• Geomechanics and Engineering
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• 제35권1호
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• pp.13-27
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• 2023

The model production for large-scale (lateral length ≥ 2.0 m) capillary barrier (CB) model tests is time and cost-intensive. To address these limitations, the framework of a small-scale CB (SSCB) model test under the lateral no-flow condition has been established. In this study, to validate the experimental methodology of the SSCB model test, a series of seepage analyses on the SSCB model test and engineered slopes in the same and additional test conditions was performed. First, the seepage behavior and diversion length (L_D) of the CB system were investigated under three rainfall conditions. In the seepage analysis for the engineered slopes with different slope angles and sand layer thicknesses, the L_D increased with the increase in the slope angle and sand layer thickness, although the increase rate of the L_D with the sand layer thickness exhibited an upper limit. The L_D values from the seepage analysis agreed well with the results estimated from the laboratory SSCB mode test. Therefore, it can be concluded that the experimental methodology of the SSCB model test is one of the promising alternatives to efficiently evaluate the water-shielding performance of the CB system for an engineered slope.

• 생약학회지
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• 제46권3호
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• pp.229-233
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• 2015

The anti-nociceptive effect of an ethanol extract and its various solvent fractions from Curcuma longa Linne ethanol extract was studied using the writhing test in mice. Different fractions by various solvent extraction from Curcuma longa Linne ethanol extract were administered orally 1 hr or time-course (0.5, 1, 2 and 5 hr) before intraperitoneal injection of acetic acid. After treatment with 30% ethanol extract and n-butanol fraction, CB-1, at a dose of 250 mg/kg, the significant writhing responses were 87.5 ± 13.4 (inhibition rate 31%, p<0.01) and 75.1 ± 11.1 (inhibition rate 41%, p<0.01) lower than the control group. At the dose of CB-1 50 mg/kg and 250 mg/kg, CB-1 showed a similar activity comparing to diclofenac of 10 mg/kg. A time-course experiment was performed, which involved oral administration of CB-1 (250 mg/kg) at 0, 0.5, 1, 2, and 5 hr before acetic acid intraperitoneal injection. The most effective time of CB-1 was 30 min before treatment and persisting until 2 hr. This study showed that Curcuma longa Linne has anti-nociceptive properties comparable with those of diclofenac, which suggests promise for the treatment of intractable visceral pain in humans. Major components of the active fraction are identified as curcumin, cyclocurcumin and demethoxycurcumin.

• 컴퓨터교육학회논문지
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• 제16권3호
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• pp.49-60
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• 2013

본 연구는 블렌디드 이러닝이 대학의 강의실 위주의 수업에서 효과성을 향상시킬 수 있는지를 검증하고자 하였다. 먼저, 수업 사례를 분석하여 블렌디드 이러닝 운영방식으로 CbE(Class based E-learning)와 EbC(E-learning based Class) 방식을 도출하고, 수업구조로 Z형(Zigzag model)과 H형(Ladder model)을 정의하였다. 연구의 목적을 달성하기 위하여 A대학의 "엑셀실무" 과목에 CbE 방식의 H형 블렌디드 이러닝을 운영하였다. 집단은 사이버강의 학습참여비율의 50%이상인 집단(그룹 1)과 그렇지 않은 집단(그룹 2)으로 나누고, 자료의 분석은 $x^2$-검정, t -검정으로 학업 성취도를 비교하였다. 사이버강의 학습참여비율과 합격여부의 관계를 규명하기 위해 로지스틱 회귀분석을 실시하였다. 검정 결과, 그룹 1이 학업 성취도에서 통계적으로 유의하게 높게 나타났다. 로지스틱 회귀분석 결과에서 사이버강의 학습참여비율은 합격여부를 예측하는 유의미한 변인으로 규명됨에 따라, 블렌디드 이러닝의 효과성이 확증되었다. 연구 결과, H형 블렌디드 이러닝은 강의실 수업의 단점을 보완하여 학업 성취도와 학습 만족도를 향상시키고, 학습자가 블렌디드 이러닝 수업 방식에 대해 긍정적인 인식을 갖도록 한 것으로 나타났다. 끝으로 성공적으로 블렌디드 이러닝을 운영하기 위한 전략과 대학에서의 활성화 방안에 대해 제언하였다.

