• 제목/요약/키워드: Blood transfusion

검색결과 407건 처리시간 0.022초

Thrombin Powder와 Gelfoam Powder의 혼합물을 이용한 노출된 망상골면 출혈의 지혈효과 (Effect of the Mixture of Thrombin Powder and Gelfoam Powder on Control of Exposed Cancellous Bone Bleeding)

  • 박성완;조하영;이승명;정성헌;송진규;장석정;신호
    • Journal of Korean Neurosurgical Society
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    • 제29권5호
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    • pp.664-667
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    • 2000
  • Objective : Excessive bleeding from the exposed cancellous bone surface may cause serious problem such as hematoma formation, infection, transfusion reaction during operation and postoperative period. There are several kinds of bleeding control agent on the cancellous bone surface including bone wax, gelatin sponge ($Gelfoam^{(R)}$), oxidized cellulose($Oxycel^{(R)}$, $Surgicel^{(R)}$), thrombin, microfibrillar collagen($Avitene^{(R)}$) etc. In the past, bone wax was used to control bone bleeding but it is associated with increased infection rate and fusion failure. Recently, gelfoam paste has been used to control cancellous bone bleeding. We controlled the cancellous bone bleeding with the mixture of gelfoam powder and thrombin powder. Material and Methods : Seventeen patients of posterior fusion on the 4 motion segments of thoracolumbar spine were selected to compare the result of bone bleeding control. In the test group of 9 patients, the cancellous bone bleeding was controlled with the mixture of Gelfoam and thrombin powder during operation. In the control group of 8 cases, no chemical hemostatic agent was used to manage the bone bleeding during operation. We calculated the total amount of bleeding from cancellous bone surface during and after operation in the two groups and compared their statistic significance of the result which was judged by student t-test. Results : The average amount of intraoperative bleeding was 1825ml in control group, 811ml in test group(p<0.01). The amount of postoperative bleeding was 943ml in control group and 812ml in test group, there were no significant difference in the amount of bleeding during postoperative period between two groups(p>0.5). Total amount of blood was decreased in as much as 1150ml in test group(p<0.01). Conclusion : We concluded that the application of the mixture of thrombin and gelfoam powder on the cancellous bone surface is the effective control method of cancellous bone bleeding for multilevel posterior spinal fusion.

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시뮬레이션 교육이 간호학생의 임상추론역량과 임상수행능력 및 교육만족도에 미치는 효과 (The Effects of Simulation-based Education on the Clinical Reasoning Competence, Clinical Competence, and Educational Satisfaction)

  • 강희;강희영
    • 한국산학기술학회논문지
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    • 제21권8호
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    • pp.107-114
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    • 2020
  • 본 연구는 시뮬레이션 기반 교육이 간호학생들의 임상추론역량과 임상수행능력 및 시뮬레이션 교육만족도에 미치는 효과를 알아보고자 수행되었다. 본 연구 설계는 단일군 전후 설계이다. 대상자는 G시 C대학교의 89명 3학년 간호학생으로, 8월부터 10월까지 8주간의 시뮬레이션 교육을 참여하였다. 학습한 시나리오 주제는 전 고관절대치술 후 수혈 부작용 환자 간호, 당뇨 환자의 저혈당증 환자 간호, 간경화증 환자의 고칼륨혈증 환자 간호이다. 자료는 SPSS 23.0 프로그램을 이용하였고, 평균과 표준편차, 대응표본 t검정으로 분석하였다. 간호학생들은 시뮬레이션 교육을 적용한 후 임상추론역량(t=-17.082, p<.001)과 임상수행능력(t=-18.40, p<.001)이 통계적으로 유의하게 향상되었고, 시뮬레이션 교육만족도는 5점 만점에 4.65점으로 높은 점수를 나타내었다. 이러한 결과로 볼 때, 본 시뮬레이션 기반 교육은 간호학생에게 임상상황과 유사한 환경에서 질적이고 안전한 간호를 경험할 수 있도록 하였다. 따라서 간호학생들의 임상추론역량과 임상수행능력을 향상시키기 위해서는 임상현장에서 접할 수 있는 다양한 사례의 시나리오 개발 및 간호교육과정에서 시뮬레이션 기반 교과목들의 적용이 더 필요하다.

