• The Journal of Korean Medicine
• /
• v.30 no.6
• /
• pp.53-68
• /
• 2009

Objectives: This study demonstrates the neurological effects of Bojungikki-tang and Bojungikki-tang-gamibang on the focal cerebral ischemia of rats with ischemic damage caused by middle cerebral artery occlusion (MCAO). Methods: Rats were treated with Bojungikki-tang and Bojungikki-tang-gamibang extracts for about five days after MCAO, and the size and volume of cerebral infarction and the ratio of cerebral edema were observed. From the immunohistochemical view, significant changes of outbreak of Bax, Bcl-2, c-Fos, HSP72, and iNOS were observed in the brain tissues. Results: Bojungikki-tang repressed only brain edema and iNOS revelation led by focal cerebral ischemia, when considering significance. In contrast, Bojungikki-tang-gamibang demonstrated significant suppression of cerebral infarction, brain edema, Bax, c-Fos, HSP72, and iNOS induced by focal cerebral ischemia. Conclusions: Bojungikki-tang is considered functional treatment for cerebral ischemic damage; it can be effective to relieve secondary brain edema and immune response. Bojungikki-tang-gamibang can have a direct function to alleviate brain infarct and to control the natural death of nerve cells which cerebral ischemic damage brings about.

• The Journal of Internal Korean Medicine
• /
• v.25 no.3
• /
• pp.388-397
• /
• 2004

Object: This study was designed to investigate the clinical and practical characteristics of stroke patients treated with the age-old herbal medicines, Bojungikki-tang and Bojungikki-tang-gamibang. Methods: The 80 patients studied were all diagnosed with stroke by neurological examination, B-CT and B-MRI scan. They were treated with Bojungikki-tang and Bojungikki-tang-gamibang over 5 days and symptoms were observed. There were inpatients and outpatients at the Oriental Medical hospital of Dong-eui University from January in 2000 to June in 2003. All patients were interviewed and medical charts examined. Result and Conclusion: The results were found: 1.Many were in their sixties. Average age was 64.54. 2.Cerebral infarction was diagnosed in 86.25% of all cases. 3.30% of stroke cases occurred in spring. 4.Average blood pressure was 129/84mmHg on the fifth day of treatment with Bojungikki-tang and Bojungikki-tang-gamibang and 135/86mmHg on the first day. 5.The white color were best in facial color about 85.29%. 6.There were many who returned for treatment within 6 to 10 days. 7.Bojungikki-tang and Bojungikki-tang-gamibang were used Rt. hemiplegia more than for Lt. hemiplegia.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.25 no.5
• /
• pp.900-907
• /
• 2011

Bojungikki-tang-gamibang is a widely used herbal prescription in traditional medicine in Korea. The aim of this study is to investigate the effectiveness of Bojungikki-tang-gamibang for patients who have pontine stroke. They have problems with type of Qi deficiency(氣虛) in the rehabilitation stage. The type of Qi deficiency caused the dizziness and ataxia for the patients. In this study there are two types of patients. The first case is a patient with dizziness and ataxia because of potine hemorrhage. The second case is a patient who has the same symptoms as the first one but caused by pontine infraction. We treated the two patients with Bojungikki-tang-gamibang. The Improvement of symptom was evaluated by Korean vestibular disorders activities of daily living scale(K-VADL). As a result the degree of dizziness decreased noticeably while other symptoms improved as well. This study suggests that Bojungikki-tang-gamibang may be an effective treatment for patients who suffer stroke with type of Qi deficiency(氣虛) in the rehabilitations stage. However, more cases and methods of diagnosis are required to prove that the oriental medicine, Bojungikki-tang-gamibang can apply to patients universally.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.25 no.1
• /
• pp.144-148
• /
• 2011

The purpose of this case series was to investigate the effectiveness of Bojungikki-tang-gamibang for vascular dementia. The case subjects were nine patients who were diagnosed as vascular dementia by Mini-Mental State Examination-Korean (MMSE-K) and Hachinski's ischemic score. They were inpatients at the Kumi Oriental Medical Hospitalof Daegu Haany University from February in 2008 to Aprile in 2009. They were treated with Bojungikki-tang-gamibang. Results of before and after therapy were evaluated and scored using Korean-version Dementia Rating Scale (K-DRS). The results were analyzed using statistical methods, such as Wilcoxon signed rank test and Mann-Whitney U test. The study showed that the K-DRS score significantly increased after treatment (P<0.05). In summary, this cases report suggests that Bojungikki-tang-gamibang appears to be effective in the treatment of vascular dementia.

• Herbal Formula Science
• /
• v.21 no.2
• /
• pp.181-186
• /
• 2013

Objectives : The purpose of this study is to report the clinical effect of herbal medicine on the patient considering chronic renal failure. The patient complained of hemiparesis, general weakness, anorexia, nausea and dizziness. Methods : According to the traditional Korean medicine syndrome differentiation, the patient was classified as Deficiency of Spleen Qi and prescribed Bojungikki-tang and Bojungikki-tang gamibang as well as acupuncture and moxibustion treatment. Changes of BUN, creatinine, VAS for genaral weakness, nausea, dizziness were compared before and after treatment for 2 weeks. Results : After treatment, the level of BUN and creatinine was decreased and main symptoms were improved. Conclusions : Herbal medicine Bojungikki-tang and Bojungikki-tang gamibang with acupuncture and moxibustion treatment would be efficient to the patient of chronic renal failure.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.22 no.4
• /
• pp.943-947
• /
• 2008

This study is designed to evaluate the effects of an oriental herbal medication namely Bojungikki-tang-gamibang on vascular dementia. The Clinical data was analyzed on a patient with vascular dementia due to deficiency of Spleen Gi, whose symptoms were dementia, Rt. side hemiparesis, insomnia, anorexia et al. The patient visited at the internal medicine department of Daegu Haany University affiliated Kumi Oriental Hospital on February 14, 2008 to March 28, 2008. The improvement of symptoms were checked by Mini Mental Status Examination-Korea(MMSE-K). After treatment, dementia, Rt. side hemiparesis, insomnia, anorexia got improved and MMSE-K score increased as well. This study suggests that Bojungikki-tang-gamibang is significantly effective in treatment of vascular dementia.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.25 no.6
• /
• pp.1044-1049
• /
• 2011

The purpose of this study was to study clinical characteristics of patients complained of tremor and to evaluate availability of oriental medical treatment. This observation was made on 36 cases that were hospitalized in the Semyung University Oriental Medicine Hospital and evaluated tremor using clinical rating tremor scale(CRTS). The ratio of patients were essential tremor(50%), parkinson's disease(13.9%), psychogenic tremor(13.9%), physiologic tremor(11.1%), cerebellar tremor(11.1%). CRTS score of essential tremor patients decreased significantly. Physiologic tremor patients's CRTS score were under 15 points. Every patient's scores decreased. Two patients's score decreased to 0 point. Every patient were treated with Bojungikki-tang-gamibang. CRTS scores of psychogenic tremor patients were various.(4~24 points) Two patients's scores decreased to 0 point. The CRTS scores of three cases among four patients with cerebellar tremor were not changed. Changes of CRTS score between oriental medication group and western-oriental combined medication group were statistically significant. Changes of CRTS score between over 15 points group and under 15 points group were statistically significant. Kejigayongolmoryo-tang was one of the most widely used herbal medication, which was diagnosed as ascendant hyperactivity of liver yang.