• 대한미세수술학회:학술대회논문집
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• 대한미세수술학회 1997년도 제17차 학술대회
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• pp.121.1-121.1
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• 1997

• 한국콘텐츠학회논문지
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• 제9권12호
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• pp.348-356
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• 2009

본 연구는 요부안정화에 도움이 되는 불안정 기저면의 운동인 공운동, 전신진동운동, 매트운동을 선택하여 각 운동조건의 체간과 하지의 근 활성도(%RVC)를 비교한 결과, 배속빗근은 전신진동기조건에서 매트조건보다 유의하게 증가하였고(p<.05), 넙다리곧은근과 장딴지안쪽갈래근은 공과 전신진동기조건에서 매트조건 보다 유의하게 증가하였으며(p<.05), 오금안쪽갈래근은 공조건에서 매트조건 보다 유의하게 증가하였다(p<.05). 세 가지 운동방법으로 4주간 안정화운동프로그램을 진행시킨 결과, 세 운동군 모두 운동전보다 운동 후에 각 방향에서 안정성한계의 유의한 증가가 있었다(p<.05). 각 운동군의 운동 전 후의 안정성한계의 차이 값을 비교한 결과, 각 운동군에서 네 방향(전 후 좌 우)의 안정성한계에 유의한 차이가 없었다(p>.05). 따라서 교각자세에서의 요부안정화 운동방법 중에서 체간근과 하지근육의 근활성도는 공과 전신진동기 운동에서 더 증가되었지만, 안정화운동 4주후에는 세 운동 모두 자세안정성을 증진시키는 것으로 나타났다.

• Journal of Korean Neurosurgical Society
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• 제60권4호
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• pp.417-423
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• 2017

Objective : Repair of sensorial nerve defect is an important issue on peripheric nerve surgery. The aim of the present study was to determine the effects of sensory-motor nerve bridging on the denervated dermatomal area, in rats with sensory nerve defects, using a neural cell adhesion molecule (NCAM). Methods : We compared the efficacy of end-to-side (ETS) coaptation of the tibial nerve for sural nerve defect repair, in 32 Sprague-Dawley rats. Rats were assigned to 1 of 4 groups : group A was the sham operated group, group B rats had sural nerves sectioned and buried in neighboring muscles, group C experienced nerve sectioning and end-to-end (ETE) anastomosis, and group D had sural nerves sectioned and ETS anastomosis was performed using atibial nerve bridge. Neurological evaluation included the skin pinch test and histological evaluation was performed by assessing NCAM expression in nerve terminals. Results : Rats in the denervated group yielded negative results for the skin pinch tests, while animals in the surgical intervention groups (group C and D) demonstrated positive results. As predicted, there were no positively stained skin specimens in the denervated group (group B); however, the surgery groups demonstrated significant staining. NCAM expression was also significantly higher in the surgery groups. However, the mean NCAM values were not significantly different between group C and group D. Conclusion : Previous research indicates that ETE nerve repair is the gold standard for peripheral nerve defect repair. However, ETS repair is an effective alternative method in cases of sensorial nerve defect when ETE repair is not possible.

• Clinics in Shoulder and Elbow
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• 제26권4호
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• pp.406-415
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• 2023

Background: Surgical management of a massive rotator cuff tear (RCT) is always challenging. This study describes the clinical and radiological outcomes of patients who underwent bridging grafts using a plantaris tendon for an irreparable RCT. Methods: Thirteen patients with a massive RCT were treated with arthroscopic interposition of a folded plantaris tendon autograft between June 2017 and January 2020. For clinical evaluation, a visual analog scale (VAS), American Shoulder and Elbow Surgeons (ASES) score, Disabilities of the Arm, Shoulder, and Hand (DASH) score, Constant-Murley score, and range of motion values were collected. For radiographic evaluation, standardized magnetic resonance imaging and ultrasonography were performed to check the integrity of the interposed tendon. Results: A statistically significant improvement at the final follow-up was evident in scores for the VAS (-3.0, P=0.003), ASES (24.9, P=0.002), D ASH (-20.6, P=0.001), and Constant-Murley values (14.2, P=0.010). In addition, significant improvement was shown in postoperative flexion (17.3°, P=0.026) and external rotation (27.7°, P<0.001). In postoperative radiologic evaluations, the interposed tendons were intact at the last examination in 12 of the 13 patients. No complications related to donor sites were reported. Conclusions: An arthroscopic bridging graft for irreparable RCTs using a modified Mason-Allen stitch and a plantaris autograft resulted in improved short-term radiological and clinical outcomes. Graft integrity was maintained for up to 2 years in most patients. Level of evidence: IV.

