• Journal of Physiology & Pathology in Korean Medicine
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• v.30 no.1
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• pp.73-79
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• 2016

It was aimed to report a case of both anterior cerebral artery territory infarction patient improved by korean medical treatment. The patient was diagnosed by brain magnetic resonance imaging(MRI) and magnetic resonance angiography(MRA). The symptoms were quadriplegia, urinary frequency, urinary incontinence and abulia. I applied herbal medicine, acupuncture, moxibustion, pharmacopuncture, cupping and physical exercise therapy. As a result of them, the symptoms of the patient were improved considerably. Status of the patient was evaluated by manaul muscle test(MMT), modified barthel index(MBI) and functional independence measure(FIM) and medical interview. MBI score was changed from 35 to 95 and FIM score was changed from 66 to 115. Therefore this report suggests that korean medical treatment could be effective to the anterior cerebral artery territory infarction.

• Investigative Magnetic Resonance Imaging
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• v.19 no.4
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• pp.248-251
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• 2015

Hemangioblastomas are angioblastic tumors of the central nervous system. Cerebellar hemangioblastomas are traditionally classified into two morphologic types-cystic and solid. Cystic hemangioblastomas are associated with peritumoral edema, but solid hemangioblastomas are not. We report a case of solid cerebellar hemangioblastoma with massive peritumoral edema. An 83-year-old female visited our hospital due to a sudden headache. Five years ago, she had been admitted to our hospital with similar headache and diagnosed with cerebellar hemangioblastoma. Follow-up brain MRI 5 years later showed an increased size of a homogeneous enhancing mass with aggravated peritumoral edema in the left lower cerebellar hemisphere. Cerebral angiography showed a highly vascularized mass in the cerebellum, which was compatible with a solid-type hemangioblastoma.

• Korean Journal of Radiology
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• v.23 no.7
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• pp.720-731
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• 2022

Objective: We aimed to develop and test a deep learning algorithm (DLA) for fully automated measurement of the volume and signal intensity (SI) of the liver and spleen using gadoxetic acid-enhanced hepatobiliary phase (HBP)-magnetic resonance imaging (MRI) and to evaluate the clinical utility of DLA-assisted assessment of functional liver capacity. Materials and Methods: The DLA was developed using HBP-MRI data from 1014 patients. Using an independent test dataset (110 internal and 90 external MRI data), the segmentation performance of the DLA was measured using the Dice similarity score (DSS), and the agreement between the DLA and the ground truth for the volume and SI measurements was assessed with a Bland-Altman 95% limit of agreement (LOA). In 276 separate patients (male:female, 191:85; mean age ± standard deviation, 40 ± 15 years) who underwent hepatic resection, we evaluated the correlations between various DLA-based MRI indices, including liver volume normalized by body surface area (LV_BSA), liver-to-spleen SI ratio (LSSR), MRI parameter-adjusted LSSR (aLSSR), LSSR × LV_BSA, and aLSSR × LV_BSA, and the indocyanine green retention rate at 15 minutes (ICG-R15), and determined the diagnostic performance of the DLA-based MRI indices to detect ICG-R15 ≥ 20%. Results: In the test dataset, the mean DSS was 0.977 for liver segmentation and 0.946 for spleen segmentation. The Bland-Altman 95% LOAs were 0.08% ± 3.70% for the liver volume, 0.20% ± 7.89% for the spleen volume, -0.02% ± 1.28% for the liver SI, and -0.01% ± 1.70% for the spleen SI. Among DLA-based MRI indices, aLSSR × LV_BSA showed the strongest correlation with ICG-R15 (r = -0.54, p < 0.001), with area under receiver operating characteristic curve of 0.932 (95% confidence interval, 0.895-0.959) to diagnose ICG-R15 ≥ 20%. Conclusion: Our DLA can accurately measure the volume and SI of the liver and spleen and may be useful for assessing functional liver capacity using gadoxetic acid-enhanced HBP-MRI.

