• Radiation Oncology Journal
• /
• 제7권1호
• /
• pp.59-70
• /
• 1989

자궁경부암은 치료후의 생존율이 좋은 암으로 인정되고 있으나 전 자궁경부암의 $44\%$는 재발되며 재발암의 대부분은 국소재발이다. 더욱이 재발된 암은 어떤 방법으로 치료한다 하더라도 5년 생존율은 $2\~9\%$에 불과하다고 보고되고 있다. 이러한 사실은 적극적인 국소치료법이 필요함을 시사하고 있으나 국소방사선 조사선량을 증가시켜 치료율을 높이려 할 경우 필연적으로 따라오는 합병증의 증가가 우려되어 불충분함을 인정하면서도 전골반에 4500cGy이하, A점에 8500cGy정도가 사용되어 왔다. 1986년 4월부터 1987년 12월까지 영남대찰 치료방사선과에서 중앙차폐없이 전골반에 5000cGy, 고선량률 강내치료로 A점에 3900cGy, 외부선량을 포함한 A점 총 선량 8900cGy를 조사함으로서 종래의 치료보다 $500~1000cGy$를 더 조사받은 자궁경부암 환자 103명중 추적 치료가 불가능 하였던 환자를 제외한 96명을 대상으로 장관합병증을 분석하였다. 종래보다$500\~1000cGy$를 더 조사 받았으나 합병증이 증가되지 않았음을 보고함으로서 합병증의 증가 없이 생존율의 증가를 얻을 수 있는 최고선량을 결정하는 기초자료로 삼고자 본 연구를 시도하였다. 평균 추적기간은 21개월이었고 대부분의 증상은 12개월 이내에 나타났단. 이급후증(tenesmus), 하복부 동통을 포함한 장관합병증은 $46\%$였고 입원치료를 받은 환자는 6명 $(0\%)$이었으나 수술이 필요한 환자는 1명분이었다. X선 대장촬영과 직장경 검사를 실시하였으나 바리움 대장촬영에서 1명만이 비정상적인 소견을 보여 직장손상의 진단에 효율이 적음을 시사하였다. 환자의 연령, 총 조사선량, 총 TDF, 직장조사선량과 장관합병증은 무관함을 보여주었다. 입원치료가 필요한 6명의 환자 중 5명이 축소조사야를 사용한 추가치료를 했던 환자로서 추가치료가 합병중의 위험 인자임을 시사하였다(p<0.01). 심한 합병증을 보인 6명중 3명 이 방사선 치료전 수술경험이 있었으며 직장선량이 다른 환자들의 평균직장선량(7300cGy) 보다 작음에도 불구하고 (5252 cGy) 심한증상을 보여 치료전의 수술기왕력 이 위험 인자가 될 수 있음을 시사하였다. 종래의 치료양보다 $500\~1000cGy$ 더 높은 선량에도 불구하고 입원치료가 필요하였던 환자는 $6\%$, 수술이 필요하였던 환자는 $1\%$로 합병증의 증가 없이 A점에 8900cGy, 직장에 7300cGy정도의 국소치료가 가능함을 보여 주었으나 생존율에 대한 추후 분석이 따라야 할 것으로 사료된다.

• 한국식품영양과학회지
• /
• 제34권5호
• /
• pp.644-651
• /
• 2005

본 연구는 생약제와 식이섬유가 주성분인 다이어트 제제가 체중, 체지방, 혈액지질분획 및 배변습관에 미치는 영향을 알아보기 위하여 대학생 자원자 30명을 대상으로 5주 동안 실시하였다. 다이어트 제제는 1일 2회 섭취케 하되 본인의 일상 식사 및 생활양식을 그대로 유지케 하였으며 실험전 설문지 조사를 통한 대상자의 일반환경요인 평가와 식이섭취 평가가 실시되었다. 실험기간 중에는 주 3회 식이일지 작성과 매주 체중을 측정토록 하였고 실험 개시 일과 종료일에는 혈액채취와 신체계측이 실시되었다. 실험대상자의 특성을 보면 중산층 이상으로 평균 나이 21세로 정상체중을 유지하였다. 운동은 절어도 30분간, 주 $1\~2$회 이상하였고 음주율은 매우 높았으나 흡연은 거의 하지 않았다. 식사는 적어도 2끼 이상 먹는 편이나 외식빈도가 많았고 식습관이 불량하였으며 배변횟수는 보통이었으나 변비경험은 비교적 많았다. 영양소 섭취량은 전반적으로 낮았으며 실험개시기에 비해 종료시에 식이섭취 및 영양소 섭취량이 낮은 경향을 보였다. 체중, 체질량지수, 표준체중백분율은 물론 체지방비율, 피부지방두께, 허리둘레, 엉덩이 둘레 및 WHR등은 실험개시시에 비해 종료시 감소하였으며(p<0.05),반면에 근육량의 비율은 유의하게 증가하였다(p<0.05). 한편 혈액 총 콜레스테롤과 중성지방은 유의하게 감소하였으나(p<0.05) HDL-콜레스테롤농도는 변화가 없었고 LDL-콜레스테롤농도는 실험개시시에 비해 종료시 감소하는 경향을 보였다. 혈압은 실험 전과 후에 변화하지 않았다. 배변횟수는 실험 개시기에 비해 종료시에 증가하였다(p<0.05).위의 결과를 종합해 볼 때 본 연구의 생약제와 섬유질로 제조한 다이어트 제제가 체중과 체지방 및 비만관련 신체지표를 유의하게 감소시켰으며, 혈액 중 일부 지방분획과 배변횟수도 바람직하게 변화하였다. 그러나 더욱 통제된 후속 연구가 이뤄져야 할 것으로 사료된다.