• Asian Journal for Public Opinion Research
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• 제3권1호
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• pp.1-21
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• 2015

A recent public opinion survey found that the anti-corporate sentiment of South Korean citizens is primarily due to the misbehavior of Korean corporations. South Korean citizens' skepticism of corporations may hinder the democratic and economic development of the country. As a driving force for community development, social capital is considered to enable citizens to collaborate with one another to resolve a shared problem. Specifically, this study pays attention to the relationship among social capital, corporate capacity, and trust, which may perhaps contribute to developing a democratic environment in Korean society. The study aims to explore whether Korean citizens' perceived corporate bonding and bridging social capital affect corporate capacity for collaborative action and trust in corporations. A Web survey of 385 South Koreans was conducted. The findings show that perceived bonding social capital among employees is positively related to corporate capacity for collaboration action. Moreover, perceived bonding among employees and bridging social capital between employees and local residents are positively related to corporate capacity for collaboration action and trust in corporations. These findings suggest that researchers and practitioners for organizational development and community-building need to enhance corporate social capital.

• 유통과학연구
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• 제15권11호
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• pp.31-39
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• 2017

Purpose - This research aims to examine the influence of social capital formed on SNS on SNS users' life satisfaction. This research divides social capital into bridging and bonding social capital based on Social Capital Theory and suggests that each type of social capital will have a positive impact on SNS users' life satisfaction. In addition, this research suggests the self-construal of SNS users as a moderating variable based on Self-Construal Theory. Research design, data, and methodology - To test the hypotheses presented, an online survey was conducted with adult participants. An online research company was hired to conduct an online survey; survey participants were volunteer adult participants residing in Korea. And data was analyzed using SPSS. Results - Analysis results showed that the impact of bonding social capital on life satisfaction was not statistically different between SNS users of differing self-construals(independent vs. interdependent self-construal). However, this study also determined that the impact of bridging social capital on life satisfaction was greater for SNS users with an interdependent self-construal as opposed to those with an independent self-construal. Conclusions - The results of this study expand the scope of available research on social capital formed on SNS and provide practical implications for SNS providers.

• Journal of Korean Neurosurgical Society
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• 제60권6호
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• pp.611-619
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• 2017

Objective : In addition to bone bridging inside a cage or graft (intragraft bone bridging, InGBB), extragraft bone bridging (ExGBB) is commonly observed after anterior cervical discectomy and fusion (ACDF) with a stand-alone cage. However, solid bony fusion without the formation of ExGBB might be a desirable condition. We hypothesized that an insufficient contact area for InGBB might be a causative factor for ExGBB. The objective was to determine the minimal area of InGBB by finite element analysis. Methods : A validated 3-dimensional, nonlinear ligamentous cervical segment (C3-7) finite element model was used. This study simulated a single-level ACDF at C5-6 with a cylindroid interbody graft. The variables were the properties of the incorporated interbody graft (cancellous bone [Young's modulus of 100 or 300 MPa] to cortical bone [10000 MPa]) and the contact area between the vertebra and interbody graft (Graft-area, from 10 to $200mm^2$). Interspinous motion between the flexion and extension models of less than 2 mm was considered solid fusion. Results : The minimal Graft-areas for solid fusion were $190mm^2$, $140mm^2$, and $100mm^2$ with graft properties of 100, 300, and 10000 MPa, respectively. The minimal Graft-areas were generally unobtainable with only the formation of InGBB after the use of a commercial stand-alone cage. Conclusion : ExGBB may be formed to compensate for insufficient InGBB. Although various factors may be involved, solid fusion with less formation of ExGBB may be achieved with refinements in biomaterials, such as the use of osteoinductive cage materials; changes in cage design, such as increasing the area of polyetheretherketone or the inside cage area for bone grafts; or surgical techniques, such as the use of plate/screw systems.

• 경영정보학연구
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• 제21권3호
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• pp.131-149
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• 2019

스마트폰, 태블릿과 같은 디지털 기기의 보급이 광범위하게 확산되면서 '접근'을 중심으로 진행되던 정보격차에 대한 이론적 논의가 정보의 효과적인 '활용'과 능동적인 '생산', '공유'로 확대되고 있다. 이러한 논의가 중요한 것은 디지털 기술의 활용 행태가 개인의 인적, 물적 네트워크에 영향을 미침으로써 사회적 불평등 구조를 재생산하거나 심화시키는 결과를 가져올 수 있기 때문이다. 본 연구에서는 개인이 맺고 있는 사회적 관계가 두 가지 유형의 사회적 자본(결속형, 가교형)을 매개로 디지털 기기의 경제적 활용과 사회참여적 활용에 미치는 영향에 대해 살펴보았다. 전문리서치 업체를 통해 수집된 740건의 설문조사 데이터에 대한 실증분석 결과, 개인의 사회적 관계가 수평적일수록 결속형 사회적 자본과 가교형 사회적 자본이 증가하는 것으로 나타났다. 그러나 개인의 사회적 관계는 두 가지 형태의 디지털 기기 활용(경제적, 사회참여적) 모두에 직접적인 영향보다는 사회적 자본을 통한 간접적인 영향을 미치는 것으로 나타났다. 특히, 가교형 사회적 자본의 경우 두 가지 형태의 디지털 기기 활용 모두에 대해 매개효과가 존재했지만, 결속형 사회적 자본은 경제적 활용에 대해서만 매개효과가 존재하는 것으로 나타났다. 도출된 결과에 대한 해석과 함께 이론적, 실무적 시사점을 제시하였다.