• Sleep Medicine and Psychophysiology
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• v.25 no.2
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• pp.82-91
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• 2018

Objectives: Synchronous electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) has been used to explore sleep stage dependent functional brain networks. Despite a growing number of sleep studies using EEG-fMRI, few studies have conducted network analysis on whole night sleep due to difficulty in data acquisition, artifacts, and sleep management within the MRI scanner. Methods: In order to perform network analysis for whole night sleep, we proposed experimental procedures and data processing techniques for EEG-fMRI. We acquired 6-7 hours of EEG-fMRI data per participant and conducted signal processing to reduce artifacts in both EEG and fMRI. We then generated a functional brain atlas with 68 brain regions using independent component analysis of sleep fMRI data. Using this functional atlas, we constructed sleep level dependent functional brain networks. Results: When we evaluated functional connectivity distribution, sleep showed significantly reduced functional connectivity for the whole brain compared to that during wakefulness. REM sleep showed statistically different connectivity patterns compared to non-REM sleep in sleep-related subcortical brain circuits. Conclusion: This study suggests the feasibility of exploring functional brain networks using sleep EEG-fMRI for whole night sleep via appropriate experimental procedures and signal processing techniques for fMRI and EEG.

• Investigative Magnetic Resonance Imaging
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• v.12 no.2
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• pp.170-177
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• 2008

Purpose : To evaluate usefulness of MR imaging after serial brain US in the high-risk neonates before discharge of the neonatal intensive care unit. Materials and Methods : Retrospective comparison of 412 US and 121 MR scans in 121 neonates and young infants were performed. Grading of germinal matrix/intraventricular hemorrhage (GMH/IVH) was performed and presence of intracranial hemorrhage other than GMH/IVH and parencyma lesions was also analyzed. Results : Among the 242 lateral ventricles, Seven GMH and 46 IVH were additionally detected by MRI. On the other hand, 30 GMH were only detected by US. US demonstrated Grade 1/2/3/4 GMH/IVH in 24/8/13/0 ventricles each, while each grades were identified in 3, 49, 10, 2 ventricles on MR images. Other intracranial lesions additionally detected on MR images were cerebral hemorrhage (n=4), cerebellar hemorrhage (n=4), extraaxial hemorrhage (n=8), diffuse excessive signal change of the white matter (n=72), non-cavitary lesion (n=4), encephalomalacia (n=2), and ventriculomegaly (n=5). Conclusion : MR imaging could be an excellent complimentary study after serial brain US for additional detection of the intracranial pathology, particularly IVH and white matter lesions, though US would be better in follow-up of GMH in some neonates.

• Journal of Korean Neurosurgical Society
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• v.46 no.2
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• pp.172-175
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• 2009

We describe a case of 36-year-old man who presented with a subacute headache preceded by a 1-month history of posterior neck pain without trauma history. Head and neck magnetic resonance imaging (MRI) studies disclosed bilateral supratentorial subdural and retroclival extradural hematomas associated with marked cervical epidural venous engorgement. Cerebral and spinal angiography disclosed no abnormalities except dilated cervical epidural veins. We performed serial follow-up MRI studied to monitor his condition. Patient's symptoms improved gradually. Serial radiologic studies revealed gradual resolution of pathologic findings. A 3-month follow-up MRI study of the brain and cervical spine revealed complete resolution of the retroclival extradural hematoma, disappearance of the cervical epidural venous engorgement, and partial resolution of the bilateral supratentorial subdural hematoma. Complete resolution of the bilateral supratentorial subdural hematoma was confirmed on a 5-month follow-up brain MRI. The diagnosis and possible mechanisms of this rare association are discussed.

• Journal of Korean Neurosurgical Society
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• v.58 no.5
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• pp.479-482
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• 2015

We report a case of a 31-year-old woman with glioblastoma multiforme (GBM) in the pineal region with associated leptomeningeal dissemination and lumbar metastasis. The patient presented with severe headache and vomiting. Magnetic resonance imaging (MRI) of the brain showed a heterogeneously enhanced tumor in the pineal region with obstructive hydrocephalus. After an urgent ventricular-peritoneal shunt, she was treated by subtotal resection and chemotherapy concomitant with radiotherapy. Two months after surgery, MRI showed no changes in the residual tumor but leptomeningeal dissemination surrounding the brainstem. One month later, she exhibited severe lumbago and bilateral leg pain. Thoracico-lumbar MRI showed drop like metastasis in the lumbar region. Finally she died five months after the initial diagnosis. Neurosurgeons should pay attention to GBM in the pineal region, not only as an important differential diagnosis among the pineal tumors, but due to the aggressive features of leptomeningeal dissemination and spinal metastasis.

