• Advances in biomechanics and applications
• /
• 제1권4호
• /
• pp.253-267
• /
• 2014

The human head is identified as the body region most frequently involved in life-threatening injuries. Extensive research based on experimental, analytical and numerical methods has sought to quantify the response of the human head to blunt impact in an attempt to explain the likely injury process. Blunt head impact arising from vehicular collisions, sporting injuries, and falls leads to relative motion between the brain and skull and an increase in contact and shear stresses in the meningeal region, thereby leading to traumatic brain injuries. In this paper the properties and material modeling of the subarachnoid space (SAS) as it relates to Traumatic Brain Injuries (TBI) is investigated. This was accomplished using a simplified local model and a validated 3D finite element model. First the material modeling of the trabeculae in the Subarachnoid Space (SAS) was investigated and validated, then the validated material property was used in a 3D head model. In addition, the strain in the brain due to an impact was investigated. From this work it was determined that the material property of the SAS is approximately E = 1150 Pa and that the strain in the brain, and thus the severity of TBI, is proportional to the applied impact velocity and is approximately a quadratic function. This study reveals that the choice of material behavior and properties of the SAS are significant factors in determining the strain in the brain and therefore the understanding of different types of head/brain injuries.

• 임상간호연구
• /
• 제22권3호
• /
• pp.265-275
• /
• 2016

Purpose: The purpose of this study was to develop an evidence-based guideline for fever management for critically ill adult patients after a brain injury. Methods: Development of the guideline process was done according to the De Novo development Korean Medical Guideline Information Center (KoMGI) and consists of 12 steps. Results: This developed guideline included 3 domains and 19 recommendations. The number of recommendations for each domain was 7 on measuring temperature, 9 on managing fever, and 3 on managing shivering. The level of evidence was as follows: 58% were at level I, and 42% at level II. Of the recommendations, 58% were graded as A, 37% as B, and 5% as C. Conclusion: These findings indicate that this guideline can be used as a guide for nursing in critically ill adult patients with brain injury. This guideline can also contribute to improvements in the quality of nursing care for critically ill adult patients with brain injury.

• 한국초등과학교육학회지:초등과학교육
• /
• 제35권3호
• /
• pp.336-347
• /
• 2016

The purpose of this study is to analyze the effects of elementary science instruction applying a Brain-Based Evolutionary (ABC-DEF) approach using Rapid-cycling Brassica rapa (RcBr) on the interests of elementary school students. For this study, two elementary school classes in Seoul and one elementary school class in Gyeonggi-do were selected. Comparison group received instruction using textbook and teacher's guidebook. A class taught using only brain-based evolutionary approach is experimental group A, and a class taught through brain-based evolutionary approach using RcBr is experimental group B. In order to analyze the quantitative differences about the interests of students, three kinds of test were administered to the students: 'Applied Unit-Related Interests', 'Follow-up Interests' and 'Interests in the observation material'. To get more information, qualitative data such as portfolios and interviews were analyzed. The major findings are as follows. First, for the test of applied unit-related interests, a statistically significant difference was found between comparison group and experimental group A, and between comparison group and experimental group B. As the results of interviews, the students have shown that the intensified exploration activities on plant in Brain-Based Evolutionary approach applied to experimental groups A and B had a positive effect. Second, for test of follow-up interests, we classified the students' follow-up interests into three types: extended-developed-deepened (EDD) type, simply expanded-maintained (SEM) type, and stopped or decreased (SD) type. Both experimental group A and experimental group B showed the highest percentage of EDD. Also, observation journal applying the evolutionary process (DEF) showed a positive effect on the students' interest. Comparison group showed the highest percentage of SEM. Third, for test of applied interests in the observation material, a statistically significant difference was found between comparison group and experimental group A, and comparison group and experimental group B. Experimental group B using RcBr showed the highest average score, while experimental group A showed a higher score than comparison group. Based on these findings, educational implications of Brain-Based Evolutionary approach and using RcBr are discussed.

• Journal of Computing Science and Engineering
• /
• 제7권2호
• /
• pp.112-121
• /
• 2013

The last years have seen a rise of interest in using electroencephalography-based brain computer interfacing methodology for investigating non-medical questions, beyond the purpose of communication and control. One of these novel applications is to examine how signal quality is being processed neurally, which is of particular interest for industry, besides providing neuroscientific insights. As for most behavioral experiments in the neurosciences, the assessment of a given stimulus by a subject is required. Based on an EEG study on speech quality of phonemes, we will first discuss the information contained in the neural correlate of this judgement. Typically, this is done by analyzing the data along behavioral responses/labels. However, participants in such complex experiments often guess at the threshold of perception. This leads to labels that are only partly correct, and oftentimes random, which is a problematic scenario for using supervised learning. Therefore, we propose a novel supervised-unsupervised learning scheme, which aims to differentiate true labels from random ones in a data-driven way. We show that this approach provides a more crisp view of the brain states that experimenters are looking for, besides discovering additional brain states to which the classical analysis is blind.

