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Mind Bomb-Binding Partner RanBP9 Plays a Contributory Role in Retinal Development

  • Yoo, Kyeong-Won;Thiruvarangan, Maivannan;Jeong, Yun-Mi;Lee, Mi-Sun;Maddirevula, Sateesh;Rhee, Myungchull;Bae, Young-Ki;Kim, Hyung-Goo;Kim, Cheol-Hee
    • Molecules and Cells
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    • v.40 no.4
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    • pp.271-279
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    • 2017
  • Ran-binding protein family member, RanBP9 has been reported in various basic cellular mechanisms and neuropathological conditions including schizophrenia. Previous studies have reported that RanBP9 is highly expressed in the mammalian brain and retina; however, the role of RanBP9 in retinal development is largely unknown. Here, we present the novel and regulatory roles of RanBP9 in retinal development of a vertebrate animal model, zebrafish. Zebrafish embryos exhibited abundant expression of ranbp9 in developing brain tissues as well as in the developing retina. Yeast two-hybrid screening demonstrated the interaction of RanBP9 with Mind bomb, a component of Notch signaling involved in both neurogenesis and neural disease autism. The interaction is further substantiated by co-localization studies in cultured cells. Knockdown of ranbp9 resulted in retinal dysplasia with defective proliferation of retinal cells, downregulation of neuronal differentiation marker huC, elevation of neural proliferation marker her4, and alteration of cell cycle marker p57kip2. Expression of the $M{\ddot{u}}ller$ glial cell marker glutamine synthase was also affected in knockdown morphants. Our results suggest that Mind bomb-binding partner RanBP9 plays a role during retinal cell development of zebrafish embryogenesis.

The Effect of Food Deprivation Length of Pair House Pigs on the Running Speed and Feeding Activity in Solitary and Social Conditions

  • Hsia, L.C.
    • Asian-Australasian Journal of Animal Sciences
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    • v.17 no.2
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    • pp.271-277
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    • 2004
  • The purpose of this experiment was to study the feeding behavior and running speed under various feed deprivation lengths and social environments. Three trials were conducted. Trial 1: ten pigs were trained individually to run a course and eat their feed at the end of the course. The pigs were deprived feed for 1, 5, 10 or 20 h. Trial 2: 1. Two pigs ran and ate together. Both pigs had 5 h of feed deprivation before the run (D5). 2. Two pigs ran and ate alone, but both pigs had 5 h of feed deprivation before the run (S5). 3. Two pigs ran and ate together. Both had 1 h of feed deprivation before the run (D1). 4. Two pigs ran and ate alone and both pigs had 1 h of feed deprivation before the run (S1). 5. Two pigs ran together, one had 5 h of feed deprivation, and the other had 1 h of feed deprivation before the run (51). Trial 3: 1. On the 1st day 5 pairs of pigs had 5 h feed deprivation and could eat feed together at (B) point (D1). 2. On the 2nd day the pigs ran and ate alone at (B) point after 5 h of feed deprivation. Feed was obtainable (D2). On the 3rd to 6th days, the pigs ran in pairs after 5 h of feed deprivation and only the dominant pig ate feed at point (B). The inferior pig was chased back to room and fed there. This stage was continued for four consecutive days, d 3 to 6. In trial 1, the running speed of pigs increased with the length of feed deprivation until 10 h, then being stable afterwards. Total feeding time increased with the length of feed deprivation (p<0.001). Eating speed did not increase with the length of feed deprivation (p>0.05). In trial 2, nine of ten pigs in treatment D5 ran faster than those in S5. Seven of the ten pigs in treatment S1 ran faster than those in treatment D1. The pigs in treatment D5 had significantly higher feed intake (p<0.001) and eating speed (p<0.05) than the pigs in other treatments. In trial 3, there were significant differences on running speed between D1 and D6 (p<0.01) and between D2 and D1, D3, D4 and D5. The inferior pig ran faster in D2 but from 3 to 6 it was the dominant pig that showed the greatest speed in completing the whole course. The results demonstrated that the pigs with low feeding motivation may cause low running speed to feed and low feed intake of the neighbor when compared with pigs kept individually.

C2 Ganglion Block for Treatment of Cervicogenic Headache -A Case Report- (2예의 Cervicogenic Headache의 치료 경험 -증례보고-)

  • Kim, Young-Jin;Shin, Dong-Yeop;Hong, Ki-Hyuk;Lee, Hyo-Keun;Kim, Chan
    • The Korean Journal of Pain
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    • v.7 no.2
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    • pp.273-276
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    • 1994
  • The cervicogenic headache is not well defined for its characteristics and development of disease. It is developed by many causes including trauma principally. But, most cases have no radiologically specific clue for diagnosis. So, past hisory and clinical symptoms and signs are important for clinician to detect and diagnose the disease. Our clinic had treated the 2 cases of cervicogenic headache with different methods, and the patients were well respond the therapy.

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Performance Improvement with Intra-site CoMP for C-RAN Networks

  • Jin, Yi;Joe, InWhee
    • Proceedings of the Korea Information Processing Society Conference
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    • 2016.04a
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    • pp.98-100
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    • 2016
  • Coordinated multi-point (CoMP) transmission adopt the Base Stations (BS) cooperatively process User Equipment (UE) connected to multi-points to improve UEs spectral efficiency at the cell edge and eliminate the inter-cell interference (ICI). This technology is important for UEs at the cell edge. Considering the real environment, energy consumption and cost situation, we propose in a Local C-RAN architecture deployment of CoMP and observed its spectral efficiency and Signal-to-Interference and Noise Ratio (SINR) in intra-site CoMP scenarios. Simulation results show that this approach has significantly enhanced than Non-CoMP.