• 한국산학기술학회논문지
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• 제10권4호
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• pp.740-746
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• 2009

본 논문에서는 공진형 유도가열기를 이용한 2단 직렬 부하형 유도가열 과열증기 발생장치를 제안하였다. 발열방식은 외부의 가열코일로부터 특수 합금 발열체에 비접촉 상태로 전자유도 와전류를 구조체에 흐르게 하였다. 인버터는 풀-브리지 고주파 직렬 부하 공진형 이며, LC 공진 설계에서 부하자체를 인덕터로 선정하여 효율을 최대화 하였다. 개발된 장치는 전자유도가열 발열체와 유체이동에 의한 새로운 열교환 방식으로 일체의 연소과정 없이 기체, 액체 및 증발체 등을 상온에서 고온에 이르기까지 고정도의 가열이 가능하다.

• 한국자기공명학회논문지
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• 제20권4호
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• pp.102-108
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• 2016

With the rapid increase of data on protein-protein interactions, the need for delineating the 3D structures of huge protein complexes has increased. The protocols for determining nuclear magnetic resonance (NMR) structure can be applied to modeling complex structures coupled with sparse experimental restraints. In this report, I suggest the use of multiple rigid bodies for improving the efficiency of NMR-assisted structure modeling of huge complexes using CYANA. By preparing a region of known structure as a new type of residue that has no torsion angle, one can facilitate the search of the conformational spaces. This method has a distinct advantage over the rigidification of a region with synthetic distance restraints, particularly for the calculation of huge molecules. I have demonstrated the idea with calculations of decaubiquitins that are linked via Lys6, Lys11, Lys27, Lys29, Lys33, Lys48, or Lys63, or head to tail. Here, the ubiquitin region consisting of residues 1-70 was treated as a rigid body with a new residue. The efficiency of the calculation was further demonstrated in Lys48-linked decaubiquitin with ambiguous distance restraints. The approach can be readily extended to either protein-protein complexes or large proteins consisting of several domains.

• 한국자기공명학회논문지
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• 제16권1호
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• pp.46-66
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• 2012

Metabolomic studies using human urine have shown that human metabolism is altered by a variety of environmental, cultural, and physiological factors. Comprehensive information about normal human metabolite profiles is necessary for accurate clinical diagnosis of disease and for disease prevention and treatment. In this study, metabolite correlation analyses, using $^1H$ nuclear magnetic resonance (NMR) spectroscopy coupled with multivariate statistics, were performed on human urine to compare metabolic differences based on gender and/or obesity in healthy human subjects. First, we applied partial least squares discriminant analysis to the NMR spectral data set to verify the data's ability to discriminate by gender and obesity. Then, the differences in metabolite-metabolite correlation between male and female, and between normal and high body mass index (obese) subjects were investigated through pairwise correlations. Creatine and several metabolites, including isoleucine, trans-aconitate, and trimethylamine N-oxide (TMAO), exhibited different quantitative relationships depending on gender. Dimethylamine had a different correlation with glycine and TMAO, based on gender. The correlation of TMAO with amino acids was considerably lower in obese, compared to normal, subjects. We expect that the results will shed light on the metabolic pathways of healthy humans and will assist in the accurate diagnosis of human disease.

• 자연과학논문집
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• 제8권1호
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• pp.27-32
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• 1995

역-솔레노이드 코일 형태를 이용한 핵자기공명용 내부영상 탐침을 제작하였다. 역-솔레노이드 탐침들로 획득된 영상의 신호-대-잡음비를 시제품 탐침인 머리코일과 몸통코일로 얻은 것들과 비교하였다. 내부영상에 관한한, 본 논문에서 제작된 역-솔레이노이드 탐침들이 위의 시제품 탐침들보다 향상된 기능성을 보였다. 그리고, 역-솔레노이드 탐침들이 형성하는 RF-자기장의 분포를 컴퓨터를 이용하여 계산하였다. 아울러, 본 논문에서 제작된 역-솔레노이드 탐침을 이용한 인체의 내부영상의 가능성에 대해서도 논의하였다.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2008년도 하계학술대회 논문집 Vol.9
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• pp.343-343
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• 2008

Newly designed structure of a thin ultrasonic rotary motor was proposed. Thin brass plate was used as a cross shaped vibrator and eight ceramic plates were attached on the upper and bottom sides of the brass plate as in Figure 1. The thin type ultrasonic motor has the structure adherent piezoelectric ceramic on the top and bottom surface of the thin elastic body. The direction of polarization is decided so as to occur the elliptical displacement in regular sequence at touch point A, B, C and D of stator contacted with rotor. By applying two electric fields which have 90 degree phase difference on the ceramics, each contact points make rotational displacements as in figure 2. Finite element analysis program ATILA was used to find the optimal size of the stator. As a result of the simulation, elliptical displacements of the tips were obtained at off-resonance frequencies. The maximum displacements of the contact tips were obtained at the length of 16[mm], width of 6[mm] and thickness of 0.4[mm]. Changes of the resonance frequencies were inversely proportional to the length of ceramic and proportional to the width of ceramic. Elliptical motions of the contact tips. of the stator were consistently obtained at off resonance frequencies. From a prototype motor, speed of 600[rpm] was obtained at 20[Vrms].