• 약학회지
• /
• 제46권2호
• /
• pp.124-128
• /
• 2002

The nitrone-based free radical trapping reagent, $\alpha$-phenyl-n-tert-butyl nitrone (PBN) has been proposed as therapeutic agent for stroke. We used this for model drug of development of new drug for neuroprotection. The purpose of this study was to evaluate the blood-brain barrier (BBB) permeability of PBN in Sprague-Dawly (SD) rats. The BBB transport of PBN was investigated in SD rats using internal carotid artery perfusion (ICAP) method at a rate of 4 mι/min for 15 second. We also obtained pharmacokinetic parameters of PBN using single intravenous injection technique. When we estimated BBB permeability of PBN with ICAP method, the brain volume of distribution of PBN was 60.0 $\pm$ 12.0 $\mu\textrm{g}$/ι. The brain uptake of PBN after IV injection at 120 min was 0.15 $\pm$ 0.01%ID/g. The PBN was transported to the brain through the BBB well in rats, because PBN is small molecule (MW 177) and lipid-soluble (log P 1.23) compound.

• 한국게임학회 논문지
• /
• 제9권6호
• /
• pp.31-44
• /
• 2009

Brain-Computer Interface(이하 BCI)는 뇌파를 활용하여 인간의 의지로 컴퓨터를 제어하는 수단이나 행위이다. 뇌파 인터페이스 관련 하드웨어 제작 기술이 발전함에 따라 고가이면서 대형이었던 뇌파 측정 장비가 최근에는 소형화 되고 개인이 구매 가능한 가격대로 출시되면서 앞으로 다양한 멀티미디어 분야에서 응용이 될 것으로 예상된다. 이 논문은 뇌파 인터페이스 장치를 게임의 새로운 장치로 활용이 가능한지에 대해 게임 디자인적 관점에서 접근한다. 먼저 논문에서는 뇌파 인터페이스 장치를 적극적으로 활용할 수 있는 게임 플레이 요소를 제안하고 체계화하며, 이를 기반으로 하는 게임의 시제품을 제작하였다. 다음으로 기존의 키보드, 마우스를 입력 장치로 사용하는 게임과의 비교 체험을 통해 뇌파 인터페이스 장치의 활용이 직관적이고 효율적인 게임 플레이를 제공하는지에 대해 통계적인 분석을 하였으며, 실제로 직관성과 흥미로움을 제공한다는 사실이 검증되었다. 본 논문의 결과는 BCI 기반 게임 제작을 위한 효과적인 게임 디자인 가이드라인이 될 것으로 판단된다.

• Journal of Trauma and Injury
• /
• 제25권4호
• /
• pp.209-216
• /
• 2012

Purpose: The objectives of this study are to classify chronic subdural hematomas based on brain computerized tomographic scan (CT scan) findings and to determine the mechanism of evolution and treatment methods. Methods: One hundred thirty-nine patients who were diagnosed with a chronic subdural hematoma and who available for follow up assessment 6 months post-surgery were analyzed retrospectively. The presence of trauma and past medical history were reviewed and evaluation criteria based on brain CT scan findings were examined. Results: Initial brain CT scans revealed a chronic subdural hematoma in 106 patients, a subdural hygroma in 24 patients, and an acute subdural hematoma in 9 patients. In all cases where the initial acute subdural hematoma had progressed to a chronic subdural hematoma, final was a hypo-density chronic subdural hematoma. In case where the initial subdural hygroma had progressed to a chronic subdural hematoma, the most cases of hematoma were hyper-density and mixed-density chronic subdural hematoma. In total, 173 surgeries were performed, and they consisted of 97 one burr-hole drainages, 70 two burr-hole drainages and 6 craniotomies. Conclusion: This study demonstrates that rebleeding and osmotic effects are mechanisms for enlarging of a chronic subdural hematoma. In most cases, one burr-hole drainage is a sufficient for treatment. However, in cases of mixed or acute-on-chronic subdural hematomas, other appropriate treatment strategies are required.

