• Title/Summary/Keyword: Bonferroni Procedure

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Statistically Proper Multiple Range Tests for a Within Subject Factor in a Repeated Measures Design

  • Park, Cheol-Yong;Park, Sang-Bum
    • Journal of the Korean Data and Information Science Society
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    • v.18 no.2
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    • pp.525-534
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    • 2007
  • It is a common practice in many research areas that multiple range tests for a between subject factor such as Tukey are applied to a within subject factor in a repeated measures design. Tukey procedure, however, sometimes detects no pairs with different means even when the hypothesis of all equal level means is rejected. This study attempts to provide a rationale for the proposition that Tukey is inappropriate post hoc procedure for a within subject factor in which the observations are correlated. We introduce two multiple range tests, Bonferroni and Scheffe, for a within subject factor and show that Bonferroni is more appropriate than Scheffe for pairwise multiple comparisons. Subsequent simulation study indicates that Tukey has significantly less power than Bonferroni in detecting actual difference between means of some pairs when the observations of a within subject factor are highly correlated.

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Robustness for Pairwise Multiple Comparison Procedures with Trimmed Means under Violated Assumptions : Bonferroni, Shaffer, and Welsch Procedure

  • Kim, Hyun-Chul
    • Communications for Statistical Applications and Methods
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    • v.4 no.3
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    • pp.775-785
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    • 1997
  • Robustness rates for repeated measures pairwise multiple comparison procedures were investigated in a split plot design with one between- and one within-subjects factor using untrimmed and trimmed data. Five factors were manipulated in the study: distribution, sphericity, variance-covariance heteroscedasticity, total sample size, and sample size ratio. The Welsch test (W) and the Welsch test on trimmed data $(W_{RT})$ performed better than the other procedures, but had a liberal tendency. The trimmed difference score Bonferroni Procedure $(B_{DT})$ was a good choice in some conditions.

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Estimating the Number of Clusters using Hotelling's

  • Choi, Kyung-Mee
    • Communications for Statistical Applications and Methods
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    • v.12 no.2
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    • pp.305-312
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    • 2005
  • In the cluster analysis, Hotelling's $T^2$ can be used to estimate the unknown number of clusters based on the idea of multiple comparison procedure. Especially, its threshold is obtained according to the probability of committing the type one error. Examples are used to compare Hotelling's $T^2$ with other classical location test statistics such as Sum-of-Squared Error and Wilks' $\Lambda$ The hierarchical clustering is used to reveal the underlying structure of the data. Also related criteria are reviewed in view of both the between variance and the within variance.

Comparison and analysis of multiple testing methods for microarray gene expression data (유전자 발현 데이터에 대한 다중검정법 비교 및 분석)

  • Seo, Sumin;Kim, Tae Houn;Kim, Jaehee
    • Journal of the Korean Data and Information Science Society
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    • v.25 no.5
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    • pp.971-986
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    • 2014
  • When thousands of hypotheses are tested simultaneously, the probability of rejecting any true hypotheses increases, and large multiplicity problems are generated. To solve these problems, researchers have proposed different approaches to multiple testing methods, considering family-wise error rate (FWER), false discovery rate (FDR) or false nondiscovery rate (FNR) as a type I error and some test statistics. In this article, we discuss Bonferroni (1960), Holm (1979), Benjamini and Hochberg (1995) and Benjamini and Yekutieli (2001) procedures based on T statistics, modified T statistics or local-pooled-error (LPE) statistics. We also consider Sun and Cai (2007) procedure based on Z statistics. These procedures are compared in the simulation and applied to Arabidopsis microarray gene expression data to identify differentially expressed genes.

A novel amnion-chorion allograft membrane combined with a coronally advanced flap: a minimally invasive surgical therapy to regenerate interdental papillary soft tissue recession - a six-month postoperative image analysis-based clinical trial

  • Pitale, Unnati;Pal, Pritish Chandra;Boyapati, Ramanarayana;Bali, Ashish;Varma, Manish;Khetarpal, Shaleen
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.47 no.6
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    • pp.438-444
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    • 2021
  • Objectives: Loss of the interdental papilla is multi-factorial and creates a multitude of problems. Autogenous connective tissue/biomaterial-based regeneration has been attempted for decades to reconstitute the black space created due to the loss of papilla. The aim of this present study was to regenerate papillary recession defects using an amnion-chorion membrane (ACM) allograft and to evaluate the clinical outcome up to six months postoperatively. Materials and Methods: Twenty patients with 25 Nordland and Tarnow's Class I/II interdental papillary recession defects were treated with ACM and coronal advancement of the gingivo-papillary unit via a semilunar incision on the labial aspect followed by a sulcular incision in the area of interest. A photographic image analysis was carried out using the GNU Image Manipulation software program from the baseline to three and six months postoperatively. The black triangle height (BTH) and the black triangle width (BTW) were calculated using the pixel size and were then converted into millimeters. The mean and standard deviation values were determined at baseline and then again at three and six months postoperatively. The probability values (P<0.05 and P≤0.01) were considered statistically significant and highly significant, respectively. An analysis of variance and post hoc Bonferroni test were carried out to compare the mean values. Results: Our evaluation of the BTH and BTW showed a statistically and highly significant difference from the baseline until both three and six months postoperatively (P=0.01). A post hoc Bonferroni test disclosed a statistically significant variance from the baseline until three and six months postoperatively (P<0.05) and a non-significant difference from three to six months after the procedure (P≥0.05). Conclusion: An ACM allograft in conjunction with a coronally advanced flap could be a suitable minimally invasive alternative for papillary regeneration.

