence that air pollutants can induce liver toxicity and act to accelerate liver inflammation and steatosis. This review briefly describes examples where exposure to air pollutants was involved in liver toxicity, focusing on how particulate matter (PM) or carbon black (CB) may be translocated from lung to liver and what liver diseases are closely associated with these air pollutants.

• 사상체질의학회지
• /
• 제21권3호
• /
• pp.168-177
• /
• 2009

1. Objectives: The purpose of this case is to report the effects of Onbaek-won which is based on Sasang Constitutional Medicine for constipation in Soeumin. 2. Methods: We treated two Soeumin patients with Constipation. We prescribed Onbaek-won for their physical symptoms. The improvement of their diseases were checked from their stool and other physical symptoms. 3. Results: After the Sasang constitutional medication of Onbaek-won were given, constipation and their physical symptoms were improved. 4. Conclusions: This case study show an efficient result of using Onbaek-won in constipation of Soeumin. Onbaek-won was used instead of Semen Tiglii(巴豆).

• 동력기계공학회지
• /
• 제17권2호
• /
• pp.38-45
• /
• 2013

In this study, for carrying out the spray and combustion experiment using a Common Rail Direct Injection(CRDI) system, the controller was fabricated to drive a high speed camera, a injector and a laser beam sequentially at a low cost. CB280 module of one-chip micro processer was used for the controller. In order to confirm responsibility and utility of the controller, the current drive performance, the spray behavior and the injection rate were tested and analyzed under various experimental conditions. As this research results, we found that the fabricated controller was able to control the devices for the spray experiment precisely with the input value in program and it had the dynamic load responsibility and repetition. Also, we found that the injection rates of our experimental results were higher than those of others at the same injection pressure and the controller connected with the laser system and the data acquisition system had validity for carrying out the spray visualization experiment.

• BMB Reports
• /
• 제46권6호
• /
• pp.295-304
• /
• 2013

Extracellular acidification occurs not only in pathological conditions such as inflammation and brain ischemia, but also in normal physiological conditions such as synaptic transmission. Acid-sensing ion channels (ASICs) can detect a broad range of physiological pH changes during pathological and synaptic cellular activities. ASICs are voltage-independent, proton-gated cation channels widely expressed throughout the central and peripheral nervous system. Activation of ASICs is involved in pain perception, synaptic plasticity, learning and memory, fear, ischemic neuronal injury, seizure termination, neuronal degeneration, and mechanosensation. Therefore, ASICs emerge as potential therapeutic targets for manipulating pain and neurological diseases. The activity of these channels can be regulated by many factors such as lactate, $Zn^{2+}$, and Phe-Met-Arg-Phe amide (FMRFamide)-like neuropeptides by interacting with the channel's large extracellular loop. ASICs are also modulated by G protein-coupled receptors such as CB1 cannabinoid receptors and 5-$HT_2$. This review focuses on the physiological roles of ASICs and the molecular mechanisms by which these channels are regulated.