• 만화애니메이션 연구
• /
• 통권36호
• /
• pp.217-236
• /
• 2014

본 연구는 애니메이션의 전문적인 특성을 고려한 드로잉 교수법을 연구하기위한 문헌분석 과정으로 뇌의 기능과 학습, 창작 기제를 고려한 교수법을 적용하면 애니메이션 드로잉능력이 효율적으로 신장될 것이라는 관점의 연구를 위한 원리분석 과정이다. 최근 들어 각 분야의 교육방법에 대한 대안적인 논의로 뇌기반 학습원리가 적용된 연구결과들이 발표되고 있다. 이는 미술과 드로잉 교육 뿐만 아니라, 예술전반적인 교육적 대안으로 적용 실시되고 있다. 반면, 애니메이션 드로잉은 미술적 소양을 필요로 함과 동시에 움직임에 대한 구조적 지식과 인지적 감각, 소통방식을 숙련할 수 있는 종합적인 교수법을 요하는 것에 비해 전문적인 교수법 개발 연구는 미진하다. 이에 효과적인 교육의 원리를 뇌의 기제로 바라보고 뇌가 학습하고 창의성을 발휘하게 되는 원리를 분석하여 본다. 또한 그림그리기와 뇌의 기능에 대한 원리관계를 통해 드로잉과 뇌의 관계를 알아본다. 그 결과 구조와 형태를 그릴 수 있는 인지적 정보를 관할하는 좌뇌 뿐만 아니라, 그리기와 직접적 관련이 있는 우뇌를 통합 발달시켜야 하며, 창의성이 발현되기 위해서는 물리적, 심리적 요소가 발현되는 통합적 뇌의 기제를 이해한 교수법이 개발되어야함이 드러났다. 애니메이션드로잉교육은 드로잉 능력에 필요한 예술적 창의 속성을 발휘하는 방법을 교육하는 것이기 때문이다. 이 과정은 기존의 애니메이션드로잉 교수법과의 차별성을 찾아내는 토대가 될 뿐만 아니라, 뇌기반-원리는 이후 교육의 전략과 방법 모형을 설계하는데 핵심적인 전략적 정의로 선정될 것이다.

• 대한핵의학회지
• /
• 제37권1호
• /
• pp.63-72
• /
• 2003

Functional MRI (fMRI) provides an indirect mapping of cerebral activity, based on the detection of the local blood flow and oxygenation changes following neuronal activity (Blood Oxygenation Level Dependent). fMRI allows us to study noninvasively the normal and pathological aspects of functional cortical organization. Each fMRI study compares two different states of activity. Echo-Planar Imaging is the technique that makes it possible to study the whole brain at a rapid pace. Activation maps are calculated from a statistical analysis of the local signal changes. fMRI is now becoming an essential tool in the neurofunctional evaluation of normal volunteers and many neurological patients as well as the reference method to image normal or pathologic functional brain organization.

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권9호
• /
• pp.4233-4235
• /
• 2016

Background: Whole brain radiotherapy (WBRT) and stereotactic radiosurgery were frequently used to palliate patients with brain metastases. It remains controversial which modality or combination of therapy is superior especially in the setting of limited number of brain metastases. The availability of newer medical therapy that improves survival highlighted the importance of reducing long term radiation toxicity associated with WBRT. In this study, we aim to demonstrate the hippocampal sparing technique with whole brain and integrated simultaneous boost Materials and Methods: Planning data from 10 patients with 1-5 brain metastases treated with SRS were identified. Based on the contouring guideline from RTOG atlas, we identified and contoured the hippocampus with 5mm isocentric expansion to form the hippocampal avoidance structure. The plan was to deliver hippocampal sparing whole brain radiotherapy (HSWBRT) of 30 Gy in 10 fractions and simultaneous boost to metastatic lesions of 30 Gy in 10 fractions each. Results: The PTV, hippocampus and hippocampal avoidance volumes ranges between 1.00 - 39.00 cc., 2.50 - 5.30 cc and 26.47 - 36.30 cc respectively. The mean hippocampus dose for the HSWBRT and HSWBRT and SIB plans was 8.06 Gy and 12.47 respectively. The max dose of optic nerve, optic chiasm and brainstem were kept below acceptable range of 37.5 Gy. Conclusions: The findings from this dosimetric study demonstrated the feasibility and safety of treating limited brain metastases with HSWBRT and SIB. It is possible to achieve the best of both worlds by combining HSWBRT and SIB to achieve maximal local intracranial control while maintaining as low a dose as possible to the hippocampus thereby preserving memory and quality of life.