• Pediatric Infection and Vaccine
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• 제11권2호
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• pp.212-215
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• 2004

보체계는 우리 몸에서 감염에 대한 초기 방어를 담당하는데 그중 후기 보체 성분의 결핍시 수막구균의 감염에 쉽게 노출된다. 특히 재발 감염된 수막구균 혈증 환자에서 보체계의 검사가 반드시 필요할 것으로 생각되는 바이다. 저자들은 재발성 수막구균 혈증으로 치료받은 환자에서 C7 결핍증을 경험하였기에 이를 보고하는 바이다.

• Journal of Biosystems Engineering
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• 제34권6호
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• pp.470-475
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• 2009

This study was performed to present the diagnosis basis of cooling performance deficiency according to air quantity included in refrigerant of air-conditioner by detecting the temperatures and pressures of refrigerant pipeline. The car air-conditioner of SONATA III (Hyundai motor Co., Korea) was tested by maximum cooling condition at 1500 rpm of engine speed in the room with controlled air condition at $33\sim35^{\circ}C$ and 55~57% RH. Measured variables were temperature differences between inlet and outlet pipe surface of the compressor (Tcom), condenser (Tcon), receive dryer (Trec) and evaporator (Teva), and high pressure (HP) and low pressure (LP) in the refrigerant pipeline, and temperature difference (Tcoo) between inlet and outlet air of the cooling vent of evaporator. Control variables were the refrigerant charging weight and the vacuum degree in the refrigerant pipeline before charging refrigerant. From the test, it was represented that the measuring values of (Tcom), LP and (Tcoo) were enabled to make the diagnosis of cooling performance deficiency according to quantity included in refrigerant of air-conditioner. The ranges of Tcom, LP and Tcoo to make the diagnosis of cooling performance deficiency were respectively less than $55^{\circ}C$, more than 166.7 kPa-g(1.7 kgf/$cm^2$) and less than $13.7^{\circ}C$. In the case of using only external sensors and the condition under the normal performances of air conditioner, it was considered that the ranges of LP and Tcoo to make the diagnosis of cooling performance deficiency were respectively more than 166.7 Pa and less than $12^{\circ}C$.

• Journal of Nutrition and Health
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• 제32권7호
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• pp.787-792
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• 1999

The purpose of this study was to estimate the iron availability and to analyze dietary factors which influence hematological indices of 130 female adolescents with iron deficiency anemia. Intakes of iron and other nutrients were estimated using a self-administrated questionnaire combined with the 24-hour recall mehtod and iron availability was calculated by Monsen's method. Mean daily intakes of calorie, protein and vitamin C were 1631.0kcal(77.7% of RDA), 54.7g(84.2% of RDA) and 45.7mg(83.0% of RDA), respectively. In terms of iron, mean daily intake was 8.7mg(48.3% of RDA) and heme iron intake was 3.0mg which correspond to 34% of total iron intake. The amount of total absorbable iron was 1.5mg and the estimated bioavailability of dietary iron was 17.2%. In summary, intake of several nutrients for most of the subjects were under RDA. Dietary factors affecting hematological indices were analyzed by stepwise multiple regression. Intake of vitamin C was a major determinant of Hb level, while both intake of enhancing factor and iron availability were major determinants of serum ferritin level. In conclusion proper nutritional education and guidance for iron deficiency anemic female adoalescent needs to be developed and to improve their iron storage should be increased intakes of enhancing factors, female adoalescents.

• 대한유전성대사질환학회지
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• 제15권3호
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• pp.165-170
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• 2015