• 대한한방내과학회지
• /
• 제22권4호
• /
• pp.647-657
• /
• 2001

In the oriental medicine field, researches have been in progress regarding oriental medical factors. I also carried out a clinical study on stroke, from which I discovered meaningful results about important factors that impact on the prognosis of stroke. We studied 132 patients after diagnosis of stroke through a Brain-CT scan and MRI sea, to the oriental internal medicine department at the Hospital affiliated to Oriental Medical College, Dongeui University. All the patients showed meaningful improvement in the examination of their symptoms after four weeks, compared with the first week. Between strokes involving meridian system and strokes involving internal organs, the symptom of paralysis caused by strokes involving meridian system, which patients were in favorable initial condition, had improved significantly and that by strokes involving internal organs had not. The group whose initial bowel movement since the stroke was delayed, whose coating on the tongue was thick or the tongue was dry, whose pulse was tachycardiac, or who had a history of hypertension or diabetics showed a significantly worse symptom after 4 weeks than that of groups in the opposite cases.

• Advances in pediatric surgery
• /
• 제10권2호
• /
• pp.127-130
• /
• 2004

Appendectomy is the most common emergency surgical operation in children. The laparoscopic treatment of pediatric appendicitis is controversial, particularly in complicated cases. The purpose of this study is to evaluate laparoscopic appendectomy (LA) and open appendectomy (OA) for simple and perforated appendicitis (SA, PA) in children. A total of 188 patients, operated from January 1992 to September 2003, were reviewed. Ninety-one patients underwent OA (65 SA and 26 PA) and 97 had LA ( 67 SA, 30 PA). There was one conversion of LA to OA in PA. Operative time for LA was longer for OA in PA (55.8 vs. 45.7 min; p=0.0467). Recovery of bowel movement, diet starting time, length of hospital stay for LA were significantly shorter than those for OA. Postoperative complication rate was not different between LA and OA in each group. Laparoscopic appendectomy is a safe and effective method for both simple and perforated appendicitis.

• 응용통계연구
• /
• 제22권5호
• /
• pp.1047-1057
• /
• 2009

The nonparametric bivariate two-sample test of Bennett (1967) is extended to the multivariate k sample test. This test has been easily modified for a monotone trend among k samples. Often in applications it is important to consider a set of multivariate response variables simultaneously, rather than individually, and also important to consider testing k samples altogether. Different approaches of estimating the null covariance matrices of the test statistics resulted in the same limiting form. The multivariate k sample test is applied to the non-normal data of a randomized trial conducted for a period of four weeks in mental hospitals. The purpose of the trial is to compare the efficacy of three different interventions for a relief of the frequently occurring problems of constipation, caused as a side effect of antipsychotic drugs during hospitalization. The bowel movement status of patient for a week is summarized into a single severity score, and severity scores of four weeks comprise a four-dimensional multivariate variable. It is desirable with this trial data to consider a multivariate testing among k samples.

• 대한영양사협회학술지
• /
• 제10권1호
• /
• pp.58-64
• /
• 2004

This study was performed to investigate the kinds of health food advertised and sold through media like printed matter, TV broadcasting or internet. It was found that fifty three percent of the health food was circulated through internet, 27% through printed matter, 9% through TV Broadcasting. When the health foods was classified, the proportion of special purpose nutritious foods was 36.1%, health aid foods 33.9%, uncooked powdered foods 18.5%, functional foods for health 4.9%, Ginseng products 3.9%, and tea 0.9%. The special purpose nutritious foods was composed of 59% of nutrition supplementary foods, 24% of dietary fiber foods, 9% of weaning foods, 7% of milk formula and 2% of HCA. Vegetable extracts occupied 21.1% of health aid foods, yeast 7.5%, mushroom extracts 7.0%, chitosan 6.2%, aloe 5.3%. Dried powdered type health food occupied the highest proportion. The other type were capsule(18.8%), tablet(18.1%), and liquid type(16.4%). When the health food was classified with health claim, the proportion of "nutrition supplementation" was the highest (23.9%), "diet" 14.9%, "ergogenic"(18.8%), "promoting bowel movement" 7.8%, "growth" 5.7%, "regulation of blood sugar" 4.5%, "improving of immunity"(2.4%) and anti-aging effect(2.4%).

