• Macromolecular Research
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• 제12권4호
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• pp.407-412
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• 2004

A new hydroxyl group-containing conjugated ionic polymer, poly[2-ethynyl-N-(p-hydroxyphenylethyl)pyridinium bromide], was synthesized by the activated polymerization of 2-ethynylpyridine with p-(2-bromoethyl) phenol without any additional initiator or catalyst. The polymerization proceeded well to give a moderate yield (65%) of polymer at a reaction temparature of 90$^{\circ}C$. Another polymer, poly[2-ethynyl-N-(p-hydroxyphenylethyl)pyridinium tetraphenylborate], was readily prepared by the ion-exchange reaction of poly[2-ethynyl-N-(p-hydroxyphenylethyl)pyridinium bromide] with sodium tetraphenylborate. These polymers were completely soluble in organic solvents such as DMF, DMSO, and acetone, but insoluble in water and ether. Instrumental analyses, such as NMR, IR, and UV-Vis spectroscopies, indicated that the new materials have conjugated polymer backbone systems with the designed substituents and counter anions. X-Ray diffraction analyses of the polymers indicated that they were mostly amorphous.

• 분석과학
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• 제11권2호
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• pp.88-91
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• 1998

정상인과 메칠브로마이드 중독에 의하여 사망한 사람의 혈액 및 조직에서 이온크로마토그라프를 이용하여 브롬이온의 함량을 측정하였다. 용리액은 $2.8mM-NaHCO_3/2.2mM-Na_2CO_3$를 사용하였으며, 브롬이온은 8.9분에 검출되었고, 검출한계는 2.5 ng이었다. 정상인 혈액 및 조직에서 브롬이온의 함량은 각각 2.0~5.8 ppm 및 1.0~5.3 ppm 범위였다. 메칠브로마이드중독에 의해 사망한 사람의 경우 혈액중 브롬이온의 농도는 4사례에서 74.2~139 ppm 범위였으며, 조직중 브롬이온의 농도는 1사례에서 76(심장)~201(폐)ppm 범위였다. 메칠브로마이드중독에 의해 사망한 사람의 경우 혈중 브롬이온의 농도는 정상인에 비해 12~22배 높았다.

• 약학회지
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• 제31권2호
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• pp.45-51
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• 1987

Methyl orange(MO) and cetyltrimethylammonium bromide(CTA) were mixed and added to 10ml of the buffer solution and then the solution was shaken for 5 minutes. The maximum absorption wavelength of the reaction product was 419nm. Dichloromethane was the best extracting solvent among the several organic solvents and the most suitable pH range was 2~8. When the CTA-MO calibration curve was made in the best experimental condition, the Lambert-Beer's law was obeyed in the range of CTA concentration of $1.5\times$$10^{-5}$~1.0$\times$$10^{-4}M$ by UV spectrophotometer. This method was possible to determine quaternary ammonium salts in the pharmaceutical preparations.

• KSBB Journal
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• 제25권5호
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• pp.459-465
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• 2010

A simple and efficient analytical method for the simultaneous determination of seven tar color additives was developed using ion pair high performance liquid chromatography. The conditions for HPLC analysis were as follows: column, ${\mu}$-Bondapak C18 (10 ${\mu}m$, 300 ${\times}$ 3.9 mm i.d.); gradient mobile phase, 0.025 mol/L ammonium acetate (containing 0.01 mol/L tetrabutylammonium bromide)-acetonitrile-methanol (65:25:10) as a mobile for fraction A and 0.025 mol/L ammonium acetate (containing 0.01 mol/L tetrabutylammonium bromide)-acetonitrilemethanol (40:50:10) as a mobile for fraction B; flow rate, 1.0 mL/ min; detection wavelength, 254/520/620 nm. We could attain to the detection limits as 0.01~0.05 ${\mu}$g/mL (254 nm) and 0.005~0.01 ${\mu}$g/mL (520 nm) for six red tar color additives, and 0.05 ${\mu}$g/mL (254 nm) and 0.002 ${\mu}$g/mL (620 nm) for Fast green FCF. This analytical method was applicable to determine the tar color additives contained in several commercial cold syrups.

