• The Korean Journal of Pharmacology
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• v.2 no.1 s.2
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• pp.99-109
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• 1966

It has been known that the pronounced hypotension resulting from hemorrhage gives rise to compensatory stimulation of the adrenosympathetic system, which leads to an increase of liberation of catecholamines from sympathetic nervous system and adrenal medulla. It is obvious, therefore, that numerous physiological and biochemical changes during the hemorrhagic hypotention might be mediated through the increased liberation of catecholamines. Although an extensive studies have been reported on changes of protein and carbohydrate metabolism in hemorrhagic shock a few studies on the changes of lipid metabolism have been reported. Levenson(1961) observed a marked increase of serum lipids content during hemorrhagic shock and also noticed a marked elevation of serum free fatty acids. He suggested that these effects were due to mobilization and accelerated metabolic breakdown of lipids which might be resulted by sympathetic stimulation as a cause. To elucidate the mechanism of this, author studied the change of serum free fatty acids and blood sugar with relation to catecholamines during experimentally induced hemorrhagic shock in dog. Healthy male mongrel dogs weighing approximately 15kg were used. Under the general anesthesia with pentobarbital, rapid hemorrhage was produced from the femoral artery maintaining blood pressure level of 40 mmHg measured by the manometer connected with the opposite femoral artery throughout the experiment. Serum free fatty acids(FFA) and blood sugar were measured by the methods of Dole(1956) and Folin-wu,(1920) respectively. Tissue catecholamine was measured by Shore and Olin method(1958) using Aminco-Bowman spectrophotofluorometer.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.16 no.1 s.106
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• pp.75-80
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• 2006

This paper introduces the mechanism of the ESD(electrostatic discharge) in the HDD spindle system using FDBs(fluid dynamic bearings). When a HDD(hard disk drive) spindle system is rotating, triboelectric charging occurs in the FDBs through the friction between the lubricant and the rotating shaft or between the lubricant and stationary sleeve. And this electrostatic charge is accumulated in the rotating parts of the HDD spindle system because they are insulated from the ground by the lubricant. This research shows experimentally that the behavior of electric charge and discharge in the FDB spindle system is the same as that of a capacitor. It also measures the electrostatic voltage difference between the rotating and stationary parts in the FDB spindle system due to the change of humidity, supporting load and motor speed. This research shows that the control of ESD is required in the HDD spindle system using FDBs, because the electrostatic charge accumulated in the FDB spindle system may cause the breakdown damage of the GMR head and data loss consequently.

• The Transactions of the Korean Institute of Electrical Engineers C
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• v.49 no.7
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• pp.400-405
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• 2000

In order to improve the reliability of XLPE cables, it is necessary to understand the mechanism of electrical and water tree degradation. Especially, electrical tree initiation and propagation are important in XLPE cable insulation. This paper deals with the changes of electrical properties of XLPE cable insulation with electrical tree degradation. To understand the electrical properties of XLPE insulation, specimens were prepared by 22.9kV distribution cable and made in a type of block. Ogura needles having tip radius of 10${\mu}{\textrm}{m}$ were inserted into each block pieces. AC voltages of 8kV, 10kV and 12kV at 60Hz were applied to needle. We investigated the relationship between electrical properties(PD quantity, tan$\delta$ and DC current) and the growth of electrical tree. The electrical properties of the specimens were measured from initiation of tree to breakdown and their characteristics were analyzed.

• Proceedings of the KIEE Conference
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• 1999.07e
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• pp.2262-2264
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• 1999

절연체 내부의 보이드로 인하여 부분방전이 발생하면 국부 파괴와 완전절연파괴의 원인이 된다. 부분방전으로 생기는 트리잉은 절연재료를 열화시키며 부분방전 메카니즘 연구의 한 축을 이룬다. 이에 절연 파괴를 미연에 예측하고 감시하는 기술의 개발은 매우 중요하다. 이러한 관점에서, 부분방전의 메카니즘을 본래의 관점에서 비 선형적으로 해석할 수 있는 기법의 도입은 중요한 의미를 갖는다. 절연체의 부분방전을 시간 전개에 따라 해석함으로써 이후 실시간 감시 시스템 구축에 기초가 될 것이며 지금까지 수없이 시도 되어온 통계적인 방법과의 비교분석 및 데이터 베이스화에 따른 더욱 객관적이고 정확한 감지 결과가 기대된다. 부분방전 신호는 음향센서를 거쳐 개인용 컴퓨터에서 비선형적 해석기법과 통계적인 $\Phi$-q 기법을 적용하여 해석하였으며, 이 해석 결과는 다양한 해석 기준을 제공해 줄 것으로 기대된다.

• Corrosion Science and Technology
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• v.10 no.4
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• pp.118-124
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• 2011

Alloy 600 (Ni 75 wt%, Cr 15 wt%, Fe 10 wt%) as a heat exchanger tube of the steam generator (SG) in nuclear power plants (NPP) has been degraded by various corrosion mechanism during the long-term operation. Especially lead (Pb) is known to be one of the most deleterious species in the secondary system causing outer diameter stress corrosion cracking (ODSCC). Oxide formation and breakdown is requisite for SCC initiation and propagation. Therefore it is expected that a property change of the oxide formed on SG tubing materials by lead addition into a solution is closely related to PbSCC. In the present work, the SCC susceptibility was assessed by using a slow strain rate test (SSRT) in caustic solutions with and without lead for Alloy 600 and Alloy 690 (Ni 60 wt%, Cr 30 wt%, Fe 10 wt%) used as an alternative of Alloy 600 because of outstanding superiority to SCC. The results were discussed in view of the oxide property formed on Alloy 600 and Alloy 690. The oxides formed on Alloy 600 and Alloy 690 in aqueous solutions with and without lead were examined by using a transmission electron microscopy (TEM), equipped with an energy dispersive x-ray spectroscopy (EDXS).

