• 한국가시화정보학회지
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• 제21권1호
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• pp.74-79
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• 2023

Thrombogenesis, which is the process of blood clot formation, can be initiated by platelet activation. Excessive formation of blood clot in the bloodstream can lead to thrombosis. Therefore, when dealing with patients with disseminated intravascular coagulation (DIC) or children, it is necessary to use small amounts of blood. Hence, it is important to develop methods for the rapid and accurate measurement of the platelet function using a small amount of blood. In this study, 3D printing technology was utilized to facilitate the production of micro channels. The amount of platelet adhesion in smokers and non-smokers was compared by repeatedly exposing the structure of the channel to adjust the number of blood injections and facilitate thrombosis attachment to simple stenosis structures.

• 대한의용생체공학회:의공학회지
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• 제45권1호
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• pp.49-55
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• 2024

Accurate measurement of blood pressure is essential for classifying an individual's disease, identifying blood pressure-related risks, and managing health. Due to the environmental and health hazards of mercury sphygmomanometers, automatic sphygmomanometers using the oscillometric method are widely used in hospitals as well as in general homes, and have established themselves as a practical standard sphygmomanometer. In this study, we developed a blood pressure simulator using an actuator that provides simulated pressure to an automatic blood pressure cuff. The developed blood pressure simulator adopts an arm-shaped cylindrical shape similar to the situation in which a person measures blood pressure with an automatic blood pressure monitor, and implements a method of transmitting pressure to the cuff using a pressure plate. Accuracy was evaluated through the mean and standard deviation of the difference with the commercialized blood pressure simulator BP PUMP 2, and reproducibility was confirmed using two automatic blood pressure monitors. The developed blood pressure simulator enables automatic blood pressure monitoring in a simple manner and also meets the evaluation standards for accuracy and reproducibility. In the future, as a standardized blood pressure simulator, it is expected to be of great help in evaluating and verifying the performance of automatic blood pressure monitors by supplementing precise hardware and software and building a blood pressure database.

• 대한전기학회논문지:시스템및제어부문D
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• 제51권10호
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• pp.477-482
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• 2002

One of the key technologic requirements for rotary blood pumps is the sealing of the motor shaft. A mechanical seal, a journal bearing, magnetic coupling, and magnetic suspension have been developed, but they have drawbacks such as wear, thrombus formation, and power consumption. A magnetic fluid seal is durable, simple, and non power consumptive. Long-term experiments confirmed these advantages. The seal body was composed of a Nd-Fe-B magnet and two pole pieces; the seal was formed by injecting magnetic fluid into the gap (50${\mu}m$) between the pole pieces and the motor shaft. To contain the ferro-fluid in the seal and to minimize the possibility of magnetic fluid making contact with blood, a shield with a small cavity was attached to the pole piece. While submerged in blood, the sealing pressure of the seal was measured and found to be 31kPa with magnetic fluid LS-40 (saturated magnetization, 24.3 KA/m) at a motor speed of 10,000 rpm and 53kPa under static conditions(0mmHg). The specially designed magnetic fluid seal for keeping liquids out is useful for axial flow blood pumps. The magnetic fluid seal was incorporated into an intra-cardiac axial flow blood pump.

• Journal of Preventive Medicine and Public Health
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• 제22권4호
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• pp.486-494
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• 1989

Lead, iron, and zinc concentrations in whole blood were determined by atomic absorption spectrophotometry, using a simple one-step dilution procedure, which were measured in 3 groups, 98 officers unexposed to dust or to metal, 58 coal miners without pneumoconiosis, and 113 coal workers' pneumoconiosis (CWP) patients. The results were as follows : 1. The precisions (C. V.%) of lead, iron, and zinc in blood were $12.65{\pm}6.95%,\;1.47{\pm}1.25%\;and\;6.35{\pm}3.34%$, respectively. 2. Lead and zinc in blood showed the log-normal distribution unlike iron in blood which showed normal distribution. 3. Lead, iron, and zinc concentrations in blood of 3 groups were follows : There was significant difference of concentration for zinc in blood by groups statistically. 4. The difference of lead, iron, and zinc concentrations in blood was not significant (p>0.05) by profusion on chest radiographs.

