• Journal of Preventive Medicine and Public Health
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• 제20권1호
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• pp.49-55
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• 1987

전라북도 전주, 이리지역에 거주하는 $31{\sim}49$세의 여성 72명을 조사 대상으로 혈액 및 뇨를 채취하여 일부 중금속을 원자 흡광 광도법으로 측정하고 각각의 중금속 함량에 대한 상관 관계를 조사하여 다음과 같은 결과를 얻었다. 1) 혈액내 중금속 농도는 카드뮴 $0.010{\pm}0.014({\mu}g/ml)$, 납 $0.028{\pm}0.138({\mu}g/ml)$, 구리 $0.899{\pm}0.513({\mu}g/ml)$ 및 아연 $0.277{\pm}0.192({\mu}g/ml)$였다. 2) 뇨중 중금속 농도는 카드뮴 $0.003{\pm}0.002({\mu}g/ml)$, 납 $0.025{\pm}0.018({\mu}g/ml)$, 구리 $0.031{\pm}0.012({\mu}g/ml)$ 및 아연 $0.277{\pm}0.192({\mu}g/ml)$였다. 3) 혈액과 뇨중 카드뮴, 납, 구리 및 아연의 농도에 대한 상관 관계를 조사한 결과 아연 (r=0.363, p<0.01)에서 유의 한 상관 관계를 보였다. 4) 혈액내 카드뮴 농도와 납, 구리, 아연의 농도에 대한 상관 관계를 조사한 결과 납(r=0.518, p<0.01)과 아연(r=0.367, p<0.01)에서 유의한 상관 관계를 보였다. 5) 혈액내 카드뮴 농도와 뇨중 납, 구리, 아연의 농도에 대한 상관 관계를 조사한 결과 아연(r=0.241, p<0.05)에서 유의한 상관 관계가 나타났다.

• 한국환경보건학회:학술대회논문집
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• 한국환경보건학회 2001년도 Proceedings of the 3rd Annual Meeting of Yellow Sea Environment
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• pp.30-41
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• 2001

Rapid economic development and industrialization has been accompanied by an increase of energy demand and environmental pollution. The consumption of gasoline has increased totally, but decreased in use of leaded gasoline after 1988 in Korea. On the other hand, risk assessment of environmental pollutants requires reliable dose estimates. Source oriented monitoring is not providing adequate information to estimate human exposure. The Health Surveillance Project has been launched in Korea from 1980, which questioned their symptoms based on questionnaires and medical examinations for inhabitants in the vicinity of 13 industrial areas and 2 non-industrial areas. 10, 598 inhabitants living in these 15 areas had medical checkups and donated their blood f3r heavy metal analysis from 1980 to 2000 through this project. Especially lead levels in inhabitants' blood of these areas were determined and monitored. Totally 4, 967 samples in target areas were used to review the trend of blood lead level in this paper. Average lead concentrations by areas were from 15.2 to 21.0 ug/dl in 1981 and 22.3 to 34.3 ug/dl in 1988, but were 8.8 to 11.1 ug/dl in 1992 and 4.4 to 4.8 ug/dl in 1995. On the other hand, the consumption of leaded gasoline was at a peak in 1958. Blood lead level showed a very close relationship with the consumption of leaded gasoline in the change pattern(p<0.01) and showed a rapid declining trend since the use of unleaded gasoline, especially from 1988 when Seoul held the olympic games. For example, the blood lead levels were 15.2 ug/dl in 1981, 20.2 ug/dl in 1955. 24.3 ug/dl in 1988 and 3.9 ug/dl in 1993 in Yochon area. China also had monitored blood lead levels of general population. 7, 015 inhabitants living in 28 areas donated their blood far heavy metal analysis from 1981 to 1988. Average lead concentrations by areas were from 5.1 to 5.6 ug/dl before. 1984 but were form 2.8 to 11.2 ug/dl after 1984. Average lead concentration in blood showed increasing trends clearly in most of the areas. The recent policy of unleaded gasoline use for automobile will be a very beneficial policy for the management of atmospheric lead pollution & health risk assessment for the general population in China. It is recommended that it should be propelled more widely and rapidly to the entire country.

• 한국환경보건학회지
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• 제45권3호
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• pp.258-266
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• 2019

Objectives: In this study, blood lead was analyzed using graphite furnace atomic absorption spectrometry (GF-AAs) and inductively coupled plasma mass spectrometry (ICP-MS). We tried to examine the difference and consistency of the analytical values and the applicability of the analytical method. Methods: We selected 57 people who agreed to participate in this study. After confirming the linearity of the calibration standard curves in GF-AAs and ICP-MS, the concentrations of lead in quality control material and samples were measured, and the degree of agreement was compared. Results: The detection limit of the ICP-MS was lower than that of GF-AAs. The coefficient of variation of reference materials was shown to be stable in the ICP-MS and GF-AAs. When the correspondence between the two equipments was verified by bias of the analysis values, a concordance was shown, and approximately 98% of the ideal reference lines were present within ${\pm}40%$ of the deflection. Conclusion: GF-AAs showed high sensitivity to single heavy metal analysis, but it took much time and showed higher detection limit than ICP-MS. Therefore, it would be considered necessary to switch to ICP-MS analysis method, considering that the level of lead exposure is gradually decreasing.