Phase II Trial of Loubo® (Lobaplatin) and Pemetrexed for Patients with Metastatic Breast Cancer not Responding to Anthracycline or Taxanes

  • Deng, Qian-Qian;Huang, Xin-En;Ye, Li-Hong;Lu, Yan-Yan;Liang, Yong;Xiang, Jin
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권1호
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    • pp.413-417
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    • 2013
  • Purpose: This phase II study was undertaken to determine the efficacy and safety of Loubo$^{(R)}$ (Lobaplatin) in combination with pemetrexed in treating patients with metastatic breast cancer who failed to respond to anthracycline or taxanes. Patients and Methods: Metastatic breast cancer cases who had previously received an anthracycline and a taxane in either adjuvant or metastatic settings, were enrolled. All patients were recruited from Jiangsu Cancer Hospital and Research Institute, and were treated with Loubo$^{(R)}$ (Lobaplatin) 35 $mg/m^2$ (intravenous; on day 1) and pemetrexed 500 $mg/m^2$ (intravenous; on day 1) every 21 days. Efficacy and side effects were evaluated after at least two cycles of chemotherapy. Results: All eligible 19 patients completed at least 2 cycles of chemotherapy with pemetrexed and lobaplatin, and were evaluable. Overall, 3 (15.8%) patients achieved partial response, 11 (57.9%) stable disease, 5 (26.3%) progression of disease, with no complete remission. Response rate was 15.8%, disease control rate was 42.1%. The median survival time was 10.3 months. Neutrophil suppression occurred in 36.8% of patients who had grade 2 toxicity, and 26.3% had grade 3, 26.4% had grade 4. Thrombocytopenia was encountered as follows: 21.1% grade 2, 15.8% grade 3 and 5.5% grade 4. Incidences of anemia were 10.5% in grade 2, 5.3% grade 3 and 0% grade 4. Only 5.3% of patients required packed red blood cell transfusion. Grade 3 digestive tract toxicity occurred in 5.5% of patients. Other toxicities included elevated transaminase,oral mucositis and skin rashes. Conclusions: The regimen of lobaplatin and pemetrexed is modestly active in metastatic breast cancer patients who failed anthracycline or taxanes, and the toxicity profile suggesting that the doses of chemotherapy should be further modified.

암 환아 부모의 경험에 대한 질적 연구 (The Experience of Parents Whose Child is Dying with Cancer)

  • 조영숙;김수지
    • 대한간호학회지
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    • 제22권4호
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    • pp.491-505
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    • 1992
  • The purpose of this research was to understand the structure of the lived experience of parents of a child terminally ill with cancer The research question was “What is the structure of the experience of parents of a child terminally ill with cancer\ulcorner” The sample consisted of 17 parents of children admitted to the cancer units of two university hospitals in Seoul. The unstructured interviews were carried out from October 10, 1991 through January 10, 1992. They were audio-recorded and analysed using Van Kaam's method. Parents ascribed the cause of the cancer to the mother's emotional imbalance during pregnancy, the mother's stress, failure to observe religious rites, food, the parent's sin, misfortune and pollution. The theme clusters were tension, fear and depression experienced during pregnancy, stress that children suffer from abusive parents, failure to observe religious activites, bad luck, and sins committed during a previous life. When the child suffered a recurrence of cancer, the parents experienced negative emotions, nervousness, sorrow. depression and death. The theme clusters were feelings of despair, helplessness, regret, guilt, insecurity, emptyness and apathy. The long struggle with cancer resulted in the loss of economic security, loss of psychological and physical well being, and social withdrawal. The theme clusters were the economic burden of medical cost, giving up treatment, debt, limited medical insurance coverage and blood transfusion. The loss of psychological well being included stress, lack of support systems, inability to carry out responsibilities, lack of trust of the medical ten family breakdown, inappropriate expression of emotion and not disclosing the diagnosis to the child. Physically the parents suffered fatigue, insomnia, loss of appetite, loss of weight, dizzness, headache, psychosomatic symptoms, and increased consumption of liquor and cigarettes. Social withdrawal was manifested by taking time off from work to look after the child, decrease of outside social activities and feelings of isolation. Influences on family life were spousal conflicts, negative response of siblings, separation of the family members and economic hardship. The theme clusters were blaming a spouse for the cause of the illness and disagreements, maladjustment, lonliness, hostility and depression of siblings. The high price of medical care over the long period was a major factor influencing the life of the family. Positive experiences during the child's long illness were the strengthening of support systems and religious beliefs and financial help from social organizations. The support of one's spouse primarily helped to overcome the stress of the long illness. In addition, support was received from parents of other children with cancer and from nurses and religious leaders. The nurse, by providing empathetic support, should be a person with whom parents can express their feelings and share their experiences.

