• Endocrinology and Metabolism
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• v.33 no.4
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• pp.435-444
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• 2018

The prevalence of chronic diseases including osteoporosis and sarcopenia increases as the population ages. Osteoporosis and sarcopenia are commonly associated with genetics, mechanical factors, and hormonal factors and primarily associated with aging. Many older populations, particularly those with frailty, are likely to have concurrent osteoporosis and sarcopenia, further increasing their risk of disease-related complications. Because bones and muscles are closely interconnected by anatomy, metabolic profile, and chemical components, a diagnosis should be considered for both sarcopenia and osteoporosis, which may be treated with optimal therapeutic interventions eliciting pleiotropic effects on both bones and muscles. Exercise training has been recommended as a promising therapeutic strategy to encounter the loss of bone and muscle mass due to osteosarcopenia. To stimulate the osteogenic effects for bone mass accretion, bone tissues must be exposed to mechanical load exceeding those experienced during daily living activities. Of the several exercise training programs, resistance exercise (RE) is known to be highly beneficial for the preservation of bone and muscle mass. This review summarizes the mechanisms of RE for the preservation of bone and muscle mass and supports the clinical evidences for the use of RE as a therapeutic option in osteosarcopenia.

• Journal of the Korean Society of Physical Medicine
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• v.14 no.3
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• pp.134-141
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• 2019

PURPOSE: This study conducted aA forward-looking study of elite water polo athletes, who trained at National Training Center, was conducted to determine the correlation between the incidence of sports injuries and the bone density among national water polo players. METHODS: Data on the general characteristics of all study subjects were analyszed usingin descriptive statistics. The incidence of sports injuries was calculated from the incidence of sports injuries per 1,000 hours and the incidence of sports injuries resulting from exposure to 1,000 training sessions. The incidence of all sports injuries was calculated with a 95% confidence interval. Furthermore, Pearson's correlation was calculated conducted to determine the correlation between sports injuries and bone density, bone mass and body composition. RESULTS: Water polo athletes suffered a total of 127 sports injuries in the three-year period, while the athletes suffered 3.5 sports injuries each year. The Ooverall injury rate of 3.2(95% CI 2.68-3.81) per 1,000h, 18.0(15% CI 14.89-21.16) of sports injuries per 1,000AE. For all athletes, 50.4% of the injuries were classified as mild, followed by moderate (26.8%) and severe (22.8%). The lower the bone density in all areas of sports injuries, the higher the incidence of sports injuries. In addition, and the lower the bone mass in all areas except for light injuries, the higher the incidence of sports injuries. CONCLUSION: In tThe correlation between sports injuries and bone density and bone composition of water polo athletes, revealed a significant correlation between the bone density and bone mass were statistically significant, and the lower the bone density and bone mass, the higher the incidence of sports injuries.

• Journal of International Academy of Physical Therapy Research
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• v.3 no.1
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• pp.383-390
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• 2012

The aim of this study was to investigate the correlation among bone mineral density(BMD), body composition and body circumference on 20's college women in Hwaseong. A total of 86 subjects were measured with BMD and body composition and body circumference. To evaluate the correlation between BMD and body composition, bone density and body weight, body mass index(BMI), lean body mass, muscle mass, fat mass and body fat mass were compared. The results of this study, weight was considered the strong correlation with BMD than the height and BMI seems to be greater significance rather than the lumbar spine and femur BMD. In addition, the relationship between body composition and BMD, lean body mass, muscle mass, body fat mass were the most relevant factors and BMD. The relationship between BMD and body circumference that have been difficult because of not enough previous studies but somewhat the study showed that association.

• Journal of the Korea Society of Computer and Information
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• v.24 no.9
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• pp.97-102
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• 2019

Several studies have recently demonstrated that skeletal muscle is an endocrine organ releasing and expressing myokines acting in an endocrine or paracrine manner. Irisin is a hormene-like myokine induced after physical exercise by muscle fibers. It was primarily recognized as a molecule able to advance the "browning response" in white adipose tissue, however, it has been recetly identified that irisin also has a fundamental role in the control of bone mass. We study evidence for its possible skeletal effects, including the fundamental role that irisin is involved in the control of bone mass, with beneficial effects on geometry and cortical mineral density. As loss of muscle mass and bone density occurs with immobility, metabolic disease and aging, future studies researching the efficacy of irisin in reversing muscle wasting and restoring bone would be important to proving irisin as a molecule that combines helpful effects for treating muscular atrophy and osteoporosis in elderly people.

