• 제목/요약/키워드: Broad spectrum

검색결과 856건 처리시간 0.052초

당뇨병성 족부 감염 환자의 초기 선택 항생제 효율성 (Analysis of Initial Choice Antibiotics Efficacy in Diabetic Foot Infection)

  • 이두형;한승환;박민정
    • 대한족부족관절학회지
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    • 제13권2호
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    • pp.146-149
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    • 2009
  • Purpose: Foot infections are common complications in patients with diabetes. The patients are usually immune-compromised; therefore the pathogens could be resistant to narrow spectrum antibiotics. Those drugs, however, are categorized as specially managed antibiotics, and access are difficult without confirming of the pathogens. Our aim was to analyze the common pathogens in diabetic foot infection and figure out the proper antibiotics. Materials and Methods: We studied 68 patients treated with diabetic foot infection. The pathogens which caused the infection and their sensitivity to initial antibiotics were analyzed. We also investigated the change of the antibiotics after the confirming of the culture result and average time to get the result. Results: Among the 68 patients, 56 (82%) received cephalosporin and beta-lactam antibiotics. Only 12 (18%) who were confirmed the drug resistant pathogens from previous culture, were treated with broad spectrum antibiotics such as vancomycin and tazoperan. Average culture study time was 6 days. Methicillin-resistant staphylococcus aureus (MRSA) was cultured in 19 patients (28%), Methicillin-resistant coagulase negative staphylococcus (MRCNS) in 11 patietns (17%), pseudomonas in 11 patients (17%). Total 44 (65%) including 3 of other antibiotics resistant pathogen needed broad spectrum antibiotics. Thirty two patients (47%) were resistant to initial antibiotics.irt follow up culture, 2 MRSA and 2 MRCNS were found. The antibiotics resistant pathogens were confirmed in 48 (71%) patients at last. Conclusion: Diabetic patients with foot infection need proper antibiotics from initial treatment. The proper broad spectrum antibiotics should assigned to the patients from the first time without the confirming of the culture results.

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An Integrated Game Theoretical Approach for Primary and Secondary Users Spectrum Sharing in Cognitive Radio Networks

  • Kim, Jong-Gyu;Nguyen, Khanh-Huy;Lee, Jung-Tae;Hwang, Won-Joo
    • 한국멀티미디어학회논문지
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    • 제14권12호
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    • pp.1549-1558
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    • 2011
  • In this paper, we address the problem of bandwidth sharing among multiple primary users and multiple secondary users in a cognitive radio network. In cognitive radio networks, effective spectrum assignment for primary and secondary users is a challenge due to the available broad range of radio frequency spectrum as well as the requisition of harmonious coexistence of both users. To handle this problem, firstly, Bertrand game model is used to analyze a spectrum pricing in which multiple primary users emulate with each other to acquire maximal profit. After that, we employ Cournot game to model the spectrum sharing of secondary users to obtain optimal profit for each user also. Simulation results show that our scheme obtains optimal solution at Nash equilibrium.

Wicaltin, a New Protein Toxin Secreted by the Yeast Williopsis californica and Its Broad-Spectrum Antimycotic Potential

  • Theisen, Simone;Molkenau, Elisabeth;Schmitt, Manfred J.
    • Journal of Microbiology and Biotechnology
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    • 제10권4호
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    • pp.547-550
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    • 2000
  • The yeast Williopsis californica was shown to secrete a unique broad-spectrum killer toxin (Wicaltin) with antifungal activity against 14 yeast genera, including yeast-like and mycelial forms of the human pathogens Candida albicans and Sporothrix schenkii. Agar diffusion bioassays indicated that its activity was more pronounced than the antifungal potential of frequently used antimycotics; 0.07 pmol Wicaltin showed the same toxicity as 0.2 pmol miconazole and 29 pmol clotrimazole. Since the toxin's primary target would appear to be the yeast cell wall, Wicaltin may be attractive in combatting clinically relevant yeast and fungal infections.

