• Biomolecules & Therapeutics
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• 제16권2호
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• pp.141-146
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• 2008

Imbalance in calcium and phosphorous metabolism due to aging or menopause leads to osteoporosis. In contrast to patients with normal blood pressure, hypertensive patients have a higher loss of calcium in the urine with its attendant risk of osteoporosis. The high blood pressure is associated with the risk of bone loss and abnormalities in calcium metabolism leading to calcium loss. So we retrospectively investigated the changes of bone mineral density (BMD) which drugs can have clinical influences over osteoporosis treatments of patients with calcium-antagonists as common antihypertensive drugs and with bisphosphonates which causes a most effective inhibition of osteoclasts resorption. As a result over 70 years of age group and within bisphosphonates group, alendronate 70 mg once-weekly group showed significant increase of BMD in lumbar area. Combination group of cilnidipine and $maxmarvil^{(R)}$ showed very significant decrease of BMD. In conclusion, it is desirable that combination therapy with calcium-antagonists is used carefully in the treatment of osteoporosis with high blood pressure.

• 대한지역사회영양학회지
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• 제18권3호
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• pp.269-282
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• 2013

This study was carried out to investigate bone mineral density (BMD), blood pressure, calcium, sodium intake and related biochemical variables, and to analyze the relationship between BMD, and blood pressure, physical characteristics, nutrient intakes of Korean adult women. The study subjects were 30~80years old, 513 women living in Seoul and Kyunggi area who participated in 2011 KNHANES. The study subjects were divided into three BMD groups; normal, n = 259 (50.4%), osteopenia, n = 169 (32.9%), and osteoporosis, n = 85 (16.7%). Average height and weight and fat free mass decreased with a decrease in BMD. Average BMD of normal, osteopenia, osteoporosis were 0.87, 0.79, $0.70g/cm^2$, and T-score were 0.42, -0.66, -1.62, respectively. Higher systolic blood pressure, alkaline phosphatase, and triglyceride were significantly associated with a decrease in the BMD. The rates of hypertension were significantly increased from normal to osteoporosis. i.e. 18.5% in normal, 34.3% in osteopenia and 63.5% in osteoporosis. Average nutrientintakes such as protein, fat, calcium, phosphorus, iron, sodium, potassium, vitamin A, vitamin B, vitamin B2, and vitamin C were significantly lower in subjects with lower BMD.n. Average calcium intake of normal, osteopernia and osteoporosis were 528.50, 416.96, 389.56 mg, respectively. There were significant negative correlations between calcium, phosphorus and age, systolic blood pressure, triglyceride. Also, there were negative correlation systolic blood pressure (incomplete sentence). In this study, we found low BMD according to low calcium intake increase the risk of osteoporosis and hypertension rather than sodium intake, also calcium intake decreased with increase age. Therefore, in order to prevent osteoporosis and hypertension, subjects need to be educated regarding the importance of calcium nutrients in diet.

• 대한의용생체공학회:의공학회지
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• 제19권2호
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• pp.171-176
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• 1998

본 연구에서는 뼈의 특성을 파악하는 초음파감쇠 파라미터를 재평가하였다. 초음파 속도, 특정 주파수(0.5MHz)에서의 초음파감쇠 및 광역 밴드 초음파감쇠와 같은 초음파 파라미터들을 해면골 입방체 시편의 세 직교방향(전/후, 내/외, 상/하)에서 측정하였다. 그리고 컴퓨터 영상장치를 사용하여 골밀도를 측정했으며, 골 시편의 무게와 부피를 이용하여 외형밀도도 함께얻었다. 이와같이 구해진 외형밀도와 초음파 속도로부터 초음파 탄성영률을 계산하였다. 주파수 0.5MHz에서의 초음파감쇠와 광역밴드감쇠는 골밀도 및 세 직교방향의 초음파 영률과 서로 관련시켜 연관성을 조사하였다. 그 결과 특정 주파수 초음파감쇠가 골밀도 및 탄성영률을 평가하는 능력에 있어서 광역밴드 감쇠보다 우수함을 알 수 있었다. 따라서 광역밴드 초음파감쇠를 측정하여 골의 상태를 평가하는 형행 초음파 진단 기법이 재검토 되어야 하며 본 연구에서 증명된 특정주파수(0.5MHz) 초음파감쇠를 이용하여 골 다공증 진단 예측율을 향상시킬 수 있다.

