• 대한방사선치료학회지
• /
• 제30권1_2호
• /
• pp.177-183
• /
• 2018

목 적 : 체적변조회전방사선치료(VMAT)는 종양의 모양에 맞게 균일하면서도 정밀한 방사선 조사를 하면서 동시에 정상조직의 방사선 손상위험을 줄이는 장점이 있어 뇌암, 두경부암 및 전립선암 등의 종양과 정상장기가 가까운 암의 치료에 사용되고 있다. 본 연구의 목적은 뇌암 및 두경부암 환자의 VMAT 방사선 치료 시 Jaw-Tracking technique(JTT)의 선량학적 유용성을 평가하고자 한다. 대상 및 방법 : 본원에서 VMAT 치료기법으로 방사선치료를 받은 뇌암 및 두경부암 환자 8명을 선택하였다. 환자의 종양 및 정상 장기의 윤곽그리기(contouring) 정보를 Velocity(Varian, USA)의 deformable registration을 이용하여 Rando phantom에 fusion하였다. Varian Eclipse(ver 15.5, Varian, USA)를 사용하여 Jaw-Tracking 사용 유무를 제외하고 환자 치료 시 사용한 beam parameter와 동일하게 치료계획을 진행하였다. 평가 지표로써 target과 OAR의 최대선량, 평균선량을 사용하여 비교하였고 치료계획 검증을 위해 Portal dosimetry를 시행하였다. 결 과 : JTT를 사용했을 경우는 Static-Jaw technique(SJT)을 사용하였을 경우보다 OAR의 상대 선량이 각각 평균선량은 5.24 %, 최대선량은 7.05 % 감소한 것으로 나타났다. 다양한 OAR에서 평균선량과 최대선량의 감소의 범위는 각각 0.01~3.16 Gy, 0.12~6.27 Gy로 나타났다. Target의 경우는 JTT의 경우가 SJT보다 GTV, CTV, PTV의 최대선량이 각각 0.17 %, 0.43 %, 0.37 % 감소하였으며, 평균선량은 0.24 %, 0.47 %, 0.47% 감소하였다. 감마분석은 3 %/3 mm, 통과율 95 % 이상을 통과 기준으로 설정하였고 JTT, SJT 통과율은 각각 $98{\pm}1.73%$, $97{\pm}1.83%$이었다. 실험에 적용된 모든 OAR의 선량을 비교해 보았을 때, JTT을 사용하였을 경우가 SJT보다 MLC 외에 추가적인 jaw 차폐로 인하여 선량이 유의미하게 줄어들었다는 것을 알 수 있었다. 결 론 : VMAT 치료계획을 이용한 방사선 치료시 뇌암, 두경부암과 같이 종양과 정상 장기가 인접한 경우와 MLC를 통한 누설선량을 증가시킬 수 있는 넓은 조사야 및 높은 에너지의 사용을 필요로 하는 방사선 치료 시 JTT를 적용함으로써 종양주변 정상조직의 피폭선량을 낮추고 이로 인해 PTV의 target coverage를 높일 수 있을 것이라 판단된다.

• International Journal of Control, Automation, and Systems
• /
• 제1권3호
• /
• pp.385-389
• /
• 2003

In this paper, an improved technique for multiresolutive reconstruction of magnetoencephalography (MEG) source distribution is proposed. Using the proposed technique, focal solution with higher energy density can be reconstructed. Moreover, the proposed approach is very easy to implement compared to conventional ones. The usefulness of the proposed technique is verified by the application to a real brain model.

• Journal of international Conference on Electrical Machines and Systems
• /
• 제3권4호
• /
• pp.481-486
• /
• 2014

The demand for a DC power distributed system is increasing as renewable energy sources and DC electrical load are proliferating. For the automation of a power system, a magnetic contactor for the DC power system is required. The conventional magnetic contactors are mostly equipped with a solenoid magnetic actuator. However, the conventional magnetic contactor has problems with continuous power consumption, and heat generation. To address these problems, a permanent magnet type DC magnetic contactor is proposed in this paper.

• 전자통신동향분석
• /
• 제35권4호
• /
• pp.34-41
• /
• 2020

The existing Von Neumann architecture places limits to data processing in AI, a booming technology. To address this issue, research is being conducted on computing architectures and artificial neural networks that simulate neurons and synapses, which are the hardware of the human brain. With high-speed, high-throughput data communication infrastructures, photonic solutions today are a mature industrial reality. In particular, due to the recent outstanding achievements of artificial neural networks, there is considerable interest in improving their speed and energy efficiency by exploiting photonic-based neuromorphic hardware instead of electronic-based hardware. This paper covers recent photonic neuromorphic studies and a classification of existing solutions (categorized into multilayer perceptrons, convolutional neural networks, spiking neural networks, and reservoir computing).

