• Current Research on Agriculture and Life Sciences
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• 제23권
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• pp.43-51
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• 2005

멕시코와 네팔에서 수집한 고추 유전자원 50점과 이병성 및 저항성 대조품종에 Stemphylium solani와 S. lycopersici 의 혼합접종으로 흰별무늬병(gray leaf spot)에 대한 저항성을 검정하고, 살균제를 살포하여 회복시킨 다음 다시 Xanthomonas campestris pv. vesicatoria를 접종하여 더뎅이병에 대한 저항성을 검정하였다 더뎅이병에는 KC866, KC872, KC902, KC905이 이미 알려진 KC43, KC47, KC220, KC319, KC320, KC380 등과 함께 저항성으로 나타났다. 더뎅이병, bacterial spot)에는 KC897이 이미 저항성으로 보고된 KC177(PI163192)보다 발병이 적어 가장 우수한 것으로 나타났으며 이어서 네팔에서 도입된 KC889, KC896, KC898이 저항성으로 나타났다.

• 한국수산과학회지
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• 제43권1호
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• pp.39-45
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• 2010

Chlorella has been reported to have certain beneficial physiological effects, including hypocholesterolemic, antihypertensive, antioxidative, and anti-tumor activities in animal and human studies. The aim of this study was to determine the anti-inflammatory activities of an 80% methanol extract(CE-Met), hexane fraction (CE-Hex), and ethyl acetate fraction (CE-EA) of Chlorella ellipsoidea in lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophage. Treatment with various concentrations of the C. ellipsoidea extract resulted m a significant, dose-dependent reduction in nitric oxide (NO) production by LPS-induced macrophages. The C. ellipsoidea extract significantly inhibited LPS-induced NO production accompanied by an attenuation of IL-6 and TNF-$\alpha$ formation in macrophages. These results suggest potent inhibit이y effects on the production of inflammatory mediators by a C. ellipsoidea extract. Thus, C. ellipsoidea extract may be a potent anti-inflammatory agent for troubled skin.

• Clinical and Experimental Pediatrics
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• 제59권12호
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• pp.461-465
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• 2016

This report includes the recommended immunization schedule table for children and adolescents based on the 8th (2015) and revised 7th (2012) Immunization Guidelines released by the Committee on Infectious Diseases of the Korean Pediatric Society (KPS). Notable revised recommendations include: reorganization of the immunization table with a list of vaccines on the vertical axis and the corresponding age on the horizontal axis; reflecting the inclusion of Haemophilus influenzae type b vaccine, pneumococcal conjugate vaccine, and hepatitis A vaccine into the National Immunization Program since 2012; addition of general recommendations for 2 new Japanese encephalitis (JE) vaccines and their interchangeability with existing JE vaccines; addition of general recommendations for quadrivalent meningococcal conjugate vaccines and scope of the recommended targets for vaccination; and emphasizing catch-up immunization of Tdap vaccine. Detailed recommendations for each vaccine may be obtained from the full KPS 8th Immunization Guidelines.

• 한국수산과학회지
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• 제47권3호
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• pp.264-273
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• 2014

To investigate species composition and seasonal variation of demersal organisms in the coastal waters off the Taean peninsula, otter trawl surveys were conducted from April 2010 to January 2011. A total of 75 species were collected, including 44 species of Pisces, 19 species of Crustacea, 6 species of Cephalopoda, 4 species of Gastropoda, and 1 species each of Bivalvia and Echinoidea. The dominant species in each season were Palaemon gravieri in spring, Charybdis bimaculata in summer, Loligo japonica in autumn, and Crangon hakodatei in winter. The number of species, individuals and biomass were highest in autumn and lowest in winter. The diversity index was highest in summer and lowest in winter. The dominance index was highest in winter and lowest in summer. The richness index was highest in autumn and lowest in winter. The evenness index was highest in summer and lowest in autumn. A cluster analysis showed that demersal organisms were divided into two groups; spring and winter organisms (Group 1) and summer and autumn organisms (Group 2). We detected a significant difference (P<0.05) between these groups, mainly owing to Platycephalus indicus, Repomucenus koreanus, and Paralichthys olivaceus within Pisces: Trachysalambria curvirostris, Metapenaeopsis dalei, P. gravieri, and C. hakodatei within Crustacea: and L. japonica within Cephalopoda.

