• Journal of Society of Preventive Korean Medicine
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• v.8 no.2
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• pp.171-184
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• 2004

In order to study the effects of Gagamyounjo-Tang(加減潤燥湯) on the experimentally hypercoagulable state and hyperlipidemia in rats, we have made the hypercoagulable state in rats by injection of Bothrops jararaca venom (0.1ml/200g : Control group), and have administered solid extract of Gagamyounjo-Tang(加減潤燥湯)(132mg/200g : Sample group). After 1 hour we measured the platelet count, fibrinogen level, APTT, FDP and D-dimer. And we have made the hyperlipidemia in rats by injection of Triton WR-1339 for 3 days(30mg/200g/day : Control group), and have administered solid extract of Gagamyounjo-Tang(加減潤燥湯)(132mg/200g : Sample group), then we measured the total cholesterol, triglyceride, phoshpolipid and HDL-cholesterol levels. The results are summarized as follows : 1. In the hypercoagulable state, Sample group significantly decreased in platelet count compared with Control group(p<0.01), and significantly prolonged in APTT compared with Control group(p<0.05). 2. In the hyperlipidemia, Sample group significantly decreased in the total cholesterol, triglyceride and phoshpolipid compared with Control group(p<0.01), and significantly increased in HDL-cholesterol level compared with Control group(p<0.01). According to the above experimental results, Gagamyounjo-Tang(加減潤燥湯)is assumed to have curative effects against the hypercoagulable state in rats induced by Bothrops jararaca venom and the hyperlipidemia in rats induced by Triton WR-1339. And we can suppose that Gagamyounjo-Tang(加減潤燥湯) has a curative effect against the cerebrovascular accident caused by blood stasis.