Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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Effect of dietary Calcium Level on Cadmium and Lead Toxicity in Rats

식이내 Calcium 수준이 흰쥐의 카드뮴과 납중독에 미치는 영향

  • 김미경 (이화여자대학교 식품영양학과)
  • Published : 1996.11.01
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Abstract

This study was performed to investigate the effect of dietary calcium level on cadmium and lead toxicity in rats. Fifty-four male rats of Sprague-Dawely strain weighing 152$\pm$12g were blocked into 9 groups according to body weight, and were raised for 30 days. Nine experimental diets different with cadmium(0%, 0.04%), lead (0%, 0.071%) and calcijm(0.5%, 1.0%, 1.5%) levels were prepared. The results are summarized as follow. Weight gain, F.E.R.(food efficiency ratio), and weights of liver, kidney and femur were lower in cadmium exposed groups than those of heavy metal free groups. Weight gain F.E.R. and ash weight of lead groups were lower than those of heavy metal free groups. But, these were increased with increasing dietary calcium level. Cadmium and lead concentrations in blood, liver, kidney and femur were lower in rats fed 1.5% calcium than 0.5% calcium diet. Fecal cadmium and lead excretions were remarkably increased in 1.5% calcium groups, and cadmium and lead retention rates were decreased in 1.5% calcium groups. Metallothionein concentrations in liver, kidney and small intestine were higher in rats exposed to cadmium and lead. Calcium content in blood, femur and daily urinary and fecal calcium excretion were decreased by cadmium and lead additions, and increased in 1.5% calcium groups. Creatinine clearance were decreased with cadmium administratino and calcium addition. In conclusion, weight gain and organ weights were decreased with cadmium or lead administration. But, cadmium administration was more toxic than lead adminstration. Cadmium or lead toxicity was alleviated by increasing dietary calcium level. Especially, lead toxicity was alleviated in proportion to dietary calcium level.

