• 동의생리병리학회지
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• 제23권6호
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• pp.1460-1464
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• 2009

In spite of many studies on statistical model for pattern identifications (PIs), little attention has been paid to the complexity of pattern diagnosis processed by oriental physicians. The aim of this study is to develop a statistical diagnostic model which discriminates four PIs using multiple indicators in stroke. Clinical data were collected from 981 stroke patients and 516 data of which PIs were agreed by two independent physicians were included. Discriminant analysis was carried out using clinical indicators such as symptoms and signs which referred to pattern diagnosis, and applied to validation samples which contained all symptoms and signs manifested. Four Fischer's linear discriminant models were derived and their accuracy and prediction rates were 93.2% and 80.43%, respectively. It is important to consider the pattern diagnosis processed by oriental physicians in developing statistical model for PIs. The discriminant model developed in this study using multiple indicators is valid, and can be used in the clinical fields.

• ETRI Journal
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• 제46권2호
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• pp.263-276
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• 2024

Different diseases occur in the brain. For instance, hereditary and progressive diseases affect and degenerate the white matter. Although addressing, diagnosing, and treating complex abnormalities in the brain is challenging, different strategies have been presented with significant advances in medical research. With state-of-art developments in artificial intelligence, new techniques are being applied to brain magnetic resonance images. Deep learning has been recently used for the segmentation and classification of brain images. In this study, we classified normal and pathological brain images using pretrained deep models through transfer learning. The EfficientNet-B5 model reached the highest accuracy of 98.39% on real data, 91.96% on augmented data, and 100% on pathological data. To verify the reliability of the model, fivefold cross-validation and a two-tier cross-test were applied. The results suggest that the proposed method performs reasonably on the classification of brain magnetic resonance images.

• 대한의용생체공학회:의공학회지
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• 제9권1호
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• pp.31-36
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• 1988

A personal computer-based brain map is described which will display a gray scale maps showing the distribution of signals derived from the electrical activity of the brain such as EEG or EP This topographic brain mapping system has a flexibility which describe the electrode number and placement mapping onto any shaped space and generate a brain maps by incoorporated the data acquisition and processing software with conventional EEG machine.

• 동의신경정신과학회지
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• 제25권4호
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• pp.333-350
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• 2014

Objectives: The purpose of this study was to research learning based on brain science and the learning methodology of Korean Medicine according to disparity of age. Through this, the study aimed to provide a guideline to related Korean Medicine treatments as well as the common nurturing/educational institutions. Methods: All journals and dissertations on brain science based learning methods studied in Korea to date that could be found in the National Assembly Library and the RISS were implemented in the analysis. The terminology used for search was as follows: 1st search, 'Brain'; 2nd search, 'Learning', 'Education'; 3rd search, 'Baby, 'Infant', 'Child'. For the learning methodology of Korean Medicine according to disparity of age, the related contents were extracted from Donguibogam and Liuyi, Sasang constitutional medicine. Results: A total of 30 studies, were collected as data. In the baby stage, the development and myelination of brain neurons are accelerated by experience and learning, highly influenced by social, cognitive and emotional movement. In infancy, the frontal lobe actively develops, so education for development of the prefrontal cortex is suggested. The brain of the infant at this stage can be developed by arts and physical education. In the child stage, the parietal and temporal lobe develop actively. Thus, programs to stimulate brain activity including brain respiration would be helpful in enhancing learning ability, concentration, etc. As evidence for learning and nurturing methodology according to disparity of age from Korean Medicine prospective, the following are listed: Location and time for sexual intercourse before pregnancy, stabilization during pregnancy, baby nurturing methods for nurturing from Donguibogam. Also Liuyi and Sasanag constitutional medicine can be the learning methodology according to disparity of age. And there are acupuncture points on each head section according to age in Donguibogam. Conclusions: Studies on 'brain-science based learning' are continuously being conducted. Based on these studies, diverse new brain-science based learning will be developed in the future. There is also a need to develop the learning methodology of Korean Medicine according to disparity of age in a more systematic and diverse way.

