• Journal of Veterinary Clinics
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• v.7 no.2
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• pp.451-469
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• 1990

The present study was carried out to investigate whether the aloe had a radioprotective effect in mice exposed to cobalt-60 gamma radiation or not. The survival ratio of mice for 30 days, hematopoiesis of blood-forming stem cells by spleen colony assay, chromosomal aberration frequency of bone marrow cells and histopathological findings of bone marrow were investigated. The survival ratios of aloe administered groups with concentration of 250, 500, 1,000 and 1,500mg for 3 days before irradiation and control group in cobalt-60 gamma irradiated mice(700rads whole body irradiation, dose rate of 50rads/min.) were 77.4, 79.3, 80.6, 90.0 and 53.1％, respectively. The survival ratios of pre-irradiation aloe administered groups were superior to those of post-irradiation aloe groups and control group. In spleen colony assay, Aloe vera administration before irradiation enhanced the recoveries of numbers of blood-forming stem cells of bone marrow of irradiated mice. There were decreased chromosomal aberrations of bone marrow cells at the first day after irradiation in aloe administered groups compared to that of control group. Histopathological findings in the bone marrow of irradiated mice were hypocellularity due to the depletion of myelocytes, abundant of fat vacuoles and these changes were weakened in aloe administered groups compared to that of control group.

• Clinical and Experimental Pediatrics
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• v.57 no.1
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• pp.35-40
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• 2014

Purpose: Height-specific blood pressure (BP) is the standard parameter used to diagnose childhood hypertension. However, there has been some argument that weight may be a better variable than height in the reference BP standards. Therefore, before assessing the BP status using the reference BP standards, a basic understanding of the fundamental association of weight and height with BP is required. Methods: In the present study, we analyzed the correlation of BP with height and weight in Korean adolescents (age, 10-19 years), using data from the Korean National Health and Nutrition Examination Surveys (2009-2011). Results: Systolic BP (SBP) was more closely correlated with weight than with height in the normal weight (body mass index [BMI], ${\leq}85th$ percentile) and overweight (BMI, >85th percentile) groups and in the normal waist circumference (WC, ${\leq}90th$ percentile) and high WC (>90th percentile) groups in both sexes. Diastolic BP (DBP) had a higher correlation with height than with weight in the normal weight and normal WC groups, whereas weight was more closely associated with DBP than height in the overweight and high WC groups in both boys and girls. Conclusion: In Korean adolescents, weight had a greater effect on SBP than height in both the normal weight and overweight groups. DBP was mainly affected by height in the normal weight group, whereas weight was the major determinant of DBP in the overweight group. Therefore, it may be necessary to consider weight in the establishment of reference BP standards.

• The Korean Journal of Ecology
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• v.9 no.4
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• pp.193-200
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• 1986

In order to investigate the antiotoxic effect of red ginseng extract on serum protein of mouse treated with methyl mercury playing a role as toxic contaminant in ecosystem, variations of the serum protein contents, electrophoretic patterns, and blood components were studied. Mice were divided into 3 groups: Control, group I treated only with methyl mercury, and group II treated together with methyl mercury and red ginseng extract. The total serum protein content of the control group was 5.8g/dl and those of groups I and II were slightly decreased as compared with the control. The control group showed 11 serum protein fractions and groups I and II showed 10 fractions except prealbumin. The amounts of albumin, ${\alpha}_1-$, ${\alpha}_2-$ globulin fractions were decreased and those $\beta$-, $\gamma$-globulin fractions were increased in groups I and II. The amount of each serum protein fraction in group II showed approximately the same level as the control. The hematocrit value and the number of white blood cells of groups I and II were increased, whereas the number of red blood cells showed the decrease as compared with the control.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.11
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• pp.4643-4650
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• 2014

