• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2021년도 춘계학술대회
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• pp.134-136
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• 2021

인공지능 알고리즘을 이용한 유방암의 조기진단에 관련된 연구는 최근들어 활발하게 진행되고 있다. 이는 연구용으로 공개된 초음파 유방 이미지를 활용하여 다양하게 개발되고 있으나, 사용자의 목적에 맞는 처리 속도 및 정확도 등에 다양한 한계점을 보인다. 이러한 문제를 해결하기 위해, 본 논문에서는 ImageNet에서 학습된 ResNet 모델을 현미경 기반 암세포 이미지에서 활용이 가능한 다단계 전이 학습을 제안하고, 이를 다시 전이 학습하여 초음파 유방암 영상을 양성 및 악성으로 분류하는 실험을 진행하였다. 실험을 위한 영상은 양성과 악성이 포함된 250장의 유방암 초음파 영상과 27,200장의 암 세포주 영상으로 구성되었다. 제안된 다단계 전이 학습 알고리즘은 초음파 유방암 영상을 분류하였을 때 96% 이상의 정확도를 보였으며, 향후 암 세포주 및 실시간 영상처리 등의 추가를 통해 보다 높은 활용도와 정확도를 보일 것으로 기대한다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제17권3호
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• pp.678-700
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• 2023

Diagnosing breast diseases using ultrasound (US) images remains challenging because it is time-consuming and requires expert radiologist knowledge. As a result, the diagnostic performance is significantly biased. To assist radiologists in this process, computer-aided diagnosis (CAD) systems have been developed and used in practice. This type of system is used not only to assist radiologists in examining breast ultrasound images (BUS) but also to ensure the effectiveness of the diagnostic process. In this study, we propose a new approach for breast lesion localization and segmentation using a multi-scale pyramid of the ultrasound image of a breast organ and a convolutional semantic segmentation network. Unlike previous studies that used only a deep detection/segmentation neural network on a single breast ultrasound image, we propose to use multiple images generated from an input image at different scales for the localization and segmentation process. By combining the localization/segmentation results obtained from the input image at different scales, the system performance was enhanced compared with that of the previous studies. The experimental results with two public datasets confirmed the effectiveness of the proposed approach by producing superior localization/segmentation results compared with those obtained in previous studies.

• Journal of information and communication convergence engineering
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• 제20권1호
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• pp.58-64
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• 2022

Breast ultrasonic reading is critical as a primary screening test for the early diagnosis of breast cancer. However, breast ultrasound examinations show significant differences in diagnosis based on the difference in image quality according to the ultrasonic equipment, experience, and proficiency of the examiner. Accordingly, studies are being actively conducted to analyze the texture characteristics of normal breast tissue, positive tumors, and malignant tumors using breast ultrasonography and to use them for computer-assisted diagnosis. In this study, breast ultrasonography was conducted to select 247 ultrasound images of 71 normal breast tissues, 87 fibroadenomas among benign tumors, and 89 malignant tumors. The selected images were calculated using a statistical method with 21 feature parameters extracted using the gray level co-occurrence matrix algorithm, and classified as normal breast tissue, benign tumor, and malignancy. In addition, we proposed five feature parameters that are available for computer-aided diagnosis of breast cancer classification. The average classification rate for normal breast tissue, benign tumors, and malignant tumors, using this feature parameter, was 82.8%.

• International Journal of Internet, Broadcasting and Communication
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• 제16권1호
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• pp.124-131
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• 2024

Breast cancer classification using ultrasound, while widely employed, faces challenges due to its relatively low predictive value arising from significant overlap in characteristics between benign and malignant lesions, as well as operator-dependency. To alleviate these challenges and reduce dependency on radiologist interpretation, the implementation of automatic breast cancer classification in ultrasound image can be helpful. To deal with this problem, we propose a semi-supervised deep learning framework for breast cancer classification. In the proposed method, we could achieve reasonable performance utilizing less than 50% of the training data for supervised learning in comparison to when we utilized a 100% labeled dataset for training. Though it requires more modification, this methodology may be able to alleviate the time-consuming annotation burden on radiologists by reducing the number of annotation, contributing to a more efficient and effective breast cancer detection process in ultrasound images.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2021년도 추계학술대회
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• pp.655-657
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• 2021

인공지능 알고리즘을 이용한 유방암의 조기진단에 관련된 연구는 최근들어 활발하게 진행되고 있으나, 사용자의 목적에 맞는 처리속도 및 정확도 등에 다양한 한계점을 보인다. 이러한 문제를 해결하기 위해, 본 논문에서는 ImageNet에서 학습된 ResNet 모델을 현미경 기반 암세포 이미지에서 활용이 가능한 다단계 전이 학습을 제안하고, 이를 다시 전이 학습하여 초음파 유방암 영상을 양성 및 악성으로 분류하는 실험을 진행하였다. 제안된 다단계 전이 학습 알고리즘은 초음파 유방암 영상을 분류하였을 때 96% 이상의 정확도를 보였으며, 향후 암 세포주 및 실시간 영상처리 등의 추가를 통해 보다 높은 활용도와 정확도를 보일 것으로 기대한다.

