• Journal of applied mathematics & informatics
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• v.9 no.2
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• pp.731-744
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• 2002

The temperature distribution in human skin and subdermal tissue layer is presented using bioheat transfer equation. The body temperature is determined by the balance between heat produced and heat lost by our body. The time-dependent solutions have been found to be affected by the metabolic heat generation rate, blood mass flow, the rate of evaporation of perspiration and also by the atmospheric temperature. The analytic solutions for different layers have been calculated numerically and are also shown graphically.

• Proceedings of the Optical Society of Korea Conference
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• 2007.07a
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• pp.81-82
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• 2007

• Journal of Korean Medicine for Obesity Research
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• v.8 no.2
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• pp.25-35
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• 2008

Objectives This study was performed to find out the characters about distribution of abdominal fat(especially superficial and deep subcutaneous fat) in obese premenopausal Korean women. Methods 39 obese premenopausal women were recruited in 2008. Anthropometry and body impedance analysis have been done and abdominal fat distribution had been assessed by computed tomography scan at the level of L4-5. Blood test and questionnaires about depression, eating attitude and physical activity were underwent. Result Abdominal total fat area, subcutaneous fat area including superficial and deep were significantly correlated with anthropometry and BIA result while visceral fat was correlated only with age and waist circumference. In blood profile, only visceral fat area was correlated with HDL cholesterol and triglyceride. And there were no correlation among questionnaires and abdominal fat. There were no difference between superficial and deep subcutaneous fat. Conclusion Abdominal subcutaneous fat including superficial and deep did not have any correlation with heart risk factor. superficial and deep subcutaneous fat had no differences with each other and they did not show any correlation with visceral fat in obese perimenopausal Korean women.

• YAKHAK HOEJI
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• v.43 no.6
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• pp.729-735
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• 1999

Scopolia rhizome is mistaken as an atractylodes rhizome because of their similarities in shape. That is why atractylodes rhizome imported from China sometimes contain scopolia rhizome, which is very toxic. 8 persons were intoxicated atractylodes after taking imported atractylodes rhizome which is tainted. In kampo medicine prepared with such imported atractylodes rhizome, the level of tropane alkaloids ranged from 1.12∼4.34 mg/dose. In this study, we tried to investigate the tissue distribution of scopolia rhizome in rats. The extracts of scopolia was administered orally to rats (a single dose of 10mg/kg, 20mg/kg and 7 days repeated dose of 10mg/kg). Their blood was collected at 0.5, 1, 2, 4, 6 hrs, and liver, kidney, lung and spleen were collected after 6 hrs. The tissue homogenate was applied to solid phase extraction column for the determination of tropane alkaloids. After the oral administration of 20mg/kg scopolia extracts, l-hyoscyamine was detected in rat blood to 2 hrs after dosing. The concentration of tropane alkaloids was the highest in liver followed by lung, kidney and spleen. However, lung, kidney and spleen were similar in amount.

• Journal of Pharmaceutical Investigation
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• v.33 no.4
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• pp.287-292
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• 2003

A novel antitumor agent, antibody-endostatin fusion protein $(anti-HER2/neu\;IgG3C_H3-Endostatin,\;AEFP)$ formed by genetic engineering procedure from antibody (Ab) which specifically targets to tumor cells ad angiogenesis inhibitor, endostatin (Endo) that has excellent antitumor effect, minimizes the toxicity of normal cells and selectively kills only tumor cells. The purpose of this study is to evaluate the phamacokinetic parameters and to analyze the localization of AEFP. After an intravenous injection of $150\;{\mu}l\;(5\;{\mu}Ci)\;[^{125}I]Ab,\;[^{125}I]AEFP$ to mice, blood was collected though retroorbital plexus from 15 min to 2880 min. Following the jugular vein injetion of $150\;{\mu}l\;(10\;{\mu}Ci)\;[^{125}I]Endo$, blood was collected by the use of carotid artery cannulation from 0.25 min to 30 min. Consequently, Endo was very rapidly removed from plasma compartment within 30 min. On the other hand, AEFP similar to Ab was slowly cleared from plasma. Also, Endo was metabolized about 40% within 30 min. However, AEFP was shown to metabolize less than 10% within 2880 min. The organ distribution of Endo was in order kidney, lung, spleen. Both Ab and AEFP were localized in order spleen, kidney, liver. Futhermore the tumor/blood distribution ratio of AEFP at 96 hours after injection is about 20 times higher than it of Endo at one hour after injection. In conclusion, these studies demonstrate that the anti-cancer or suppression of angiogenesis effect of Endo may be improved by the use of AEFP because the longer half life and stability of AEFP is able to selectively target antigens expressed on tumors.

• Journal of the Korean Society of Food Science and Nutrition
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• v.11 no.2
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• pp.27-30
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• 1982

The effect of magnesium on the electrolytes distribution and transport in mice was studied using isocalorie and isonitrogenous diets added magnesium salt. The results are summarized as follows: 1. The body weight was the highest value in group C fed with basal diet and 0.4 mg of magnesium per day rather than others. 2. In blood plasma tile content of sodium of group B was higher than others in both male and female. The content of potassium of group B was higher than others in female, and the content of calcium of group B in female and group D in male was higher than others in blood plasma. 3. In case of muscle the content of sodium of group B was higher than others in both male and female. The content of potassium of group B was higher than others in female, but of group C was higher than others in male. The content of calcium of group B was higher than others in female, but of group D was higher than others in male. 4. Magnesium effect on the distribution electrolytes such as sodium, potassium and calcium ions in muscle and blood vessel.

