• YAKHAK HOEJI
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• v.27 no.3
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• pp.207-213
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• 1983

Chloramphenicol (CAF) was esterified with aspirin, naproxen and acetaminophen in order to develop new prodrugs which have double effect-antibiotic activity and antipyretic effect. Chloramphenicol acetylsalicylate (CAF-ASP), chloramphenicol naproxenate (CAF-NAX), and chloramphenicol acetaminophen succinate (CAF-SUC-ACET) were synthesized by using dicyclohoxylcarbodiimidc (D.C.C.) because of two hydroxyl group of chloramphenicol. Three synthetic prodrugs did not show bitterness and antibiotic activity in vitro, and were hydrolyzed in liver homogenate, but weren't in acid.

• Science of Emotion and Sensibility
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• v.14 no.4
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• pp.663-674
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• 2011

Two experiments were conducted to examine how additional dotted lines and peripheral stimulus to the caf$\grave{e}$ wall illusion affect on the degree of perceived tilt (amount of illusion) and confidency of illusionary perception. The experiment 1 tested the effects of adding mortar (solid line) and bright contrast dotted lines to the borderline of 3 layers of blocks, which are consisted of black and white blocks. On the experiment 2, effects of adding peripheral stimulus on caf$\grave{e}$ wall illusion were tested. The results of experiment 1 showed that adding dotted line on the borderline mortar between blocks has additive effects on confidency of illusory perception. However, no effect on perceived amount of illusion was noted. On the other hand according to the results of experiment 2, adding blocks did increase amount, but not confidency of illusory perception. These results imply that the perception of caf$\grave{e}$ wall illusion is related with response of orientation selective neurons.

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 2014.11a
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• pp.61-74
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• 2014

전자제품에서 반도체 부품의 협피치화가 진행됨에 따라 PCB의 회로와 회로 사이의 간격 혹은 Hole과 Hole간의 간격이 줄어듬에 따라 ECM(Electrochemical Migration)과 CAF(Conductive Anodic Filament)의 불량이 증가하게 되었다. 특히 열악한 환경에서 사용되는 Power Supplier나 사용전압이 높아지는 전기 및 수소연료 자동차 분야에선 이들 불량방지에 노력을 기울여야겠다.

• Advances in Traditional Medicine
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• v.8 no.4
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• pp.416-422
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• 2008

This study evaluated the anti-inflammatory potential of the crude alkaloidal fraction (CAF) of methanol extract of Solanum trilobatum Linn. (Solanacea) root in animal models of inflammation. Crude alkaloidal fraction at doses of 25, 50 and 100 mg/kg significantly (p < 0.01) reduced carrageenan induced rat paw volume at 3 h after carrageenan challenge as compared to control group of animals. CAF (25, 50 and 100 mg/kg) significantly (p < 0.01) and dose dependently suppressed cotton pellet induced granuloma formation. Topical application of CAF (1, 5 and 10 mg/ear) markedly inhibited multiple application of TPA in mice. CAF elicited pronounced inhibitory effects on formaldehyde and adjuvant induced arthritis in rats. These results indicate that CAF of methanol extract of the Solanum trilobatum has anti-inflammatory activity in acute and chronic inflammation.

• Journal of Oral Medicine and Pain
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• v.44 no.1
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• pp.35-39
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• 2019

Calcifying aponeurotic fibroma (CAF) is an uncommon benign soft-tissue fibroblastic tumor with characteristic histological features. It mainly occurs in the distal part of the extremities, such as the hands and feet, in children and adolescents. Males are twice as commonly affected as females. CAF exhibits local invasiveness, and hence, its recurrence rate is also high. Therefore, complete surgical excision is both diagnostic and therapeutic. The occurrence of CAF in the maxillofacial region, especially the temporomandibular joint (TMJ), is very rare, and this necessitates its differentiation from other TMJ neoplasms. The differential diagnosis of CAF requires microscopic examination. Herein, we report a rare case of CAF located at the left mandibular condyle, which was confirmed by histopathological analysis.

• Journal of Institute of Control, Robotics and Systems
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• v.21 no.6
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• pp.589-594
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• 2015

In this paper, we described the Cramer-Rao Lower Bound (CLRB) performances of Time Difference of Arrival (TDOA) and Frequency Difference of Arrival (FDOA) methods when there are multiple emitters. The TDOA and FDOA values between two receivers can be simultaneously estimated by using the so-called Complex Ambiguity Function (CAF). In the case of multiple emitters, there exist Inter Symbol Interferences (ISIs) in the measurement data. Therefore, it is required to reduce the effect of ISI and provide a performance evaluation method of TDOA and FDOA estimations. In order to eliminate the ISIs, using of a filter bank before calculating CAF is proposed when the carrier frequencies of the emitters are different to one another. Angle of Arrival (AOA) or Received Signal Strength (RSS) methods before calculating CAF were proposed to reduce the ISIs when the carrier frequencies are the same. In order to evaluate the CRLB of TDOA and FDOA estimations, we employed the conditional probability distribution method and described the numerical comparison results.