A Simulation Study for Comparison and Evaluation of Alternative Plans for the Productivity Improvement (생산성 향상을 위한 대안들의 비교 평가 시뮬레이션 사례연구)

  • 김원경
    • Journal of the Korea Society for Simulation
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    • v.10 no.1
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    • pp.51-62
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    • 2001
  • For the productivity improvement, it is necessary to analyze problem of the system and evaluate alternative plans. But, it if hard to experiment and evaluate alternative plans in real existing system. Therefore, it is necessary to synthetically analyze and evaluate alternative plans using simulation and statistical analysis method. In this case study, as a simulation language, Promodel is used to compare and evaluate four alternatives which are considered to improve the productivity of an object system. The object system is constituted of a pretreatment line and a painting line. The purpose of this study is to analyze whether the decrease of the down time in pretreatment line can be effective to the productivity improve comparing with exiting system and other alternatives. The other purpose is to choose an alternative that has the best productivity improvement. The results of the simulation show that the possibility of improvement in productivity by decreasing the down time of pretreatment line. Two-Stage Bonferroni Procedure is used to choose the best alternative.

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In vitro performance and fracture resistance of novel CAD/CAM ceramic molar crowns loaded on implants and human teeth

  • Preis, Verena;Hahnel, Sebastian;Behr, Michael;Rosentritt, Martin
    • The Journal of Advanced Prosthodontics
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    • v.10 no.4
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    • pp.300-307
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    • 2018
  • PURPOSE. To investigate the fatigue and fracture resistance of computer-aided design and computer-aided manufacturing (CAD/CAM) ceramic molar crowns on dental implants and human teeth. MATERIALS AND METHODS. Molar crowns (n=48; n=8/group) were fabricated of a lithium-disilicate-strengthened lithium aluminosilicate glass ceramic (N). Surfaces were polished (P) or glazed (G). Crowns were tested on human teeth (T) and implant-abutment analogues (I) simulating a chairside (C, crown bonded to abutment) or labside (L, screw channel) procedure for implant groups. Polished/glazed lithium disilicate (E) crowns (n=16) served as reference. Combined thermal cycling and mechanical loading (TC: $3000{\times}5^{\circ}C/3000{\times}55^{\circ}C$; ML: $1.2{\time}10^6$ cycles, 50 N) with antagonistic human molars (groups T) and steatite spheres (groups I) was performed under a chewing simulator. TCML crowns were then analyzed for failures (optical microscopy, SEM) and fracture force was determined. Data were statistically analyzed (Kolmogorow-Smirnov, one-way-ANOVA, post-hoc Bonferroni, ${\alpha}=.05$). RESULTS. All crowns survived TCML and showed small traces of wear. In human teeth groups, fracture forces of N crowns varied between $1214{\pm}293N$ (NPT) and $1324{\pm}498N$ (NGT), differing significantly ($P{\leq}.003$) from the polished reference EPT ($2044{\pm}302N$). Fracture forces in implant groups varied between $934{\pm}154N$ (NGI_L) and $1782{\pm}153N$ (NPI_C), providing higher values for the respective chairside crowns. Differences between polishing and glazing were not significant ($P{\geq}.066$) between crowns of identical materials and abutment support. CONCLUSION. Fracture resistance was influenced by the ceramic material, and partly by the tooth or implant situation and the clinical procedure (chairside/labside). Type of surface finish (polishing/glazing) had no significant influence. Clinical survival of the new glass ceramic may be comparable to lithium disilicate.

The Effect of New Product Development Activity on New Product Development Performance (신제품 개발활동이 신제품 개발 성과에 미치는 영향)