• Fisheries and Aquatic Sciences
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• 제12권4호
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• pp.286-292
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• 2009

We have constructed a cDNA library using brain samples of olive flounder Paralichthys olivaceus. Here, we described the study on gene identification by screening 356 clones from the brain cDNA library of olive flounder. Here, we screened 356 clones from the library to identify genes. Of these, 176 (49.5%) were identified as orthologs of known genes from olive flounder and other organisms. Among the 176 EST clones, 33 (18.7%) represented 11 unique genes that are identical to expressed sequence tags (ESTs) reported for olive flounder, and 120 (68.2%) represented 102 unique genes known from other organisms. The percentage of unknown genes (50.5%) is higher than in other olive flounder cDNA libraries (Lee et al., 2003, 2006, 2007), reflecting the high complexity of brain tissue. Further studies of expression characterization and developmental behavior related to these genes should provide useful insight into the physiological functions of the brain in olive flounder.

• 한국초등수학교육학회지
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• 제17권1호
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• pp.67-86
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• 2013

본 연구는 수학영재학생들의 뇌선호유형에 따라 그들이 문제를 해결하는 과정에서 Schoenfeld의 문제해결 행동요인 4가지가 어떻게 활용되고 있는지를 분석하고 이를 통해 수학영재 수업 시 고려해야 될 뇌기능 분화와 관련된 교육적 시사점을 찾아보고자 하는 것이다. 연구 대상자는 BPI검사를 통해 좌, 우뇌별 선호도가 높은 6학년 영재학급 학생 4명이다. 분석 결과 좌뇌선호형 학생들의 경우 객관적이고 논리적인 판단을 좋아하는 좌뇌의 특성이, 우뇌선호형 학생들의 경우 주관적이고 직관적인 판단을 좋아하는 우뇌의 특성이 많이 관찰되었다. 또한 문제해결과정에 나타나는 Schoenfeld의 문제해결 행동요인도 뇌선호유형의 특성에 맞게 서로 다른 것들이 주로 선택되는 것을 확인하였다. 따라서 좌뇌선호형 학생들과 우뇌선호형 학생들이 각각 선택한 문제해결 행동요인을 분석하고 그들에게 상호 보완될 수 있는 문제해결 행동요인을 안내 및 제안해 줌으로써 뇌선호유형별 학생들의 문제해결지도에 활용할 수 있을 것이다.

• 한국초등과학교육학회지:초등과학교육
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• 제34권2호
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• pp.252-263
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• 2015

This study analyzed the effects of science outdoor activity applying a Brain-Based Evolutionary (ABC-DEF) approach on elementary school students' interest and academic achievement. Samples of the study were composed of 3 classes of 67 sixth graders in Seoul, Korea. Unit of 'Ecosystem and Environment' was selected as a object of the research. Textbook- and teachers' guidebook-based instruction was implemented in comparison group, brain-based evolutionary approach within classroom in experimental group A, and science outdoor learning by a brain-based evolutionary approach in experimental group B. In order to analyze the quantitative differences of students' interests and achievements, three tests of 'General Science Attitudes', 'Applied Unit-Related Interests', and 'Applied Unit-Related Achievement' were administered to the students. To find out the characteristics which would not be apparently revealed by quantitative tests, qualitative data such as portfolios, daily records of classroom work, and interview were also analyzed. The major results of the study are as follows. First, for post-test of interest, a statistically significant difference between comparison group and experimental group B was found. Especially, the 'interests about biology learning' factor, when analyzed by each item, was significant in two questions. Results of interviews the students showed that whether the presence or absence of outdoor learning experience influenced most on their interests about the topic. Second, for post-test of achievement, the difference among 3 groups according to high, middle, and low levels of post-interest was not statistically significant, but the groups of higher scores in post-interest tends to have higher scores in post-achievement. It can be inferred that outdoor learning by a brain-based evolutionary approach increases students' situational interests about leaning topic. On the basis of the results, the implications for the research in science education and the teaching and learning in school are discussed.

