• 대한한방내과학회지
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• 제41권6호
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• pp.1265-1273
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• 2020

Objectives: Patients with polycythemia vera can experience many symptoms, including dizziness, headache, and fatigue, caused by a high red blood cell mass and blood viscosity. Some symptoms persist even after appropriate treatment. The purpose of this study was to examine the effect of Korean medicine on dizziness following polycythemia vera treatment. Methods: A patient diagnosed with polycythemia vera was treated with Korean medicine, including pharmacopuncture, acupuncture, and herbal medicine. We used a numeral rating scale (NRS) and the Dizziness Handicap Inventory (DHI) to observe the effects of the treatment. Results: After treatment, the hematocrit and hemoglobin increased to within normal range, and the NRS scores for dizziness and fatigue, subjective discomfort, and DHI scores decreased compared with the preadmission values. Conclusions: This report shows that Korean medicine helped to relieve dizziness in a patient with polycythemia vera. However, we need further studies to establish treatment regimens for polycythemia vera symptoms.

• Journal of Acupuncture Research
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• 제39권3호
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• pp.182-189
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• 2022

To evaluate the effectiveness of electroacupuncture treatment for primary dysmenorrhea (PD), a literature review of a randomized controlled trials (RCTs) was performed where electroacupuncture was used as a treatment intervention in patients diagnosed with PD. Relevant clinical studies (N = 226) were retrieved from multiple databases according to the study inclusion/exclusion criteria, and interventions and outcomes were analyzed. As a result of the review, there were 6 RCTs which met the criteria. In all 4 studies that measured pain indicators (visual analog scales), electroacupuncture showed significantly positive changes. In addition, positive changes were observed in most indicators (MMDQ, PGF2a, PGE2, 6-keto PGF1, TXB2, clinical efficacy score, uterine arterial blood flow parameters, and blood viscosity). 2 studies showed that electroacupuncture had a stronger therapeutic effect than NSAIDs. No major side effects were reported. Electroacupuncture may be an effective and safe treatment for PD however, further RCTs are required.

• 한국임상수의학회지
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• 제8권1호
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• pp.11-26
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• 1991

The effects of intra-articula. sodium hyaluronate(SH) and polysulfated glycosaminoglycan(PSGAG) on degenerative joint disease of the carpus were compared each other In 20 racehorses. Ten horses were dosed with intra-articula. injection of 20mg SH(2 times/2 weeks interval) and ten horses were dosed with intra-articular injection of 250mg of PSGAG(4 times/1 week into.val). Synovial fluid analysis and clinical examination were made to evaluate the effects of the drugs on degenerative joint disease at before injection and 2 weeks after the last injection, respectively. Appearance and mucinous precipitate quality oi synovial fluids of the group injected with 58 and PSGAG were improved by 40～50% and 60～80%, respectively. The chemical values of alkaline phosphatase, lactic dehydrogenase, aspartate aminotransferase, total protein, A/G ratio and glucose of synovial fluid in the group injected with PSGAG were more clearly returned to the normal values than those of the group injected with SH. Relative viscosity and total white blood cells of synovial fluid were returned to the normal walues after the treatments in both groups. Clinical symptoms(swelling, heat and pain on carpal joint, and lameness) of the horses in the group injected with SH and PSGAG were disappeard by 56～67% and 67～80%, respectivelty. Conclusively, the PSGAG was superior to SH in the effects on treatment of the degenerative joint disease in the horses.

• International Journal of Industrial Entomology and Biomaterials
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• 제30권2호
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• pp.81-85
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• 2015

Recently, many researchers have studied silk sericin because of its high water retention, good wound healing, good cyto-compatibility, and blood-glucose- and cholesterol-lowering effects. Although sericin film can be used in wound dressing and cosmetic packs, its poor mechanical properties have prevented its use in industrial fields. In the present study, sericin was obtained from different silkworm varieties, and the effect of silkworm variety on the structure and properties of sericin was examined. Except for a small difference in serine content, no significant difference in sericin was noted among the silkworm varieties. In addition, silkworm variety almost had no effect on solution viscosity, implying that it does not influence the molecular weight of sericin. Mechanical properties of sericin film were strongly affected by silkworm variety. Wonwon 126 showed the best mechanical properties, while N74 and Geumgwangju displayed the worst properties.