• Journal of the Korea Computer Graphics Society
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• v.10 no.4
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• pp.1-5
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• 2004

본 논문에서는 인체의 머리 부분을 촬영한 자기 공명 촬영 영상(MRI: Magnetic Resonance Imaging)에서 뇌 영역의 대뇌 피질 만을 분할하는 방법에 대해 제시하고자 한다. 뇌의 해부학적 구조를 파악할 경우에 영상 내에 함께 보여지는 두개골과 뇌척수액 등을 제외한 대뇌피질 영역을 분할하면 보다 효과적인 정보 분석 및 진단이 가능하게 된다. 본 논문에서는 3단계 알고리즘을 제시한다. 첫번째 단계에서는 Speckle reducing anisotropic diffusion (SRAD)를 이용하여 영상 내에 존재하는 잡음을 제거하기 위한 필터링이다. 두번째 단계에서는 필터링된 결과를 이용하여 추출된 임계값과 사용자의 인터렉션인 씨드 포인트를 통해 영상분할을 수행하고, 세 번째 단계에서는 후 처리를 통해 분할 결과를 보완한다. 영상분할 결과의 정확성을 측정하기 위하여 현재 병원의 의료진들이 사용하고 있는 Mayo clinic사의 Analyze를 이용하여 분할된 결과와의 오류를 측정하였다. 또한 최종 결과에 대해 ultravis를 이용한 볼륨 렌더링으로 영상분할의 최종 결과를 제시하였다.

• Proceedings of the Korea Institute of Convergence Signal Processing
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• 2003.06a
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• pp.1-5
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• 2003

의료영상의 분할은 의료영상을 컴퓨터 진단 및 가시화에 필요한 같은 성질을 가진 여러 조직으로 나누어주는 방법이다. 즉 입력되어진 영상을 처리하여 유사한 화소들의 집합인 영역들로 화소들을 구분하는 작업이며 영상분할의 결과는 영상인식의 정확성에 큰 영향을 미친다. MRI(Magnetic Resonance Imaging)으로부터 정상적인 세포조직 또는 뇌종양과 같은 비정상적인 세포조직의 가시화와 분석을 위해서는 대상 세포조직의 적절한 분류를 필요로 한다. 하지만 기존의 영역 검출 방법으로는 잡음이 섞여 있는 영상에서 여러 가지의 처리과정(주로 잡음 제거)이 필수적이고 그런 과정으로 인해 정확한 영역 검출이 힘들게 된다. 이에 잡음이 있더라도 이를 제거하기 위한 처리가 필요 없이 영역기반으로 필요한 파라미터의 추정을 통한 MRF(Markov Random Field)를 이용하여 보다 효율적이고 정확하게 MRI에서 질환 영역을 검출할 수 있다.

• Investigative Magnetic Resonance Imaging
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• v.7 no.2
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• pp.137-143
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• 2003

Purpose : B1 field of birdcage RF (radiofrequency) coil that is used most for brain imaging in magnetic resonance imaging (MRI) decreases toward endring from the coil center. We investigated how much RE B1 homogeneity effect the endcap shield brings form the coil center as it towards to endcap region. Materials and Methods : We compared RF B1 field distribution by each finite difference time domain (EDTD) simulations for lowpass, highpass and hybrid birdcage RF coils. We selected the highpass birdcage RF coil that was the highest RF B1 field condition as simulation result, and studied how much RF B1 homogeneity effect was occurred when endcap shield was applied to endring area. Results : B1 field of the highpass birdcage RF coil was higher than other birdcage RF coil types as simulation result. However, the RF B1 homogeneity was lower than other coil types. RE B1 field of highpass birdcage RF coil with endcap shield is similar with RF B1 field of hybrid birdcage RF coil and the overall RE B1 homogeneity in sagittal direction was better. Conclusion In this paper, proposed method can apply improving RF B1 homogeneity of RF coil in clinical examination.