• 한국영재학회:학술대회논문집
• /
• 한국영재학회 2005년도 추계학술대회
• /
• pp.27-32
• /
• 2005

As humanity embarks on its learning journey in the 21st century, education needs to take on new dimensions. This discourse focuses on the essentials of what educators could do to promote creative development in young gifted and talented students.Current practices in Singapore's Gifted Education Programme are shared. Future possibilities of educating the young gifted studentson their creative attributes like Piirto's 7 Is, brain functions, energy levels or intensities, volition, virtues and other personal and interpersonal skills will be explained. Gifted students are the captains of their own ships, the pilot of their own planes. Teaching them about their creative potential is the first step in awakening their consciousness from within. It is up to them to decide to become more creative with support from parents and teachers thereafter.

• Clinical and Experimental Pediatrics
• /
• 제54권6호
• /
• pp.241-245
• /
• 2011

Tuberous sclerosis complex (TSC) is a genetic multisystem disorder that results from mutations in the TSC1 or TSC2 genes, and is associated with hamartomas in several organs, including subependymal giant cell tumors. The neurological manifestations of TSC are particularly challenging and include infantile spasms, intractable epilepsy, cognitive disabilities, and autism. The TSC1- and TSC2-encoded proteins modulate cell function via the mammalian target of rapamycin (mTOR) signaling cascade, and are key factors in the regulation of cell growth and proliferation. The mTOR pathway provides an intersection for an intricate network of protein cascades that respond to cellular nutrition, energy levels, and growth factor stimulation. In the brain, TSC1 and TSC2 have been implicated in cell body size, dendritic arborization, axonal outgrowth and targeting, neuronal migration, cortical lamination, and spine formation. The mTOR pathway represents a logical candidate for drug targeting, because mTOR regulates multiple cellular functions that may contribute to epileptogenesis, including protein synthesis, cell growth and proliferation, and synaptic plasticity. Antagonism of the mTOR pathway with rapamycin and related compounds may provide new therapeutic options for TSC patients.

• 기술혁신연구
• /
• 제10권1호
• /
• pp.1-21
• /
• 2002

This paper suggests a new paradigm of science and technology (S&T) policy for the purpose of the new national development that pursues not the scale expansion of a industrial production but the qualitative enhancement of industrial and S&T comparativeness. The new S&T policy paradigm includes new policy directions such as the density increasement of high quality- brain power and the energy supply for crossing the threshold from imitative R&D to creative R&D. Also, this paper argues that it is necessary not only to acquire the support of the local S&T community and policy-makers on the new S&T policy paradigm, but also to develop and implement policy measures in details on the basis of the new paradigm suggested by the paper.

• 대한약리학회지
• /
• 제5권1호
• /
• pp.29-33
• /
• 1969

The effects of Ginseng saponin on respiration and $Na^+$, $K^+$ content of rat cerebral cortex slices were investigated to determine the action of Ginseng saponin on brain cortex at cellular level. There are many reports for the study of Ginseng on central stimulatory action in experimental animals. The electrical stimulation of slices of cortex causes a loss of potassium. And the respiration is needed to maintain a supply of energy for active cation transport. The reduction in $Qo_2$ is a consequence of primary cessation of active cation transport. Ginseng saponin stimulated respiration which was depressed by Morphine. But there was no significant change of electrolyte. It is suggested that the Ginseng saponin act rather on metabolic process than neural excitatory mechanism in vitro.

• 동아시아식생활학회지
• /
• 제5권3호
• /
• pp.233-238
• /
• 1995

CDP-choline is known as an intermediate of lecithin biosynthesis, and as an important drug for nervous diseases of the brain, For the bioconversion of CMP and choline to CDP-choline, ATP is required as an energy source. In these studies, the biosynthetic reaction of CDP-choline was coupled with ATP regenerating system by glycolysis. As a microorganism containing the highest conversion activity of CMP and choline to CDP-choline, Candida utilis ATCC 42416 was selected. The optimum reaction condition were 50mM choline chloride, 20mM CMP, 100mM potassium phosphate (pH8.0), 300mM glucose, 50mM MgSO4, 10% dried cells with shaking incubation at 3$0^{\circ}C$. The reaction was thus performed for 10 hours under the above optimum conditions. The concentration of CDP-choline was 16mM(80% in conversion ratio).

• 지질동맥경화학회지
• /
• 제8권1호
• /
• pp.1-7
• /
• 2019

Vascular dementia is the most common neuropsychiatric syndrome and is characterized by synaptic dysfunction, neuroinflammation, and cognitive dysfunction. Vascular dementia is associated with various environmental, genetic, and lifestyle risk factors. Recent research has focused on the association between vascular dementia and dietary patterns, suggesting that dietary regulation leads to better control of energy metabolism, improvements in brain insulin resistance, and the suppression of neuroinflammation. Intermittent fasting is a calorie-restriction method known to be more effective in promoting fat loss and regulating the impairment of glucose metabolism as compared with other dietary restriction regimens. Herein, the authors review the effects of intermittent fasting with regard to vascular dementia based on recent evidence and propose that intermittent fasting could be a therapeutic approach for ameliorating vascular dementia pathology and preventing its onset.