• Journal of Chest Surgery
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• 제19권1호
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• pp.18-24
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• 1986

The mean perfusion pressure produced by 20 different design and size of disposable aortic perfusion cannulas [size range: 18F to 20F] at flow rates of 1 to 5 L/min was compared. A roller pump with perfusion tubing 10mm in inner diameter was used with a mixture of 0.9% normal saline and 100% glycerin [mixing ratio of 6.72:13.28] to make the viscosity as normal blood in 20oC as the test solution. Line pressure in these cannulas at a flow rate of 3L/min ranged from 13.2$\pm$4.47 to 157$\pm$1 34 mmHg in a case of absence of resistance, and from 11.4$\pm$1.14 to 227.2$\pm$4.47 mmHg in a case of presence of resistances 14 cannulas had gradients of less than 100Hg at a flow rate of 3L/min and 9 cannulas less than 100mmHg at 4L/min. The following results were obtained from this experimental study: .1] A wide range of line pressure was observed in disposable aortic perfusion cannulas currently in clinical use; 2] Some cannulas currently used for cardiopulmonary bypass in adults generated excessive line pressure; 3] Both the material and design affect function, with some designs safer than others. Cardiac surgeons should base the choice of aortic perfusion cannula on the best performance and safest design available to avoid cannula-related problems during operation.

• 한국임상수의학회지
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• 제32권4호
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• pp.366-369
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• 2015

A 12-year-old, castrated male, mixed-breed dog was referred to us with a history of depression, lameness, neck and multiple joints pain. Clinical signs had been deteriorating from rear limbs lameness leading to pain on all four limbs lameness for 7 days. Mild leukocytosis and increased C-reactive protein concentration were revealed in blood work. On radiography, degenerative change of humerus and cervical intervertebral space narrowing were found. The results of synovial fluid analysis revealed severe neutrophilic pleocytosis, decreased viscosity, increased turbidity and bacterial culture was negative. The antinuclear antibody test was negative and MRI results revealed mild cervical intervertebral disk disease (IVDD). Based on all tests, we diagnosed this case as idiopathic immune-mediated polyarthritis (IMPA). Prednisolone and mycophenolate mofetil were administered and clinical signs were resolved after 7 days. This case report demonstrated that clinical, diagnostic imaging and synovial fluid analysis findings and successful treatment result with prednisolone and mycophenolate mofetil in canine idiopathic IMPA.

• Archives of Pharmacal Research
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• 제11권2호
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• pp.149-154
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• 1988

Impaired erythrocyte deformability was considered to paly an important role in microcirculatory disturbances. We recently confirmed that the brazilin, the main active principle of Caesalpinia sappan, enhanced activity of erythrocyte deformability and reduced blood viscosity. In this study, we examined the effects of brazilin on three biochemical parameters (ATP, 2, 3-diphosphoglycerate, and calcium) which influenced erythrocyte deformability. Treatment with barzilin increased erythrocyte deformability and ATP concentrations in streptozotocin-induced diabetic rats. Concentrations of 2, 3-diphosphoglycerate and calcium in diabetic rats following brazilin administration were decreased significantly compared to those of diabetic control rats. The results suggest that brazilin have a potential effect to improve rheological abnormalities in diabetes.

