• 한국환경과학회지
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• 제28권5호
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• pp.475-483
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• 2019

The purpose this study was to investigate the influences of 5% turmeric (Curcuma longa L.) supplementation on enzyme activities such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), amylase, lipase and catalase in serum of dyslipidemic rats. Sprague-Dawley (SD) rats (24 male) were divided into four groups, namely the ND group (normal-nondyslipidemic diet), NT group (normal-nondyslipidemic diet+5% turmeric), DD group (control-dyslipidemic diet), and DT groups (dyslipidemic diet+5% turmeric). Serum concentrations of blood urea nitrogen (BUN), creatinine and uric acid were significantly decreased (p<0.05) by turmeric supplementation diet. The activities of AST, ALT, ALP, LDH, amylase and lipase in sera of turmeric diet group were significantly decreased (p<0.05). The catalase activity in serum of turmeric supplementation group was significantly increased than dyslipidemic diet (p<0.05). In vivo experiment with dyslipidemic rats showed that ingestion of turmeric were effective in kidney and hepatic functional enzyme activities. Which suggests that turmeric material could be used for further studies as a potential source for nutraceutical foods.

• Reproductive and Developmental Biology
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• 제34권3호
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• pp.201-205
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• 2010

The objective of this study was investigate the superovulation treatment and to relate concentrations of blood urea nitrogen(BUN) in Hanwoo donors. Thirty six, at random stages of the estrous cycle, received a CIDR. Four days later, the animals were superovulated with a total of 28AU FSH (Antorin, 2AU=1 ml) administered twice daily in constant doses over 4 days. On the 3th administration of FSH, CIDR was withdrawn and 25 mg $PGF_2a$ was administered. Cows were artificially inseminated twice after estrous detection at 12 hr intervals. The cows received $100\;{\mu}g$ GnRH at the time of 1st insemination. Embryos were recovered 7 or 8 days after the 1st insemination. Cows with BUN <10, 11~18 and ${\geq}$19 mg/dl had return of estrus of 34.6, 30.5 and 30.4 days respectively. Return of estrus after superovulation treatment was not significantly lower for cows with blood urea nitrogen (BUN) above 10 mg/dl than for cows with BUN below 10 mg/dl. Cows with BUN <10, 11~18 and ${\geq}$19 mg/dl had number of transferable embryos of $3.2{\pm}1.2$, $5.4{\pm}1.9$ and $4.1{\pm}2.1$ respectively.

• 한국환경과학회지
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• 제29권4호
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• pp.351-359
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• 2020

The purpose of this study was to investigate the improvement effect of mung bean (Phaseolus aureus L.) on the hepatic functional enzyme and catalase activity of streptozotocin (STZ)-induced diabetic rats. Sprague-Dawley (SD) male rats were divided into four groups (n=6), and fed experimental diets containing mung bean meal [basal diet+5% mung bean (BM), basal diet+STZ+5% mung bean (SM)], and control (Basal Diet, BD), BS groups (basal diet+STZ). Serum concentrations of Blood Urea Nitrogen (BUN) and creatinine were significantly decreased (p<0.05) by 5% mung bean supplementation diet. The activities of aspartate transaminase (AST), alanine transaminase (ALT), akaline phosphatase (ALP), lactate dehydrogenase (LDH), amylase and lipase were decreased in the BD, BM and SM group than BS group. The catalase (CAT) activity was significantly increased (p<0.05) in mung bean supplementation diet (BM, SM group) than diabetic group (BS). In vivo experiments with diabetic rats showed that ingestion of mung bean supplementation diet were effective in BUN concentration, and hepatic functional enzyme activities.

• Biomolecules & Therapeutics
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• 제3권4호
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• pp.260-265
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• 1995

In an attempt to define the early biochemical determinants that participate in the pathogenesis of glycerol-induced nephrotoxicity, especially focusing on oxygen free radicals, we studied malondialdehyde (MDA) level and the activities of catalase and superoxide dismutase in the renal cortex of rats, and the concentrations of blood urea nitrogen(BUH) and serum creatinine of rats at 24hr after the injection of a 50% solution of glycerol. Sprague-Dawley albino rats weighing 240 to 260 mg were injected intramuscularly with a 50% solution of glycerol(2 mι/kg, 4 mι/kg and 8 mι/kg). The group treated with glycerol showed significantlv higher MDA level and catalase activity, lower SOD activity and higher BUN and serum creatinine concentrations at 24 hr after the injection as compared to those of control group. These results suggest that the excessive oxygen free radicals resulting from the depression of SOD activity is an important determinant in the pathogenesis of glycerol-induced nephrotoxicity.

