• Title/Summary/Keyword: Breakthrough time

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Lung Cancer Detection by Screening - Presenting Circulating miRNAs as a Promising Next Generation Biomarker Breakthrough

  • Ramshankar, Vijayalakshmi;Krishnamurthy, Arvind
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.4
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    • pp.2167-2172
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    • 2013
  • Lung cancer remains a major cause of morbidity and mortality worldwide, accounting for more deaths than any other cause. All the clinical practice guidelines recommended against routine screening for lung cancer have cited lack of robust evidence, at least until a few years back. However, the potential to screen lung cancers has received renewed interest due to superior performance of low dose CT (LD-CT) in detecting early stage cancers. The incremental costs and risks involved due to the invasive procedures in the screened population due to a high false positivity rate questions the use of LD-CT scan as a reliable community based screening tool. There is therefore an urgent need to find a less invasive and a more reliable biomarker that is crucial to increase the probability of early lung cancer detection. This can truly make a difference in lung cancer survival and at the same time be more cost and resource utilization effective. Sampling blood serum being minimally invasive, low risk and providing an easy to obtain biofluid, needs to be explored for potential biomarkers. This review discusses the use of circulatory miRNAs that have been able to discriminate lung cancer patients from disease free controls. Several studies conducted recently suggest that circulating miRNAs may have promising future applications for screening and early detection of lung cancer.

Adsorption Characteristics of $CH_4/CO_2$ Mixed Gases on Activated Carbon Fibers (활성탄소섬유상에서 CH4/CO2 혼합가스의 흡착 특성)

  • Moon, Seung-Hyun;Shim, Jae-Woon
    • Journal of Korean Society for Atmospheric Environment
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    • v.20 no.5
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    • pp.655-662
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    • 2004
  • An adsorption process to recover the pure $CH_4\;and\;CO_2$ from its mixture was examined. In this study, activated carbon fibers were used as a selective adsorbent. The activated carbon fibers has 78~94% micropore volume and 10.5~20.3${\AA}$ narrow pore size, and showed high adsorption rate and the good selectivity for $CO_2$ under the ambient pressure. The ACF with high surface area showed short mass transfer zone and long breakthrough time and, its adsorption capacity depended on the microporosity. Compared with single component adsorption, the amount adsorbed $CO_2$ on ACF increased by the roll-up of $CH_4$ in mixed gases. The adsorption selectivity increased as now rate and $CO_2$ concentration of mixed gases increased, showing 5.2 selectivity for 75% $CO_2$ concentration.

Adsorption of THMs and THM Precursors on Activated Carbon Fibers (섬유상활성탄에 의한 THMs 및 THMs 전구물질의 흡착특성)

  • Han, Myung-Ho;Lee, Jin-Sik;Yoon, Yi-Yong
    • Journal of Korean Society of Water and Wastewater
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    • v.10 no.1
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    • pp.121-130
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    • 1996
  • Adsorption isotherms of three trihalomethanes(THMs: $CHCl_3$, $CHBrCl_2$ and $CHBr_2Cl$) and the other organics(p-chlorophenol and sucrose)on activated carbon fibers(ACFs) were measured. Adsorption capacities of the ACFs for these THMs were found to be comparable with or slightly larger than those of granular activated car bons(GACs) which have been widely used for trihalomethanes control in drinking water. Also, the breakthrough curve prediction was successfully carried out using a mathematical model on basis of the assumption that the adsorption equilibrium is instantaneously established when a THM solution contacts the ACF. In practice, THM removal from drinking water was investigated at water works using benchscale ACF adsorptJOn columns. The volume of water treated at a space velocity(SV) of about $100h^{-1}$ was approximately 40 l/g-ACF. The practical adsorption capacities of PCP and sucrose in column adsorption were in good agreement with those of theoretically calculated results using the batch adsorption measurments. And the saturation time model of these substrates in the columns was also agreed succesfully with practical measurments.