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2004년도 춘계학술대회 논문집 방전 플라즈마 유기절연재료 초전도 자성체연구회
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• pp.173-176
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• 2004

The piezoelectric ceramics for AE sensor piezoelectric devices are desirable to possess higher resonance vibrations. The compositions of $0.9Pb(Zr_xTi_{1-x})O_3-0.1Pb(Mn_{1/3}Nb_{1/3}Sb_{1/3})O_3$ (PZT-PMNS) in this work are selected for obtaining especially large electromechanical coupling factor, high mechanical quality factor and high Curie temperature. This ceramic has higher piezoelectric activity and higher electromechanical coupling factor, but the ceramic has lower Curie temperature. The piezoelectric and dielectric characteristics of PZT-PMNS ternary system are investigated as functions of $Ti^{2+}$, $Zi^{2+}$ mol rate. As the results, MPB(morphotropic phase boundary) in this piezoelectric ceramic is x=0.522. Resonance vibrations of PZT ceramics are investigated as ball-bearing drop test. For the use of AE sensor that driving with pre-amplifier, filter circuit after packed this ceramic and an elastic body.

• 한국정밀공학회지
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• 제33권9호
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• pp.707-714
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• 2016

This paper describes analysis results of vibration characteristics and modal test for a small-scale quad-rotor drone. The rotor arm has a slender body with a propeller and motor at its tip. Rotor system generates excitation for an unbalanced mass. Therefore, the drone platform is involved in the possibility of resonance. For advance identification of the possibility of resonance, confirmation of eigen-mode being closest to the propeller operation range is necessary. Material properties of CFRP tubes used for the rotor arm were acquired by finding the natural frequency based on Rayleigh method. A simplified quad-rotor FE model consisting of rotor arm assembly with tip mass was built to perform numerical analysis, and a free-free boundary condition was applied to provide flight status. Modal tests for the actual platform with impact hammer instrument were performed to verify analysis results. Separation margin from hazardous eigen-mode was checked on the propeller operation range.

• Investigative Magnetic Resonance Imaging
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• 제23권1호
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• pp.34-37
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• 2019

Gadolinium contrast agents (CAs) are integral components of clinical magnetic resonance imaging (MRI). However, safety concerns have arisen regarding the use of gadolinium CAs, due to their association with nephrogenic systemic fibrosis (NSF). Furthermore, recently the long-term retention of $Gd^{3+}-based$ CAs in brains patients with normal renal function raised another possible safety issue. The safety concerns of $Gd^{3+}-based$ CAs have been based on the ligand structure of $Gd^{3+}-based$ CAs, and findings that $Gd^{3+}-based$ CAs with linear ligand structures showed much higher incidences of NSF and brain retention of CAs than $Gd^{3+}-based$ CAs with macrocyclic ligand structure. In the current study, we report the in vivo biodistribution profile of a new highly stable multifunctional $Gd^{3+}-based$ CA, with macrocyclic ligand structure (HNP-2006). MR imaging using HNP-2006 demonstrated a significant contrast enhancement in many different organs. Furthermore, the contrast enhanced tumor imaging using HNP-2006 confirmed that this new macrocyclic CA can be used for detecting tumor in the central nervous system. Therefore, this new multifunctional HNP-2006 with macrocyclic ligand structure shows great promise for whole-body clinical application.

• 한국임상수의학회지
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• 제37권6호
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• pp.317-323
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• 2020

The aims of this study were to describe the appearance and size of the normal canine prostate using magnetic resonance (MR) imaging and to calculate the apparent diffusion coefficient (ADC) values. MR images were obtained from seven intact male beagle dogs using a 1.5 T MR unit. The sequences included pre- and post-contrast T1- and T2-weighted imaging with and without fat saturation. The signal intensity of the prostate was compared with the adjacent musculature, fat, and urine in the urinary bladder. We recorded the mean prostatic length, width, and height and the length of the sixth lumbar vertebral body (L6). In addition, the prostatic length (rL), width (rW), and height (rH) ratios to L6 were calculated. Diffusion-weighted images of the prostate were obtained and ADC values were calculated. The prostate was bilobed and oval-shaped, homogenous on T1-weighted images, and heterogeneous with radiating lines on T2-weighted images. Post-contrast T1-weighted sequences showed contrast enhancement of the central and radiating striations. The prostatic capsule was clearly identified on post-contrast T1-weighted images with fat saturation. The ADC values were 1.72-2.04 × 10-3mm2/sec (mean, 1.88 × 10-3mm2/sec). Knowledge of the normal appearance of the prostate on MR images is essential to assess prostatic diseases in dogs.

• 한국임상수의학회지
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• 제40권5호
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• pp.370-374
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• 2023

Oral melanoma is the most common type of oral tumor in dogs. In this report, computed tomography (CT) and magnetic resonance imaging (MRI) were performed to diagnose a right oral pigmented mass in an 8-year-old dog. The oral mass appeared as a homogeneous soft tissue density parenchyma on pre-contrast CT images, and with heterogeneous enhancement on post-contrast images. Bone destruction of the right mandibular body around the mass and mild enlargement of the right mandibular lymph node were also found. On MRI, the bulky oral mass showed mixed hyperintensity and isointensity compared to the adjacent muscle, where irregular hyperintensity on T1-weighted images corresponded to hypointensity on the T2-weighted images. Based on the physical examinations and imaging results, melanoma was suspected and confirmed via fine-needle aspiration. These unique MRI signals were due to the high paramagnetic melanin content in the tumor, therefore MRI examination could be useful for diagnosis of melanoma.