• 한국수정란이식학회지
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• 제22권2호
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• pp.127-135
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• 2007

본 연구에서 Holstein 유우 78두로부터 분만 후 9주까지 1주 간격으로 혈액과 우유를 채취하여 cholesterol, glucose, 광물질(selenium, Ca, p), vitamin E 및 혈장내 progesterone을 분석하여, 이들 성분의 변화와 성분간의 상관 관계 및 변화 요인에 관하여 조사하였으며, 결과는 다음과 같다. 1. 분만 후 9주까지의 각 성분별 평균 수준은 혈액에서 cholesterol, glucose, selenium, Ca, P, vitamin E 및 BUN이 각각 78.8 mg/dl, 62.3 mg/dl, 8.9mg/dl, 7.4 mg/dl, 52.2 ng/ml, $10.3{\mu}g/l$ 및 16.3 mg/dl이었으며, MSe와 MUN은 15.3 ng/ml과 15.8 mg/dl이었다. 2. 혈액내 cholesterol, glucose, selenium, Vitamin E 및 MSe는 분만 후 시일 경과에 따라 증가되었다. 3. 성분간의 유의적 상관관계를 보면 cholesterol은 P와 부(-), selenium과 U과는 정(+)의 상관이 었고, glucose는 P, MSe와 정(+), P는 selenium 와 부(-) 상관이었으며 그리고 BUN과 MUN은 정(+) 상관을 나타내었다. 4. 성분 변화의 요인으로서 유우 나이는 glucose와 selenium, 산차는 selenium과 vitamin E, 유량은 glucose와 MSe 수준에 차이가 나타났으며 청초와 건초 급여간에는 혈액내 Ca와 selenium를 제외 한 성분에서 차이를 보였다. 요소태 질소에서는 MUN에서만 나이와 산차간에 차이가 있었다. 이상의 결과로 분만 후 급여 사료에 따라 혈액 및 우유의 성분에 차이를 보이며, 특히 혈액 및 우유내의 selenium은 분만 후 젖소에는 중요한 요소임을 확인할 수 있었다.

• Asian-Australasian Journal of Animal Sciences
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• 제12권5호
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• pp.682-688
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• 1999

Thirty nine pregnant Javanese thin-tail ewes (20 and 19 carried a single and multiple [2 to 3] fetuses, respectively), and six nonpregnant ewes as controls were used to measure maternal serum hormone and blood metabolite concentrations as predictors of number of fetuses carried during pregnancy. Serum hormones (progesterone, estradiol, triiodothyronine, and cortisol) and blood metabolites (b-hydroxy butyric acid [BHBA], and blood urea nitrogen [BUN]) were determined every four weeks during pregnancy and were used to predict litter size by discriminant analysis. The results of data analysis indicated that serum progesterone and estradiol concentrations at weeks 8, 12, 16 of pregnancy could be used to predict the number of fetuses carried with precision of 86.7 to 95.6%. Serum triiodothyronine, cortisol, BHBA, and BUN concentrations during pregnancy, however, were not good predictors of the number of fetuses carried. Serum progesterone and estradiol concentrations as early as 8 weeks of pregnancy in sheep could predict the number of fetuses carried with 86.7% precision.

• 한국동물위생학회지
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• 제45권4호
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• pp.337-342
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• 2022

Calf diarrhea is a major health concern in the livestock industry that requires accurate analysis for appropriate treatment. Dehydration and electrolyte imbalance are the most significant consequences of diarrhea in calves. Until now, the reference values of blood analysis of Hanwoo neonatal calves have not been well known. Recently, portable blood analyzers have made it possible to immediately analyze blood in the farm and provide suitable treatment for the patients. We analyzed electrolytes, blood urea nitrogen (BUN) and glucose in the blood of 179 Hanwoo neonatal calves, including 79 with diarrhea. These 179 calves were divided into 3 groups based on their age. Values of sodium (Na⁺ ) and glucose were significantly lower in diarrheic calves (1~30 days), while potassium (K⁺ ) and chloride (Cl^- ) values were higher in diarrheic calves (1~30 days). BUN values, which are closely related to dehydration due to diarrhea, increased in diarrheic calves of all ages. Therefore, these data can be used as reference values for blood analysis and treatment of healthy or diarrheic Hanwoo neonatal calves within 30 days of age.

