• 대한영상의학회지
• /
• 제84권2호
• /
• pp.427-440
• /
• 2023

목적 MRI Dixon method (이하 DIXON) 기법을 이용하여 슬관절 지방우세 골조직의 지방신호분율(fat signal fraction; 이하 FF)을 구하고 골밀도(bone mineral density; 이하 BMD)와 상관관계 분석을 시행하였다. 대상과 방법 본원 슬관절 DIXON 영상을 촬영한 환자들 중 일 년 이내의 dual energy X-ray absorptiometry가 있는 환자 93명을 후향적으로 분석하였다. DIXON 영상에서 원위부 대퇴골 골간단(femur metaphyseal; 이하 Fm)과 근위부 경골 골간단(tibia metaphyseal; 이하 Tm)의 FF를 계산하였다. FF와 BMD 간 상관관계를 분석하였다. 또, 요추(lumbar spine; 이하 L), 대퇴경부(femoral neck; 이하 FN), 총대퇴골(femur total; 이하 FT)의 BMD 별로 나누고 FF에 대하여 Kruskal-Wallis H test를 시행하였다. 결과 전체 환자군에서 TmFF와 FN-BMD 사이에 유의미한 음의 상관관계를 보였다(r = -0.26, p < 0.05). 여성 환자에서는 TmFF가 FN-BMD, FT-BMD 및 L-BMD와 음의 상관관계를 보였다(r = -0.38, -0.28과 -0.27, p < 0.05). 남성 환자에서는 FmFF가 FN-BMD 및 FT-BMD와 음의 상관관계를 보였다(r = -0.58과 r = -0.42, p < 0.05). 여성 환자들을 세 군으로 나누었을 때 TmFF에 유의한 차이를 보였다(p < 0.05). 남성 환자들을 두 군으로 나누었을 때, FmFF이 군간에 유의미한 차이를 보였다(p < 0.05). 결론 슬관절 주변의 FF와 BMD는 음의 상관관계를 보였으며, DIXON을 이용한 FF 측정이 BMD 스크리닝에 사용될 수 있는 가능성을 보였다.

• Journal of Preventive Medicine and Public Health
• /
• 제53권5호
• /
• pp.342-352
• /
• 2020

Objectives: The aim of this retrospective cohort study was to investigate whether non-alcoholic fatty liver disease (NAFLD) was associated with incident bone mineral density (BMD) decrease. Methods: This study included 4536 subjects with normal BMD at baseline. NAFLD was defined as the presence of fatty liver on abdominal ultrasonography without significant alcohol consumption or other causes. Decreased BMD was defined as a diagnosis of osteopenia, osteoporosis, or BMD below the expected range for the patient's age based on dual-energy X-ray absorptiometry. Cox proportional hazards models were used to estimate the hazard ratio of incident BMD decrease in subjects with or without NAFLD. Subgroup analyses were conducted according to the relevant factors. Results: Across 13 354 person-years of total follow-up, decreased BMD was observed in 606 subjects, corresponding to an incidence of 45.4 cases per 1000 person-years (median follow-up duration, 2.1 years). In the model adjusted for age and sex, the hazard ratio was 0.65 (95% confidence interval, 0.51 to 0.82), and statistical significance disappeared after adjustment for body mass index (BMI) and cardiometabolic factors. In the subgroup analyses, NAFLD was associated with a lower risk of incident BMD decrease in females even after adjustment for confounders. The direction of the effect of NAFLD on the risk of BMD decrease changed depending on BMI category and body fat percentage, although the impact was statistically insignificant. Conclusions: NAFLD had a significant protective effect on BMD in females. However, the effects may vary depending on BMI category or body fat percentage.

• 대한의용생체공학회:학술대회논문집
• /
• 대한의용생체공학회 1998년도 추계학술대회
• /
• pp.155-156
• /
• 1998

Screw loosening and subsequent pullout can be attributed to the reduction in bone mineral density in the vertebrae manifested by osteoporosis in which the decrease in fixation strength between the cancellous bone and screw threads are accelerated by repeated loads exerted by patients own weight and activities following the surgery. In this study, the change in pullout strength of the pedicle screws was investigated before and after repeated loads were imparted. For this purpose. Diapason pedicle screws $(6.7\times40mm)$ were inserted onto fresh porcine spine specimens (T1-L5) after bone mineral density was measured using a DEXA. With an MTS, an axial load was applied at a loading rate of 0.33mm/sec until failure to measure the maximum pullout strength. Flexion moment of 7.5N-m was then imparted at 0.5Hz for 2000 cycles. It was found that the maximum pullout strength was exponentially related to BMD regardless of load types ($107.71\;\times\;\exp^{(1.43{\times}BMD)}r^2=0.93$, P<0.0001 without repeated load; ($107.71\;\times\;\exp^{(2.19{\times}BMD)}r^2=0.78$, P<0.0001 with repeated load). The results suggest that the reduction in pullout strength for pedicle screws is far more prominent in osteoporotic spine than in normal spine especially as number of repeated load was increased. More importantly, it was demonstrated that the level of bone mineral density and the activity level of the patient should be evaluated in more detail for successful implementation of pedicle screw systems in spinal surgery.