• Journal of Biomedical Engineering Research
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• v.16 no.4
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• pp.517-524
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• 1995

This paper is a study on the design of the cascade adaptive filter (CAF) for baseline wandering elimination in order to enhance the performance of the detection of ST segments in ECG. The CAF using Least Mean Square (LMS) algorithm consists of two filters. The primary adaptive filter which has the cutoff frequency of 0.3Hz eliminates the baseline wandering in raw ECG The secondary adaptive filter removes the remnant baseline wandering which is not eliminated by the primary adaptive filter. The performance of the CAF was compared with the standard filter, the recursive filter, and the adaptive impulse correlated filter (AICF). As a result, the CAF showed a lower signal distortion than the standard filter and the AICF. Also, the CAF showed a better perf'ormance in noise elimination than the standard filter and the recursive filter. In conclusion, considering the characteristics of the noise elimination and the signal distortion, the CAF shows a better performance in the removal of the baseline wandering than the other three Otters and suggests the high performance in the detection of ST segment.

• Molecules and Cells
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• v.43 no.9
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• pp.831-840
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• 2020

The β-class of carbonic anhydrases (β-CAs) are zinc metalloenzymes widely distributed in the fungal kingdom that play essential roles in growth, survival, differentiation, and virulence by catalyzing the reversible interconversion of carbon dioxide (CO₂) and bicarbonate (HCO₃^-). Herein, we report the biochemical and crystallographic characterization of the β-CA CafA from the fungal pathogen Aspergillus fumigatus, the main causative agent of invasive aspergillosis. CafA exhibited apparent in vitro CO₂ hydration activity in neutral to weak alkaline conditions, but little activity at acidic pH. The high-resolution crystal structure of CafA revealed a tetramer comprising a dimer of dimers, in which the catalytic zinc ion is tetrahedrally coordinated by three conserved residues (C119, H175, C178) and an acetate anion presumably acquired from the crystallization solution, indicating a freely accessible "open" conformation. Furthermore, knowledge of the structure of CafA in complex with the potent inhibitor acetazolamide, together with its functional intolerance of nitrate (NO₃^-) ions, could be exploited to develop new antifungal agents for the treatment of invasive aspergillosis.

• Journal of the Korean Recycled Construction Resources Institute
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• v.11 no.1
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• pp.9-15
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• 2023

The cement is a typical CO₂ emission industry. Manufacturing process improvements and increased use of alternative materials are needed to reduce energy consumption and CO₂ emissions. This study confirmed the basic characteristics of cement hydration by sintering CAF at low temperature as a CO₂ adsorbent material. For the hydration product of the synthetic CAF, crystal phase analysis, porosity, and structural images were confirmed, and the compressive strength was measured. The replacement rate of SCAF was 10, 20, and 100 %, and the compressive strength tended to decrease as the replacement rate increased. In addition, when the SCAF substitution rate is 100 %, the hydration products of the early age are calcium aluminum oxide hydrate (Ca₃Al₂O₆ x H₂O) and calcium iron hydroxide (Ca₃Fe(OH)₁₂), and at substitution rates of 10 and 20 %, CAF compounds other than general cement hydrates brownmillerite was observed. As for the porosity, the pore size increased and the porosity increased with the increase of the replacement ratio. As a result of this study, CAF manufactured by low-temperature sintering seems to be difficult to use alone and general curing for utilization as a CO₂ adsorbing material.

• Journal of the Korean Society of Hazard Mitigation
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• v.10 no.5
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• pp.35-40
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• 2010

The present study proposes the strengthening method to use Conclinic Advanced FiberWrep(CAF) so as to improve Load Carrying Capacity of the RC slab bridge. In order to evaluate the strengthening performance, we strengthen 50cm per unit-width of CAF to the slab's bottom of the test bridge that designed with DB 18, then perform Static and Dynamic Field Load Test. As a result of this, 14.7% of the maximum displacement, 5.0% of the strain and 33.7% of the impact factor are reduced after strengthening. At the middle of the test spans, nominal resisting ratio is increased by 27% and Service Load Carrying Capacity is increased by 44.6%, 48.9% of each span 1 and 2. In conclusion, this study indicates that the strengthening method using CAF is very effective to improve the deteriorated RC slab bridge designed with DB 18, to the DB 24 of the first class bridge design load.