• Archives of Pharmacal Research
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• 제13권2호
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• pp.174-179
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• 1990

Second derivative (D2) spectrometry using ion-pair extraction technique was development for the determination of total glycyrrhetic acid (GA) in Glycyrrhizae Radix, Glycyr-rhizin (G) obtained from Glycyrrhizae Radix was hydrolyzed into GA in 2 N-HCI and methanol (1:1) and extracted from aqueous phase in the form of an ion-pair complex with tetrapentylammonium bromide (TPA) as a counter ion. Maximum D2 amplitude (Z value) was obtained when 1000-fold or greater molar ratio of TPA was used at pH 11. Reaction an effective extraction solvent of the ion-pair complex. The linearity of standard curve of ion-pair GA was obtained in the range of 4.120 $\mu$g/ml as GA. Assayed contents of GA in dry powder by D2 UV spectrometry and HPLC method were 5.31 $\pm$ 0.04% and 5.20 $\pm$ 0.008%, respectively.

• Bulletin of the Korean Chemical Society
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• 제10권4호
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• pp.357-359
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• 1989

The ion aggregates formed between cationic triphenylmethane dyes and tetraphenylborate(TPB) or tetrakis(4-fluorophenyl) borate (TFB) anions have been investigated spectroscopically. The photometric sensitivities of the dyes are found to be increasing in the order pararosaniline < malachite green < methyl violet 2B < crystal violet < ethyl violet. Cetyltrimethylammonium bromide(CTAB) and Triton X-100(TX-100) destroy the ion aggregates. By comparing the concentration of surfactant beyond which dye-borate mixed solutions behave identically with the dye blank, the order of hydrophobicity appears to be parallel with that of photometric sensitivity.

• 분석과학
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• 제7권3호
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• pp.413-419
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• 1994

생체시료 중에 함유된 베크로늄브로마이드(VeBr)를 정량하기 위해 로즈벵갈(RB)과 이온쌍착물(ion-pair complex)을 형성시켜 유기용매층으로 이행시킨 다음 형광광도법 및 형광검출기를 이용한 고속액체크로마토그래프(HPLC)법으로 정량하였다. 이 때 이온쌍착물의 최적 추출조건을 검토하기 위하여 완충액의 pH, 추출용매, 진탕시간의 영향을 실험하였다. 한편, 이온착물의 형성 및 조성은 연속변화법, 몰비법, IR, $^1H$-NMR로 확인하였으며, 또한 베크로늄브로마이드와 동시 투여될 수 있는 약물의 영향도 검토하였다.

• Bulletin of the Korean Chemical Society
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• 제29권12호
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• pp.2496-2498
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• 2008

• Bulletin of the Korean Chemical Society
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• 제11권4호
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• pp.347-350
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• 1990

The association between psoralens and some micelles is measured by the fluorescence quenching of psoralens by methylviologen $(MV^{2+})$ and bromide ion in some ionic micellar solutions. The association constants were estimated to be ca. $10^4$ for all the psoralens studied even though they show different hydrophobicity.

• 대한화학회지
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• 제30권2호
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• pp.224-230
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• 1986

알킬처리된 실리카(ODS)칼럼을 이용하여 역상 이온쌍 크로마토그래피방법으로 방향족 술폰산들의 분리 인자를 조사하였으며 또한 분리를 시도하였다. 반대이온으로서 브롬화 도데실 트리메틸암모늄(DTAB)을 사용하였으며, 시료의 분리인자는 반대이온의 농도, 메탄올의 농도, 전해질의 종류 및 농도, 시료 분자에 붙어있는 작용기의 종류 및 위치등에 의하여 영향을 받았다. 최적 조건하에서 몇 가지 혼합시료를 분리할 수 있었다.