• 대한음성학회:학술대회논문집
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• 대한음성학회 2003년도 10월 학술대회지
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• pp.43-49
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• 2003

This study reveals the perceptual role of stop release burst to Koreans' recognition of POA(place of articulation) and voicing in the English word-final stops. 10 Korean subjects participated in a perception experiment wherein the stimuli are prepared on the basis of the amount of acoustic information, which includes the release burst. The result shows that i) release burst plays an important role in the recognition of POA in the order of velar, alveolar, and bilabial stops, and ii) the release burst more enhances the correct recognition of voiceless stops than that of voiced stops. This result leads us to conclude that the role of stop release burst differs with respect to the POA and voicing of the stops, and it is possibly related to the different intensity of release in voicing and in each POA.

• 한국통신학회논문지
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• 제30권10A호
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• pp.912-921
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• 2005

Optical Burst Switched (OBS)는 If over WDM 망에서 테라비트 전송을 하기 위한 진보된 기술이다. OBS의 핵심 기술 중 하나는 데이터 버스트(DB : Data Burst)의 경쟁을 막기 위한 채널 스케쥴링 이다. OBS망에서 버스트의 제어패킷(CHP : Control Header Packet)과 데이터 버스트는 시간 간격(Time Gap)을 가지고 전송된다. 버스트 스위치 노드에 CHP가 도착하면 데이터 버스트을 위해 스케줄링 알고리즘을 사용하여 파장/채널(wavelength/channel)과 같은 자원을 예약하여 광전광(O/E/O)변환 없이 데이터 버스트를 전송해준다. 데이터 버스트를 위해 채널 스케줄링 과정에서 버스트간의 경쟁과 시간 간격이 발생되어 자원의 사용율과 버스트 손실 확률이 떨어진다. 기존에 제안된 방법들은 이러한 문제를 해결하기 위하여 많은 연구가 되어 지고 있다. 본 논문에서는 데이터 할당에서 발생되는 데이터간 간격과 데이터 손실에 중점을 두어 버스트 손실 확률과 자원 사용율을 극대화하기 위하여 버스트의 개방 시간)Release Time)을 이용한 채널 스케줄링 알고리즘 RTUC(Release Time Unscheduled Channel)을 제안한다. 시뮬레이션 결과 기존에 제안된 스케쥴링 알고리즘(LAUC, LAUC-VF)보다 버스트의 생존(Survival)과 효율적인 자원 사용 및 지연에서 개선된 성능을 확인하였다. 하지만, 로드가 적었을 경우 상대적으로 기존의 스케줄링 알고리즘보다 성능저하가 확인되었고, 로드가 증가했을 경우에는 데이터 손실 면에서 우수함을 확인하였다.

• Archives of Pharmacal Research
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• 제9권2호
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• pp.87-91
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• 1986

In attempt to develop a drug delivery system using serum albumin microspheres, bovine serum albumin microspheres containing antitumar agent. Cytarabine, were prepared. The shape, surface characteristics, size distribution, behavior of in vivo distribution, drug release behavior, and degradation of albumin microsphers in animal liver issue homogenate and proteolytic enzyme were investigated. The shape of albumin microspheres was spherical and the surface was smooth and compact. The size distribution of the albumin microspheres was effected by dispertion forces during emulsification and albumin concentration. Distribution of albumin microspheres after imtravenous administration in rabbit was achieved immediately. In vitro, albumin microsphere matrix was so hard that it retained most of cytarabine except initial burst during the first 10 minutes, and the level of drug release during the initial burst was affected by heating temperature, drug/albumin microsphere matrix was so hard that it retained most of cytarabine except initial burst during the first 10 minutes, and the level of drug release during the initial burst was affected by heating temperature, drug/albumin concentration ratio and size distribution. After drug release test, the morphology of albumin microspheres was not changed. Albumin microsphere matrix was degraded by the animal liver issue homogenate and proteolytic enzyme. The degree of degradation was affected by heating temperature.