  • Rhee, Doyun;Ha, Kyu Soo
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
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    • v.9 no.6
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    • pp.183-198
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    • 2014
  • This study analyzed the effect of NPD(New Product Development) strategy and standardized NPD activity on NPD performance in KODAK companies. As a result of this study, companies with a specific NPD strategy that can lead and integrate NPD programs were 48.5% and companies without NPD strategy were 51.5% among KOSDAQ companies, which showed that companies without NPD programs were relatively higher than companies with NPD programs. According to result of NPD performance, success rate of new product showed 51.2% and success rate of new product revenue showed 44.87%, but respondents who evaluated NPD performance as "very successful" and "successful" were 53% based on the study of 77 various industries by Kuczmarski & Associates in America in 1993, and the companies in this study showed relatively below-average marks to the result of the study examined by USA PDMA in 1995 as compared to 59% of NPD success rate according to the 2nd study of best practice in 1995 by USA PDMA(Product Development & Management Association). As a result of testing the difference between NPD performances depending on whether company has NPD strategy or not, it showed a significant difference in success rate of NPD depending on NPD strategy and had a higher success rate of NPD as company has NPD strategy. Although NPD activity does not provide with documented process, companies which follow clearly recognized procedure until individual business for product development is completed were 39.6%, indicating that KOSDAQ companies still have fewer standardized NPD procedure than USA companies with 76% as compared to the result of 1990 PDMA in America. As a result of ANOVA test, NPD success rate showed the difference depending on the presence of officially documented process. As a result of Scheffe and Bonferroni test as post hoc test, companies with officially documented process, carrying out a series of business in a given section showed a higher NPD success rate by 18.385 at the 5% significance level than companies with individual business procedure without officially documented process. The difference of this research from the previous studies is that the findings of PDMA in America throughout the United States were applied to the domestic KOSDAQ companies. In addition, the existing studies related to NPD in Korea were conducted for some limited industries in the past, but this study was applied to various industries of KOSDAQ companies. The implications of this study suggest that it is necessary for KOSDAQ Industry Association or other related governmental departments to educate and guide the standardized process about NPD for increasing survival rate and reinforcing competitiveness of the companies.

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Reducing Irrational Beliefs and Pain Severity in Patients Suffering from Non-Cardiac Chest Pain (NCCP): A Comparison of Relaxation Training and Metaphor Therapy

  • Bahremand, Mostafa;Moradi, Gholamreza;Saeidi, Mozhgan;Mohammadi, Samira;Komasi, Saeid
    • The Korean Journal of Pain
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    • v.28 no.2
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    • pp.88-95
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    • 2015
  • Background: Patients suffering from non-cardiac chest pain (NCCP) can interpret their chest pain wrongly despite having received a correct diagnosis. The objective of this study was to compare the efficacy of the relaxation method with metaphor therapy for reducing irrational beliefs and pain severity in patients with NCCP. Methods: Using a randomized controlled trial, 33 participants were randomly divided into a relaxation training group (n= 13), a metaphor therapy group (n = 10), and a control group (n = 10), and were studied for 4 weeks. The two tools used in this research were the Brief Pain Inventory (BPI) index for determining the degree of pain and the short version of the Jones Irrational Belief Test. Metaphor therapy and a relaxation technique based on ${\ddot{O}}$st's treatment were used as the interventions. The collected data were analyzed with a multivariate analysis of covariance (MANCOVA), a Chi-square test, and the Bonferroni procedure of post-hoc analysis. Results: The relaxation training method was significantly more effective than both metaphor therapy and the lack of treatment in reducing the patients' beliefs of hopelessness in the face of changes and emotional irresponsibility, as well as the pain severity. Metaphor therapy was not effective on any of these factors. In fact, the results did not support the effectiveness of metaphor therapy. Conclusions: Regarding the effectiveness of the relaxation method as compared with metaphor therapy and the lack of treatment in the control group, this study suggests that relaxation should be paid greater attention as a method for improving the status of patients. In addition, more studies are needed to determine the effectiveness of metaphor therapy in this area.

Effects of Three Different Hip Positions in Frontal Plane on Activity of Abdominal Muscles During Active Straight-Leg Raise

  • Yoon, Tae-Lim;Kim, Ki-Song
    • Physical Therapy Korea
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    • v.20 no.3
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    • pp.81-88
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    • 2013
  • Active straight-leg raise (ASLR) is a physical evaluation procedure to test lumbar spine stability. Several previous studies have reported various methods to control the activation of abdominal muscles during ASLR. We investigated the effects of three different hip positions in frontal plane on abdominal muscles to increase or decrease the difficulty level of lumbar spine stability exercise during ASLR in pain free subjects. Eleven young and healthy subjects voluntarily participated in this study (6 men, 5 women; mean age=$24.0{\pm}1.2$ years, height=$160.0{\pm}7.3cm$, weight=$55.0{\pm}10.6kg$, body mass index=$21.5{\pm}2.3kg/m^2$). The subjects had three trials on each ASLR with hip $10^{\circ}$ adduction, neutral hip, and hip $30^{\circ}$ abduction. Separate repeated-measures analysis of variance (ANOVA) and the post hoc Bonferroni tests (with ${\alpha}$=.05/3=.017) were performed for each muscle among the three different hip positions in frontal plane (ASLR with hip $10^{\circ}$ adduction, neutral hip, and hip $30^{\circ}$ abduction). The ipsilateral external oblique (EO), contralateral EO, ipsilateral internal oblique/transverse abdominis (IO/TrA), and contralateral IO/TrA were significantly greater in ASLR with hip $30^{\circ}$ abduction compared with ASLR with hip $10^{\circ}$ adduction. Also, the ipsilateral EO, contralateral EO, and ipsilateral IO/TrA were significantly greater in ASLR with hip $30^{\circ}$ abduction compared with ASLR with neutral hip. These results suggest that ASLR with hip $30^{\circ}$ abduction and neutral would be useful method to strengthen the EO and IO/TrA. And, ASLR with hip $10^{\circ}$ adduction would be effective in early stages of lumbar stabilization program due to low activation of EO and IO/TrA during maintaining of ASLR position with low load.