• 한국멀티미디어학회논문지
• /
• 제19권8호
• /
• pp.1248-1259
• /
• 2016

Classification methods based on dual energy X-ray absorptiometry, ultrasonic waves, and quantitative computed tomography have been proposed. Also, a classification method based on machine learning with bone mineral density and structural indicators extracted from the CT images has been proposed. We propose a method which enhances the performance of existing classification method based on bone mineral density and structural indicators by extending structural indicators and using principal component analysis. Experimental result shows that the proposed method in this paper improves the correctness of osteoporosis classification 2.8% with extended structural indicators only and 4.8% with both extended structural indicators and principal component analysis. In addition, this paper proposes a method of automatic phantom analysis needed to convert the CT values to BMD values. While existing method requires manual operation to mark the bone region within the phantom, the proposed method detects the bone region automatically by detecting circles in the CT image. The proposed method and the existing method gave the same conversion formula for converting CT value to bone mineral density.

• Journal of Acupuncture Research
• /
• 제31권3호
• /
• pp.25-33
• /
• 2014

Objectives : The purpose of this study is to evaluate the correlation between bone mineral density(BMD), age, weight, visual analog scale(VAS), menopausal rating scale(MRS), and to compare the difference between BMD, age, weight, VAS, MRS according to severity of the menopausal symptoms. Methods : The participants were 62 menopausal women diagnosed with osteoporosis who visited Cheonan Oriental Hospital, Daejeon University from December, 2011 to July, 2014. Age, weight, VAS, MRS were used as an evaluation tool. Results : 1. In all 62 cases of menopausal patients diagnosed with osteoporosis, the study found a statistically significant correlation between BMD and weight, while inverse correlation between BMD and MRS index. 2. Among menopausal patients with above 9 MRS index(group B), BMD and weight showed statistically significant correlation, while VAS and MRS index showed statistically significant inverse correlation. 3. Among group B, VAS were higher compared to control group(group A). Conclusions : This study showed that as patients with severer menopausal symptoms apt to show increased VAS and decreased BMD. Therefore, long-term follow-up in patients with menopausal syndrome is needed to improve the patients' quality of life.

• 근관절건강학회지
• /
• 제16권2호
• /
• pp.135-144
• /
• 2009

Purpose: The purpose of this study was to develop an exercise program to prevent osteoporosis in working women and to examine its effects on bone mineral density (BMD). Method: The subjects of the study were 55 working women. The experimental group participated three times per week for twelve weeks in this exercise program. T-test and ANOVA, Pearson's correlation coefficients were used to analyze the data. Results: The BMD of the experimental group prior to participating in the exercise program was 0.9301 $(\pm08620)g/cm^2$. However, after the exercise program, the BMD increased to 0.9415 $(\pm1117)g/cm^2$ (t=-2.338, p=.026). Moreover, in relations to BMD and physiological variables, there were significant correlations between BMD and physical activity (r=.294, p=.030), as well as between BMI and physical activity (r=.267, p=.049). Conclusion: In this study, BMD in the experimental group had significantly increased after their participation, while the control group had decreased. Thus, this study showed that the exercise program developed for working women is effective in maintaining BMD and consequently preventing osteoporosis.

• 사상체질의학회지
• /
• 제13권3호
• /
• pp.52-58
• /
• 2001

Purposes : As the population of old people has increased by the improvement of medical techniques, the concern on degenerative diseases has increased gradually. Especially the researches of osteoporosis have been carried out in view of prevention and treatment. But there wasn't any research related with Sasang Constitution. So we investigated the relation between Sasang Constitution and BMD(bone mineral density). Methods : Authors measured BMD and BMI(body mass index) of healthy women. We devided our subjects into Young age group and Old age group, and analyzed the data of Sasang Constitution subgroup. Results : 1. BMD of Taeumin was higher than those of Soyangin and Soeumin in Lumbar spine and Femoral neck in both Young and Old age group. In Old age group, there were significant differences in Taeumin vs Soeumin, and Soyangin vs Soeumin in BMD of Lumbar spine 2. BMI of Taeumin was higher than those of Soyangin and Soeumin in both Young and Old age group. In Young age group, there were significant differences in Taeumin vs Soyangin and Taeumin vs Soeumin. In Old age group, there were significant differences in Taeumin vs Soyangin, Taeumin vs Soeumin and Soyangin vs Soeumin. Conclusion : BMD and BMI of Taeumin was higher than those of Soyangin and Soeumin.