• Journal of the Korean Society of Physical Medicine
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• v.15 no.1
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• pp.95-104
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• 2020

PURPOSE: A prospective study was conducted to investigate the correlation between the inspiration ability, bone mineral density, lumbar muscle strength, and muscular endurance for the national softball athletes in the national training center. METHODS: The general characteristics of study subjects, inspiration ability, bone mineral density, muscle strength, and muscular endurance data were analyzed using descriptive statistics. In addition, the Pearson product moment correlation was performed to investigate the correlation between the inspiratory capacity, bone mineral density, muscle strength, and muscular endurance. RESULTS: The inspiration, flow rates, and volume were not correlated with the bone mass and bone mineral density. Inspiration and the flow rates and volume were not correlated with the bone mass and bone mineral density. On the other hand, inspiration was correlated with the Extensor muscles (r=.464, p=.006) at an angular velocity of 60°/s and the flexors (r=.463, p=.006) and extensor muscles (r=.615, p<.001) at an angular velocity of 180°/s. The flow rate was also correlated with the extensor muscles (r=.444, p=.009) at an angular velocity of 60°/s and with flexor muscles (r=.432, p=.011) and extensor muscles (r=.589, p<.001) at an angular velocity of 180°/s. Finally, the volume was correlated at the extensor muscles at an angular velocity of 180°/s (r=.534, p=.001). CONCLUSION: The correlation between the inspiratory capacity, bone mineral density, muscle strength, and muscular endurance of softball athletes did not correlate with the bone mass and bone density. On the other hand, the lumbar muscle strength increased with increasing inspiratory capacity.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.27 no.1
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• pp.87-97
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• 1997

The purpose of this study was to evaluate the method for quantitative assessment of bone mass from aluminum-equivalent value of hydroxyapatite by using digital imaging system consisted of Power Macintosh 7200/120, 15-inch color monitor, and GT-9000 scanner with transparency unit. After aluminum-equivalent image made from correlation between aluminum thickness and grey scale, the accuracy of conversion to mass from aluminum-equivalent value was evaluated. Measured bone mass was compared with converted bone mass from aluminum-equivalent value of hydroxyapatite block by correlation formula between aluminum-equivalent value of hydroxyapatite block and hydroxyapatite mass. The results of this study were as follow; 1. Correlation between aluminum thickness and grey level for obtaining aluminum-equivalent image was high positively associated(r²=0.99). Converted masses from aluminum-equivalent value were very similar to measured masses. There was, statistically, no significant difference(P<0.05) between them 2. Correlation between hydroxyapatite aluminum-equivalent and hydroxyapatite mass was shown to linear relation (r²=0.95). 3. Converted masses from aluminum-equivalent value of 3 dry mandible segments were similar to measured masses. The difference between the exposure directions was not significantly different(P<0.05).

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.05a
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• pp.146-149
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• 2002

It is reported that the mechanical properties of vertebral trabecular bone depend on the density and the mass of bones. Osteoporosis is a systemic skeletal disease caused by low bone mass and microstructure deterioration of trabecular bone. Silva and Gibson (1997) studied the treatment of age-related bone loss using drug therapy. Vertebroplasty is a minimally invasive surgery for the treatment of osteoporosis vertebrae. This procedure includes puncturing vertebrae and filling with Polymethylmethacrylate (PMMA). However, the relative effect of drug therapy and bone cement for osteoporosis treatment is not reported yet. In this study, several 2D models of human vertebral trabecular bone are analyzed by finite element method. The mechanical behaviors of the vertebral trabecular bone treated by the drug therapy and the bone cement are compared. This study shows that bone cement treatment is more effective strategy than drug therapy to prevent the degradation of bone strength.