• International Journal of Oral Biology
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• 제32권4호
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• pp.143-151
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• 2007

This study was conducted to investigate the preventing effects of OPB (Rehmannia glutinosa Libosch and Eleutherococcus senticosus Max extracts) and combined OPB/Calcium therapy on bone loss in ovariectomized rats. Sixty Sprague Dawley rats of 12-week-old were divided into eight groups: OVX (ovariectomized), OPBL (OPB 50 mg/kg), OPBM (OPB100 mg/kg), OPBH (OPB 200 mg/kg), OPBL/CAL(OPBL+CAL), OPBM/CAL (OPBM+CAL), OPBH/CAL (OPBH+CAL) and CAL (Calcium citrate 88.33 mg/kg+1$\alpha$, 25-dihydroxy-vitamin $D_3$ 33.33 IU/kg). Bone mineral density (BMD), bone mineral content (BMC), bone strength indices and cortical thickness were analyzed by peripheral quantitative computerized tomography (pQCT). pQCT scanning showed that OVX induced a significant decrease in trabecular bone mineral density and bone mineral content in the proximal tibia $(-36.4\pm2.4%,\;-21.8\pm12.7%)$. These decreases were significantly prevented by the administration of OPBM and OPBM/CAL. Cortical BMD and BMC of tibia were slightly enhanced by OPB and OPB/CAL. However there was no significant difference between OVX and OPB, OPB/CAL treated group. Bone strength indices and cortical thickness were not significantly different. Our results suggest that OPB and combined OPB/Calcium therapy are effective in preventing the development of bone loss induced by ovariectomy in rats.

• 대한영양사협회학술지
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• 제20권2호
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• pp.110-122
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• 2014

This study investigated factors affecting the bone mineral density (BMD) of Korean young adult women (20~30 yrs) living in Seoul, according to the state of employment. Data on BMD and anthropometric and biochemical measurements were obtained from the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V) (2010~2011). BMD of the working group (WG) was generally higher than that of the non-working group (NWG). The prevalence of osteopenia, and osteoporosis between the groups was 29.0/31.5%, and 12.9/18.5% from 20~29 yrs as well as 25.5/24.1%, and 20.2/20.5% from 30~39 yrs, respectively. From 20~29 yrs, prevalence of osteopenia and osteoporosis in the WG was lower than that of the NWG. Alkaline phosphatase activity of the WG was lower than that of the NWG. In the WG, from 20~29 yrs, total femur BMD showed significant positive correlations with waist circumstance and BMI. In the NWG, from 20~29 yrs, total femur, femoral neck, and lumbar spine BMDs showed significant positive correlations with weight and fat mass, whereas they showed significant negative correlations with vitamin D. In the WG, from 30~39 yrs, total femur and femoral neck BMDs showed significant positive correlations with weight and free fat mass. The results of this study show that BMD of young adult women is insufficient regardless of their employment status. Therefore, practical and systematic programs are required to improve the BMD of young adult women as well as to maintain healthy bone levels.

• Nutrition Research and Practice
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• 제3권2호
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• pp.108-113
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• 2009

Taurine supplementation has been shown to have a beneficial effect on femur bone mineral content in ovariectomized rats. It therefore seemed desirable to find out whether the beneficial effect of taurine on ovariectomized rats fed calcium deficient diet could also be reproduced. Forty female Sprague-Dawley rats were divided into two groups, One group was OVX and the other group received sham operation (SHAM), and received either control diet or a taurine supplemented diet for 6 weeks. All rats were fed on calcium deficient diet (AIN-93: 50% level of calcium) and deionized water. Bone mineral density (BMD) and bone mineral content (BMC) were measured in spine and femur. The serum and urine concentrations of calcium and phosphorus were determined, Bone formation was measured by serum osteocalcin and alkaline phosphatase (ALP) concentrations, Bone resorption rate was measured by deoxypyridinoline (DPD) crosslinks immunoassay and corrected for creatinine. Urinary calcium and phosphorus excretion, osteocalcin in blood and cross link value were not significantly different among the groups. Within the OVX group, the taurine supplemented group had not higher femur bone mineral content than the control group. This study established the need for a study on the taurine effect on bone with different calcium levels.

