• 제목/요약/키워드: Blood Pressure

검색결과 4,637건 처리시간 0.03초

경동맥 초음파로 진단된 죽상동맥경화증과 위험인자의 관련성 분석 (Correlation Analysis of Clinical Risk Factors and Atherosclerosis Diagnosed by Carotid Artery Ultrasonography)

  • 박지연;양성희
    • 한국방사선학회논문지
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    • 제17권3호
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    • pp.465-472
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    • 2023
  • 본 연구는 혈관질환을 예측하는 데 있어서 일차 선별검사로서 경동맥 초음파 검사와 혈액학적 검사를 실시한 환자를 대상으로 경동맥 내중막 두께의 변화를 확인하고 죽상경화반의 발현에 위험인자들이 미치는 영향을 알아보고자 하였다. 일개 병원에서 건강검진을 목적으로 내원하여 경동맥 초음파 검사를 실시한 건강한 성인 469명을 대상으로 후향적으로 분석하였다. 그 결과 경동맥 내중막 두께, 연령, 체질량지수, 허리둘레, 수축기 혈압, 총콜레스테롤, 고비중지단백 콜레스테롤, 저비중지단백 콜레스테롤, 공복혈당이 죽상경화반의 유의한 예측인자로 분석되었다(p<0.001). ROC curve 분석을 통해 결정된 죽상경화반 위험인자들의 Cut off value를 기준으로 위험비를 산출하였으며 경동맥 내중막 두께는 8.06배, 연령은 7.53배, 허리둘레는 3.97배, 공복혈당은 2.02배 순으로 높게 나타났다. 따라서 본 연구에서는 죽상경화반의 유무에 영향을 주는 임상학적 위험요인들의 한국인 기준치를 마련할 수 있었으며, 초음파를 이용한 경동맥의 관찰은 심뇌혈관 질환을 조기에 진단하거나 예측하는데 도움이 될 것으로 생각된다.

Impact of Alcohol Consumption on Quality of Life, Depressive Mood and Metabolic Syndrome in Obstructive Lung Disease Patients: Analysis of Data from Korean National Health and Nutrition Examination Survey from 2014 and 2016

  • I Re Heo;Tae Hoon Kim;Jong Hwan Jeong;Manbong Heo;Sun Mi Ju;Jung-Wan Yoo;Seung Jun Lee;Yu Ji Cho;Yi Yeong Jeong;Jong Deog Lee;Ho Cheol Kim
    • Tuberculosis and Respiratory Diseases
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    • 제86권2호
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    • pp.111-119
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    • 2023
  • Background: The objective of this study was to investigate whether alcohol consumption might affect the quality of life (QOL), depressive mood, and metabolic syndrome in patients with obstructive lung disease (OLD). Methods: Data were obtained from the Korean National Health and Nutrition Examination Survey from 2014 and 2016. OLD was defined as spirometry of forced expiratory volume in 1 second/forced vital capacity <0.7 in those aged more than 40 years. QOL was evaluated using the European Quality of Life Questionnaire-5D (EQ-5D) index. Patient Health Questionnaire-9 (PHQ-9) was used to assess the severity of depressive mood. Alcohol consumption was based on a history of alcohol ingestion during the previous month. Results: A total of 984 participants with OLD (695 males, 289 females, age 65.8±9.7 years) were enrolled. The EQ-5D index was significantly higher in alcohol drinkers (n=525) than in non-alcohol drinkers (n=459) (0.94±0.11 vs. 0.91±0.13, p=0.002). PHQ9 scores were considerably lower in alcohol drinkers than in non-alcohol drinkers (2.15±3.57 vs. 2.78±4.13, p=0.013). However, multiple logistic regression analysis showed that alcohol consumption was not associated with EQ-5D index or PHQ-9 score. Body mass index ≥25 kg/m2, triglyceride ≥150 mg/dL, high-density lipoprotein <40 mg/dL in men and <50 mg/dL in women, and blood pressure ≥130/85 mm Hg were significantly more common in alcohol drinkers than in non-alcohol drinkers (all p<0.05). Conclusion: Alcohol consumption did not change the QOL or depressive mood of OLD patients. However, metabolic syndrome-related factors were more common in alcohol drinkers than in non-alcohol drinkers.

