• 대한간호학회지
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• 제36권4호
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• pp.604-611
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• 2006

Purpose. Koreans are one of the fastest growing Asian populations in the U.S. since 1960s. In Korean immigrant women (KIW), breast cancer was reported as the most frequently diagnosed cancer. However, their screening rates for breast cancer are lower than national guidelines; it is assumed that underlying cultural schemas of breast, breast cancer, and its screening modalities exist and need to be studied. This study was aimed to investigate cultural meanings of breast, breast cancer, and breast cancer screenings in KIW. Methods. Using cultural models theory from cognitive anthropology, naturalistic qualitative methodology was utilized. Three focus group interviews with fifteen KIW were conducted. Thematic analysis with constant comparison technique was performed eliciting units of meaning, categories, and themes. Results. The cultural schema of the meaning of breast is 'mother who is breast-feeding her baby,' with two themes of 'balance in size,' and 'shyness.' Regarding breast cancer, three themes, i.e., 'indifference,' 'fear,' and 'uncertainty' are emerged. 'Lack of information about screening modalities' is the overarching schema with reference to breast cancer screenings. Conclusions. The findings of this study demonstrate unique cultural models of KIW related to breast cancer and its screenings, which are critical to understand and penetrate their barriers to breast cancer screening.

• 대한물리의학회지
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• 제16권4호
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• pp.45-53
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• 2021

PURPOSE: This study examined women's attitudes toward the use of physical therapy in the treatment process after breast cancer surgery and the degree of interest in this application. Path analysis was conducted to discover the approaches to improve awareness of the necessity of physical therapy intervention after breast cancer surgery. METHODS: This study was a cross-sectional survey of 230 women aged 20 years and over with no history of breast cancer. The measurement tool used in this study was a structured questionnaire, composed of 17 items in five fields: five items on the demographic characteristics, four items related to health checkups, four items involving the viewpoints on breast cancer, one item related to the interest in breast cancer, and four items related to physical therapy after surgery. RESULTS: Women's attitudes toward regular health checkups were major factors in the prevention and treatment of breast cancer. In addition, those with higher levels of interest in breast cancer showed stronger interest in using physical therapy after breast cancer surgery. CONCLUSION: Women believe that breast cancer can be prevented through the health checkups implemented by the government. Therefore, there is a need to utilize public relations to promote methods for the self-diagnosis of breast cancer in the health checkup system and the use of physical therapy after breast cancer surgery.

• 한국의류학회지
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• 제40권3호
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• pp.526-538
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• 2016

Breast cancer surgery result in changes in clothing style due to changes in the size of the breast as well as body shape. This study provides basic data as a fashion therapy to improve the quality of life for breast cancer patients who have to change clothing habits after surgery. The regression results found that the most important factor are pain and the amount of breast loss for clothes style changes after breast cancer surgery. Breast cancer patients suffer pain relative to the proximity to the date of surgery and regardless of the breast cancer resection range. However, the changes in clothes style relates to the amount of pain and breast reduction range. The t-test results on the change of the clothing styles for before and after breast cancer surgery showed that women significantly prefer comfortable clothes with sleeves and consider a closure style on clothes to put on and take off instead of clothes that are tight-fitting, have thin fabric or deep neck lines. Painful breast cancer results in women who prefer closure style on clothes, front closure clothes and garments that hide body shape. However, the larger reduction range of breast cancer patients and those with painful breast cancer prefer garments that hide body shape and are looser size clothes with sleeves.

• Perspectives in Nursing Science
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• 제4권1호
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• pp.1-8
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• 2007

Aim: The purpose of this paper is to present the importance of multidisciplinary strategies in cancer prevention and control, especially comprehensive breast cancer care. Background: Worldwide, breast cancer is the most common cancer diagnosed among women and is the leading cause of cancer deaths. Although the incidence of breast cancer in Asian countries is still lower than in Western countries, the rate of increase for the last two decades is striking. Methods: Data on cancer mortality, incidence, and risk factors were summarized by using the most recent data available from population-based cancer registries affiliated with the International Union Against Cancer, the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program and the CDC's National Program of Cancer Registries (NPCR). Results: Global differences in breast cancer incidence and fluctuations in rates within a country still exist. The incidence of breast cancer in Asian countries was lower than in Western countries. Breast cancer incidence in the United States decreased each year during 1999-2003. On the other hand, morbidity and mortality related to breast cancer in Asia has increased significantly. Conclusion: Multidisciplinary strategies to reduce breast cancer mortality and promote breast cancer awareness are addressed. Lessons learned from multidisciplinary approaches to cancer treatment and control will be valuable in implementing future breast cancer research in the fields of basic, clinical, and population research in Asia.