• 한국수산과학회지
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• 제43권3호
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• pp.270-276
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• 2010

This study estimated the heavy metal concentrations in octopus (Octopus minor) and conducted a food safety assessment of octopus. Octopus, a benthic cephalopod, was collected from the Seosan intertidal zone on the west coast of Korea. The samples were digested with acids, and then the cadmium (Cd), copper (Cu), and zinc (Zn) contents were analyzed using inductively coupled plasma mass spectrometry (ICP-MS). The Cd, Cu, and Zn range of concentrations in octopus were 0.06-19 (mean 5.8), 44-1,463 (mean 354.8), and 76-929 (mean 247.9) mg/kg on a dry weight basis, respectively. The concentrations of heavy metals were higher in the internal organs than in the mantle. Of the three heavy metals, copper had the highest concentrations in the internal organs because of the existence of hemocyanin bound with copper in octopus blood, whereas zinc had the highest concentrations in the mantle. No relationship between the concentration of heavy metals and biological parameters (length, weight, and sex) was found. The ratios (I/M) of the heavy metal concentrations in internal organs and mantle were highest for cadmium, although cadmium had much lower concentrations in the internal organs compared with copper and zinc. Considering the provisional tolerable weekly intake (PTWI) of the three heavy metals and the average intake of octopus per day, all three elements should have no adverse effects on humans.

• 대한임상독성학회지
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• 제19권2호
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• pp.127-132
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• 2021

Purpose: It is known that the most common cause of gas poisoning in Korea is suicide attempts by burning ignition coals. Ignition coals are made from waste wood, and studies have been reported that heavy metals are emitted when this coal is burned. However, there was no study on how much heavy metal poisoning occurs in the human body through this, so this study was planned to find out whether the concentration of heavy metals in the blood increased in patients exposed to ignition coal combustion. Methods: From April 2020 to April 2021, blood lead, mercury, and cadmium concentrations were investigated in carbon monoxide poisoning patients who visited one regional emergency medical center in Seoul, and their association with exposure time, source of poisoning, and rhabdomyolysis were investigated. Results: During the study period, a total of 136 carbon monoxide poisoning patients were tested for heavy metals, and 81 cases of poisoning by ignition coal were reported. When comparing poisoning caused by combustion of ignition coal and other substances, there was no difference in the concentrations of lead, mercury, and cadmium in the blood, and there was no difference in the number of patients above the reference range. However, the patients exposed to more than 5 hours of ignition coal gas exposure are more frequent than those in the group less than 5 hours in lead (51.4% vs. 23.9%, p=0.012). Conclusion: Compared to poisoning with other combustible substances, the blood concentration of lead, mercury, and cadmium does not increase further in patients with gas poisoning by ignition coal. However, prolonged exposure may result in elevated levels of lead.

• 한국환경보건학회지
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• 제44권4호
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• pp.348-359
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• 2018

Objectives: The purpose of this study was to investigate the relationship between frequency of alcohol drinking and blood mercury concentration in Korea. Methods: This was a cross-sectional study that used data from the Korean National Health and Nutrition Examination Survey. Among them, 3,174 persons were selected for the final study. Results: The concentration of mercury in the blood increased as the frequency of drinking soju or beer increased. Similarly, in the multiple-linear regression analysis model, the frequency of soju drinking was identified as an independent variable showing a statistically significant positive linearity (p<0.001). After controlling for confounding factors, comparing those drinking 'more than twice a week' with those who almost do not drink alcohol, the adjusted ORs for exposure to high concentrations of mercury were 3.24 (95% CI, 2.10-4.99) for drinking soju and 2.07 (95% CI, 1.33-3.22) for drinking beer. The interaction effect between 'soju drinking' and 'spicy pollack and seafood stew' was not statistically significant (p=0.098) for evaluating the interaction effect between the two variables. Conclusions: The concentration of mercury in the blood increased as the frequency of drinking of soju or beer increased. The higher the frequency of alcohol drinking, the more likely is the blood mercury to be included in the high-concentration group. The results of this study can be used as important scientific evidence for the field of environmental health related to alcohol drinking and blood heavy metal exposure in Korea.

• 분석과학
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• 제36권6호
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• pp.332-339
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• 2023

Urea는 혈액의 hemoglobin을 변성시켜 효소 활성 자리를 노출시킴으로써 혈액-luminol 반응의 화학발광 세기를 향상시킨다는 가설을 검증하고자 하였다. 이를 위해 혈액을 urea로 전처리한 경우 urea의 농도가 더 높아지거나 전처리 시간이 늘어날수록 혈액-luminol 반응의 화학발광 세기가 증가하였고 이는 기존의 가설과 부합되는 결과였다. 하지만 8 M urea용액을 미리 혼합하여 제조한 luminol로 혈액을 처리하면 혈액을 urea로 미리 전처리한 경우에 비해 urea가 hemoglobin을 변성시키는 시간이 짧아짐에도 화학발광 세기가 오히려 증가하는 현상이 나타났다. 또한 hemoglobin이 없는 전이금속을 urea가 포함된 luminol과 반응시켰을 때 화학발광이 강해지는 현상이 관찰되었다. 이러한 점으로 미루어 볼 때 urea는 hemoglobin을 변성시킬 뿐만 아니라 luminol-hydrogen peroxide 반응에도 관여하는 것으로 예상된다.