한국성인 여성의 혈압수준에 따른 체력의 차이 (The Difference of Fitness according to Blood Pressure Level in Korean Women)

  • 소위영;최대혁
    • 한국노년학
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    • 제29권1호
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    • pp.135-147
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    • 2009
  • 최근 우리나라는 식생활의 서구화와 더불어 운동부족 등으로 고혈압 발병률이 급격히 증가하고 있다. 많은 연구자들은 운동요법으로서의 고혈압 처치 및 예방을 위하여 다각도적인 접근을 시도하고 있다. 그러나 대부분의 연구들이 혈압강하와 관련된 운동의 효과 분석, 운동프로그램의 유용성 분석 등에 한정되어 있으며, 연령별 고혈압여부에 따른 체력의 차이에 대한 분석은 이루어지지 않고 있다. 본 연구자는 국민건강 관점에서 볼 때 연령별 고혈압여부에 따른 체력 수준 차이에 대한 확인은 고혈압 예방 및 처치를 위한 핵심적인 자료가 될 수 있기 때문에 금후에 진행되어야 할 중요한 연구 과제라 생각한다. 따라서 본 연구는 20대 이상의 성인 여성을 대상으로 연령별 고혈압여부에 따른 체력의 차이를 확인하여 고혈압 예방에 대한 체력수준의 중요성을 강조하고자 한다. 또한, 심폐기능의 차이를 추가적으로 살펴봄으로써 보다 가치 있는 연구를 도모하고자 한다. 2004년 1월 2일부터 2008년 9월 31일까지 S시 Y구 보건소 내 건강증진센터를 방문하여 고혈압검사가 포함된 종합검진을 받은 20세 이상의 성인 여성 8889명을 분석대상으로 하였다. 미국 고혈압 합동위원회의 제7차보고서(JNC7)의 고혈압 기준에 따라서 정상군, 조기고혈압군, 고혈압1기군과 고혈압2기군으로 나누었다. 심폐기능의 평가는 안정시심박수와 폐활량으로 체력의 평가는 심폐지구력, 근지구력, 근력, 순발력, 민첩성, 평형성, 유연성으로 하였고, 고혈압 발병에 영향을 미치는 독립 위험변수인 체질량지수, 음주, 흡연을 보정한 공변량분석(ANCOVA)을 이용하여 체력차이를 분석하였다. 연구결과 2가지의 모든 심폐기능 변인, 7가지의 모든 체력 변인에서 대부분의 연령대별로 4집단 간의 유의한 차이가 나타나는 것을 확인하였다. 이를 통하여 정상군에서 고혈압군으로 혈압수준이 높아질수록 낮은 심폐기능과 낮은 체력수준을 소유하고 있는 것을 확인하였다.

간헐적인 걷기가 고령여성의 건강관련체력과 대사증후군 위험요인에 미치는 영향 (Effects of Intermittent Walking for Health Related Physical Fitness and Metabolic Syndrome Risk Factors in Elderly Women)

  • 김상훈
    • 한국노년학
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    • 제29권4호
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    • pp.1397-1411
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    • 2009
  • 본 연구는 고령여성을 대상으로 간헐적인 걷기의 반복을 통해 신체활동량을 축적시켜 건강관련체력과 대사증후군 위험요인에 미치는 영향을 살펴보고자 시도하였다. 이를 위해 규칙적인 운동경험이 없는 65세 이상의 여성 자원자 총45명을 대상으로 간헐적 걷기집단, 지속적 걷기 집단, 통제집단의 세 집단으로 각각 15명씩 무작위 배정하였다. 간헐적 걷기집단은 매회 10분의 걷기를 4시간 간격으로 하루 3회 실시하고 지속적 걷기집단은 1일 1회 30분의 지속적인 걷기를 실시하였으며, 두 집단 모두 주 3회의 빈도로 12주간 실시하였다. 12주의 걷기 프로그램 종료 후 건강관련체력 측정결과 두 집단 모두 신체조성, 근지구력, 유연성, 전신지구력 항목에서 유의한 변화가 관찰되었으며, 근력에서는 지속적 걷기집단에서만 유의한 변화가 나타났다. 대사증후군 위험요인의 분석결과에서는 이완기혈압을 제외한 수축기혈압, 중성지방, 고밀도 지단백, 혈당에서 걷기를 실시한 두 집단 모두 긍정적인 개선효과가 나타났다. 결론적으로 매회 10분의 걷기를 하루 3회 실시하여 30분의 신체활동시간을 축적한 결과 30분간 지속적으로 걷기를 실시했을 때 나타나는 유산소 운동의 긍정적인 효과와 유사한 결과가 나타났으며, 체력수준이 약한 고령여성의 신체활동 증가를 위한 실용적이며 효율적인 운동방법으로 추천될 수 있을 것이다.