• Nuclear Engineering and Technology
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• 제52권10호
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• pp.2402-2409
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• 2020

Analytical criteria for the onset of fuel fragmentation and Burst Fission Gas Release in fuel rods with ballooned claddings are formulated. On that basis, the GRSW-A model integrated with a fuel behaviour code is updated. After modification, the updated code is successfully applied to simulation of the Halden LOCA test IFA-650.12. Specifically, the calculation with Burst Fission Gas Release during the test resulted in prediction of cladding failure, whereas it could not be predicted at the test planning, before new models were implemented. A good agreement of the current model with experimental data for transient Fission Gas Release in the tests IFA-650.12 and IFA-650.14 is shown, as well.

• Archives of Pharmacal Research
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• 제27권1호
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• pp.1-12
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• 2004

Initial burst is one of the major challenges in protein-encapsulated microparticle systems. Since protein release during the initial stage depends mostly on the diffusional escape of the protein, major approaches to prevent the initial burst have focused on efficient encapsulation of the protein within the microparticles. For this reason, control of encapsulation efficiency and the extent of initial burst are based on common formulation parameters. The present article provides a literature review of the formulation parameters that are known to influence the two properties in the emulsion-solvent evaporation/extraction method. Physical and chemical properties of encapsulating polymers, solvent systems, polymer-drug interactions, and properties of the continuous phase are some of the influential variables. Most parameters affect encapsulation efficiency and initial burst by modifying solidification rate of the dispersed phase. In order to prevent many unfavorable events such as pore formation, drug loss, and drug migration that occur while the dispersed phase is in the semi-solid state, it is important to understand and optimize these variables.

• 약학회지
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• 제44권6호
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• pp.511-520
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• 2000

Various bupivacaine-loaded microspheres were prepared from poly (d,l-lactide) (PLA) or poly (d,l-lactic-co-glycolide) (PLGA) by a solvent evaporation method for the sustained release of drug. PLA and PLGA microspheres were prepared by w/o/w and w/o/o multiple emulsion solvent evaporation, respectively. The effects of process conditions such as emulsification speed, emulsifier type, emulsifier concentration and internal/external phase ratio on the characteristics of microspheres were investigated. The prepared microspheres were characterized for their drug loading, size distribution, surface morphology and release kinetics. Drug loading efficiency was higher in the microspheres prepared by w/o/o multiple emulsion than that by w/o/w multiple emulsion method, because the solubility of bupivacaine HCI was decreased in oil phase compared with water phase. The prepared microspheres had an average diameter between 1 and $2\;{\mu}M$ in all conditions of two methods. In morphology studies the PLA microspheres showed an irregular shape and smooth surface, but PLGA microspheres had a spherical shape and smooth surface. The release pattern of the drug from microspheres was evaluated on the basis of the burst effect and the extent of the release after 24h. The in vitro release of bupivacaine HCl from microspheres showed a large initial burst release and $60{\sim}80%$ release within one day in all conditions of two methods. The extents of the burst release against PLA and PLGA microspheres were $30{\sim}50%$ and $50{\sim}80%$ within 20min, respectively. This burst release seems to be due to the smaller size of microspheres and the solubility of drug in water.

• 한국농림기상학회지
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• 제7권3호
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• pp.185-191
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• 2005

An accurate prediction of dormancy release and bud burst in temperate zone fruit trees is indispensable for farmers to plan heating time under partially controlled environments as well as to reduce the risk of frost damage in open fields. A thermal time-based two-step phenological model that originated in Italy was applied to two important grapevine cultivars in Korea for predicting bud-burst dates. The model consists of two sequential periods: a rest period described by chilling requirement and a forcing period described by heating requirement. It requires daily maximum and minimum temperature as an input and calculates daily chill units (chill days in negative sign) until a pre-determined chilling requirement for rest release is met. After the projected rest release date, it adds daily heat units (anti-chill days in positive sign) to the chilling requirement. The date when the sum reaches zero isregarded as the bud-burst in the model. Controlled environment experiments using field sampled twigs of 'Campbell Early' and 'Kyoho' cultivars were carried out in the vineyard at the National Horticultural Research Institute (NHRI) in Suwon during 2004-2005 to derive the model parameters: threshold temperature for chilling and chilling requirement for breaking dormancy. The model adjusted with the selected parameters was applied to the 1994-2004 daily temperature data obtained from the automated weather station in the NHRI vineyard to estimate bud burst dates of two cultivars and the results were compared with the observed data. The model showed a consistently good performance in predicting the bud burst of 'Campbell Early' and 'Kyoho' cultivars with 2.6 and 2.5 days of root mean squared error, respectively.