저자들은 출생 직후에서 생후 7개월까지는 특별한 과거력 없이 건강하게 지내던 여아에서 생후 11개월에 반복적인 구토 및 간헐적인 의식변화와 경련으로 시행한 검사 결과 고암모니아 혈증 및 소변 orotic acid의 증가를 통해 OTC 결핍증을 진단하고, 분자 유전자 검사로 418번째 염기인 G가 C로 치환되어 140번 아미노산이 alanine에서 proline으로 바뀌는 돌연변이(p. Ala140Pro)를 확인한 1례를 경험하였기에 보고하는 바이다. 본 증례의 돌연변이는 환아의 부모 유전자 분석 결과 정상 소견으로 de novo mutation으로 사료된다. 환아는 출생 후 수 개월간 큰 이상 없이 성장 및 발달을 보였으나 생후 7개월 경부터 주기적인 구토 증세를 보였던 지발형 OTC 결핍증에 해당한다. 진단 후 arginine 및 phenylbutylate를 지속적으로 복용하며 저단백 식이를 유지하는 보존적 치료를 지속하여 현재 발달 및 성장 속도 양호하며 일상생활에 문제없이 지내고 있다. 따라서 출생 후 수개월간 특이 질환력이 없는 환아, 특히 여아에서 주기적인 구토, 기면, 경련 및 혼수 등의 증상을 보일 때 지발형 OTC 결핍증과 같은 대사질환을 의심할 수 있어야 한다. 본 증례는 반복적인 구토 및 의식변화를 보인 기저질환 없는 11개월 여아에서 OTC 결핍증을 진단하고 즉각적인 대처를 통해 7세까지 심각한 신경학적 장애 없이 정상적인 성장과 발달을 보인 환자를 보고하는 바이다.

• Nutrition Research and Practice
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• 제7권6호
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• pp.495-502
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• 2013

Recent studies suggest that vitamin D deficiency and cardiometabolic disorders are becoming increasingly more prevalent across multiple populations. However, there is a lack of comprehensive data for Korean adults. We investigated the vitamin D status, the prevalence of vitamin D deficiency and its association with metabolic syndrome (MS) risk in Korean adults aged 20 years or older. The study subjects (n = 18,305) were individuals who participated in the Korean National Health Examination and Nutrition Survey (KNHANES) in 2008-2010. Vitamin D status (25-hydroxyvitamin D [25(OH)D]) was categorized as < 20, 21-29, and ${\geq}$ 30 ng/mL, which are the cut-off points for deficiency, insufficiency and normal limits. A wide variety of cardiometabolic risk factors were compared according to the vitamin D status. Vitamin D deficiency was found in 53.9% of men and 70.5% of women. Mean BMI, systolic BP, HbA1c and low density lipoprotein cholesterol (LDL-C) were highest in the vitamin D deficiency group in both genders. Further, the MS was most prevalent in the vitamin D deficiency group in both genders (12.3%, P = 0.002 in men and 9.2%, P < 0.001 in women). Compared to the vitamin D normal group, the adjusted odds ratio (ORs) (95% confidence interval [95% CI]) for MS in the vitamin D deficiency group were 1.46 (1.05-2.02) in men and 1.60 (1.21-2.11) in women, after adjusting for confounding variables. In conclusion, Vitamin D deficiency is a very common health problem in Korean adults and is independently associated with the increasing risk of MS.

• 대한치과교정학회지
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• 제35권3호
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• pp.196-206
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• 2005

이 연구는 비타민 C 결핍이 guinea pig에서의 실험적 치아이동속도와 치조골 개조에 미치는 영향을 알아보고자 시행되었다 이를 위하여 웅성 guinea pig 30마리를 대상으로 정상량의 비타민 C (5 mg/day) 를 투여한 군(정상군)과 결핍량(0.2mg/day)을 투여한 군(결핍군)으로 나누고 치아이동 실험을 시행하였다. 초기 교정력 75gm으로 상악의 좌우 중절치를 이개시키는 치아이동을 시행하고, 순차적으로 실험 경과기간이 지나면 치아이동양을 계측하고 희생시켜 조직 소견을 관찰하였다. 실험 결과. 결핍군에서 치조골과 치주인대의 교원섬유 함량은 현저한 감소와 불규칙한 배열을 보였으며 인대세포의 수적 감소 및 출혈이 관찰되었고 치조골에서 골형성의 감소와 파골세포의 출현 및 골소강의 크기증가와 골소강내의 다수의 파골세포가 관찰되었다. 정상군의 인장측 치조골은 치아이동 시간경과에 따라 조골세포와 골형성이 지속적인 증가를 보였으나, 결핍군에서는 조골세포가 감소하고 골형성은 미약한 양상을 보였다. 치아 이동양은 실험 초기 1일, 3일, 5일, 7일 결핍군의 치아이동양이 정상군보다 많게 나타났다 (p<0.05) 이상의 결과에서 비타민 C 결핍은 치주조직의 교원질의 합성을 억제하여 치조골의 형성을 감소시키고 흡수를 증가시키는 골개조를 초래하며, 치아이동중 인장측 치조골 형성을 억제하고 압박측 치조골 흡수를 촉진하여 치아이동 초기에는 빠른 치아이동을 가져오는 것을 시사한다.