• 대한임상검사과학회지
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• 제48권4호
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• pp.296-303
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• 2016

본 연구는 대학생을 대상으로 혈색소와 골밀도를 평가하고, 혈색소와 골밀도 정량 분석 결과를 보기 위하여 시작되었다. 본 연구는 골밀도에 미치는 혈색소의 영향을 목적으로 하였다. 연구대상자는 20~30세의 건강한 대학생 52명을 직접 실험을 진행하였다. 골다공증은 전통적 노화 여성의 질병으로 간주되었지만, 점차 남성의 건강 문제로 되고 있다. 골다공증의 진단은 골밀도의 정량적 평가로 계산된다. 검사실에서 실시하는 혈액과 소변 검사는 주로 뼈의 신진 대사의 장애의 원인을 파악하기 위해 낮은 BMD 또는 취약성 골절에 사용된다. 본 연구는 성별에 따른 골밀도의 차이는 없었다. 평균 적혈구수, 혈색소 및 적혈구 용적은 남성에게서 상당히 높은 값을 나타내었다(p<0.01). 요추 척추, 골격근양, 기초대사량 사이의 상관 관계는 통계적으로 유의 한 수준에서 정의 관계로 나타났다(p<0.01). 다중회귀분석결과 혈색소는 골밀도에 51.7% 통계적 영향을 나타냈다. 이러한 연구 결과는 골밀도와 혈색소에서 유의한 관계를 이해하는데 유용하며, 혈색소 수준은 골밀도 수준을 예측하는데 강력한 인자이다. 결론적으로, 본 연구에서 낮은 Hb 값이 낮은 뼈 질량을 가진 피험자에서 유의한 결과를 보여, 낮은 Hb 값이 골밀도를 감소시키는 뼈 회전율 변화의 위험 요소로서의 규칙을 가짐을 의미한다고 사료된다.

• The Journal of Korean Physical Therapy
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• 제15권4호
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• pp.466-478
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• 2003

This study was to evaluate the body composition and bone mineral density according to aging in adult and investigated the relationship between various parameters such as body mass index(BMI), bone mineral density(BMD), bone mineral content(BMC), lean body mass(LBM), fat mass(FM) and the value obtained from dual energy X-ray absorptiometry(DEXA). The subjects were composed of healthy adult male and female who were $20^{\sim}73$ years old and they were divided three group according to age (A group : 20-39 yrs., B group : 40-59 yrs., C group : more than 60 yrs.). The conclusion derived from statistical analysis was as follows : 1. Bone mineral content and density were significantly affected by lean body mass(relatively, R=0.85 - 0.63). 2. There was significant difference among age groups in total bone mineral density. 3. There was significant difference among age groups in bone mineral content of male and female. 4. Lean body mass is diminished according to age, but there was not significant difference among age groups. 5. Fat mass of A group in male had the highest mass and followed by C group and B group. In female groups, fat mass of A group had the highest mass and followed by B group and C group. Abdominal fat mass is increased according to age. This result suggest that aging was closely relation with loss of muscle mass, bone mineral density and bone mineral content.

• 대한한의학회지
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• 제42권2호
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• pp.90-97
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• 2021

DXA로 측정한 요추 부위와 대퇴골경의 골밀도 수치가 2년간 지속적으로 연령대 평균 이하였던 중년의 사무직 남성 환자가 접골탕을 복용하고 골밀도 수치가 개선되었다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제11권12호
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• pp.6054-6068
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• 2017

In this paper, we defined the relative cross-sectional area of forearm cortical bone and investigated its correlation with hip bone mineral density values of total femur, femoral neck, femoral trochanter, femoral inter-trochanter and femoral ward's triangle, respectively. Based on the correlations, we established a linear transformation between the relative cross-sectional area of forearm cortical bone and each hip bone BMD. We obtained forearm images using CBCT and hip bone BMDs using dual-energy X-ray absorptiometry (DXA) for 28 subjects. We also investigated the optimal forearm region to provide the strongest correlation coefficient. We used the optimized forearm region to establish each linear transformation to estimate BMD values for total femur, femoral neck, femoral trochanter, femoral inter-trochanter and femoral ward's triangle from the relative cross-sectional area of forearm cortical bone, respectively. We observed the strong correlations with total femur (r=0.889), femoral neck (r=0.924), femoral trochanter (r=0.821), femoral inter-trochanter (r=0.867) and femoral ward's triangle (r=0.895), respectively. The strongest correlation was observed in the forearm mid-shaft regions. Our results suggest that the hip bone BMD values can be simply estimated from forearm CBCT images in a convenient sitting position without X-ray exposure on a hip including genital organs, and may be useful for screening osteoporosis.