• Journal of Preventive Medicine and Public Health
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• v.32 no.3
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• pp.395-399
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• 1999

Backgroud: Excess abdominal fat, expressed as an increased ratio of waist to hip circumferences (WHR), is independently associated with higher levels of blood pressure. Although a WHR greater than 1.0 in men has been shown to predict complications from obesity, the WHR has not been evaluated in all ethnic groups. Methods: In order to ascertain the association between WHR and classification of blood pressure and to investigate the critical value of WHR as a predictive factor of hypertension in Korean middle-aged men, we compared the mean of WHRs according to the classification of blood pressure in Seoul Cohort participants. Results: Through a surrey of direct measurement of waist and hip girth, 452 subjects were recruited from the cohort. The mean of WHR was 0.88 and its standard deviation was 0.04. The mean of WHRs was higher in the systolic blood pressure group (above 140 mmHg), diastolic blood pressure group (above 90 mmHg), and hypertension group than in the systolic blood pressure group (below 140 mmHg), diastolic blood pressure group (below 90 mmHg), and normotensive group, respectively. And WHR of above 0.89 was associated with hypertension (z-value =6.66). Conclusion: It is necessary for Korean males with WHR greater than 0.89 to recommend the primary prevention and early defection of hypertension.

• Parasites, Hosts and Diseases
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• v.56 no.2
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• pp.167-173
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• 2018

Malaria is one of the most important public health problems in tropical areas on the globe. Several factors are associated with susceptibility to malaria and disease severity, including innate immunity such as blood group, hemoglobinopathy, and heme oxygenase-1 (HO-1) polymorphisms. This study was carried out to investigate association among ABO blood group, thalassemia types and HO-1 polymorphisms in malaria. The malarial blood samples were collected from patients along the Thai-Myanmar border. Determination of ABO blood group, thalassemia variants, and HO-1 polymorphisms were performed using agglutination test, low pressure liquid chromatography and polymerase chain reaction, respectively. Plasmodium vivax was the major infected malaria species in the study samples. Distribution of ABO blood type in the malaria-infected samples was similar to that in healthy subjects, of which blood type O being most prevalent. Association between blood group A and decreased risk of severe malaria was significant. Six thalassemia types (30%) were detected, i.e., hemoglobin E (HbE), ${\beta}$-thalassemia, ${\alpha}$-thalassemia 1, ${\alpha}$-thalassemia 2, HbE with ${\alpha}$-thalassemia 2, and ${\beta}$-thalassemia with ${\alpha}$-thalassemia 2. Malaria infected samples without thalassemia showed significantly higher risk to severe malaria. The prevalence of HO-1 polymorphisms, S/S, S/L and L/L were 25, 62, and 13%, respectively. Further study with larger sample size is required to confirm the impact of these 3 host genetic factors in malaria patients.

• Korean Journal of Veterinary Service
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• v.43 no.3
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• pp.161-165
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• 2020

In order to effective treats a sick calf, it is necessary to obtain accurate information about the patient's condition. However, the standard references for Korean cattle claves are not well known. Therefore, this study aims to present useful clinical values by analyzing normal blood and diarrhea blood of Hanwoo calf. Recently, with the advent of a portable blood analyzer, it is possible to immediately analyze the patient's condition and severity in the field, not in the laboratory, and to calculate a suitable dosage for supporting fluid therapy. Therefore, in this study, the distribution of red blood cells (RBC) and white blood cells (WBC) were analyzed in normal and diarrhea Hanwoo calves. As a result, Hematocrit (HCT) levels increase significantly between 1 and 20 days in diarrhea positive calves. Changes in leukocyte composition had similar growth patterns in normal and diarrhea calves. As it grew, the proportion of neutrophils decreased and lymphocytes increased. However, the number of WBCs increased from 1 to 10 and 21 to 30 days in diarrhea positive calves, which is closely related to the increase in neutrophils. Therefore, those data can be used for diagnosis and treatment of diarrhea calf.

• Korean Journal of Veterinary Research
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• v.8 no.2
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• pp.121-124
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• 1968

For 8 months, from January to August, 1967, the author made a stuffy of blood total ketones and of korean cattle in different sexes and age groups in winter and summer. The results were summarized as follows : 1. The mean values of blood total ketones and acetone in Korean cattle were $2.31{\pm}0.18mg/dl$ and $0.76{\pm}0.10mg/dl$ in female and $2.35{\pm}0.19mg/dl$ and $0.74{\pm}0.12mg/dl$ in male respectively. 2. The mean values of blood total ketones and acetone during winter season were 2.39mg/dl and 0.84mg/dl in female, and 2.38mg/dl and 0.84mg/dl in male respectively. 3. No statistical significance was recognized among the sexes, the age groups and the seasons by F-distribution. 4. The mean values of blood total ketone and acetone during summer season were 2.25mg/dl and 0.67mg/dl in female, and 2.32mg/dl and 0.64mg/dl in male respectively.