• Journal of Nutrition and Health
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• v.34 no.5
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• pp.532-540
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• 2001

This study explored the effect of calcium levels and/or ovariectomy on bone composition and its related factors using the female Sprague-Dawley rats which achieved peak bone mass in normal(0.5%) calcium intake during growth period. The rats were randomly divided into six groups and fed 0.1%, 0.5% and 1.5% calcium diets for 8 weeks after ovariectomized and sham operation. The results indicated that body weight gain was higher in ovariectomized groups than sham groups, regardless of dietary calcium levels and food intakes. Serum Ca and P concentrations were normal level regardless of dietary calcium levels and operation. Estrogen concentration was decreased in ovariectomized rat groups. Serum alkaline phosphatase activity and urinary hydroxyproline were increased in ovariectomized groups. When rats were fed normal Ca diet during growing period, weight, length and breaking force of femur were not significantly different in all groups but increased the same level. Generally, lipid contents in lumbar and femur were lower in low calcium groups and this effect was more pronounced in femur. In case of femur, the significant decrease in Ca contents of bone was observed in a relatively short period of feeding low Ca diet, even though it appeared th desirable peak bone mass had achieved through the growing period by supplementing the adequate amount of calcium. The marked decrease of estrogen levels after ovariectomy did not seem to influence greatly bone parameters measured except bone wet weight. Therefore, this study indicated that lower intake of Ca might be more important determinating factor against osteoporosis than postmenopausal state stimulated by ovariectomy in female rats. With normal or high intake of Ca it appears possible to prevent bone loss in postmenopausal period, and this might apply only in case of achieving peak bone mass in the growing with the adequate intake of calcium. (Korean J Nutrition 34(5) : 532∼540, 2001)

• Korean Journal of Exercise Nutrition
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• v.23 no.3
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• pp.45-49
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• 2019

[Purpose] Recent studies suggest that ursolic acid (UA) is a potential candidate for a resistance exercise mimetic that can increase muscle mass and alleviate the deleterious effect of skeletal muscle atrophy on bone health. However, these studies evaluated the effects of UA on skeletal muscle and bone tissues, and they have not verified whether such effect could occur concurrently on muscle and bone, as is the case with resistance exercise. Thus, the aim of this study was to analyze the effect of UA injection on muscle mass and bone microstructure using an animal model of atrophy to demonstrate the potential of UA as a resistance exercise mimetic. [Methods] The immobilization (IM) method was used on the left hindlimb of Sprague Dawley (SD) rats for 10 days to induce muscle atrophy, whereas the right hindlimb was used as an internal control (IC). The animal models were divided into two groups, SED (sedentary, n=6) and UA (n=6) to demonstrate the effect of UA on atrophic skeletal muscles. The UA group received a daily intraperitoneal injection of UA (5 mg/kg/day) for 8 weeks. After 10 days of IM, the data collected for the IC were compared with that of IM to determine whether muscle atrophy might occur. [Results] Muscle atrophy was induced and bone mineral density (BMD) decreased significantly. The 8-week UA treatment significantly increased the gastrocnemius muscle mass compared to the SED group. In regard to the effect of UA on bones, negative results such as a decrease in BMD, trabecular bone volume fraction, and trabecular number, and an increase in trabecular separation, were observed in the SED group, but no such difference was observed in the UA group. No significant difference was observed in atrophic hindlimbs between SED and UA groups. [Conclusion] These results alone are insufficient to suggest that UA is a potential resistance exercise mimetic for atrophic skeletal muscle and weakened bone. However, this study will help determine the potential of UA as a resistance exercise mimetic.

• Journal of the Korean Applied Science and Technology
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• v.36 no.3
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• pp.797-803
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• 2019

Recently, osteosarcopenic obesity (OSO) has been identified and notified world wide. Therefore, this study reviewed OSO related to lifestyle factors such as nutritional intake and exercise. Due to aging, OSO may be initiated by dietary factors and obesity related factors. Reduced muscle mass and increased fat mass may negatively impact bone health causing OSO. The complication of OSO development should be related to dietary imbalance combined with declined exercise and this may contribute to induce OSO by decreasing bone mass, muscle mass, and increasing obesity with aging. To prevent OSO, reaching peak bone mass and building optimal muscle and fat mass through exercise would be recommended. For treating OSO, balanced dietary intake and regular exercise through a whole life would be needed. In addition, sufficient carbohydrate and fat intake for minimizing protein catabolism would be recommended to prevent OSO. The combination of aerobic exercise and resistance training also would be an effective intervention for OSO population.