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심폐소생술금지 동의 전·후 말기암환자의 연명치료 변화 (Changes in Life-sustaining Treatment in Terminally Ill Cancer Patients after Signing a Do-Not-Resuscitate Order)

  • 김현아;박정윤
    • Journal of Hospice and Palliative Care
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    • 제20권2호
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    • pp.93-99
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    • 2017
  • 목적: 본 연구는 심폐소생술금지에 동의한 암환자를 대상으로 연명치료 변화를 확인하기 위해 시도된 후향적 조사연구이다. 방법: 연구대상자는 S시에 소재한 A종합병원에서 2013년 1월 1일부터 12월 31일까지 종양내과 병동에 입원치료하고 사망한 암환자로 심폐소생술금지에 동의한 250명이 선정되었으며, 이중 심폐소생술금지를 입원당일 동의하였거나(N=40) 동의 후 3일 이내 사망한(N=10) 경우는 제외하였다. 대상자의 특성과 연명치료의 변화를 의무기록을 통해 조사하였으며, 심폐소생술금지 지시 동의 전 1일과 심폐소생술금지 지시 동의 후 3일 혹은 사망시점까지 조사하여 유지, 중단, 추가로 연명의료 변화를 판정하였다. 수집된 자료는 SPSS Win 21.0 프로그램을 이용하여 분석하였다. 결과: 연구대상자는 총 200명으로, 50~59세 나이 군이 36.0%로 가장 많이 차지하였고 남자가 62%였다. 재원일은 15일이었고, 입원하여 10일되는 시점에서 심폐소생술금지에 동의하였다. 심폐소생술금지에 동의 후 35.7~100%에서 연명치료가 계속 유지되었다. 인공호흡기 치료는 중단되지 않고 100% 유지되었으며, 수혈(37%), 혈액검사(37.4%), 산소요법(23.5%) 순으로 추가되었다. 중단된 연명치료 중 가장 빈도가 높은 것은 수혈(13.5%)이었고, 다음으로 혈액검사(11.5%), 비경구성 영양제투여(8.5%) 순이었다. 결론: 심폐소생술 지시 동의 후에 대부분 연명치료는 계속되었고 중단되는 경우는 드물었다. 의료진과 가족들 간의 연명치료 범위에 대한 이견을 좁히고, 무의미한 연명치료 중단에 대한 결정을 합의하기 위한 적극적인 논의가 요구된다.

개정 의료법상 설명의무에 관한 비판적 고찰 (A critical review on informed consent in the revised Medical Law)

  • 현두륜
    • 의료법학
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    • 제18권1호
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    • pp.3-35
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    • 2017
  • 우리나라에서는 1979년 대법원이 처음 설명의무 위반으로 인한 손해배상을 인정하였고, 그 후 판례를 통해서 설명의무의 구체적 내용이 형성 발전되어 오고 있다. 의사의 설명의무는 헌법 제10조와 진료계약상의 의무에 근거하고 있고, 보건의료기본법 제12조 및 개별 법률에서도 설명의무에 관한 내용을 규정하고 있다. 그런데, 2016. 12. 20. 개정된 의료법 제24조의2에 설명의무에 관한 규정이 신설되었고, 개정 의료법은 2017. 6. 21.부터 시행될 예정이다. 개정 의료법에 따르면, 설명의무의 대상이 되는 의료행위는 '사람의 생명 또는 신체에 중대한 위해를 발생하게 할 우려가 있는 수술, 수혈, 전신마취'이다. 이러한 의료행위를 할 때에는 반드시 사전에 법정사항이 기재된 서면으로 설명을 하고 동의를 받아야 한다. 만약, 이를 위반하면 300만원 이하의 과태료 처분을 받게 된다. 개정 의료법의 내용과 학설 및 판례를 통해서 인정되어 온 설명의무에 관한 기존 법리를 비교 검토해 보면, 양자 간에 상당한 차이가 있음을 확인할 수 있다. 그에 따라 개정의료법의 시행 이후에도, 기존 설명의무에 관한 법리는 크게 영향을 받지 않을 것으로 보인다. 그러나, 동일한 사안에서 설명의무 위반 여부에 관한 판단이 민사상 손해배상사건과 의료법 위반으로 인한 과태료처분사건에서 서로 달라지는 것은 법적 안정성이나 법질서 전체 통일의 관점에서 바람직하지 않다. 개정 의료법상의 설명의무에 관한 내용을 기존 법리에 맞게 수정하거나 독일의 경우와 같이 진료계약의 내용에 포함시켜 민법에서 규율하는 것이 바람직하다고 생각한다.