Background: For decades, studies have been performed to evaluate the association between ABO blood groups and risk of cancer. However, whether ABO blood groups are associated with overall cancer risk remains unclear. We therefore conducted a meta-analysis of observational studies to assess this association. Materials and Methods: A search of Pubmed, Embase, ScienceDirect, Wiley, and Web of Knowledge databases (to May 2013) was supplemented by manual searches of bibliographies of key retrieved articles and relevant reviews. We included case-control studies and cohort studies with more than 100 cancer cases. Results: The search yielded 89 eligible studies that reported 100,554 cases at 30 cancer sites. For overall cancer risk, the pooled OR was 1.12 (95%CI: 1.09-1.16) for A vs. non- A groups, and 0.84 (95%CI: 0.80-0.88) for O vs. non-O groups. For individual cancer sites, blood group A was found to confer increased risk of gastric cancer (OR=1.18; 95%CI: 1.13-1.24), pancreatic cancer (OR=1.23; 95%CI: 1.15-1.32), breast cancer (OR=1.12; 95%CI: 1.01-1.24), ovarian cancer (OR=1.16; 95%CI: 1.04-1.27), and nasopharyngeal cancer (OR=1.17; 95%CI: 1.00-1.33). Blood group O was found to be linked to decreased risk of gastric cancer (OR=0.84; 95%CI: 0.80-0.88), pancreatic cancer (OR=0.75; 95%CI: 0.70-0.80), breast cancer (OR=0.90; 95%CI: 0.85-0.95), colorectal cancer (OR=0.89; 95%CI: 0.81-0.96), ovarian cancer (OR=0.76; 95%CI: 0.53-1.00), esophagus cancer (OR=0.94; 95%CI: 0.89-1.00), and nasopharyngeal cancer (OR=0.81; 95%CI: 0.70-0.91). Conclusions: Blood group A is associated with increased risk of cancer, and blood group O is associated with decreased risk of cancer.

• The Korean Journal of Food And Nutrition
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• v.24 no.1
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• pp.1-11
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• 2011

This study was designed to investigate the relationships among blood lipid levels, nutrient intakes, oxidation and inflammation markers of overweight adults(23$\leq$BMI<25) and obese(BMI$\geq$25) in Korea. The subjects were classified as control, borderline hyperlipidemia. and hyperlipidemia groups based on The Korean Guidelines of Hyperlipidemia Treatment for the Prevention of Atherosclerosis. The study was conducted through questionnaires, anthropometric checkups, 2-days of 24 hr recalls, and blood biomarker analyses. Systolic blood pressure(SBP) was significantly increased in the hyperlipidemia group(p=0.0464). Intakes of nutrients were not significantly different among the three groups. Blood oxidized-LDL levels were significantly increased in the hyperlipidemia group(p<0.0001). Blood triglyceride(TG) levels were positively associated with BMI(p=0.0498), SBP(p=0.0158), and diastolic blood pressure(DBP; p=0.0076). Blood total cholesterol levels were positively associated with SBP(p=0.0005), and blood HDL-cholesterol levels were negatively associated with body fat (p=0.0408). Blood LDL-cholesterol levels were negatively associated with height(p=0.0207), and blood VLDL-cholesterol levels were positively associated with SBP(p=0.0011) and DBP(p=0.0490). Intakes of protein(p=0.0257) and dietary fiber (p=0.0094) were positively associated with blood HDL-cholesterol levels. Frap levels were positively associated with TG levels(p=0.0001) and VLDL-cholesterol levels(p=0.0077). Oxidized-LDL levels were positively associated with LDL-cholesterol levels(p=0.0135). These results suggest that oxidation and inflammation markers may be related to hypercholesterolemia progress, and dietary fiber intake may play a role in preventing hyperlipidemia in overweight and obese adults.

• Korean Journal of Food Science and Technology
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• v.12 no.1
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• pp.77-81
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• 1980