• 대한유전성대사질환학회지
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• 제17권2호
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• pp.69-76
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• 2017

Citrin 결핍증은 요소회로 이상 질환 중 하나로, 7q21.3에 위치한 SLC25A13 유전자에 돌연변이로 발생하는 상염색체 열성 유전질환이다. 세 가지 표현형 중에 신생아 간내 담즙 정체형, 제 2형 시트룰린혈증은 잘 알려졌지만, 성장부진과 이상지질혈증형은 최근에 밝혀지고 있는 표현형으로 아직 우리나라에 보고된 적이 없다. 성장부진과 이상지질혈증형에서는 경미할 수는 있으나 식욕감소, 피곤함, 성장부진, 저혈당, 시트룰린 상승, 이상지질혈증, 젖산염/피루브산염 상승과 같은 이상이 관찰될 수 있다. 또한 저혈당으로 내원하였을 때 일반적인 검사로는 원인 규명이 어려울 수 있다. 저자들은 생후 30개월에 반복적인 저혈당으로 내원하여 소변 유기산 분석, 호르몬 검사와 같은 대사 이상 검사에서 명확한 특정 진단명이 의심되지 않아, 생후 31개월에 targeted exome sequencing을 통해 복합이형접합 SLC25A13 유전자 돌연변이[c.852_855del (p.Met285Profs*2), c.1177+1G>A]를 발견하여 성장부진과 이상지질혈증으로 발현한 citrin 결핍증을 우리나라에서 최초로 진단하여 보고하는 바이다.

• 대한한방부인과학회지
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• 제15권4호
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• pp.111-127
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• 2002

Purpose : This study investigated reliability of Oriental OB&GY questionnaires, valued the items and correlated relation of differentiation of syndromes of Oriental OB&GY questionnaires which is used by Dong-Eui OB&GY. Method : We analysised the result of 721 outpatients's questionnaires from March. 1. 1998 to March. 30. 2002 Results : 1. The reliability of Oriental OB&GY questionnaires above 95% is deficiency of Ki, deficiency of blood, dry of blood, deficiency of Um, stagnation of Ki, insuficiency of the kidneys, liver, heart, above 90% under 95% is deficiency of Yang, heat of constitution, heat of disease, dampness, stagnated blood, above 85% under 90% is phlegm, spleen above 80% under 85% is cold syndrom. 2. The order of frequency diagnosed by Oriental OB&GY questionnaires is dampness(78.7%), heart(66.8%), stagnation of Ki(63.8%), deficiency of blood(53.5%), deficiency of Ki(53.1%), phlegm(53.7%), insuficiency of the kidneys(50.1%), dry of blood(45.1%), spleen(41.4%), liver(36.2%), stagnated blood(36.2%), deficiency of Yang(35.6%), cold syndrom(29.8%), deficiency of Um(24.1%), heat of disease(22.5%), heat of constitution(20.1%). 3. The average of item of differentiation of syndromes above 90 is dampness, above 80 under 90 is deficiency of Ki, deficiency of blood, dry of blood, deficiency of Yang, cold syndrom, heat of constitution, stagnation of Ki, phlegm, stagnated blood, insuficiency of the kidneys, liver, heart, spleen, above 70 under 80 is deficiency of Um, heat of disease. 4. Deficiency of Ki is connected with question compounded of stagnation of Ki, deficiency of Yang is connected cold syndrom, cold syndrom is connected deficiency of Yang, stagnation of Ki is connected deficiency of Ki. 5. The differentiation of syndromes accompanied with others which is related to compounded question is deficiency of Ki, deficiency of blood, cold syndrom, stagnation of Ki, dampness, phlegm, stagnated blood, insuficiency of the kidneys, liver, heart, spleen, which isn't related to compounded question is dry of blood, deficiency of Um, deficiency of Yang, heat of disease.