• International Journal of Industrial Entomology and Biomaterials
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• 제45권2호
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• pp.70-77
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• 2022

Wet-spun regenerated silk fibroin (RSF) fibers have been extensively studied owing to their 1) useful properties as biomaterials, including good blood compatibility and cyto-compatibility; 2) the various methods available to control the structural characteristics and morphology of the fiber, and 3) the possibility of fabricating blended fibers and new material-embedded fibers. In this study, silk nanofibrils prepared using a new method were embedded in RSF to fabricate wet-spun silk nanofibril/RSF composite fibers. Up to 2% addition of silk nanofibril, the silk nanofibril/RSF dope solution showed slight shear thinning, and the G' and G" of the dope solution were similar. However, above 3% silk nanofibril content, the viscosity of the dope solution significantly increased. In addition, shear thinning was remarkably evident, and the G' of the dope solution was much higher than the G", indicating a very elastic state. As the silk nanofibril content was increased, the wet-spun silk nanofibril/RSF composite fiber became uneven, with a rough surface, and more beaded fibers were produced. Scanning electron microscopy observations revealed that the beaded fibers were attributed to the inhomogeneous dispersion and presence of agglomerates of the silk nanofibrils. As the silk nanofibril content and RSF concentration increased, the maximum draw ratio decreased, indicating the deterioration of the wet spinnability and post-drawing performance of silk nanofibril/RSF.

• 대한한방부인과학회지
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• 제36권4호
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• pp.121-139
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• 2023

Objectives: This study was performed to analyze randomized controlled trial, which studied the effect of Saenghwa-tang treatment on postpartum prolonged lochia and uterine subinvolution. Methods: Researchers searched for randomized controlled trial of based on postpartum prolonged lochia, uterine subinvolution and Saenghwa-tang. The paper search was conducted through 6 online databases on August 10, 2023. Results: 8 studies were included after selection and exclusion criteria. 5 studies compared Saenghwa-tang alone with western medicine. 3 studies compared combined treatment of Saenghwa-tang and western medicine, with western medicine alone. Comparing with control group, the treatment group showed statistically significant improvement on total effective rate, uterine involution, serum fibrinogen, D-dimer, viscosity of blood and plasma, Erythrocyte aggregation, and various symptoms. Conclusions: This study suggests that Saenghwa-tang has benefit for treating prolonged lochia and uterine subinvolution. For reliable evidence, further research is needed to establish safety of Saenghwa-tang, standardize diagnosis criteria and specify the treatment course.

• 대한방사선기술학회지:방사선기술과학
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• 제32권1호
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• pp.61-67
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• 2009

연구목적 : poly-L-guluronic alginate(PGA) 겔이 혈관색전술에 적용가능한지 시뮬레이션을 통해 확인하고, PGA 겔이 혈관 내에서도 유용한지 혈관조영술을 통해 알아보고자 하였다. 연구방법 : 겔을 형성하는 PGA는 다시마에서 추출하여 생물학적 적합성 시험을 거쳤고, 단백질 불순물을 완전히 정제한 후 실험에 이용하였다. 유리 동맥류 모형을 이용하여 PGA가 겔을 형성하여 색전을 일으키는지 확인하였고, 가토의 신장 혈관에서도 PGA가 색전을 일으키는지 혈관조영술을 통해 확인하였다. 결 과 : 유리 동맥류 모형에서 PGA는 자동 주입기를 이용하여 카테타를 통해 주입한 후 염화칼슘($CaCl_2$)을 주입하니 유리 동맥류 모형 내에서 겔을 형성하며 색전을 일으켰다. 가토 실험에서는 우신 동맥과 대동맥을 결찰한 후 혈관조영술을 통해 좌신의 혈류를 확인하였다. 좌신동맥으로 PGA와 염화칼슘($CaCl_2$)을 동일한 카테터를 통해 순서대로 주입한 후 우신동맥과 대동맥의 결찰을 제거하였다. 혈관조영술을 다시 실시하여 좌신동맥의 혈류를 확인하니 좌신동맥이 보이지 않았다. 이는 좌신 혈관 내에세 PGA가 겔을 형성하여 혈류를 완전히 차단하였기 때문이었다. 결 론 : PGA는 혈관 내에서 혈관을 완전히 차단하고 색전을 일으킴을 확인하였다. 그러므로 PGA는 혈관 색전물질로 유용할 것이고, 혈관색전술과 조영술 적용에 상당히 효과적일 것이다.