• 대한지역사회작업치료학회지
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• 제2권1호
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• pp.13-23
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• 2012

목적 : 외상성 뇌손상 환자의 지역사회 재활치료의 중재방법 및 중재효과를 알아보기 위하여 체계적 고찰을 하였다. 연구방법 : 자료는 데이터베이스인 Ovid와 PubMed를 통해 검색하였다. 사용된 검색어는 "community-based rehabilitation"와 "traumatic brain injury rehabilitation"이었다. 그 중 외상성 뇌손상 환자를 대상으로 지역사회 재활치료를 실시한 7편의 연구결과를 가지고 대상자, 평가도구, 중재방법과 중재결과를 분석하였다. 결과 : 연구 대상자의 수, 연령, 손상정도, 손상기간은 다양하였다. 연구 설계는 모두 실험연구의 형태로, 평가도구는 작업수행을 평가하는 영역이 5개(27.7%)로 가장 많았다. 중재방법은 작업치료사가 참여하는 전반적 재활프로그램, 인지치료, 인지행동치료, 가정방문 작업치료를 시행하였다. 중재효과는 결과측정 방법에 따라 작업수행, 참여, 예방, 그리고 작업 정의 영역에서 효과적이었고 적응, 건강과 안녕 영역에서 부분적으로 효과를 보였으며, 역할능력에서는 효과가 없었다. 결론 : 지역사회를 기초로 한 재활치료는 작업수행, 참여, 예방, 작업 정의에서 효과적이었으나 역할능력에서는 효과적이지 않았다. 앞으로 지역사회 재활에서 각 영역별 중재 프로그램 및 평가도구에 대한 연구가 지속적으로 필요하다.

• 감성과학
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• 제13권1호
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• pp.225-234
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• 2010

본 연구는 효과적인 감성교육의 방향을 모색하기 위하여, 학습자의 긍정적 감성과 학습 및 동기의 관계에 대한 연구의 흐름을 고찰하였다. 이를 위하여 본 연구는 긍정적 감성의 정의를 살펴보고, 긍정적 감성이 인간의 인지적 영역, 창의성, 사회성, 삶의 만족도 등의 심리적 자원에 미치는 긍정적 효과, 긍정적 감성과 동기의 정적 관계에 대한 선행연구들, 긍정적 감성과 학습에 대한 연구들을 살펴보았다. 특히 본 연구는 교육에서의 긍정적 감성의 역할을 보다 과학적으로 탐구하기 위하여, 최신 뇌기반 학습과학(brain-based learning) 연구결과들을 살펴보았다. 즉 교육학, 심리학, 인지과학, 뇌과학 분야 등의 다양한 연구결과들을 고찰하여 교육에서의 긍정적 감성의 역할을 확인하였다. 또한 본 연구는 긍정적 감성이 실제적으로 긍정적 감성을 향상시키기 위한 구체적 교육 프로그램을 살펴보기 위하여, 자율성 지지적 환경에 대한 연구도 예시적으로 고찰하였다. 향후 긍정적 감성과 동기 및 학습의 유기적 상호작용을 극대화 하는 효과적인 감성교육의 방법론으로서 뇌기반 학습과학의 가능성과 한계점에 대하여 논의하였으며, 학교현장에서의 활용 방안 등에 대해서도 살펴보았다.

• The Korean Journal of Physiology and Pharmacology
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• 제11권3호
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• pp.113-119
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• 2007

Developmental disability shows life-long behavioral abnormality with no significant physical malformation. This study was undertaken to develop an animal model for developmental disability by using two-factor approach. Lipopolysaccharide (LPS), a bacterial toxin, and NAN-190, a $5-HT_{1A}$ receptor antagonist, were administered to Sprague-Dawley rats on postnatal day (PND) 5 to induce inflammation and an altered 5-HT system, respectively. Long-term alteration of behavior occurred in the drug-treated groups. The LPS-treated group showed impaired motor coordination in the Rota-rod test. The LPS- treated or both LPS and NAN-190-treated groups showed impaired fore-paw muscle power in the wire maneuver test. These groups also showed decreased white matter volume and increased serotonergic fibers. The LPS and NAN-190-treated group also exhibited neurologic deficit in the placing reaction test and impaired equilibrium function in the tilt table test. The results showed that a variety of altered behaviors can be generated by two factor model, and suggested that combination of important etiologic factors and possible underlying defects is a promising strategy of establishing an animal model for developmental disabilities.