• 대한한의학원전학회지
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• 제19권1호통권32호
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• pp.137-154
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• 2006

From the Study on the Pricking blood therapy of ${\ulcorner}$HwangjeNaegyeong${\lrcorner}$, we conclude as follows; 1. The blood is apt to coagulate because of having concreteness. The blood is mainly coagulate as the collateral Meridian, minute collaterals, superficial collaterals and superficial vessels. By way of the Pricking blood therapy, the Stagnation of blood can be circulated, pathogenic factor removed, Eum-Yang(陰陽) and Gi and blood(氣血) can reach their balance. 2. To bloodletting, we should examine minutely, touch carefully with the region of the stagnated blood. After close observation of the stagnated blood, we should remove the stagnated blood up to clear. At the same time, we should observe carefully the color of the stagnated blood. 3. The acupuncture used for the Pricking blood therapy were stone needle, Bongchim(鋒鍼), Chamchim(?鍼), Pichim(?鍼) and Hochim(毫鍼) etc: After ages, from the base of Bongchim(鋒鍼), the three-edged needle became typical form. The skill of the Pricking blood therapy also became diverse, clinical application became wide. 4. After giving medical treatment with the Pricking blood therapy, reactions are various. Among them are side effects and normal effects. 5. The Pricking blood therapy is usually considered as simple sectional curing method, while it was considered as curing disease of JangBu(臟腑) or meridians in ${\ulcorner}$Hwangje-Naegyeong${\lrcorner}$. Therefore, if we sould apply the Pricking blood therapy on the basis of ${\ulcorner}$Hwangje-Naegyeong${\lrcorner}$, we should carefully understand the pattern identification according to Meridians and collaterals, and pattern identification of the Jang-Bu organs.

• 전기전자학회논문지
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• 제26권1호
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• pp.27-35
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• 2022

본 논문은 낮은 연산 복잡도를 지니는 초음파 혈관 패턴 영상 알고리즘을 제안한다. 제안하는 혈관 패턴 영상 알고리즘은 혈류의 흐름 만 감지하여 혈관 패턴을 영상화하는 알고리즘이며 손가락 혈관의 패턴 영상을 추출하는 실시간 신호처리 하드웨어에 적용할 수 있다. 기존의 초음파 의료영상장비의 혈류영상 모드와 달리 제안하는 알고리즘은 혈류의 흐름 만 감지하여 영상으로 복원한다. 즉, 제안하는 영상 알고리즘은 I/Q 복조를 사용하지 않으며 클러터 필터의 출력 신호의 절대 값을 누적하는 방식으로 혈류 흐름의 유무를 검출하기 때문에, 알고리즘의 구조가 비교적 간단하다. 제안하는 영상 알고리즘의 복잡도를 검증하기 위해, Field-II 프로그램을 이용하여 손가락 혈관을 모사하는 시뮬레이션 모델을 구현하였다. 행위모사 시뮬레이션을 통해, 제안하는 알고리즘의 연산시간이 일반적인 color-flow 모드보다 약 54배 작은 것으로 확인되었다. 제안하는 영상 알고리즘에서 요구되는 주요 구성 블록과 연산량을 고려할 때, 제안하는 알고리즘은 FPGA 또는 ASIC과 같은 하드웨어에 구현되기에 용이하다.