• Journal of Nutrition and Health
• /
• 제36권2호
• /
• pp.154-166
• /
• 2003

To investigate the effects of isoflavone supplementation on both bone mineral density and hormone variation in premenopausal women who had decreased bone mass, the 24 subjects were divided into two groups: one was the underweight group, consisting of 13 subjects, and the other was the normal weight group consisting of 11 subjects. For each group, we investigated the effects of isoflavone supplementation of 90 mg/day on both bone mineral density and hormone variation during 3 menstrual cycles. Anthropometric measurements, dietary recall, and analyses of blood and urine were assessed from baseline to post-treatment. The results were as follows: The average age of the underweight group was 21.8 years old and that of the normal weight group was 23.2 years old. The comparative results for the two groups at baseline were as follows: Onset of menarche, menstrual cycle, and menstrual length were not significantly different between the groups. Serum protein, total, HDL-, LDL-cholesterol, triglyceride, Ca, P, Mg, Cu, and Zn level were not significantly different between the groups. Serum estradiol, SHBG, LH, and FSH level were also not significantly different between the groups. Lumbar spine BMD by T scores of the underweight group was significantly lower than that of the normal weight group. Serum osteocalcin, urinary DPD, and urinary pH were not significantly different between the groups. The comparative results for the two groups at post-treatment were as follows: From baseline to post-treatment, the intake of energy, nutrients and isoflavone in food did not significantly change in either group. Serum protein, total cholesterol, HDL-, LDL-cholesterol, and triglyceride levels did not significantly change in either group. Serum Ca, Cu, and Zn levels were significantly lower in both groups and serum Mg level significantly decreased only in the underweight group. Serum estradiol levels were significantly lower in both groups, but serum SHBG, LH, and FSH levels did not significantly change in either group. Lumbar spine BMD by T score of the underweight group significantly increased to 15%, but that of the normal weight group did not significantly change. Serum osteocalcin of the underweight group significantly increased to 28%, while that of the normal weight group significantly increased to 40%. Urinary DPD of the normal weight group significantly increased to 12%. The results show that the BMD of the underweight group was lower than that of the normal weight group. Therefore, the underweight group had a disadvantage in obtaining maximum bone mineral density. The results also show that isoflavone supplementation during 3 menstrual cycles was effective in increasing the bone mineral density of the lumbar spine and affected bone metabolism markers in premenopausal underweight women. Therefore, it can be concluded that sufficient intake of isoflavone could be helpful in preventing decreases in bone mass among premenopausal women, especially underweight women.

• 한국산학기술학회논문지
• /
• 제10권12호
• /
• pp.3943-3952
• /
• 2009

본 연구는 청년기 여대생을 대상으로 신체 각 부위의 골밀도와 생화학적 골대사지표를 측정한 후 1년 뒤의 변화를 추적 조사하였다. 각 신체부위별 주요 골격의 1년 후 평균 골밀도변화에서 전완부 골밀도는 유의하게 변화한 반면 요추골, 대퇴골 근위부(경부, 전자부, 워드 삼각부) 및 전신골밀도에서는 변화가 없었다. 골대사지표 중 골형성지 표인 혈청 오스테오칼신과 골흡수지표인 요중 디옥시피리디놀린은 모두 유의하게 변화하였다. 초기 청년기 여성에서 골밀도의 뚜렷한 변화가 없어도 골대사는 여전히 활발히 이루어지고 있음을 알 수 있었다.

• Reproductive and Developmental Biology
• /
• 제34권3호
• /
• pp.123-126
• /
• 2010

The purpose of present study was to analyze mineral contents in various tissues and investigate theirs relation with bone mineral density (BMD) in rats. Fifteen Sprague-Dawley rats were fed standard diet for 4 weeks. Body weight gain, feed intake, and feed efficiency ratio were 41.00 g/week, 171.15 g/week, and 0.24 respectively. Among 12 minerals in serum, Ca is the highest with 6.86 mg/dl. Serum Mg, Se, and Cu were 2.52 mg/dl, 0.23 mg/dl and 0.22 mg/dl respectively. Mg contents in liver, spleen, and kidney were $246.36\;{\mu}/g$, $105.01\;{\mu}/g$, and $273.38\;{\mu}/g$ respectively. Tibia contents of Ca, Mg, Zn, Fe and V were 194.91 mg/g, 23.10 mg/g, 0.60 mg/g, 0.35 mg/g and 0.14 mg/g respectively. BMDs of right tibia and spine were 122.04 mg/cm and $153.61\;mg/cm^2$. There were significantly positive correlations between tibia BMD and Se (p<0.05), tibia BMD and V (p<0.01), spinal BMD and V(p<0.05), respectively. It's expected that these results are used as a reference data in following study to elucidate physiological function of minerals.