오령산 구성성분-타겟 네트워크 분석 (Analysis of a Compound-Target Network of Oryeong-san)

  • 김상균
    • 한국지식정보기술학회논문지
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    • 제13권5호
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    • pp.607-614
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    • 2018
  • 오령산은 몸 속의 수분을 순환시키고 소변으로 배출이 잘 되게 하는 효능이 있어 수분이 정체되어 나타나는 질환에 많이 쓰이는 처방이다. 본 연구에서는 시스템 약리학 접근 방법을 이용해서 오령산의 작용 기전을 탐색하기 위해서 오령산의 구성약재의 성분-타겟 네트워크를 구축하고 분석하였다. 우선, 오령산의 475개 성분에 대해서 STITCH 데이터베이스에서 연관된 타겟을 검색하였으며, 성분과 타겟의 상호작용에 대한 검색 결과는 XML 파일로 다운로드하였다. 본 연구에서 성분-타겟 네트워크는 Gephi를 이용해서 시각화하고 탐색하였다. 노드는 성분과 타겟이 되고, 링크는 성분과 타겟들간에 상호작용이 존재하면 연결되며, 상호작용의 신뢰도에 따라 링크에 가중치를 부여하였다. MCL 알고리즘을 이용해서 네트워크를 클러스터링 하였으며, 총 130개의 클러스터가 생성되었다. 가장 많은 노드를 가지는 클러스터에서 노드의 개수는 32개였다. 성분-타겟 네트워크에서 약재의 유효 성분들이 신장의 혈압 조절 기능과 관련된 타겟들과 연결되어 있는 것을 발견할 수 있었다. 향후에는 질병 데이터베이스와 연계해서 보다 명확한 오령산의 작용 기전을 밝힐 수 있도록 할 계획이다.

Efficacy and safety of losartan in childhood immunoglobulin A nephropathy: a prospective multicenter study

  • Hyesun Hyun;Yo Han Ahn;Eujin Park;Hyun Jin Choi;Kyoung Hee Han;Jung Won Lee;Su Young Kim;Eun Mi Yang;Jin Soon Suh;Jae Il Shin;Min Hyun Cho;Ja Wook Koo;Kee Hyuck Kim;Hye Won Park;Il Soo Ha;Hae Il Cheong;Hee Gyung Kang;Seong Heon Kim
    • Childhood Kidney Diseases
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    • 제27권2호
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    • pp.97-104
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    • 2023
  • Purpose: Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers (ARBs) are frequently employed to counteract the detrimental effects of proteinuria on glomerular diseases. However, the effects of ARBs remain poorly examined in pediatric patients with immunoglobulin A (IgA) nephropathy. Herein, we evaluated the efficacy and safety of losartan, an ARB, in pediatric IgA nephropathy with proteinuria. Methods: This prospective, single-arm, multicenter study included children with IgA nephropathy exhibiting proteinuria. Changes in proteinuria, blood pressure, and kidney function were prospectively evaluated before and 4 and 24 weeks after losartan administration. The primary endpoint was the difference in proteinuria between baseline and 24 weeks. Results: In total, 29 patients were enrolled and received losartan treatment. The full analysis set included 28 patients who received losartan at least once and had pre- and post-urinary protein to creatinine ratio measurements (n=28). The per-protocol analysis group included 22 patients who completed all scheduled visits without any serious violations during the study period. In both groups, the mean log (urine protein to creatinine ratio) value decreased significantly at 6 months. After 24 weeks, the urinary protein to creatinine ratio decreased by more than 50% in approximately 40% of the patients. The glomerular filtration rate was not significantly altered during the observation period. Conclusions: Losartan decreased proteinuria without decreasing kidney function in patients with IgA nephropathy over 24 weeks. Losartan could be safely employed to reduce proteinuria in this patient population. ClinicalTrials.gov trial registration (NCT0223277)

IT 기업 사무직 근로자의 대사증후군 예방을 위한 맞춤형 운동프로그램의 효과 (Effect of Individualized Exercise Program for Preventing Metabolic Syndrome among IT Company Office Workers)