• Molecules and Cells
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• 제45권9호
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• pp.631-639
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• 2022

Breast cancer is the leading cause of cancer-related death in women worldwide, despite medical and technological advancements. The RhoBTB family consists of three isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. RhoBTB1 and RhoBTB2 have been proposed as tumor suppressors in breast cancer. However, the roles of RhoBTB3 proteins are unknown in breast cancer. Bioinformatics analysis, including Oncomine, cBioportal, was used to evaluate the potential functions and prognostic values of RhoBTB3 and Col1a1 in breast cancer. qRT-PCR analysis and immunoblotting assay were performed to investigate relevant expression. Functional experiments including proliferation assay, invasion assay, and flow cytometry assay were conducted to determine the role of RhoBTB3 and Col1a1 in breast cancer cells. RhoBTB3 mRNA levels were significantly up-regulated in breast cancer tissues as compared to in adjacent normal tissues. Moreover, RhoBTB3 expression was found to be associated with Col1a1 expression. Decreasing RhoBTB3 expression may lead to decreases in the proliferative and invasive properties of breast cancer cells. Further, Col1a1 knockdown in breast cancer cells limited the proliferative and invasive ability of cancer cells. Knockdown of RhoBTB3 may exert inhibit the proliferation, migration, and metastasis of breast cancer cells by repressing the expression of Col1a1, providing a novel therapeutic strategy for treating breast cancer.

• BMB Reports
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• 제44권9호
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• pp.595-600
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• 2011

Pax 6, a member of the paired box (Pax) family, has been implicated in oncogenesis. However, its therapeutic potential has been never examined in breast cancer. To explore the role of Pax6 in breast cancer development, a lentivirus based short hairpin RNA (shRNA) delivery system was used to knockdown Pax6 expression in estrogen receptor (ER)-positive (MCF-7) and ER-negative (MDA-MB-231) breast cancer cells. Effect of Pax6 silencing on breast cancer cell proliferation and tumorigenesis was analyzed. Pax6-RNAi-lentivirus infection remarkably downregulated the expression levels of Pax6 mRNA and protein in MCF-7 and MDA-MB-231 cells. Accordingly, the cell viability, DNA synthesis, and colony formation were strongly suppressed, and the tumorigenesis in xenograft nude mice was significantly inhibited. Moreover, tumor cells were arrested at G0/G1 phase after Pax6 was knocked down. Pax6 facilitates important regulatory roles in breast cancer cell proliferation and tumor progression, and could serve as a diagnostic marker for clinical investigation.

• 대한지역사회영양학회지
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• 제3권5호
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• pp.722-728
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• 1998

The purpose of this study was to compare dietary patterns, dietary behaviors and life styles before and after breast cancer surgery in Korea. The subjects were 220 females who underwent surgery for stage I-III breast cancer at general hospitals. Food intake, eating habits, snacks, eating-out, use of nutritional supplements and healthy foods, and drinking and smoking habits were studied using a questionnaire. SAS program was used for statistical analysis of the data. The results are as follows : 1) Most subjects were housewives aged more than 40 years. 2) After breast cancer surgery, intakes of fruits and vegetables were increased and those of meat, salty and spicy foods were decreased. 3) There was a significant difference in takes of caffeine beverages, snacks, fast foods and instant foods before and after breast cancer surgery. 4) There was a significant difference in meal regularity and skipping breakfast before and after breast cancer surgery. 5) The frequency of eating-out was decreased and low-fat foods, such as Japanese foods, were preferred after breast cancer surgery. 6) Nutritional supplements and natural healthy foods were used more after breast cancer surgery. 7) Most subjects were non-smokers and drank little alcohol and the rate of regular drinking significantly decreased after breast cancer surgery. Therefore, there was a significant difference in dietary patterns and behaviors resulting form breast cancer. Further more, dietary factors may be a contributing factor in the incidence at breast cancer in Korea.

• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1675-1682
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• 2012

Aim: The study aim was to determine the frequency with which women decline clinicians' treatment recommendations and variations in this frequency by age, cancer and service descriptors. Design: The study included 36,775 women diagnosed with early invasive breast cancer in 1998-2005 and attending Australian and New Zealand breast surgeons. Rate ratios for declining treatment were examined by descriptor, using bilateral and multiple logistic regression analyses. Proportional hazards regression was used in exploratory analyses of associations with breast cancer death. Results: 3.4% of women declined a recommended treatment of some type, ranging from 2.6% for women under 40 years to 5.8% for those aged 80 years or more, and with parallel increases by age presenting for declining radiotherapy (p<0.001) and axillary surgery (p=0.006). Multiple regression confirmed that common predictors of declining various treatments included low surgeon case load, treatment outside major city centres, and older age. Histological features suggesting a favourable prognosis were often predictive of declining various treatments, although reverse findings also applied with women with positive nodal status being more likely to decline a mastectomy and those with larger tumours more likely to decline chemotherapy. While survival analyses lacked statistical power due to small numbers, higher risks of breast cancer death were suggested, after adjusting for age and conventional clinical risk factors, (1) for women not receiving breast surgery for unstated reasons (RR=2.29; p<0.001); and (2) although not approaching statistical significance $p{\geq}0.200$), for women declining radiotherapy (RR=1.22), a systemic therapy (RR1.11), and more specifically, chemotherapy (RR=1.41). Conclusions: Women have the right to choose their treatments but reasons for declining recommendations require further study to ensure that choices are well informed and clinical outcomes are optimized.

• 대한물리의학회지
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• 제13권1호
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• pp.39-47
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• 2018

PURPOSE: The purpose this study was to investigate the awareness of physical therapy as one of rehabilitation interventions for post-operative women with breast cancer in healthy Korean women. METHODS: This study recruited 223 adult women aged 20 and older who never had breast cancer but received physical therapy. This study used a structured questionnaire consisting of 13 items in 3 fields designed to focus on socio-demographic characteristics, breast cancer experience of friends or family, and awareness of physical therapy as one of methods to improve rehabilitation of patients following breast cancer surgery. RESULTS: Among respondents who completed the survey, 62.8% were interested in breast cancer. However, 78.1% had never heard of physical therapy as a rehabilitation intervention for post-operative women with breast cancer. 44.4% believed that physical therapy is necessary after breast cancer surgery. 69.5% of the respondents were willing to participate in a physical therapy rehabilitation program if there were diagnosed with breast cancer, and 59.2% believed that the participation in this program would be beneficial. 42.9% acquired some information that physical therapy is one type of rehabilitation to improve physical condition for women with breast cancer from the Internet or television. In addition, education level affected interest and awareness of physical therapy for breast cancer. Awareness about breast cancer and physical therapy were higher among well-educated respondents. CONCLUSION: This study suggests that a physical therapy rehabilitation program is specifically developed, and correct information on it is provided to improve health condition in women following breast cancer surgery.

• 가정∙방문간호학회지
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• 제28권2호
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• pp.186-196
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• 2021

Purpose: Breast cancer is becoming increasingly prevalent among young Korean women. During pregnancy, women's concern regarding their breasts heightens. Thus, pregnancy provides a window of opportunity for breast cancer prevention and management along with antenatal care. This study developed and evaluated an integrated breast health program for pregnant women. Methods: This study employed a non-equivalent control group and non-synchronized design (22 experimental, 29 control). Women pregnant for over 28 weeks participated. The two-session integrated breast health program focused on breast management during breastfeeding and education about breast cancer prevention and early screening. Results: During the early postpartum period (within three months after the program), there were statistically significant differences in knowledge and attitude about breast cancer and breast self-examination before and after the program. There were also statistically significant differences in BSE at 6 and 12 months after the program and mammography at 12 months after the program. However, there were no statistically significant differences in clinical breast examination and breast ultrasonography at 6 and 12 months after the program. Conclusion: The integrated breast health management program was effective in increasing knowledge and improving attitudes regarding breast cancer, BSE, and early screening practices among pregnant women. Further studies should consider providing breast health programs differently for each phase of pregnancy and continuing the same after delivery.