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New Red Phosphor with the Improved Color Purity for PDP Applications

  • Mho, Sun-Il
    • 한국정보디스플레이학회:학술대회논문집
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    • 한국정보디스플레이학회 2002년도 International Meeting on Information Display
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    • pp.257-259
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    • 2002
  • As a new host material for a red phosphor for PDP applications, has studied (Y,Gd)$Al_3(BO_3)_4$ which gives non-centrosymmetric sites for $Eu^{3+}$ activators. Vacuum ultraviolet (VUV) excitation spectrum of new red phosphor (Y,Gd)$Al_3(BO_3)_4$:$Eu^{3+}$ has two broad bands. One band with the absorption edge at ca. 168 nm is the band-gap absorption of aluminoborate and the other broad band centered 240 nm is the charge transfer transition between $Eu^{3+}$ and the neighboring oxygen anions. The PL spectrum shows the strongest emission at 617 nm due to the electric dipole $^5D_0{\rightarrow}^7F_2$ transition of $Eu^{3+}$, whose luminescent chromaticity is (0.67, 0.33).

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Removal of a synthetic broad-spectrum antimicrobial agent, triclosan, in wastewater treatment systems: A short review

  • Lee, Do Gyun
    • Environmental Engineering Research
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    • 제20권2호
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    • pp.111-120
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    • 2015
  • Contaminants of emerging concern (CECs) including endocrine disrupting compounds (EDCs) and pharmaceuticals and personal care product chemicals (PPCPs) have recently received more attention because of their occurrence in water bodies and harmful impacts on human health and aquatic organisms. Triclosan is widely used as a synthetic broad-spectrum antimicrobial agent due to its antimicrobial efficacy. However, triclosan detected in aquatic environment has been recently considered as one of CECs, because of the potential for endocrine disruption, the formation of toxic by-products and the development of cross-resistance to antibiotics in aquatic environment. This comprehensive review focuses on the regulations, toxicology, fate and transport, occurrence and removal efficiency of triclosan. Overall, this review aims to provide better understanding of triclosan and insight into application of biological treatment process as an efficient method for triclosan removal.

Synthetic $\beta$-Lactam Antibiotics IV. Antibacterial activity of some 7 $\beta$-[2-(2-Aminothizol-4-yl)-2-(methoxyimino) acetaido]-3-(1-alkyl-1H-terazol-5-yl)thiomethyl-cephalospoins

  • Lee, Duck-Hyung;Kim, Sam-Min;Park, Sang-Woo;Kim, You-Seung
    • Archives of Pharmacal Research
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    • 제13권4호
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    • pp.385-387
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    • 1990
  • 3-[(1-Methyl-1H-tetrazol-5-y)thiomethyl] is one of the most important side chains in cephaloporins. This side chain which occures in numerous antibacterial agents, suc as cefamandole, latamoxef, cefoperazone, and cefmenoxime, contributes remarkable potency and broad spectrum. For the continuous work of study on the development of broad spectrum cephalosporins, we become interested in the effect of structural modification of the substituent at the N-1 position of mercaptoterazole toward biological activity because our recent work had demonstraated that the arylsubstituted mercaptotetrazoles (Fig. 1) had favorable effect on the activity against gram-positive bacteria. The main focus of this report was to investigate the relationship between activity and functional groups in the mercaptotetrazole.

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광대역 이득 레이저 다이오드 설계 및 제작 (Design and Fabrication of Broad Gain Laser Diodes)

  • 권오기;김강호;김현수;김종회;심은덕;오광룡
    • 한국광학회지
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    • 제14권3호
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    • pp.286-291
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    • 2003
  • 광대역 이득 특성을 얻기 위한 InGaAsP-InP 응력보상 비대칭 다중 양자우물(Asymmetric Multiple Quantum Well, AMQW) 구조를 성장하고, Ridge Waveguide Laser Diodes(RWG-LDs)를 제작하였다. 제작 후 소자의 동작변수와 모드 이득을 측정하였으며, 얻어진 결과를 비교, 분석하였다. 외부 공진기형 구조에서 넓고 평탄한 이득특성을 얻기 위해 한쪽 단면에 Anti-Reflection(AR) 코팅을 수행하여 AR coated AMQW RWG LD의 이득특성을 분석하였다.