  • 배경운;유승현;신다비;하윤철;김홍민;박병찬;김효상;박신애
    • 한국산업보건학회지
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    • 제34권1호
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    • pp.77-84
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    • 2024
  • Objectives: Interventions promoting physical exercise and healthy habits in workplaces have been shown to be effective in reducing risk factors for metabolic syndrome. This study was conducted to examine the effects of an individualized conditioning exercise program of IT company office workers with or at higher risk of metabolic syndrome. Methods: A total of 444 IT company office workers with or at higher risk of metabolic syndrome participated in a 3-month conditioning exercise program. Body composition data using bioelectrical impedance analysis and cardiopulmonary data using cardiopulmonary exercise testing from 53 individuals (mean age: 34.8 ± 7.1 years, sex : 21% female, height : 170.4 ± 6.8 cm, weight : 75.2±12.2 kg, body mass index : 25.8±3.3 kg/m2) who have successfully completed pre-test, intervention, and post-test were analyzed. The 12 weeks intervention encompassed: (1) health counseling (2) supervised exercise(endurance-based, aerobic exercise, or circuit training once a week for 50 minutes at heart rate reserve(HRR) of 77-95%) (3) self-directed exercise and biweekly health screening checks. Results: The results indicated a significant decrease in body weight, body fat mass and body mass index, respectively. Moreover, VO2peak, AT VO2 and AT Time significantly improved, respectively. Resting blood pressure(SBP/DBP) showed positive changes but were not statistically significant. We observed the correlation between characteristics of participants and rate of changes in cardiopulmonary outcomes of participants, there are no significant correlation. These results indicate positive changes in body composition and cardiorespiratory fitness parameters following individualized conditioning exercise program. Conclusions: Individualized workplace exercise program for preventing metabolic syndrome can lead to improvements in body composition and cardiorespiratory fitness.

Identification of an effective and safe bolus dose and lockout time for patient-controlled sedation (PCS) using dexmedetomidine in dental treatments: a randomized clinical trial

  • Seung-Hyun Rhee;Young-Seok Kweon;Dong-Ok Won;Seong-Whan Lee;Kwang-Suk Seo
    • Journal of Dental Anesthesia and Pain Medicine
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    • 제24권1호
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    • pp.19-35
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    • 2024
  • Background: This study investigated a safe and effective bolus dose and lockout time for patient-controlled sedation (PCS) with dexmedetomidine for dental treatments. The depth of sedation, vital signs, and patient satisfaction were investigated to demonstrate safety. Methods: Thirty patients requiring dental scaling were enrolled and randomly divided into three groups based on bolus doses and lockout times: group 1 (low dose group, bolus dose 0.05 ㎍/kg, 1-minute lockout time), group 2 (middle dose group, 0.1 ㎍/kg, 1-minute), and group 3 (high dose group, 0.2 ㎍/kg, 3-minute) (n = 10 each). ECG, pulse, oxygen saturation, blood pressure, end-tidal CO2, respiratory rate, and bispectral index scores (BIS) were measured and recorded. The study was conducted in two stages: the first involved sedation without dental treatment and the second included sedation with dental scaling. Patients were instructed to press the drug demand button every 10 s, and the process of falling asleep and waking up was repeated 1-5 times. In the second stage, during dental scaling, patients were instructed to press the drug demand button. Loss of responsiveness (LOR) was defined as failure to respond to auditory stimuli six times, determining sleep onset. Patient and dentist satisfaction were assessed before and after experimentation. Results: Thirty patients (22 males) participated in the study. Scaling was performed in 29 patients after excluding one who experienced dizziness during the first stage. The average number of drug administrations until first LOR was significantly lower in group 3 (2.8 times) than groups 1 and 2 (8.0 and 6.5 times, respectively). The time taken to reach the LOR showed no difference between groups. During the second stage, the average time required to reach the LOR during scaling was 583.4 seconds. The effect site concentrations (Ce) was significantly lower in group 1 than groups 2 and 3. In the participant survey on PCS, 8/10 in group 3 reported partial memory loss, whereas 17/20 in groups 1 and 2 recalled the procedure fully or partially. Conclusion: PCS with dexmedetomidine can provide a rapid onset of sedation, safe vital sign management, and minimal side effects, thus facilitating smooth dental sedation.

Usefulness of presepsin as a prognostic indicator for patients with trauma in the emergency department in Korea: a retrospective study

  • Si Woo Kim;Jung-Youn Kim;Young-Hoon Yoon;Sung Joon Park;Bo Sun Shim
    • Journal of Trauma and Injury
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    • 제37권1호
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    • pp.13-19
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    • 2024
  • Purpose: Trauma is an important public health concern, and it is important to increase the survival rate of patients with trauma and enable them to return to society in a better condition. Initial treatment in the emergency department (ED) is closely associated with the prognosis of patients with trauma. However, studies regarding laboratory biomarker tests that can help predict the prognosis of trauma patients are limited. Presepsin is a novel biomarker of inflammation that can predict a poor prognosis in patients with sepsis. This study aimed to determine whether presepsin could be used as a prognostic indicator in patients with polytrauma. Methods: The study included patients with trauma who had visited a single regional ED from November 2021 to January 2023. Patients who had laboratory tests in the ED were included and analyzed retrospectively through chart review. Age, sex, injury mechanism, vital signs, surgery, the outcome of ED treatment (admission, discharge, transfer, or death), and trauma scores were analyzed. Results: Overall, 550 trauma patients were enrolled; 59.1% were men, and the median age was 64 years (interquartile range, 48.8-79.0 years). Patients in a hypotensive state (systolic blood pressure, <90 mmHg; n=39) had higher presepsin levels (1,061.5±2,522.7 pg/mL) than those in a nonhypotensive state (n=511, 545.7±688.4 pg/mL, P<0.001). Patients hospitalized after ED treatment had the highest presepsin levels (660.9 pg/mL), followed by those who died (652.0 pg/ mL), were transferred to other hospitals (514.9 pg/mL), and returned home (448.0 pg/mL, P=0.041). Conclusions: Serum presepsin levels were significantly higher in trauma patients in a hypotensive state than in those in a nonhypotensive state. Additionally, serum presepsin levels were the highest in hospitalized patients with trauma, followed by those who died, were transferred to other hospitals, and returned home.

