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Role of polyethylene glycol (PEG) linkers: trends in antibody conjugation and their pharmacokinetics

  • Kondapa Naidu Bobba;Abhinav Bhise;Subramani Rajkumar;Woonghee Lee;Jeongsoo Yoo
    • Journal of Radiopharmaceuticals and Molecular Probes
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    • v.6 no.2
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    • pp.155-164
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    • 2020

  • Polyethylene glycol (PEG) has been the most commonly used polymer for the past few decades in the field of biomedical applications due to its gold standard stealth effect. PEGylation of antibody-drug conjugates, liposomes, peptides, nanoparticles, and proteins is done to improve their pharmaceutical efficacy and pharmacokinetic properties. PEGylation of antibodies with various PEG linkers improves targeting ability by increasing the blood circulation time and thus enhances the biodistribution profiles. It also assists in minimizing the immediate capture by the reticuloendothelial system. In this review, we summarize the effect of PEG linkers in an antibody conjugation and their pharmacokinetics in the field of biomedical imaging.

  • https://doi.org/10.22643/JRMP.2020.6.2.155 인용 PDF KSCI

CHEMOPREVENTIVE EFFECTS IN MOUSE SKIN CARCINOGENESIS AND INDUCTION OF APOPTOSIS IN HUMAN PROMYELOCYTIC LEUKEMIA(HL-60) CELLS BY XANTHORRHIZOL

  • Kim, Heui-og;Chung, Won-Yoon;Park, Min-Ah;Kim, Mi-Jeong;Park, Jae-Hee;Park, Kwang-Kyun
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.10a
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    • pp.141-142
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    • 2001

  • Curcuma xanthorrhiza Roxb(Zingiberaceae) has been traditionally used in Indonesia for dietry and medicinal purposes. Xanthorrhizol is a sesquiterpenoid isolated from C. xanthorrhiza that has been known to possess anti-inflammatory and anticarcinogenic defects.(omitted)

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Electrochemical Impedance Characteristics of Anodic Oxide Layer Formed on Titanium Binary Alloy Surface

  • Lee, Kang;Choe, Han-Choel;Ko, Yeong-Mu
    • Proceedings of the Korean Institute of Surface Engineering Conference
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    • 2008.11a
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    • pp.30-30
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    • 2008

  • In this study, electrochemical impedance characteristics of anodic oxide layer formed on titanium binary alloy surface have been investigated. Titanium oxide layers were grown on Ti-$_XTa$ and Ti-$_XNb$(X=10, 20, 30 and 40 wt%) alloy substrates using phosphoric acid electrolytes.

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