• BMB Reports
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• v.37 no.4
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• pp.445-453
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• 2004

We identified apoptosis as being a significant mechanism of toxicity following the exposure of HeLa cell cultures to abrin holotoxin, which is in addition to its inhibition of protein biosynthesis by N-glycosidase activity. The treatment of HeLa cell cultures with abrin resulted in apoptotic cell death, as characterized by morphological and biochemical changes, i.e., cell shrinkage, internucleosomal DNA fragmentation, the occurrence of hypodiploid DNA, chromatin condensation, nuclear breakdown, DNA single strand breaks by TUNEL assay, and phosphatidylserine (PS) externalization. This apoptotic cell death was accompanied by caspase-9 and caspase-3 activation, as indicated by the cleavage of caspase substrates, which was preceded by mitochondrial cytochrome c release. The broad-spectrum caspase inhibitor, benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone (zVAD-fmk), prevented abrin-triggered caspase activation and partially abolished apoptotic cell death, but did not affect mitochondrial cytochrome c release. These results suggest that the release of mitochondrial cytochrome c, and the sequential caspase-9 and caspase-3 activations are important events in the signal transduction pathway of abrin-induced apoptotic cell death in the HeLa cell line.

• Corrosion Science and Technology
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• v.19 no.3
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• pp.115-121
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• 2020

In this study, erosion tests and erosion-corrosion tests of Al5083-H321 aluminum alloy were conducted at various flow rates in seawater. The erosion tests were conducted at a flow rate of 0 to 20 m/s, and erosion-corrosion tests were performed by potentiodynamic polarization method at the same flow rate. Characteristic evaluation after the erosion test was conducted by surface analysis. Characteristic evaluation after the erosion-corrosion test was performed by Tafel extrapolation and surface analysis. The results of the surface analysis after the erosion test showed that surface damage tended to increase as the flow rate increased. In particular, intermetallic particles were separated due to the breakdown of the oxide film at 10 m/s or more. In the erosion-corrosion test, the corrosion current density increased as the flow rate increased. Additionally, the surface analysis showed that surface damage occurred in a vortex shape and the width of the surface damage tended to increase as the flow rate increased. Moreover, damage at 0 m/s, proceeded in a depth direction due to the growth of pitting corrosion, and the damaged area tended to increase due to acceleration of the intermetallic particle loss by the fluid impact.

• The Transactions of the Korea Information Processing Society
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• v.6 no.9
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• pp.2350-2364
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• 1999

In this paper, we propose a method of class library repository design for provide reuser the object-oriented C++ class component. To class library design, we started by studying the characteristics of a reusable component. We formally defined the reusable component model using an entity relationship model. This formal definition has been directly used as the database schema for storing the reusable component in a repository. The reusable class library may be considered a knowledge base for software reuse. Thus, we used that Enumerative classification of breakdown of knowledge based. And another used classification is clustering of based on class similarity. The class similarity composes member function similarity and member data similarity. Finally, we have designed class library for hierarchical inheritance mechanism of object-oriented concept Generalization, Specialization and Aggregation.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2005.11a
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• pp.318-323
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• 2005

This paper introduces the mechanism of the ESD (Electrostatic discharge) in the HDD spindle system using FDBs (Fluid Dynamic Bearings). When a HDD (Hard Disk Drive) spindle system is rotating, triboelectric charging occurs in the FDBs through the friction of the lubricant between the rotating shaft and stationary sleeve. And this electrostatic charge is accumulated in the rotating part of the HDD spindle system because it is insulated from the ground by the lubricant. This research shows experimentally that the behavior of electric charge and discharge in the FDB spindle system is the same as that of a capacitor. It also measures the electrostatic charge and discharge of the FDB spindle system due to the chanse of humidity, supporting load and motor speed. This research shows that the control of ESD is required in the HDD spindle system using FDBs, because the electrostatic charge accumulated in the FDB spindle system may cause the breakdown damage of the GMR head and data loss consequently.

• Bulletin of the Korean Chemical Society
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• v.12 no.5
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• pp.510-514
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• 1991

Second-order rate constants have been determined spectrophotometrically for reactions of S-p-nitrophenyl substituted thiobenzoates with various phenoxide ions and S-aryl substituted thiobenzoates with $HO^-$ ion. Thiol esters have been found to be more reactive than the corresponding oxygen esters toward phenoxide ions. The high reactivity of thiol esters relative to oxygen esters becomes insignificant as the basicity of the nucleophile increases. Furthermore, the highly basic $HO^-$ ion is less reactive toward thiol esters than oxygen esters. The significant dependence of the reactivity of thiol esters on the basicity of nucleophiles has been attributed to the nature of the HSAB principle. The present kinetic study has also revealed that the reactivity of thiol esters compared to oxygen esters is not so pronounced as expected based on the enhanced nucleofugicity of thiol esters. However, the effects of substituents in the nucleophile and in the acyl moiety of the substrate on rate appear to be significant. These kinetic results have led to a conclusion that the present reactions proceed via a rate-determining formation of a tetrahedral intermediate followed by a fast breakdown of it. The magnitude of the ${\beta}$ values shows no tendency either to increase or to decrease with the intrinsic reactivity of the reagents. The constancy of ${\beta}$ values in the present system is suggestive that the RSP should have limited applicability.