The Survey of Dentists: Updated Knowledge about Basic Life support and Experiences of Dental Emergency in Korea

  • Cho, Kyoung-Ah;Kim, Hyuk;Lee, Brian Seonghwa;Kwon, Woon-Yong;Kim, Mi-Seon;Seo, Kwang-Suk;Kim, Hyun-Jeong
    • 대한치과마취과학회지
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    • 제14권1호
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    • pp.17-27
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    • 2014
  • Background: Various medical emergency situations can occur during dental practices. Cardiac arrest is known to comprise approximately 1% of emergency situation. Thus, it is necessary for dentists to be able to perform cardiopulmonary resuscitation (CPR) to increase the chance of saving patient's life in emergency situation. In this paper, we conducted a survey study to evaluate to what extent dentists actually understood CPR practice and if they had experience in handling emergency situations in practice. Method: The survey was done for members of the Korean Dental Society of Anesthesiology (KDSA), who had great interest in CPR and for whom survey-by-mail was convenient. We had selected 472 members of the KDSA with a dental license and whose office address and contact information were appropriate, and sent them a survey questionnaire by mail asking about the degree of their CPR understanding and if they had experience of handling emergency questions before. Statistical analyses -frequency analysis, chi-square test, ANOVA, and so on- were performed by use of IBM SPSS Statistics 19 for each question. Result: Among 472 people, 181 responded (38.4% response rate). Among the respondents were 134 male and 47 female dentists. Their average age was $40.4{\pm}8.4$. In terms of practice type, there were 123 private practitioners (68.0%), 20 professors (11.0%), 16 dentists-in-service (8.8%), 13 residents (specialist training) (7.2%) and 9 military doctors (5%). There were 125 dentists (69.1%) who were specialists or receiving training to be specialist, most of whom were oral surgeon (57, 31.5%) and pediatric dentists (56, 30.9%). There were 153 people (85.0%) who received CPR training before, and 65 of them (35.9%) were receiving regular training. When asked about the ratio of chest pressure vs mouth-to-mouth respiration when conducting CPR, 107 people (59.1%) answered 30:2. However, only 27.1% of them answered correctly for a question regarding CPR stages, C(Circulation)- A(Airway)- B(Breathing)- D(Defibrillation), which was defined in revised 2010 CPR practice guideline. Dentists who had experience of handling emergency situations in their practice were 119 (65.6%). The kinds of emergency situations they experienced were syncope (68, 37.6%), allergic reactions to local anesthetic (44, 24.3%), hyperventilation (43, 23.8%), seizure (25, 13.8%), hypoglycemia (15, 8.3%), breathing difficulty (14, 7.8%), cardiac arrest (11, 6.1%), airway obstruction (6, 3.3%), intake of foreign material and angina pectoris (4, 2.2%), in order of frequency. Most respondents answered that they handled the situation appropriately under the given emergency situation. In terms of emergency equipment they had blood pressure device (70.2%), pulse oximetry (69.6%), Bag-Valve-Mask (56.9%), emergency medicine (41.4%), intubation kit (29.8%), automated external defibrillator (23.2%), suction kit (19.3%) and 12 people (6.6%) did not have any equipment. In terms of confidence in handling emergency situation, with 1-10 point scale, their response was $4.86{\pm}2.41$ points. The average point of those who received regular training was $5.92{\pm}2.20$, while those who did not was $4.29{\pm}2.29$ points (P<0.001) Conclusion: The result showed they had good knowledge of CPR but the information they had was not up-to-date. Also, they were frequently exposed to the risk of emergency situation during their dental practice but the level of confidence in handling the emergency situation was intermediate. Therefore, regular training of CPR to prepare them for handling emergency situation is deemed necessary.