The effect of dietary vegetable oils, sesame, perilla, soybean and rice bran oils, on the blood cholesterol level of rabbit was examined using isocaloric and isonitrogenous diets. The gain in body weight, liver weight, serum and liver cholesterol levels, globulin, blood sugar and acid phosphatase activity in relation to cholesterol level were studied. The results are summarized as follows : 1. The gain in body weight (g/day) of rabbit was 16.3 for control, 15.3 for A, 18.3 for 15.3 for A, 18.3 for B, 15.3 for C and 18.1 for D groups. 2. Liver weight of the control A, B, C and D groups were 30.35, 37.25, 38.25, 31.05 and 39.54, respectively. 3. Serum cholesterol levels (mg/100 ml serum) of the control, A, B, C, and D groups were 71.5, 112.0, 110, 93 and 96 respectively. 4. Liver cholesterol levels (mg/100 ml liver fat) of the control, A, B, C and D groups were 255, 292, 255, 317 and 195 respectively. 5. The contents of alpha-1-globulin for control was 0.60 %, for C, 0.35 % and for D groups, 0.32% of total globulin. The content of alpha-2-globulin for control was 0.68 % of total globulin and for D, 0.26 % of total globulin. 6. The contents of blood glucose (mg/100 ml) of the control, A, B, C and D groups were 40.34, 22.37, 77.0, 28.6 and 34.1 respectively. 7. Acid phosphatase of the control, A, B, C, and D groups were 3.95, 4.52, 3.98, 4.55 and 4.53 nM/hr/l serum respectively. 8. According to the regression and correlation in coefficient in blood components of rabbit, there were positive correlations between serum cholesterol and alpha-1-globulin, and between liver cholesterol and gamma-globulin.

• Asian-Australasian Journal of Animal Sciences
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• v.19 no.10
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• pp.1422-1428
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• 2006

In order to investigate the effect of different levels of niacin supplementation on growth, nutrient utilization, their balance and blood biochemical profile, 15 male buffalo calves (9-10 months of age, $88.4{\pm}4.37kg$ average body weight) were divided into 3 equal groups each of 5 calves, following a completely randomized design, and fed individually for 120 days with wheat straw and concentrate mixture to meet their nutrient requirements. In addition calves were supplemented with 0 ppm (control, group I), 100 ppm (group II) and 200 ppm (group III) niacin. After 90 days of experimental feeding a metabolism trial was conducted to estimate the digestibility of nutrients and their balance. Fortnightly body weights were recorded to assess their growth rate and blood was collected from the jugular vein at day 0 and subsequently at 30-day intervals from all the experimental buffalo calves to study blood biochemical parameters. Results showed that intake and digestibility of dry matter, organic matter, crude protein, ether extract, total carbohydrates, neutral detergent fibre, acid detergent fibre, cellulose and hemicelluloses were statistically similar in the 3 groups. Buffalo calves in all three groups were in positive nitrogen, calcium and phosphorus balance, without showing any significant effect of the treatments. Dry matter, crude protein, digestible crude protein and total digestible nutrient intake ($g/d/kgW^{0.75}$) were similar in the control and niacin supplemented groups. Digestible crude protein (%) and total digestible nutrients (%) in the ration of the 3 groups were 8.07, 7.99, 7.92 and 56.70, 56.63, 56.74, respectively, and were comparable among the groups. The average daily gain (g) in-group II (567.50) was not significantly (p>0.05) higher than group I (500.0) and group III (510.0). Blood biochemical constituents (glucose, total protein, albumin, globulin, urea-N, insulin) showed no significant effect of niacin supplementation. However, serum cholesterol (mg/100 ml) was significantly (p<0.01) lower in the 200 ppm niacin-supplemented group than in the control and 100 ppm niacin-supplemented groups. It can be concluded that supplementation of niacin at 100 and 200 ppm in the diet of buffalo calves had no significant beneficial effect on their growth and nutrient utilization.

• Journal of Oriental Neuropsychiatry
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• v.28 no.3
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• pp.287-302
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• 2017

Objectives: To evaluate effects of Resina Dendropanacis Morbiferus (RDM) on stress and sleep hormones when administered to Chronic Mild Stressed (CMS) rats. Methods: Twenty-five healthy rats were randomly divided into 5 groups; Normal, CMS (Control), Resina Dendropanacis Mobiferus 50 mg/kg (RDM 50), 100 mg/kg (RDM 100), and 200 mg/kg (RDM 200). All rats except the normal group were exposed to unpredicted stress conditions such as water deprivation, empty bottles, forced thread mill, etc. according to timetable of CMS for 3 weeks. After a week starting experiments, rats in RDM 50, RDM 100, and RDM 200 groups were fed orally once a day for 2 weeks. Afterward, blood samples were taken from rats to analyze complete blood count, AST, ALT, and glucose. Noradrenalin, GABA and Melatonin were measured by ELISA kit. BDNF, CREB and TrkB were measured by RT-PCT. Results: 1. In Noradrenalin content, RDM 100 and RDM 200 groups revealed significant decrease compared to the control group. 2. In GABA content, RDM 50 and RDM 100 groups revealed significant decrease compared to the control group. 3. In Melatonin content, RDM 100 and 200 groups revealed significant decrease compared to the control group. 4. In Activity of BDNF, RDM 100 and 200 groups revealed significant increase compared to the control group. 5. In Activity of CREB and TrkB, RDM 100 group revealed significant increase compared to the control group. 6. In Erythrocyte and Thrombocyte changes, red blood cells and hematocrit significantly increased in RDM 50 and RDM 200 groups than the control group. Hemoglobin and platelet significantly increased in all experimental groups and the control group. 7. In Weight gain content, all RDM groups revealed insignificant increase compared to the control group. 8. In Glucose content, RDM 50, RDM 100, and RDM 200 groups revealed significant decrease compared to the control group. Conclusions: Results suggest that RDM have effects on stress and sleep hormones when administered to Chronic Mild Stressed (CMS) rats.