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외상환자의 전산화 단층촬영소견에서 나타난 달무리 소견의 임상적 유용성 (The Clinical Usefulness of Halo Sign on CT Image of Trauma Patients)

  • 이승용;손유동;안희철;강구현;최정태;안무업;서정열
    • Journal of Trauma and Injury
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    • 제20권2호
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    • pp.144-148
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    • 2007
  • Purpose: The management of hemorrhagic shock is critical for trauma patients. To assess hemorrhagic shock, the clinician commonly uses a change in positional blood pressure, the shock index, an estimate of the diameter of inferior vena cava based on sonography, and an evaluation of hypoperfusion complex shown on a CT scan. To add the finding for the hypoperfusion complex, the 'halo sign' was introduced recently. To our knowledge, this 'halo sign' has not been evaluated for its clinical usefulness, so we designed this study to evaluate its usefulness and to find the useful CT signs for hypoperfusion complex. Methods: The study was done from January 2007 to May 2007. All medical records and CT images of 124 patients with trauma were reviewed, of which 103 patients were included. Exclusion criteria was as follows: 1) age < 15 year old and 2) head trauma score of AIS ${\geq}$ 5. Results: The value of kappa, to assess the inter-observer agreement, was 0.51 (p < 0.001). The variables of the halo-sign-positive group were statistically different from those of the halo-sign-negative group. The rate of transfusion for the halo-sign-positive group was about 10 times higher than that of the halo-sign-negative group and the rate of mortality was about 6 times higher. Conclusion: In the setting of trauma, early abdominal CT can show diffuse abnormalities due to hypoperfusion complex. Recognition of these signs is important in order to prevent an unwanted outcome in hemorrhagic shock. We conclude that the halo sign is a useful one for hypoperfusion complex and that it is useful for assessing the degree of hemorrhagic shock.

Prediction of Risk Factors after Spine Surgery in Patients Aged >75 Years Using the Modified Frailty Index

  • Kim, Ji-Yoon;Park, In Sung;Kang, Dong-Ho;Lee, Young-Seok;Kim, Kyoung-Tae;Hong, Sung Jin
    • Journal of Korean Neurosurgical Society
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    • 제63권6호
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    • pp.827-833
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    • 2020
  • Objective : Spine surgery is associated with higher morbidity and mortality rates in elderly patients. The modified Frailty Index (mFI) is an evaluation tool to determine the frailty of an individual and how preoperative status may impact postoperative survival and outcomes. This study aimed to determine the usefulness of mFI in predicting postoperative complications in patients aged ≥75 years undergoing surgery with instrumentation. Methods : We retrospectively reviewed the perioperative course of 137 patients who underwent thoracolumbar-instrumentation spine surgery between 2011 and 2016. The preoperative risk factors were the 11 variables of the mFI, as well as body mass index (kg/㎠), preoperative hemoglobin, platelet, albumin, creatinine, anesthesia time, operation time, estimated blood loss, and transfusion amount. The 60-day occurrences of complication rates were used for outcome assessment. Results : Major complications after spinal instrumentation surgery occurred in 34 of 138 patients (24.6%). The mean mFI score was 0.18±0.12. When we divided patients into a pre-frail group (mFI, 0.09-0.18; n=94) and a frail group (mFI ≥0.27; n=44), only the rate of sepsis was statistically higher in the frail group than in the pre-frail group. There were significantly more major complications in patients with low albumin levels or in patients with infection or who had experienced trauma. The mFI was a more useful predictor of postoperative complications than the American Society of Anesthesiologists physical status score. Conclusion : The mFI can successfully predict postoperative morbidity and mortality in patients aged ≥75 years undergoing spine surgery. The mFI improves perioperative risk stratification that provides important information to assist in the preoperative counselling of patients and their families.