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References

  1. J Indus Med v.34 Heavy metal pollution among auto workers Clausen,J.;S.C.Rostog
  2. 국립보건연구원보 v.13 식품중 유해성 미량금속에 대한 연구 송철
  3. 국립보건연구원보 v.18 야채 및 과실류중의 미량 금속에 대한 연구 김길생
  4. Expert Committee on Food Additives WHO Tech Rep Ser v.505 Joint FAO/WHO
  5. 식품의 안전성 연구 이서래
  6. Arch Environ Health v.24 Cadmium and zinc binding in mammalian liver and kidneys Shaikh,Z.A.;Lucis,O.J.
  7. Environ Health Perspect v.28 Renal tubular disfunction and abnormalities of calcium metabolism in cadmium workers Kazantizis,G.
  8. Japan J Pharmacol v.35 Defense mechanisms against cadmium toxicity Morita,S.
  9. Am J Physiol v.202 Hypertension induced in rats by small doses of cadmium Schroeder,H.A.;Vinton,W.H.
  10. Arch Environ Health v.12 Renal damage after prolonged exposure to cadmium : An Experimental Study Axelsson,B.
  11. Isr J Med Sci v.7 Effect of cadmium on skeletal tissue in normal and calcium-deficient rats Larsson,S.;Piscator,M.
  12. Am J Med v.75 Effect of 1.25-dihydroxyvitamin D₃ on calcium and magnesium absorption in the healthy human jejunum and ileum Krejs,G.J.
  13. Nephron v.20 Disturbances in kidney functions and calcium and phosphate metabolism in cadmium-poisoned rats Kawamura,J.
  14. Medicine v.4 Lead poisoning Aub,J.C.;Reznikoff,P.
  15. Horm Metab Res v.24 Differential effect of adrenalectomy on rat liver metallothionein mRNA levels in basal and stress condition Hidalgo,J.
  16. Life Science v.23 Metallothioneins and their role in the metabolism and toxicity of metals Cherian,M.G.;Robert,A.G.
  17. Environ Health Perspect v.54 General aspects of cadmium : Transport, uptake, and metabolism by the kidney Nordberg,M.
  18. IARC Scientific Publication Lyon No.118 Metallothionein and tissue damage;In Cadmium in Health Environment Toxicity and Carcinogenecity Manuel,Y.;Thomas Y.Pellegrini
  19. IARC Scientific Publication Lyon. No.118 Application of the 'critical concentration' concept to human risk assessment for cadmium;In Cadmium in Health Environment Toxicity and Carcinogenecity Nordberg,G.F.
  20. Trace element metabolism in animals v.2 Hill,R.
  21. J Nutr v.109 Effect of dietary supplemention of iron and ascorbic acid on lead toxicity in rats Tadashi,S.
  22. J Lab Clin Med v.82 Dose-response to lead ingestion in rats fed low dietary calcium Mahaffey,K.R.;Haseman,J.K.
  23. Br J Nutr v.34 The effects of dietary calcium and phosphorus on the retention and excretion of lead in rats Quarterman,J.
  24. J Nutr v.102 Effect of age on gastrointestinal absorption(Fe, Sr, Pb) in the rat Forbes,G.B.;Reina,J.C.
  25. 이대 박사학위 청구논문 식이 단백질과 Calcium수준이 흰쥐의 Cadmium 중독 및 해독에 미치는 영향 권오란
  26. 이대 석사학위 청구논문 식이내 Cadmium과 단백질 수준이 흰쥐의 단백질 대사 및 Cadmium중독에 미치는 영향 이혜영
  27. 이대 석사학위 청구논문 식이내 Calcium수준이 흰쥐의 Cadmium중독에 미치는 영향 배계현
  28. Korean J Nutr v.19 no.5 납과 단백질 수준을 달리한 식이로 사육한 성장기 흰쥐의 체내 대사 변화 김미경;조경희
  29. 이대 석사학위 청구논문 식이내 납과 지방수준이 흰쥐의 체내 지방대사에 미치는 영향 김정숙
  30. 한국영양식량학회 v.20 no.4 식이내 단백질과 칼슘의 수준이 납중독 된 흰쥐의 혈액학적 성상 및 신기능에 미치는 영향 이정숙;조수열
  31. 식품학개론 김영수;김용곤
  32. J Lab Clin Med v.78 Atomic absorption determination of lead in blood and urine in the presence of EDTA Zinterhofer,L.T.M.
  33. Environmental Science and technology v.5 Determination of lead in biological and related material by atomic absorption spectrophotometry Yeager,D.W.;Cholak,J.;Henderson,E.W.
  34. Toxicol Appl Pharmacol v.63 Comparison of metallothionein determination by polarographic and cadmium-saturation methods Onosaka,S.;Chrian,M.G.
  35. Toxicol Appl Pharmacol v.66 Evalution of the Cd/Hb affinity assay for the rapid determination of metallothionein in biologocal tissue Eaton,D.L.;Toal,B.F.
  36. Methods in enzymology v.205 Determination of metallothionein in tissues by cadmium-hemoglobin affinity assay Eaton,D.L.
