• The Korean Journal of Physiology and Pharmacology
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• v.27 no.4
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• pp.311-323
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• 2023

Ion homeostasis, which is regulated by ion channels, is crucial for intracellular signaling. These channels are involved in diverse signaling pathways, including cell proliferation, migration, and intracellular calcium dynamics. Consequently, ion channel dysfunction can lead to various diseases. In addition, these channels are present in the plasma membrane and intracellular organelles. However, our understanding of the function of intracellular organellar ion channels is limited. Recent advancements in electrophysiological techniques have enabled us to record ion channels within intracellular organelles and thus learn more about their functions. Autophagy is a vital process of intracellular protein degradation that facilitates the breakdown of aged, unnecessary, and harmful proteins into their amino acid residues. Lysosomes, which were previously considered protein-degrading garbage boxes, are now recognized as crucial intracellular sensors that play significant roles in normal signaling and disease pathogenesis. Lysosomes participate in various processes, including digestion, recycling, exocytosis, calcium signaling, nutrient sensing, and wound repair, highlighting the importance of ion channels in these signaling pathways. This review focuses on different lysosomal ion channels, including those associated with diseases, and provides insights into their cellular functions. By summarizing the existing knowledge and literature, this review emphasizes the need for further research in this field. Ultimately, this study aims to provide novel perspectives on the regulation of lysosomal ion channels and the significance of ion-associated signaling in intracellular functions to develop innovative therapeutic targets for rare and lysosomal storage diseases.

• Proceedings of the Korean Institute Of Construction Engineering and Management
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• 2007.11a
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• pp.396-400
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• 2007

Various ways of automated guideway transit construction are being planned recently owing to the policies of the national government and local municipalities as well as increasing investment from the private sector. Particularly, the increase in the private investment is increasing greatly in SOC (Social Overhead Cost). This trend of promoting private sector investment must be conducted on the basis of a thorough analysis of the economic feasibility of the project from the government and construction companies in the private sector. In other words, an accurate cost analysis of initial investment cost (Construction cost), maintenance/repair cost, profit making through the operation of the concerned facilities, cost of dissolution, etc. in terms of the life cycle is very much in need. Nevertheless, the analysis of uncertainty factors and its probabilistic theory are in need of development so that they can be used in the analysis of the economic feasibility of a construction project. First of all, the actual studies on maintenance/repair cost of automated guideway transit are scarce as of yet, prohibiting an accurate computation of the cost and its economic analysis. Accordingly, this study focused on the uncertainty analysis of the economic feasibility for civil engineering structures among automated guideway transit construction projects based on the rapidly increasing investment on such structures from the private sector. For this research purpose, a cost classification system for the automated guideway transit is proposed, first of all, and the data On the cost cycle of the civil structure facilities and their unit cost are collected and analyzed. Then, the uncertainty in the cost is analyzed from the perspective of LCC. In consideration of the current status with almost no. studies on maintenance/repair of such facilities, it is expected that the cost classification system and the uncertainty analysis technique proposed in this study will greatly enhance LCC analysis and economic feasibility studies for automated guideway transit projects in the future.

• Journal of the Korea institute for structural maintenance and inspection
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• v.15 no.5
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• pp.150-159
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• 2011

The need of securing the stability and extending service lives by efficient maintenance of deteriorated tunnels for several decades has been increased. The stability and the usability of conventional tunnels can be decreased by change of physical properties of the surrounding ground, geometrical properties of the tunnel, an underground water level, environmental conditions, oxidation of lining and the breakdown of constituent materials. In respect of a long-term view, it is need to check all sorts of degradation, the degree of damage and durability to improve the serviceability and to come up with measures to maintain effectively. This paper is about study to analyze the stability of conventional tunnels(American Steel Support Method. ASSM). Three tunnels are chosen in those built in the 1930s and 1960s and the locations of tunnels are selected variously(ChungCheong, GyungBuk, GangWon, Jeolla, etc.) to secure reliability of this study. The state of repair and reinforcement of linings, cracks, and thickness and strength of lining of conventional tunnels in service are researched, compared and analyzed. The crack gauge, the GPR, the schmitt hammer was used for the crack investigation, cavitation, the strength respectively. By using these, the comparative analysis for conventional tunnels was conducted. As a result, there are more cracks in tunnels built in the 1930s than those of tunnels built in the 1960s, and lining strength of the 1930s is higher than those of the 1960s. The thickness of lining in tunnels built in the 1960s is higher than those in tunnels built in the 1930s. In proportion to thickness, cavitation occurred more frequently in tunnels built in the 1960s compared to those in tunnels built in the 1930s.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.15 no.3
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• pp.175-180
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• 2015

With progress in industrialization, facilities for generating, delivering, and receiving high levels of electric power are in great demand. The scale of electric power equipment is increasing in both size and complexity. This has contributed to the development of our modern, high-tech and information-based society. However, if the generation of electric power is suspended due to unexpected accidents at power facilities or power stations, a range of equipment the operations of which are dependent on electric power can be damaged, causing substantial socioeconomic losses in an industrial society. A great deal of time and money would be expended to repair damaged facilities at a power station, causing enormous economic loss.In order to detect the deterioration processes of power cables, and to prevent the destruction of power cables, the operation status of power cables should be monitored on a regular basis. We have installed equipment at Korea Western Power Co., Ltd., located in Taean, in order to predict and prevent the destruction of power cables. This is an entirely new installation: a set of equipment invented specifically to measure the insulation resistance of power cables. Installation of the equipment does not cause the flow of earth fault current. This ensures accurate measurement of insulation resistance values by the equipment. We have been studying this equipment in order to develop preventive technology that would show the deterioration processes of power cables.