개심술 환자의 수술 후 급성 신부전 발생 위험요인 (Risk Factors for Development of Acute Renal Failure in Patient undergoing Open Heart Surgery)

  • 전현례;박정숙
    • 한국산학기술학회논문지
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    • 제14권4호
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    • pp.1728-1736
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    • 2013
  • 본 연구의 목적은 개심술 후 급성 신부전 발생 빈도와 급성 신부전 발생의 예측요인을 분석하기 위함이다. 2008년 1월에서 2011년 12월까지 A 대학병원에서 개심술을 시행한 483명을 대상으로 전자의무기록을 후향적으로 조사하여 복막투석, 혈액투석, 지속적신대체요법을 사용한 급성 신부전 발생군(n=59)과 신대체 요법을 시행하지 않은 대조군(n=424)으로 분류하였다. 연구결과 개심술 후 급성 신부전 발생률은 12.2%로 나타났다. 다변량 로지스틱 회귀분석 결과 수술 전 위험요소로는 크레아티닌(OR 3.92, p=<.001), 고령(OR 2.142, p=.015), 여자(OR 2.165, p=.015), 고혈압(OR 2.513, p=.005), NYHA(New York Heart Association) class II(OR 3.081, p=.003), NYHA class III(OR 6.759, p=.004)이었으며, 수술 중 위험요소로는 수혈량(OR 3.753, p=<.001), 수술 후 위험요소로는 빌리루빈(OR 4.541, p=.028), 크레아티닌(OR 8.554, p=.003), 심박출량(OR 0.214, p=.033)이 의미 있는 예측인자로 확인되었다. 심장수술 후 급성 신부전 발생은 합병증과 사망률을 증가시키는 원인이 되므로 조기에 위험인자를 발견하여 예방하는 것이 중요하다.

유착태반환자의 예방적 내장골동맥 풍선카테터 설치술 시행 시 태아선량 평가 (Evaluation of the Fetal Dose during Prophylactic Placement of Internal Iliac Artery Balloon Occlusion Catheters in Placenta Accreta)

  • 김동식;안성민
    • 대한방사선기술학회지:방사선기술과학
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    • 제39권3호
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    • pp.313-321
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    • 2016
  • 유착태반환자는 분만 시 발생하는 대량의 출혈로 모성 사망률이 높아 수술 중 출혈량 감소를 목적으로 수술 전 예방적 내장골동맥 풍선카테터 설치술(Prophylactic placement of Internal Iliac Artery Balloon Occlusion Catheters;PIIABOCs)을 시행하는데, 시술 중 발생하는 산모와 태아의 방사선 피폭에 대한 연구가 미흡한 실정이다. 본 연구는 PIIABOCs 시술 시 태아가 받는 선량을 측정하여 피폭의 정확한 정보를 제공하고자 본 연구를 시행하였다. MRI영상을 이용하여 선량측정 위치를 설정하고 팬텀과 선량계를 이용하여 실제 시술 시와 같은 환경으로 흡수선량을 측정하였다. 태아의 장기별 평균 흡수선량은 2.38~8.83 mGy로, 중심선속-수정체-위-방광 순으로 높게 측정되었고, 투시시간이 길어질수록, 장기의 위치가 선속의 중심에서 가까울수록, 산모의 복부두께가 두꺼울수록 태아선량이 증가하였다. 조사면적를 각각 25%, 50% 감소시켰을 때 각각 19.0%, 39.4%의 선량 감소, 조사야 전체에 차폐체를 사용하였을 때 약 56.3%의 선량 감소를 보였다. 시술테이블의 높이가 75 cm에서 가장 높게 나타났고 85, 95 cm 순으로 선량 감소를 보였다. 의료행위로 인한 방사선이 태아에게 미치는 영향으로 확률적 영향보다 결정적 영향이 우선 관심사이며 유의한 결정적 영향의 문턱선량은 대략 100 mGy로 알려져 있어, 실험결과 시술 시 태아 장기의 흡수선량은 0.49~18.27 mGy로 문턱선량의 10% 수준임을 확인하였다.