• Asian-Australasian Journal of Animal Sciences
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• 제16권4호
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• pp.519-528
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• 2003

A survey was conducted in certain parts of Haryana to record the prevalence of micro mineral deficiency in buffaloes. The prevalence of soil Cu, Co, Zn and Fe deficiency was 55.26%, 6.9%, 59.12% and 7.89% respectively. While that of fodder Cu, Co, Zn and Fe was 60.64%, 6.7%, 61.22% and 11.37% respectively. The overall prevalence of serum Cu, Co, Zn and Fe deficiency in Haryana was 59.2%, 19.1%, 59.2% and 19.9% respectively. The correlation co-efficient of Cu, Co, Zn and Fe in soil, fodder and serum was significant in most of the cases the values were above 0.8. Blood examination revealed significant decrease in haemoglobin and TEC level. However, no variation in level of TLC were observed in mineral deficient buffaloes. In micro mineral deficiency, thyroid hormone (T3 and T4) levels were decreased in buffaloes. Marginally lower concentration of vitamin A and E were observed in mineral deficient buffaloes in Haryana. The highest deficiency of micro minerals was 61.76% in copper at Ambala followed by 65.86% in zinc at Rhotak. For therapeutic studies a mineral mixture was prepared according to defiency obtained and fed to three groups of animals. Observation was recorded on 0, 15, 30, 45 and 60 days. Group A consist of normal healthy animals and group B mineral deficient animal untreated and group C mineral deficient animal, treated with prepared mineral mixture. 25 gram of mineral mixture was fed daily along with normal ration. There was increase in body weight, milk yield, haemoglobin concentration and total erythrocyte level in group C animals when compared to group B animals. The milk yield in group C animals increased to 6.970${\pm}$0.41 after 60th day of supplement in comparison to 0 day where it was 5.910${\pm}$0.37, similarly the body wt. of group C animals increased from 129.42${\pm}$01.13 (at 0 day) to 159.31${\pm}$03.61 at 60th day of treatment.

• 혜화의학회지
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• 제21권1호
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• pp.1-9
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• 2012

Objectives : The aim of this experiment is to find out relationship between the effect of cosmetics and 4 types of pattern identification about fluid-humor, which are based on the general idea of traditional oriental medicine, Qi-Blood and deficiency-excess. Methods : Korean female volunteers in good health (n=25, $23.12{\pm}2.83$) participated in this experiment. Three Korean medical doctors classified them into 4 groups: Blood-deficiency: group A; Blood-excess: group B; Qi-deficiency:group C; Qi-excess:group D). Cosmetics that contains herb extract for Blood deficiency were given to all volunteers and they used the cosmetics for 4 weeks. Volunteers were assessed non-invasively with the skin measuring devices before and after using cosmetics. And we analyzed the correlation of skin physiological parameters with 4 groups. Results : Three doctors diagnosed participants and classified them into 4 groups ; group A(n=8),group B(n=7), group C(n=3), group D(n=5) as highest score. After 4 weeks, facial skin moisture showed no significant difference in comparison between 4 groups. Sebum showed significant increase in Group A and significantly decreased Group B. Measurement of facial skin elasticity tended to increase in Group A, C, D but skin elasticity was decreased significantly in Group B. Conclusions : In case of a group that pattern identification about fluid-humor corresponds to herb extract in cosmetic, skin improving effect was better than the other group that pattern identification oppose to properties of herb in cosmetic. Therefore, from the view of traditional oriental medicine, it is very important to understand user's pattern of identification or physical conditions and properties of herbs in cosmetics on the matter of safety and efficacy.