• Journal of Pharmaceutical Investigation
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• 제35권6호
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• pp.437-443
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• 2005

A rapid, selective and sensitive reversed-phase HPLC method for the determination of a major metabolite of terfenadine, fexofenadine, in human serum was developed, validated, and applied to the pharmacokinetic study of terfenadine. Fexofenadine and internal standard, haloperidol were extracted from human serum by liquid-liquid extraction with acetonitrile and analyzed on a $Symmetry^{TM}$ C8 column with the mobile phase of 1% triethylamine phosphate (pH 3.7)-acetonitrile (67:33, v/v, adjusted to pH 5.6 with triethylamine). Detection wavelength of 230 nm for excitation, 280 nm for emission and flow rate of 1.0 mL/min were fixed for the study. The assay robustness for the changes of mobile phase pH, organic solvent content, and flow rate was confirmed by $3^{3}$ factorial design using a fixed fexofenadine concentration (50 ng/mL) with respect to its peak area and retention time. In addition, the ruggedness of this method was investigated at three different laboratories using same quality control (QC) samples. This method showed linear response over the concentration range of 10-500 ng/mL with correlation coefficients greater than 0.999. The lower limit of quantification using 0.5 mL of serum was 10 ng/mL, which was sensitive enough for the pharmacokinetic studies of terfenadine. The overall accuracy of the quality control samples ranged from 95.70 to 114.58% for fexofenadine with overall precision (% C.V.) being 3.53-14.39%. The relative mean recovery of fexofenadine for human serum was 90.17%. Stability studies (freeze-thaw, short-term, extracted serum sample and stock solution) showed that fexofenadine was stable during storage, or during the assay procedure in human serum. However, the storage at $-70^{\circ}C$ for 4 weeks showed that fexofenadine was not stable. The peak area and retention time of fexofenadine were not significantly affected by the changes of mobile phase pH, organic solvent content, and flow rate under the conditions studied. This method showed good ruggedness (within 15% C.V.) and was successfully used for the analysis of fexofenadine in human serum samples for the pharmacokinetic studies of orally administered Tafedine tablet (60 mg as terfenadine) at three different laboratories, demonstrating the suitability of the method.

• Journal of Pharmaceutical Investigation
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• 제35권4호
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• pp.265-271
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• 2005

A rapid, selective and sensitive reversed-phase HPLC method for the determination of etodolac in human serum was developed, validated, and applied to the pharmacokinetic study of etodolac. Etodolac and internal standard, ibuprofen were extracted from human serum by liquid-liquid extraction with hexane/isopropanol (95:5, v/v) and analyzed on a Luna C18(2) column with the mobile phase of 1% aqueous acetic acid-acetonitrile (4:6, v/v). Detection wavelength of 227 nm and flow rate of 1.0 mL/min were fixed for the study. The assay robustness for the changes of mobile phase pH, organic solvent content, and flow rate was confirmed by $3^3$ factorial design using a fixed etodolac concentration $(1\;{\mu}g/mL)$ with respect to its peak area and retention time. And also, the ruggedness of this method was investigated at three different laboratories using same quality control (QC) samples. This method showed linear response over the concentration range of $0.05-40\;{\mu}g/mL$ with correlation coefficients greater than 0.999. The lower limit of quantification using 0.5 mL of serum was 0.05 ${\mu}g/mL$, which was sensitive enough for pharmacokinetic studies. The overall accuracy of the quality control samples ranged from 92.00 to 110.00% for etodolac with overall precision (% C.V.) being 1.08-10.11%. The percent recovery for human serum was in the range of 76.73-115.30%. Stability studies showed that etodolac was stable during storage, or during the assay procedure in human serum. The peak area and retention time of etodolac were not significantly affected by the changes of mobile phase pH, organic solvent content, and flow rate under the conditions studied. This method showed good ruggedness (within 15% C.V.) and was successfully used for the analysis of etodolac in human serum samples for the pharmacokinetic studies of orally administered Lodin XL tablet (400 mg as etodolac) at three different laboratories, demonstrating the suitability of the method.