  37. Analytical Methods for Atomic Absorption Spectrophotometry Perkin Elmer Corp
  38. Anal Biochem v.83 Peterson,G.L.
  39. Journal of biological chemistry v.193 Protein measurement with the Folin phenol reagent Lowry,O.H.;Randal,R.J.
  40. 임상의학 이귀녕;김진규
  41. Hawk's Physiological Chemistry(4th Edition) Oser,B.L.
  42. Biostatistical Analysis(2nd edition) Zar,J.H.
  43. Toxicol Appl Pharmacol v.75 Interaction between calcium and cadmium in the 1,25-dihydroxyvitamin D₃stimulated rat deodenum Toraason,M.;Foulkes,E.C.
  44. J Nutr v.103 Cadmium toxicity in growing swine Cousins,R.J.;Barber,A.K.;Trout,J.R.
  45. Environ Res v.12 The effects of dietary lead content and food restriction on lead retention in rats Quarterman,J.
  46. J Lab Clin Med v.72 Experimental enhancement of lead toxicity by low dietary calcium Mahaffey,K.R.;Goyer,R.A.
  47. Nutritional Reviews v.39 no.10 Nutritional factors in lead poisoning Mahaffey,K.R.
  48. Toxicol Appl Pharmacol v.41 Behaviral effects of asymptomatic lead exposure during neonatal development in rats Stephen,R.O.
  49. Lead toxicity Effect of lead on the kidney Choie,D.D.
  50. Fed Proc v.42 Characterization studies on the 63,000 Dalton $^ {203}Pb$ binding component of rat kidney cytosol Mistry,P.;Lucier,G.W.;Fowler,B.A.
  51. Toxicol Appl Pharmacol v.61 The inhibition of vitamin D-stimulated intestinal Ca transport in rats after continuous oral administration of Cd Shimizu,M.
  52. Environ Res v.22 Effects of Cd administration on intestinal Ca absorption and vitamin D dependent Ca binding protein Fullmer,C.S.
  53. Nutr Rep Int v.8 Influence of Cd on the metabolism of 25-hydroxy cholecalciferol in Chicks Feldman,S.L.
  54. Toxicol Appl Pharmacol v.113 Cadmium effect on bone metabolism : Accelerated resorption in ovariectomized, aged beagles Sacco-Gibson,N.
  55. Environ Res v.25 Inhibition of intestinal Ca uptake by Cd and the Effects of a low Ca diet on Cd retention Hamilton,D.L.
  56. J Nutr v.107 Role of dietary Ca and CaBP in Cd toxicity Philip,W.;Wasak,M.
  57. J Physiol v.265 Cadmium inhibits Ca absorption by rat intestine Hamilton,D.L.;Smith,M.W.
  58. Int J Environ Pollution v.57;58 Cadmium-induced bone loss : Increased susceptibility in females Bhattacharyya,M.H.
  59. Calcif Tissue Int v.42 Interaction of cadmium ions with calcium hydroxyapitite crystals : A possible mechanism contributing to the pathogenesis of cadmium-induced bone diseases Christoffersen,J.
  60. J Toxicol Environ Health v.9 Tissue distribution of lead in rat pups nourished by lead poisoned mothers Milton,R.H.
  61. J Postgrad Med v.51 Review of recent advances of lead in clinical research A.Goldberg
  62. Toxicol Appl Pharmacol v.46 Studies of the disposition of Ca in bones of rats after continuous oral administration of Cd Ando,M.;Sayato,Y.
  63. J Lab Clin Med v.76 no.6 Experimental enhancement of lead toxicity by low dietary calcium Sik,K.M.;Goyer,R.A.
  64. Toxicol Appl Pharmacol v.119 Nephrotoxicity of repeated injections of Cd-MT in rats Wang,X.P.;Cherian,G.
  65. Bull Environ Contam Toxicol v.38 Role of mucosal metallothionein preinduced by oral Cd or Zn on the intestinal absorption of a subsequent Cd dose Sugawa,N.;Sugawara,C.
  66. Archs Envir Health v.12 Renal damage after prolonged exposure to cadmium Axelsson,B.;Piscator,M.
  67. Toxicol Appl Pharmacol v.31 Effects of dietary cadmium on rabbits. Ⅰ. Early signs of cadmium intoxification Noriyama,K.
  68. J Lab Clin Med v.94 Alterations of intestinal and renal functions in rats after intraperitoneal injection of lead acetate Wapnir,R.A.
  69. Toxicol Appl Pharmacol v.46 The renal toxicity of cadmium metallothionein : morphometric and X-ray microanalytical studies Fowler,B.A.;Nordberg,G.F.