• Toxicological Research
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• 제17권
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• pp.293-297
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• 2001

The international pharmaceutical and regulatory communities had been recognizing the limited utility of conventional rodent carcinogenicity study particularly on the second species, mouse, after intense investigation of carcinogenicity data base worldwide, and a new scheme for carcinogenicity testing for pharmaceuticals was proposed at the Expert Working Group on Safety in the International Conference on Harmonization (ICH) in 1996. CB6F 1-Tg rasH2 mouse carrying human prototype c-Ha-ras gene with its own promoter/enhancer is one oj the new carcinogenicity assay model for human cancer risk assessment. Studies have been conducted since 1992 to validate the transgenic (Tg) mice for rapid carcinogenicity test-ing, short term (26 weeks) studies with genotoxic (by Salmonella), non-genotoxic carcinogens, genotoxic non-carcinogens, non-genotoxic non-carcinogens revealed relatively high concordance oj the response of the Tg mouse with classical bioassay across classes of carcinogenic agents. Mechanistic basis for carcinogensis in the model are being elucidated in terms of the role of overexpression and/or point mutation of the transgene. This report review the initial studies of validation of the model and preliminary results of on-going ILSI HESI ACT project will be presented.

• Asian-Australasian Journal of Animal Sciences
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• 제26권12호
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• pp.1708-1716
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• 2013

The objective of the trial was to study the relationship between the methane ($CH_4$) production and the Cornell Net Carbohydrate and Protein System (CNCPS) carbohydrate fractions of feeds for cattle and the suitability of CNCPS carbohydrate fractions as the dietary variables in modeling the $CH_4$ production in rumen fermentation. Forty-five rations for cattle with the concentrate/roughage ratios of 10:90, 20:80, 30:70, 40:60, and 50:50 were formulated as feed samples. The Menke and Steingass's gas test was used for the measurement of $CH_4$ production. The feed samples were incubated for 48 h and the $CH_4$ production was analyzed using gas chromatography. Statistical analysis indicated that the $CH_4$ production (mL) was closely correlated with the CNCPS carbohydrate fractions (g), i.e. CA (sugars); $CB_1$ (starch and pectin); $CB_2$ (available cell wall) in a multiple linear pattern: $CH_4=(89.16{\pm}14.93)$ $CA+(124.10{\pm}13.90)$ $CB_1+(30.58{\pm}11.72)$ $CB_2+(3.28{\pm}7.19)$, $R^2=0.81$, p<0.0001, n = 45. Validation of the model using 10 rations indicated that the $CH_4$ production of the rations for cattle could accurately be predicted based on the CNCPS carbohydrate fractions. The trial indicated that the CNCPS carbohydrate fractions CA, $CB_1$ and $CB_2$ were suitable dietary variables for predicting the $CH_4$ production in rumen fermentation in vitro.

• 대한조선학회지
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• 제27권3호
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• pp.31-37
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• 1990

선박의 방향안정성 등을 논할 때 필요하게 되는 선형조종미계수에 대해서는 이론적, 실험적으로 그 추정법이 제안되고 있다. 이중, 실험적 방법은 모형선에 규칙적인 강제동요를 시켜서 원하는 값들을 구하고 있으나, 한규칙 동요에 대해서 그 주파수에 대한 값만 나오므로 넓은 범위의 운동주파수에 걸쳐 미계수의 값들을 얻고자 할 때는 방대한 회수의 실험을 행해야 한다, 이러한 단점을 개선하기 위해 고안된 것이 본 논문에서 취급하는 Transient Maneuvering Method(TMM)로서, 기본원리는 모형에게 과도적 운동을 시켜 그로 인한 동유체력을 계측하고 이를 Fourier 변환하므로서 여러가지 주파수에 대한 미계수의 값을 얻게 되는 것이다. 종래의 이 분야 연구자들은 모형을 움직일 때 전동모터를 사용했으나 모터를 사용할 경우 원하는 과도 운동을 충분히 시킬 수 없으므로 본 논문에서는 유압 펌프를 사용하여 좋은 효과를 얻었다. 그 외에도 입력신호를 다소 개량하여 최종결과의 S/N비를 개선하는데 성공하였다. 실험에 사용한 모델은 Todd의 계열 60(Cb=0.7) 2M급이고, 이 결과를 종래의 PMM 시험결과와 비교하였다.

