대한예방한의학회지 (Journal of Society of Preventive Korean Medicine)

대한예방한의학회 (Society of Preventive Korean Medicine)
권호 표지

가감윤조탕(加減潤燥湯)이 실험적으로 유발된 흰쥐의 혈액응고항진 및 고지혈증(高脂血症)에 미치는 영향

Effects of Gagamyounjo-Tang on the Experimentally Hypercoagulable State and Hyperlipidemia in Rats

  • 김용태 (세명대학교 한의과대학 한의진단학교실) ;
  • 소경순 (세명대학교 한의과대학 예방의학교실) ;
  • 정찬길 (세명대학교 한의과대학 한의진단학교실)
  • Kim Yong-Tae (Department of Oriental Diagnostics, College of Oriental Medicine, Semyung University) ;
  • Soh Kyeong-Sun (Department of Preventive Medicine, College of Oriental Medicine, Semyung University) ;
  • Jeong Chan-Gil (Department of Oriental Diagnostics, College of Oriental Medicine, Semyung University)
  • 발행 : 2004.12.29
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초록

In order to study the effects of Gagamyounjo-Tang(加減潤燥湯) on the experimentally hypercoagulable state and hyperlipidemia in rats, we have made the hypercoagulable state in rats by injection of Bothrops jararaca venom (0.1ml/200g : Control group), and have administered solid extract of Gagamyounjo-Tang(加減潤燥湯)(132mg/200g : Sample group). After 1 hour we measured the platelet count, fibrinogen level, APTT, FDP and D-dimer. And we have made the hyperlipidemia in rats by injection of Triton WR-1339 for 3 days(30mg/200g/day : Control group), and have administered solid extract of Gagamyounjo-Tang(加減潤燥湯)(132mg/200g : Sample group), then we measured the total cholesterol, triglyceride, phoshpolipid and HDL-cholesterol levels. The results are summarized as follows : 1. In the hypercoagulable state, Sample group significantly decreased in platelet count compared with Control group(p<0.01), and significantly prolonged in APTT compared with Control group(p<0.05). 2. In the hyperlipidemia, Sample group significantly decreased in the total cholesterol, triglyceride and phoshpolipid compared with Control group(p<0.01), and significantly increased in HDL-cholesterol level compared with Control group(p<0.01). According to the above experimental results, Gagamyounjo-Tang(加減潤燥湯)is assumed to have curative effects against the hypercoagulable state in rats induced by Bothrops jararaca venom and the hyperlipidemia in rats induced by Triton WR-1339. And we can suppose that Gagamyounjo-Tang(加減潤燥湯) has a curative effect against the cerebrovascular accident caused by blood stasis.

키워드

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