• 한국항공우주학회지
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• 제38권4호
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• pp.321-326
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• 2010

본 논문에서는 나사잭의 메커니즘을 이용한 인공위성의 비폭발식 분리장치를 설계 및 제작하였다. 분리장치의 구동기로는 정격토크가 $1.7kgf{\cdot}cm$의 성능을 가진 회전형 피에조 모터를 사용하여 분리장치의 안정적인 작동이 이뤄지도록 하였다. 또한 인공위성의 분리장치로의 성능을 검증하기 위하여 반응속도 실험, 준정적 하중실험, 충격실험을 수행하였다. 실험을 수행한 결과, 반응속도는 약 1.172초로 측정되었고, 45kgf의 하중에서도 안정적으로 견딜 수 있음을 확인하였다. 최대 충격 가속도는 18G가 측정이 되었는데 이것은 폭발식 분리장치에 비해 매우 작은 값이다. 우리는 이러한 실험을 통하여 제안한 분리장치의 신뢰성을 확인하였으며, 인공위성 분리장치로써의 가능성을 제시하였다.

• 한국환경과학회지
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• 제29권8호
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• pp.857-870
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• 2020

In this study, the antibiotic components in the final effluent from the 12 wastewater treatment facilities located in the Nakdong River basin were investigated, and the correlation between organic matters, nutrients and antibiotics was analyzed. In the final effluent of the wastewater treatment facilities, three sulfonamides antibiotics (sulfamethazine, sulfathiazole, sulfachlorpyridazine) and tetracyclines antibiotics (oxytetracycline, doxycycline) were detected. Sulfamethazine were detected at all points and ranged from 10.398 to 278.784 ng/L. Sulfathiazole were detected at 6 points (Andong, Gumi, Hapcheon, Miryang, Uiryeong, Haman), and ranged from 23.773 to 144.468 ng/L. The correlation coefficients between sulfathiazole and TSS, COD, TOC, NH₃-N, NO₂-N, and T-N components were high in the range of 0.73 to 0.92. The correlation coefficient between sulfamethazine and T-N was 0.48, and the correlation with the rest of the water quality components was low. The correlation coefficient between sulfamethazine and sulfathiazole was 0.78. Through this study, it was confirmed that the concentration of sulfonamides antibiotics was higher than the concentration of tetracyclines antibiotics in the final effluent of 12 wastewater treatment facilities in the Nakdong River basin, and the concentration of sulfathiazole increased with organic matters and nutrients.

• 대한의생명과학회지
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• 제10권4호
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• pp.353-360
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• 2004

Eosinophils play an essential role in allergy reaction after parasite infection. To examine the immune reaction induced by eosinophils, we investigated the allergy reaction in BALB/c mice infected with Echinostoma hortense's metacercariae, as well as the effect of ketotifen, an anti-allergy drug, on eosinophil immune reaction in the villi of host intestine. The worm recovery rate was higher in ketotifen-treated mice than in untreated mice and the worms in ketotifen-treated mice survived longer than those in untreated mice. The antibody titer in the serum of ketotifen-treated mice was very low. Especially, Echinostoma hortense infection strongly increased serum IgE level and eosinophil infiltration into the villi of the mouse intestine. Ketotifen treatment suppressed eosinophil infiltration into the infected areas and inhibited IL-4 production. The reduced IL-4 production may be related with the reduction of IgE, IgG1 and IgG2 production. In conclusion, ketotifen inhibited eosinophil infiltration functioning in the allergy reaction induced by parasite infection and the expression of immunoglobulins and cytokines.