• 핵의학기술
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• 제27권2호
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• pp.133-136
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• 2023

Purpose: Prolactin in the blood is separated into three types, and over 90% of prolactin presents as a double monomer (23 KDa). Rarely, it can exist in the size of big prolactin (150 KDa), which is called macroprolactin and is known as an autoantibody complex. When macroprolactin accounts for more than 60% of prolactin in the blood, it is called macroprolactinemia. The presence of such macroprolactin was first reported in a patient with hyperprolactinemia but without typical symptoms. Macroprolactinemia is emerging as an important cause of idiopathic hyperprolactinemia. The polyethylene glycol (PEG) precipitation method using the property of precipitating large-molecular-weight proteins is simple and recently has been widely used as a screening test. The results are in good agreement with the results of gel chromatography. The purpose of this study was to confirm the measurement method and reference value verification of monomeric prolactin in blood prolactin using the PEG precipitation method. Materials and Methods: For 40 examinees who visited the Gangnam Center of Seoul National University Hospital in 2021, the prolactin level was verified using radioimmunoassay (RIA). For macroprolactinemia PEG precipitation method, 25% PEG (molecular weight 6000kDa) solution and serum were mixed in equal amounts in a test tube, then left at room temperature for 20 minutes and centrifuged at 4℃ for 30 minutes (1500g). The prolactin level was measured in the supernatant. Results : After confirming that more than 90% of the 40 tested samples within the reference range <25 ng/mL, the same value as the reference value for prolactin was applied. Since the concentration of monomeric prolactin in serum from which macroprolactin has been removed from blood is diluted 1:1 with PEG, our laboratory is currently reporting the result by multiplying the result by a dilution factor of 2. Conclusion: Radioimmunoassay using PEG precipitation method using the property of precipitating large molecular weight proteins is simple and effective for quantitative measurement of monomeric prolactin in blood prolactin.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• 제13권2호
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• pp.123-140
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• 2009

The effect of a solute concentration difference on the osmotic transport of water through the semi-permeable membrane of a simple cell model is investigated. So far, most studies on osmotic phenomena are described by simple diffusion-type equations ignoring all fluid motion or described by Stokes flow. In our work, as the governing equations, we consider the coupled full Navier-Stokes equations which describe the fluid motion and the full transport equation that takes into account of convection and diffusion effects. A two dimensional finite difference model has been developed to simulate the velocity field, concentration field, and semi-permeable membrane movement. It is shown that the cell swells to regions of lower solute concentration due to the uneven water flux through the semi-permeable membrane. The simulation is applied on a red blood cell geometry and the relevant results are presented.

• 한국임상수의학회지
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• 제32권1호
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• pp.127-129
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• 2015

A 3-month-old, female Persian cat was presented with sclera mass. The mass was detected after cat's squeals during the playing with a dog before 2 days. On ophthalmic examination, a $2{\times}5mm$ dark purple colored raised mass was observed 1 mm behind the limbus in the right eye. Anterior chamber was filled with blood and epithelial defect was detected at 2 o'clock in the right central cornea. After general anesthesia, resection of the protruded iris was performed with iris scissors and bipolar cautery. Ruptured sclera and conjunctiva were closed with simple interrupted and simple continuous suture, respectively. Also, irrigation and aspiration (I/A) of the anterior chamber was performed to remove blood clot with bimanual I/A handpiece in the right eye. Four months after the surgery, the right eye was recovered completely and menace response was positive in spite of the retinal lesions.

• 한국산업보건학회지
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• 제8권2호
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• pp.224-230
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• 1998

In order to provide a basic data for the prevention of the adverse effect of lead on health, We examined lead level in the blood and urine of 371 healthy men living in Choongchung-do from May to June, 1997. The results were as follows ; 1. Average lead level of all the subjects was $3.98{\pm}1.02{\mu}g/dl$ in blood, and $3.94{\pm}2.09{\mu}g/L$ in urine, respectively. Lead contents examined in this study were significantly lower than those of other investigators. 2. The lead levels of all the subjects in blood and urine had almost normal distribution. 3. Relation between lead content in blood and urine was a simple linear regression; its equation was "Lead level in blood=36.76+0.77 lead level in urine".