• Nuclear Engineering and Technology
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• 제35권6호
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• pp.529-536
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• 2003

The objective of this study is to investigate the reorientation of hydrides with applied stress intensity factor, the peak temperature and the time when to apply the stress intensity factor in a Zr-2.5Nb pressure tube during its thermal cycle treatment. Cantilever beam (CB) specimens with a notch of 0.5 mm in depth made from the Zr-2.5Nb tube were subjected to electrolytic hydrogen charging to contain 60 ppm H and then to a thermal cycle involving heating to the peak temperature of either 310 or $380^{\circ}C$, holding there for 50 h and then cooling to the test temperature of $250^{\circ}C$. The stress intensity factor of either 6.13 or $18.4\;MPa\sqrt{m}$ was applied at the beginning of the thermal cycle, at the end of the hold at the peak temperatures and after cooling to the test temperature, respectively. The reorientation of hydrides in the Zr-2.5Nb tube was enhanced with the increased peak temperature and applied stress intensity factor. Furthermore, when the CB specimens were subjected to $18.4\;MPa\sqrt{m}$ from the beginning of the thermal cycle, the reoriented hydrides occurred almost all over the Zr-2.5Nb tube, surprisingly suppressing the growth of a DHC crack. In contrast, when the CB specimens were subjected to the stress intensity factor at the test temperature, little reorientation of hydrides was observed except the notch region, leading the Zr-2.5Nb to grow a large DHC crack. Based on the correlation between the reorientation of hydrides and the DHC crack growth, a governing factor for DHC is discussed along with the feasibility of the Kim's DHC model.

• 대한수의학회지
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• 제44권3호
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• pp.323-327
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• 2004

The purpose of the present experiment was to investigate the micronuclei(MN) frequency in cytokinesis-blocked(CB) cells after various doses of gamma-rays in pig (Landrace, male, 3-month-old) and so to contribute to the clarification of the question whether these species are suitable as a target organism in the test system. The frequencies of binucleated cells, and gamma-ray-induced MN in CB cells at several doses were measured in three donors. The peaks of binucleated lymphocyte formation(22%) were found at a concentration of 2% phytohaemagglutinin(PHA) and $4{\mu}g/ml$ Cytochalasin B(Cyt-B) in pig at 72 hours after incubation. Measurements performed after irradiation showed a dose-related increases in MN frequency in each of the donors studied. When analysed by linear-quadratic model the line of best fit was $y=0.0183D+0.0124D^2+0.0133$(y = number of MN/CB cells and D=irradiation dose in Gy). In conclusion, the results demonstrate that it appears feasible to use pig as target organisms in the micronucleus test to estimate the cytogenetic damage caused by ionizing radiations or, potentially, chemical compounds.

• 한국정보시스템학회지:정보시스템연구
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• 제25권4호
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• pp.63-85
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• 2016

Purpose While the popularity of C2C auction platforms such as eBay is gradually decreased, this domain is still undermined to explain online bidding behaviors. Online bidders sometimes engage in impulsive bidding due to some of the online auction characteristics. Therefore, this study develops and tests a model of the impulsive bidding exhibited by online bidders in C2C auction platforms. Based on S-O-R framework, our model posits that both perceived time-pressure and competition intensity affect cognitive absorption which ultimately influences the impulsive bidding. Design/methodology/approach This study collected survey data from 214 C2C auction participants, who have prior experience on impulsive bidding and tested both measurement model and structural model by using CB-SEM (covariate-based structural equation modelling) technique. In this study, by using AMOS 20.0, we tested the measurement model for its overall fit, item reliability, and validity and further conducted the structural model to test our proposed hypotheses. Findings Based on our results, we found that perceived tim-pressure and competition intensity were positively related to cognitive absorption. We also found that the cognitive absorption was positively associated with impulsive bidding behavior. In this study, by developing our research model in S-O-R framework, we provide an alternative theoretical mechanism to describe online impulsive bidding behavior.

• 방송공학회논문지
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• 제27권7호
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• pp.985-998
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• 2022

Even after the standardization of VVC completed in 2020, continuing efforts for developing even better video coding technology are still under way. In this context, the Joint Video Experts Group (JVET) is developing various video compression technologies under the name of enhanced compression beyond VVC capability which has reported BDBR gain of -6.75%, -14.05%, and -15.25% on its test model, ECM version 5.0, respectively in Y, Cb, and Cr channels by just having a few new or improved intra coding tools. The current activity has so far adopted 11 intra coding tools beyond VVC which can generate more sophisticated predictors, reduce signaling overhead, or combine various predictors. In this tutorial paper, we will review these techniques.