• Bulletin of the Korean Chemical Society
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• 제29권2호
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• pp.422-426
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• 2008

Hemodialysis graft coated with paclitaxel prevents stenosis; however, large initial burst release of paclitaxel causes many negative effects such as drug toxicity and inefficient drug loss. Therefore we developed and tested a novel coating method, double dipping, to provide controlled and sustained release of paclitaxel locally. Expanded polytetrafluoroethylene (ePTFE) grafts were dipped twice into a solution of several different paclitaxel concentrations. In vitro release tests of the double dipping method showed that early burst release could be somewhat retarded and followed by sustained release for a long time. We observed the effect of paclitaxel coating by double dipping in porcine model of arterio-venous (AV) grafts between the common carotid artery and the external jugular vein. 12 weeks after constructing AV grafts, cross sections of the graft venous anastomosis were obtained and analyzed. Paclitaxel coated ePTFE grafts by double dipping were observed to prevent neointimal hyperplasia and therefore reduced stenosis of the arteriovenous hemodialysis grafts, especially at the graft venous anastomosis sites. Our results demonstrate that second dipping of ePTFE graft, which was already coated once with paclitaxel, washes off the drug on a surface of the graft and affects the ratio of paclitaxel on the surface to that of the inner space, possibly by diffusion: thus the early burst of drug can be somewhat reduced.

• Bulletin of the Korean Chemical Society
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• 제35권5호
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• pp.1333-1336
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• 2014

Expanded polytetrafluoroethylene (ePTFE) grafts have been used as vascular access for many patients suffering from end stage renal disease. However, the vascular graft can cause significant clinical problems such as stenosis or thrombosis. For this reason, many studies have been performed to make drug eluting graft, but initial burst is major problem in almost drug eluting systems. Therefore we used biodegradable polymer to reduce initial burst and make sustained drug delivery. The ePTFE grafts were dipped into a paclitaxel-dissolved solution and then PLGA-dissolved solution was passed through the lumen of ePTFE. We analyzed whether the dose of paclitaxel is enough and the loading amount of PLGA on ePTFE graft increases according to the coating solution's concentration. Scanning electron microscope (SEM) images of various concentration of PLGA showed that the porous surface of graft was more packed with PLGA by tetrahydrofuran solution dissolved PLGA. In addition, in vitro release profiles of Ptx-PLGA graft demonstrated that early burst was gradually decreased as increasing the concentration of PLGA. These results suggest that PLGA coating of Ptx loaded graft can retard drug release, it is useful tool to control drug release of medical devices.

• Macromolecular Research
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• 제17권12호
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• pp.1010-1014
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• 2009

Monodispersed microparticles with a poly(D,L-lactide-co-glycolide) (PLGA) core and a poly(ethyl 2-cyanoacrylate) (PE2CA) shell were prepared by Shirasu porous glass (SPG) membrane emulsification to reduce the initial burst release of doxorubicin (DOX). Solution mixtures with different weight ratios of PLGA polymer and E2CA monomer were permeated under pressure through an SPG membrane with $1.9\;{\mu}m$ pore size into a continuous water phase with sodium lauryl sulfate as a surfactant. Core-shell structured microparticles were formed by the mechanism of anionic interfacial polymerization of E2CA and precipitation of both polymers. The average diameter of the resulting microparticles with various PLGA:E2CA ratios ranged from 1.42 to $2.73\;{\mu}m$. The morphology and core-shell structure of the microparticles were observed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The DOX release profiles revealed that the microparticles with an equivalent PLGA:E2CA weight ratio of 1:1 exhibited the optimal condition to reduce the initial burst of DOX. The initial release rate of DOX was dependent on the PLGA:E2CA ratio, and was minimized at a 1:1 ratio.