• Korean Journal of Community Nutrition
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• v.11 no.1
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• pp.143-151
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• 2006

Regular exercise training improves body composition, blood lipid profiles and exercise adaptation. This study was conducted to investigate the effect of exercise training at different times of day on body composition, blood lipids, stress hormones and nutrient intakes. Twenty four male graduate students carried out this experiment. The subjects were divided into three groups; morning exercise group, evening exercise group and control group. Two exercise groups performed running and muscular resistance training at mid intensity for 12 week periods. Body composition, blood lipid profiles, blood cortisol, ACTH and nutrient intakes were analyzed prior to, midway and after training. There were significant differences about interaction between different exercise times and training periods in plasma TG and HDL-C of the evening exercise training (p < 0.05). Also the evening exercise group was showed the decreasing of TC after training (p < 0.05). No significant differences about interaction between different exercise times and training periods were shown in body composition, stress hormones and nutrient intakes in the three groups. But evening exercise training decreased body fat ($\%$) and blood ACTH (p < 0.05). Also the increasing of carbohydrate intakes was shown by the evening exercise training (p < 0.05). In contrast, morning exercise group indicated a decrease of body fat ($\%$) after 6 week training (p < 0.05), but this effect was not maintained after 12 weeks of training. These results suggested that regular evening exercise is more effect than morning exercise from the viewpoint of improving body composition, blood lipids, nutrient intakes and exercise adaptation.

• Korean Journal of Community Nutrition
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• v.15 no.3
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• pp.403-414
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• 2010

Reducing women's bone mineral density (BMD) has close relationship to risk in osteoporosis. This study was carried out to identify bone density risk factors affecting women's BMD, and to analyze the relationship of age, between BMD and menopause, BMI, blood pressure lifestyle and dietary habits for bone health by physical measurement and questionnaires. The study subjects, 128 women living in Seoul, were divided into 4 age group; 30~39 years (17), 40~49 years (54) and 50~59 years (36) and 60~69 years (21). There were significant differences in mean height, BMI, systolic blood pressure, menache and menopause age and menopause ratio and BMD T-score among the 4 age groups. BHD was significantly decreased according to increasing age and BMI and menopause. The rate of BMD risk subjects was significantly different increasing with age and BMI. The rate of risk group were 0%, 13%, 22.2% and 71.4%, by age groups and 0%, 16.2%, 33.3% and 52.9% by BMI respectively. BMD of menopause groups was significantly decreased from 1.23 (40 years) to 1.34 (60 years). p < 0.001. Also systolic blood pressure were significantly increased from 116.5 mmHg (30 years) to 130.81 mmHg (60 years). The T-score of normal group also decreased significantly from 1.27 to 0.13 (60years) with age. There were significant negative correlation between BMD and age (r = -0.409) menopause (r = -0.346), BMI (r = -0.218) systolic blood pressure (r = -0.193), salty taste eating out (r = -0.185) (p < 0.05). There were significant positive correlation between BMD and meat fish and walking time. In conclusion, bone density decreased with age. Most of the 50 years' subjects were in risk group. BMI, menopause, systolic blood pressure, frequency alcohol consuming. To prevent osteoporosis, over 40 years needed to be educated to maintain normal weight and the improvement of eating and living habits.