• 대한방사선기술학회지:방사선기술과학
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• 제31권3호
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• pp.293-298
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• 2008

본 연구는 방사선 조사에 의해 생쥐의 혈청성분이 어떠한 변화를 일으키는가를 구명하는데 있고, 이를 위해 10MeV급 Linac 방사선치료장치를 사용하여 3Gy 방사선을 1회 전신 조사한 생쥐의 혈청(serum)을 채취하여 14가지 생화학적 분석을 실시한 후 paired t-test를 실시하였다. 그 결과 다음의 3가지 혈청성분에서 유의한 변화가 있다는 사실을 확인하였다. 첫째, glucose 측정에서 정상대조군(normal control group)의 $185.43{\pm}14.93$보다 방사선조사군(irradiation group)이 $220.00{\pm}17.58$로 높게 나타나 평균값에 매우 유의한 차이를 보였다(p<0.001). 둘째, BUN(blood urea nitrogen) 측정에서 정상대조군의 $19.61{\pm}1.65$보다 방사선조사군이 $15.70{\pm}1.48$로 낮게 나타나 평균값에 유의한 차이를 보였다(p<0.01). 셋째, albumin 측정에서 정상대조군의 $3.19{\pm}0.34$보다 방사선조사군이 $2.89{\pm}0.25$로 낮게 나타나 평균값에 유의한 차이를 보였다(p<0.05). 결론적으로, 3Gy 방사선이 조사된 생쥐의 혈청은 glucose, BUN(blood urea nitrogen), albumin 등 3가지 성분에서 유의할만한 변화를 일으켰다.

• 한국응용과학기술학회지
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• 제35권3호
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• pp.848-856
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• 2018

Krill (Euphausia superba) 분말이 Sprague Dawley계 수컷 흰쥐 혈청 중 non-esterified fatty acid (NEFA), blood urea nitrogen (BUN), creatinine, uric acid 및 전해질 농도에 미치는 영향을 조사하기 위하여 기본식이를 급여한 대조군인 BG군과 기본식이에 NaF 10 mg 경구 투여한 BFG군을 비롯하여 10%, 20%, 30%의 krill 분말을 첨가한 식이에 NaF 10 mg 경구 투여한 KMF10군, KMF20군, KMF30군, 5가지의 급여군으로 나누어 5주간 사육한 결과, 흰쥐의 NEFA와 BUN, creatinine 농도는 krill 분말 급여군인 KMF10군, KMF20군, KMF30군에서 BFG군보다 유의적으로 감소한 결과가 관찰되었으며, uric acid 농도에서 KMF10군은 BFG군과 유의적 차이가 없었으나, KMF20군과 KMF30군에서 유의적으로 감소하였다(p<0.05). 또한 전해질 농도에서 총 칼슘(T-Ca)은 군간의 유의적 차이가 없는 것으로 관찰되었지만 krill 분말 함량에 따라 증가하였으며(p<0.05), 인(Pi) 농도는 krill meal 함량에 따른 변화는 없는 것으로 나타났다. 따라서, krill 분말은 NEFA 및 BUN, creatinine, uric acid 농도 개선에 효과가 있을 것으로 사료된다.

• 한국수정란이식학회지
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• 제23권1호
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• pp.59-64
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• 2008

The objective of this study is to investigate the changes in concentrations of blood urea nitrogen (BUN) and sex steroid hormones, such as estrogen, progesterone, and testosterone in Korean cattle (Hanwoo) with reproductive disorders and to examine the relationship between BUN and body condition score (BCS) in Hanwoo. The concentration of BUN was 16.2 mg/dl, 17.8 mg/dl, 15.1 mg/dl, 17.9 mg/dl, and 28.3mg/dl in pregnancy, repeat breeding, follicular cyst, luteal cyst, and ovarian atrophy, respectively. In Hanwoo with BCS $2.0{\sim}2.9$, $3.0{\sim}3.5$ and $3.6{\sim}4.0$, the concentration of BUN was 15.8 mg/dl, 17.0 mg/dl, and 17.6 mg/dl, respectively. Fluoroimmunoassay showed that serum estrogen and progesterone levels were decreased in reproductive disorders Hanwoo, such as ovarian atrophy, endometritis, and weak estrus. The testosterone level was significantly decreased in Hanwoo with reproductive disorders compared to that in pregnant Hanwoo ($0.02{\sim}0.03\;ng/ml$ vs 0.13 ng/ml, p<0.05). The progesterone and estrogen concentrations in follicular fluid obtained from ovary with follicular cyst were significantly higher (p<0.05) than those in normal follicle fluid. These results show that there is no relationship between BUN and BCS in Hanwoo, and the concentration of sex steroid hormone in serum and follicular fluid are changed in reproductive disorders Hanwoo.