• International journal of advanced smart convergence
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• 제8권1호
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• pp.24-34
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• 2019

In this research, a practical deep learning framework to differentiate the lesions and nodules in breast acquired with ultrasound imaging has been proposed. 7408 ultrasound breast images of 5151 patient cases were collected. All cases were biopsy proven and lesions were semi-automatically segmented. To compensate for the shift caused in the segmentation, the boundaries of each lesion were drawn using Fully Convolutional Networks(FCN) segmentation method based on the radiologist's specified point. The data set consists of 4254 benign and 3154 malignant lesions. In 7408 ultrasound breast images, the number of training images is 6579, and the number of test images is 829. The margin between the boundary of each lesion and the boundary of the image itself varied for training image augmentation. The training images were augmented by varying the margin between the boundary of each lesion and the boundary of the image itself. The images were processed through histogram equalization, image cropping, and margin augmentation. The networks trained on the data with augmentation and the data without augmentation all had AUC over 0.95. The network exhibited about 90% accuracy, 0.86 sensitivity and 0.95 specificity. Although the proposed framework still requires to point to the location of the target ROI with the help of radiologists, the result of the suggested framework showed promising results. It supports human radiologist to give successful performance and helps to create a fluent diagnostic workflow that meets the fundamental purpose of CADx.

• Asian Pacific Journal of Cancer Prevention
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• 제15권24호
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• pp.10739-10743
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• 2015

The present study aimed at evaluating and comparing the diagnostic performance of B-mode ultrasound (US), elastography score (ES), and strain ratio (SR) for the differentiation of breast lesions. This retrospective study enrolled 431 lesions from 417 in-hospital patients. All patients were examined with both conventional ultrasound and elastography. Two experienced radiologists reviewed ultrasound and elasticity images. The histopathologic result obtained from ultrasound-guided core biopsy or operation excisions were used as the reference standard. Pathologic examination revealed 276 malignant lesions (64%) and 155 benign lesions (36%). A cut-off point of 4.15 (area under the curve, 0.891) allowed significant differentiation of malignant and benign lesions. ROC (receiver-operating characteristic) curves showed a higher value for combination of B-mode ultrasound and elastography for the diagnosis of breast lesions. Conventional ultrasound combined elastography showed high sensitivity, specificity, and accuracy for group II lesions (10mm${\leq}20mm$). Elastography combined with conventional ultrasound show high specificity and accuracy for differentiation of benign and malignant breast lesions. Elastography is particularly important for the diagnosis of BI-RADS 4 and small breast lesions.

• 전기학회논문지
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• 제66권8호
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• pp.1272-1277
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• 2017

To assist radiologists for the characterization of breast masses, Computer-aided Diagnosis(CADx) system has been studied. The CADx system can improve the diagnostic accuracy of radiologists by providing objective information about breast masses. Morphological and texture features were extracted from the breast ultrasound images. Based on extracted features, the CADx system retrieves masses that are similar to a query mass from a reference library using a k-nearest neighbor (k-NN) approach. Eight similarity measures of distance, Euclidean, Chebyshev(Minkowski family), Canberra, Lorentzian($F_2$ family), Wave Hedges, Motyka(Intersection family), and Cosine, Dice(Inner Product family) are evaluated by ROC(Receiver Operating Characteristic) analysis. The Inner Product family measure used with the k-NN classifier provided slightly higher performance for classification of malignant and benign masses than those with the Minkowski, $F_2$, and Intersection family measures.

• Korean Journal of Radiology
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• 제25권2호
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• pp.134-145
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• 2024

Abnormalities on breast ultrasound (US) images which do not meet the criteria for masses are referred to as nonmass lesions. These features and outcomes have been investigated in several studies conducted by Asian researchers. However, the term "nonmass" is not included in the American College of Radiology (ACR) Breast Imaging Reporting and Data System (BI-RADS) 5th edition for US. According to the Japan Association of Breast and Thyroid Sonology guidelines, breast lesions are divided into mass and nonmass. US findings of nonmass abnormalities are classified into five subtypes: abnormalities of the ducts, hypoechoic areas in the mammary glands, architectural distortion, multiple small cysts, and echogenic foci without a hypoechoic area. These findings can be benign or malignant; however, focal or segmental distributions and presence of calcifications suggest malignancy. Intraductal, invasive ductal, and lobular carcinomas can present as nonmass abnormalities. For the nonmass concept to be included in the next BI-RADS and be widely accepted in clinical practice, standardized terminologies, an interpretation algorithm, and outcome-based evidence are required for both screening and diagnostic US.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2021년도 추계학술대회
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• pp.307-310
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• 2021

지난 몇년간 유방 초음파영상을 이용한 신호 및 영상처리 기술과 자동 영상 최적화 기술, 유방 종괴 자동 검출 및 분류 기술 등, 컴퓨터 보조 진단(computer-aided diagnosis, CAD)을 활용하는 연구들이 활발히 진행되어지고 있다. 컴퓨터진단기술이 개발될수록 암의 조기 발견이 정확하고 빠르게 진행되어 건강 보험과 환자의 검사 빙용을 줄일 수 있고 조직 검사에 대한 불안감을 없앨 수 있을 것으로 기대된다. 본 논문에서는 GLCM(gray level co-occurrence matrix)을 사용하여 초음파 영상에서 종양의 정량적 분석을 진행하여 컴퓨터보조 진단에 활용 가능성을 실험하였다.