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On Minimum-Cost Rectilinear Steiner Distance-Preserving Tree (최소 비용 직각선분 Steiner 거리 유지 트리의 최적화)

  • Jo, Jun-Dong
    • The Transactions of the Korea Information Processing Society
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    • v.3 no.7
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    • pp.1707-1718
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    • 1996
  • Given a signal net N=s, 1,...,n to be the set of nodes, with s the source and the remaining nodes sinks, an MRDPT (minimum-cost rectilinear Steiner distance -preserving tree) has the property that the length of every source to sink path is equal to the rectilinear distance between the source and sink. The minimum- cost rectilinear Steiner distance-preserving tree minimizes the total wore length while maintaining minimal source to sink length. Recently, some heuristic algorithms have been proposed for the problem offending the MRDPT. In this paper, we investigate an optimal structure on the MRDPT and present a theoretical breakthrough which shows that the min-cost flow formulation leads to an efficient O(n2logm)2) time algorithm. A more practical extension is also in vestigated along with interesting open problems.

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Adsorption Characteristics of Toluene Vapor According to Pore Size Distribution of Activated Carbon (활성탄의 세공분포에 따른 Toluene Vapor의 흡착특성)

  • Lee Song-Woo;Kwon Jun-Ho;Kang Jeong-Hwa;Na Young-Soo;An Chang-Doeuk;Yoon Young-Sam;Song Seung-Koo
    • Journal of Environmental Science International
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    • v.15 no.7
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    • pp.695-699
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    • 2006
  • This study is to investigate the relationship between pore structures of activated carbons and adsorption characteristics of toluene vapor using dynamic adsorption method. The surface areas of below $10{\AA}$ in the pore diameter of activated carbons used in this experiment were in the range of 72 -93 % of total cumulative surface area and the toluene vapor equilibrium adsorption capacities were in the range of 350 - 390mg/g. Activated carbons having larger toluene adsorption capacity than the compared activated carbons had relatively pores in the pore diameter range of $7-10{\AA}$. Linear relationship between equilibrium adsorption capacity and cumulative sur- face area was in the diameter range of over $7{\AA}$. It was thought that toluene vapor was relatively well adsorbed on surfaces of pores of over $7{\AA}$.

A Fuzzy AHP Approach to Prioritize the Energy Technology Development Strategy and Policy (Fuzzy AHP기법을 적용한 에너지기술개발전략 우선순위 연구)

  • Lee, Seong-Kon;Mogi, Gento;Kim, Jong-Wook
    • New & Renewable Energy
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    • v.4 no.1
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    • pp.19-24
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    • 2008
  • Energy environment has been changing rapidly such as high oil prices and the effectuation of UNFCCC. Oil prices have continued to rise and Dubai crude prices recorded about 90 dollars per barrel in 2007. In addition, the effectuation of UNFCCC will affect Korean economy and national energy security. Korea is the 9th $CO_2$ emissions country and takes the 1st place related to the increase rate of $CO_2$ emissions globally. Energy technology development is a key breakthrough and one of the optimal alternatives to cope with national energy security. In this study, we prioritize energy technologies in the sectors of high oil prices and UNFCCC related to ETRM for well focus R&D and efficiency of finite resources allocations. We applied to the extended method of AHP, fuzzy AHP reflecting the fuzziness of human thoughts and perception, for prioritizing the relative importance among energy technologies in ETRM for the first time as we make an energy policy in Korea.

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A study on the strategic energy technology policy;Fuzzy AHP approach (Fuzzy AHP기법을 적용한 전략적 에너지기술정책 연구)

  • Lee, Seong-Kon;Mogi, Gento;Yoon, Yong-Jin;Kim, Jong-Wook
    • 한국신재생에너지학회:학술대회논문집
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    • 2007.06a
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    • pp.742-746
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    • 2007
  • Energy environment has been changing rapidly such as high oil prices and the effectuation of UNFCCC. Oil prices have continued to rise and Dubai crude prices recorded 60 or 70 dollars per barrel in 2006. In addition, the effectuation of UNFCCC will affect Korean economy and national energy security. Korea is the 9th $CO_2$ emissions country and takes the 1st place related to the increase rate of $CO_2$ emissions globally. Energy technology development is a key breakthrough and one of the optimal alternatives to cope with national energy security. In this study, we prioritize energy technologies in the sectors of high oil prices and UNFCCC related to ETRM for well focus R&D and efficiency of finite resources allocations. We applied to the extended method of AHP, fuzzy AHP reflecting the fuzziness of human thoughts and perception, for prioritizing the relative importance among energy technologies in ETRM for the first time as we make an energy policy in Korea.