• Toxicological Research
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• 제26권1호
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• pp.37-46
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• 2010

This study aimed to elucidate anti-inflammatory activities from extracts of Asterina pectinifera on nitric oxide (NO) production, TNF-${\alpha}$ and IL-6 release in lipopolysaccharide (LPS)-stimulated murine macrophage cell, RAW264.7. We prepared the methanolic extracts (60-MAP, 70-MAP, 80-MAP and 90-MAP), aqueous extract (W-AP) and functional bioactive compound fraction (He-AP and EA-AP) from Asterina pectinifera according to extract method. The 60-MAP, 70-MAP, 80-MAP, 90-MAP and W-AP were significantly suppressed LPS-induced production NO, TNF-${\alpha}$ and IL-6 secretion in a concentration-dependent manner (P < 0.05). Especially, 80-MAP by extracted 80% methanol had the strongest activity in reduction of inflammatory mediators among these extracts. Indeed, to identify active fraction, which contained potential bioactive compounds, from 80-MAP of Asterina pectinifera, we tested anti-inflammatory activity of the He-AP or the EA-AP. The He-AP was next extracted from 80-MAP and the EA-AP were extracted from the other methanol layer except the He-AP. The EA-AP demonstrated a strong anti-inflammatory effect through its ability to reduce NO production and it also inhibited the production of proinflammatory cytokines such as IL-6 and TNF-${\alpha}$ at low concentration. These results suggested that the methanolic extract from Asterina pectinifera had the potential inhibitory effects on the production of these inflammatory mediators.

• Journal of Ginseng Research
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• 제32권4호
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• pp.315-323
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• 2008

In the previous studies, we isolated the compound K rich fractions (CKRF) and showed that CKRF inhibited Toll-like receptor (TLR) 4- or TLR9-induced inflammatory signaling. To extend our previous studies,1) we investigated the molecular mechanisms of CKRF in the TLR4-associated signaling via nuclear factor (NF)-${\kappa}B$, and in vivo role of CKRF for induction of tolerance in lipopolysaccharide (LPS)-induced septic shock. In murine bone marrow-dervied macrophages, CKRF significantly inhibited the induction of mRNA expression of proinflammatory mediators such as tumor necrosis factor-${\alpha}$, interleukin-6, cyclooxygenase-2, and inducible nitric oxide synthase. In addition, CKRF significantly attenuated the transcriptional activities of TLR4/LPS-induced NF-${\kappa}B$. Nuclear translocation of NF-${\kappa}B$ in response to LPS stimulation was significantly abrogated by pre-treatment with CKRF. Furthermore, CKRF inhibited the recruitment of p65 to the interferon-sensitive response element flanking region in response to LPS. Finally, oral administration of CKRF significantly protected mice from Gram-negative bacterial LPS-induced lethal shock and inhibited systemic inflammatory cytokine levels. Together, these results demonstrate that CKRF modulates the TLR4-dependent NF-${\kappa}B$ activation, and suggest a therapeutic role for Gram-negative septic shock.

• Journal of the Korean Wood Science and Technology
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• 제33권6호통권134호
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• pp.8-16
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• 2005

산불로 인해 발생한 소나무 피해목은 귀중한 자원으로 활용가치가 있지만 과학적 근거가 없는 일반적 속설 때문에 이용이 기피되고 있다. 본 연구는 산불피해목의 산업적 활용에 필요한 재질을 평가하기 위해 수행하였다. 2000년 동해안에서 발생한 산불피해지에서 산불피해 소나무를 피해등급 "심", "중", "경"으로 구분하여 공시목으로 채취하고, 이들에 대한 물리적, 역학적, 화학적 특성을 조사하여 건전재와 비교하였다. 피해목의 육안적 현미경적 특성은 피해등급에 따른 차이가 없었다. 역학적 성능과 화학적 조성분의 비교에서도 건전재와 차이를 발견할 수 없었다. 이러한 연구결과로부터 산불 발생 직후 산불피해목의 산업적 이용에 요구되는 재질상의 제약요인은 없는 것으로 판명되었다.