• 고려인삼학회:학술대회논문집
• /
• 고려인삼학회 1978년도 학술대회지
• /
• pp.79-84
• /
• 1978

Ginseng has been widely used in the Oriental world for more than 2,000 years. Its chemical and pharmacological studies have been published by many investigators of many countries. But its clinical studies have not been performed in satsifactory amount. This study was carried out to evaluate the effect of ginsenoside-triol on the postoperative recovery in 120 cases of gynecological laparotomies. Daily dose of 0.23 gram of ginsenoside-triol was administered orally for three weeks after surgery to 60 cases, and placebo to 60 cases as control. Hemoglobin, hematocrit, leukocyte count, serum total protein, albumin, cholesterol and glucose were studied at pre- and postadministration. At the same time, body weight, blood pressure and subjective symptoms such as appetite, bowel movement and digestion were checked. The results obtained were summarized as follows: 1) The side effect was nil. 2) Hemoglobin and hematocrit Were more increased in treated group than in control group, but the changes were not significant. 3) Serum total protein was more significantly increased in treated group than in control group. 4) Serum cholesterol was significantly less increased in treated group than in control group. 5) Serum glucose level was significantly decreased in both groups, more significantly in control group. 6) Body weight was significantly increased in treated group.

• 사상체질의학회지
• /
• 제35권1호
• /
• pp.46-55
• /
• 2023

Objectives The purpose of this case study was to report a case of anorexia and fatigue after getting vaccinated COVID-19 treated based on Sasang Constitutional Medicine. Methods The patient was hospitalized for 4 days and treated with herbal medicine and moxibustion. The patient was asked to score for daily energy level out of 100 on his own and we used Karnofsky Performance Score(Karnofsky PS) on daily health status to evaluate the clinical effects. We also checked daily amount of meal and evaluated original symptoms such as insomnia, gastric discomfort, bowel movement and dysuria in four stages. Results At initial, the patient could only eat one spoon of a meal and was unable to carry on herself without any assistance, so she used a wheelchair on the day of admission. When discharged, the patient can eat half of a meal at each mealtime and perform normal activities by herself. Discussion This case demonstrates that Sasang constitutional approach to anorexia and fatigue caused by COVID-19 vaccination can be an useful treatment.

• 임상간호연구
• /
• 제15권3호
• /
• pp.17-26
• /
• 2009

Purpose: The purpose of this study was to compare the recovery outcomes between a normal weight group (BMI<25) and an overweight group ($$BMI{\geq_-}25$$), who received laparoscopic surgery for rectal cancer, to provide information for effective decision making. Methods: Data from 76 patients who received laparoscopic surgery for rectal cancer in a university hospital were reviewed retrospectively from September 2004 to March 2007. Collected data were analyzed using Win SPSS 12.0. The recovery outcomes related to the operation were the length of the operation, the amount of bleeding during the operation, the length of stay in the recovery room, first bowel movement, the length of hospital stay, and complications. Results: There was no statistical difference between the two groups with regard to the recovery outcomes. Conclusion: From the above results, nursing information can be offered to help make effective decisions before the operation for overweight patients with rectal cancer who prefer laparoscopic surgery.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제26권2호
• /
• pp.127-133
• /
• 2023

Purpose: Dyssynergic defecation (DSD) is one of the important causes of chronic constipation in children. We aimed to analyze the clinical features, diagnostic test results, and treatments for DSD in children. Methods: Children diagnosed with DSD using fluoroscopic defecography were enrolled in this study. Clinical data, including the results of colon transit time (CTT) test and biofeedback (BF) therapy, were collected from medical records retrospectively. Results: Nineteen children were enrolled. The median age was 9 years (6-18 years), the median frequency of bowel movement was 1/7 days (1-10 days), the median duration of constipation was 7.0 years (2-18 years), the median age of onset of constipation was 2.5 years (1-11 years). In the CTT test, outlet obstruction type was noted in 10/18 (55.6%), slow transit type in 5/18 (27.8%), and normal transit in 1/18 (5.6%). The median CTT was 52 hours (40-142 hours). Initial medical therapy was performed with the polyethylene glycol 4000, and the response was good in 9/19 (47.4%), fair in 9/19 (47.4%), and poor in 1/19 (5.0%). BF was performed in 8/19, with good results in 6/8 (75.0%) children and failure in 2/8 (25.0%) children. After long-term medical therapy (11/19), 3/5 showed good response with medication alone, 6/8 showed good response with BF and medication combined. Conclusion: DSD should be considered as a cause of chronic constipation in children, especially in those with abnormal CTT test results. BF combined with medical therapy is effective even with age-limited cooperation.