• 한국대기환경학회지
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• 제8권4호
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• pp.269-276
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• 1992

인체에 영향을 미치는 중금속은 대개 환경중에서 음식물, 공기, 먼지 및 음료수를 통하여 축적된다. 본 연구는 중금속중 납이 인체에 미치는 유해정도를 평가하기 위하여 서울과 여주등 대기중 납농도가 차이가 나는 지역주민들의 혈액중 납농도를 측정하여 Bio kinetic Model을 이용 납에 대한 인체의 위해성 정도를 알아보았으며 그 결과는 다음과 같다. - 지역별로는 혈액중 납농도가 별다른 차이를 보이지 않았으나 나이와 성별에 따라서는 다소 차이가 나고 있다. - 또한 혈액중 납농도는 log normal 분포를 나타내고 있음. - 기하표준편차는 1.2 $\sim$ 1.3 정도의 값으로 미국 EPA에서 추정한 1.31 $\sim$ 1.41의 값보다 약간 적은 값을 나타냈다.

• Journal of Nutrition and Health
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• 제29권9호
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• pp.958-970
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• 1996

This study was performed to investigate the effect of dietary calcium level on cadmium and lead toxicity in rats. Fifty-four male rats of Sprague-Dawely strain weighing 152$\pm$12g were blocked into 9 groups according to body weight, and were raised for 30 days. Nine experimental diets different with cadmium(0%, 0.04%), lead (0%, 0.071%) and calcijm(0.5%, 1.0%, 1.5%) levels were prepared. The results are summarized as follow. Weight gain, F.E.R.(food efficiency ratio), and weights of liver, kidney and femur were lower in cadmium exposed groups than those of heavy metal free groups. Weight gain F.E.R. and ash weight of lead groups were lower than those of heavy metal free groups. But, these were increased with increasing dietary calcium level. Cadmium and lead concentrations in blood, liver, kidney and femur were lower in rats fed 1.5% calcium than 0.5% calcium diet. Fecal cadmium and lead excretions were remarkably increased in 1.5% calcium groups, and cadmium and lead retention rates were decreased in 1.5% calcium groups. Metallothionein concentrations in liver, kidney and small intestine were higher in rats exposed to cadmium and lead. Calcium content in blood, femur and daily urinary and fecal calcium excretion were decreased by cadmium and lead additions, and increased in 1.5% calcium groups. Creatinine clearance were decreased with cadmium administratino and calcium addition. In conclusion, weight gain and organ weights were decreased with cadmium or lead administration. But, cadmium administration was more toxic than lead adminstration. Cadmium or lead toxicity was alleviated by increasing dietary calcium level. Especially, lead toxicity was alleviated in proportion to dietary calcium level.

• Safety and Health at Work
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• 제15권1호
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• pp.110-113
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• 2024

Numerous studies have indicated that organic fertilizers (OFer) might contain heavy metals (HMs) that present health risks to organic farmers (OFar). This study compared the concentrations of six HMs (Zn, Ni, Cd, Cu, Pb, Cr) in the blood of two distinct groups of farmers: 30 OFar from a designated organic area in eastern Taiwan, and 74 conventional farmers (CFar) from neighboring non-organic designated regions. The findings revealed that the OFar exhibited higher levels of Zn (1202.70 ± 188.74 ㎍/L), Cr (0.20 ± 0.09 ㎍/L), and Ni (2.14 ± 1.48 ㎍/L) in their blood compared to the CFar (988.40 ± 163.16 ㎍/L, 0.18 ± 0.15 ㎍/L, and 0.77 ± 1.23 ㎍/L), respectively. The disparities in Zn, Cr, and Ni levels were measured at 214.3 ㎍/L, 0.02 ㎍/L, and 1.37 ㎍/L, respectively. Furthermore, among the OFar, those who utilized green manures (GM) displayed significantly elevated blood levels of Zn (1279.93 ± 156.30 ㎍/L), Cr (0.24 ± 0.11 ㎍/L), and Ni (1.94 ± 1.38 ㎍/L) compared to individuals who exclusively employed chemical fertilizers (CFer) (975.42 ± 165.35 ㎍/L, 0.19 ± 0.16 ㎍/L, and 0.74 ± 1.20 ㎍/L), respectively. The differences in Zn, Cr, and Ni levels were measured at 304.51 ㎍/L, 0.05 ㎍/L, and 1.20 ㎍/L, respectively. As a result, OFar should be careful in choosing OFer and avoid those that may have heavy metal contamination.