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Equilibrium and kinetic studies on the adsorption of copper onto carica papaya leaf powder

  • Varma V., Geetha;Misra, Anil Kumar
    • Membrane and Water Treatment
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    • v.7 no.5
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    • pp.403-416
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    • 2016
  • The possibility of using carica papaya leaf powder for removal of copper from wastewater as a low cost adsorbent was explored. Different parameters that affect the adsorption process like initial concentration of metal ion, time of contact, adsorbent quantity and pH were evaluated and the outcome of the study was tested using adsorption isotherm models. A maximum of 90%-94.1% copper removal was possible from wastewater having low concentration of the metal using papaya leaf powder under optimum conditions by conducting experimental studies. The biosorption of copper ion was influenced by pH and outcome of experimental results indicate the optimum pH as 7.0 for maximum copper removal. Copper distribution between the solid and liquid phases in batch studies was described by isotherms like Langmuir adsorption and Freundlich models. The adsorption process was better represented by the Freundlich isotherm model. The maximum adsorption capacity of copper was measured to be 24.51 mg/g through the Langmuir model. Pseudo-second order rate equation was better suited for the adsorption process. A dynamic mode study was also conducted to analyse the ability of papaya leaf powder to remove copper (II) ions from aqueous solution and the breakthrough curve was described by an S profile. Present study revealed that papaya leaf powder can be used for the removal of copper from the wastewater and low cost water treatment techniques can be developed using this adsorbent.

Olanzapine for Preventing Nausea and Vomiting Induced by Moderately and Highly Emetogenic Chemotherapy

  • Wang, Shi-Yong;Yang, Zhen-Jun;Zhang, Lu
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.22
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    • pp.9587-9592
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    • 2014
  • Nausea and vomiting are common adverse events in chemotherapy. In spite of the serious effects on the quality of life and further treatment, they remain overlooked by physicians, and no standard treatment has been developed. Neurokinin-1 (NK-1) receptor antagonists and palonosetron are the major agents in the standard regimen for treating moderately and highly emetogenic chemotherapy-induced nausea and vomiting (CINV). However, NK-1 receptor antagonists first became commercially available at the end of 2013 and palonosetron has not been extensively applied in China. Olanzapine was recommended as a therapy for moderate and severe CINV in antiemesis-clinical practice guidelines in oncology in 2014 for the first time. It is an atypical antipsychotic agent, which can block multiple receptors on neurotransmitters. During more than 10 years, olanzapine has demonstrated significant effects in preventing CINV and treating breakthrough and refractor CINV, which was observed in case reports, precise retrospective studies, and phase I, II and III clinical trials, with no grade 3 to 4 adverse events. In particular, it is superior to aprepitant and dexamethasone in delayed nausea and vomiting. Therefore, this compound is worthy of further investigation.

Adsorption Characteristics of Reverse Stratified Tapered Adsorber (역층상 점증형 흡착탑에서의 흡착특성)

  • Lee, Seung-Mok;Kim, Dae-Hyun;Lee, II-Young
    • Journal of Korean Society of Environmental Engineers
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    • v.22 no.10
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    • pp.1861-1867
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    • 2000
  • Granular activated carbon(GAC) adsorption is one of the best available technology to remove synthetic organic chemicals(SOCs) from water supplies and wastewater. In order to satisfy enviromental criteria and reduce GAC treatment cost, optimal study of reverse stratified tapered adsorber(RSTA) has been conducted. The RSTA was found to provide on increase in breakthrough time when compared to a conventional cylindrical adsorber(CA). Through the RSTA optimal experiment, optimal mean bed velocity was decided 19.10cm/min and optimal angle was decided RSTA($3.0^{\circ}$). Adsorption efficiency was increased with increasing activated carbon doses and the number of activated carbon layers.

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