• Korean Journal of Veterinary Research
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• v.43 no.4
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• pp.525-529
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• 2003

The phosphorylation of extracellular signal-regulated kinases (p-ERK) in the spinal cord of rats with acute monophasic experimental autoimmune encephalomyelitis (EAE) was studied using immunohistochemistry and treatment with inhibitor. P-ERK is constitutively expressed in glial cells in the normal spinal cord. In EAE, some inflammatory cells in the subarachnoid space were positive for p-ERK at the early stage, and its immunoreactivity declined when those cells infiltrated the parenchyma at the peak stage. In a blocking experiment using its inhibitor, the intravenous administration of PD98059 from day 7 to 13 post-immunization did not modulate EAE paralysis. Considering the results, we postulate that intravenous administration of PD98059 is not effective in ameliorating EAE paralysis, although many inflammatory cells express ERK in the subarachnoid space.

• Archives of Pharmacal Research
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• v.25 no.5
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• pp.561-571
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• 2002

The action mechanisms of several chemopreventive agents derived from herbal medicine and edible plants have become attractive issues in cancer research. Tea is the most widely consumed beverage worldwide. Recently, the cancer chemopreventive actions of tea have been intensively investigated. It have been demonstrated that the active principles of tea were attributed to their tea polyphenols. Recently, tremendous progress has been made in elucidating the molecular mechanisms of cancer chemoprevention by tea and tea polyphenols. The suppression of various tumor biomarkers including growth factor receptor tyrosine kinases, cytokine receptor kinases, P13K, phosphatases, ras, raf, MAPK cascades, NㆍFB, IㆍB kinase, PKA, PKB, PKC, c-jun, c-fos, c-myc, cdks, cyclins, and related transducing proteins by tea polyphenols has been studied in our laboratory and others. The IㆍB kinase (IKK) activity in LPS-activated murine macrophages (RAW 264.7 cells) was found to be inhibited by various tea polyphenols including (-) epigallocatechin-3-gallate (EGCG), theaflavin (TF-1), theaflavin-3-gal-late (TF-2) and theaflavin-3,3'-digallate (TF-3). TF-3 inhibited IKK activity in activated macrophages more strongly than did the other tea polyphenols. TF-3 inhibited both IKK1 and IKK2 activity and prevented the degradation of IㆍBㆍand IㆍBㆍin activated macrophage cells. The results suggested that the inhibition of IKK activity by TF-3 and other tea polyphenols could occur by a direct effect on IKKs or on upstream events in the signal transduction pathway. TF-3 and other tea polyphenols blocked phosphorylation of IB from the cytosolic fraction, inhibited NFB activity and inhibited increases in inducible nitric oxide synthase levels in activated macrophage. TF-3 and other tea polyphenols also inhibited strongly the activities of xanthine oxidase, cyclooxygenase, EGF-receptor tyrosine kinase and protein kinase C. These results suggest that TF-3 and other tea polyphenols may exert their cancer chemoprevention through suppressing tumor promotion and inflammation by blocking signal transduction. The mechanisms of this inhibition may be due to the blockade of the mitogenic and differentiating signals through modulating EGFR function, MAPK cascades, NFkB activation as wll as c-myc, c-jun and c-fos expression.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.37 no.5B
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• pp.338-347
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• 2012

In this paper, we propose the cooperative transmission scheme (CTS) for system throughput maximization in OFDMA based enterprise femtocell networks. In our scheme, the user equipment (UE) can receive the desired signal from serving femtocell BS (fBS) as well as an adjacent fBS. Thus, UE achieves an improved signal to interference plus and noise ratio (SINR) by the synchronized two signals. The performances of this strategy consider not only the call-level quality of service (QoS) but also the packet-level QoS. We first measure the call blocking probability and utilization for the downlink resources for various offered load in femtocell. Based on that, the outage probability and effective throughput of the system are simulated. Simulation results show that the proposed scheme can reduce the outage probability for enterprise femtocell compared with conventional systems.

• The Journal of the Acoustical Society of Korea
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• v.33 no.1
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• pp.54-59
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• 2014

Identification of RTF (Relative Transfer Function) between sensors is essential to multichannel speech enhancement system. In this paper, we present an approach for estimating the relative transfer function of speech signal. This method adapts a CASA (Computational Auditory Scene Analysis) technique to the conventional OM-LSA (Optimally-Modified Log-Spectral Amplitude) based approach. Evaluation of the proposed approach is performed under simulated stationary and nonstationary WGN (White Gaussian Noise). Experimental results confirm advantages of the proposed approach.

• Korean Journal of Pharmacognosy
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• v.30 no.4
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• pp.404-408
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• 1999

SH2 domains and their associated catalytic or noncatalytic proteins constitute critical signal transduction targets for drug discovery. Grb2 associates with phosphotyrosine sites of the activated receptors or Shc via their SH2 domain to link receptor tyrosine kinases to ras signalling. Blocking of the Grb2-Shc complex may be to intervene the oncogenic signal transduction pathways and to develop a new antitumor drug. In the search for blockers of Grb2 SH2-Shc interaction, Lutein, a family of carotenoids, was isolated from the extract of the leaf of Agastache rugosa O. Kuntze as SH2 domain antagonists. The $IC_{50}$ of Lutein against Grb2-Shc binding was $6.8\;{\mu}M$.

• Journal of Korea Multimedia Society
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• v.6 no.1
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• pp.105-113
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• 2003

In CDMA cellular system, inefficient Channel assignment for high-speed mobile host increase call blocking probability For it has been method proposed to guarantee QoS upon tn the speed of hierarchical cell that is allocated Queues and dedicated channels of high speed mobile host's speed. In this paper, We allocated the dedicated channel of high-speed handoff In FA (Foreign Agent), only if the receive signal strength of mobile host in current cell that there is low traffic in HA (Home Agent). also, we created new Circular queue LiFA (Limited Foreign Agent) for high-speed handoff call that signal strength is weak in certain FA, and had this High-speed handoff call to be ready for Life time to the new Circular queue LiFA. Thus improve the rate of the forced call termination.

• Archives of Pharmacal Research
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• v.28 no.1
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• pp.1-15
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• 2005

Cancer is still a major global health concern even after an everlasting strive in conquering this dread disease. Emphasis is now given to chemoprevention to reduce the risk of cancer and also to improve the quality of life among cancer afflicted individuals. Recent progress in molecular biology of cancer has identified key components of the cellular signaling network, whose functional abnormality results in undesired alterations in cellular homeostasis, creating a cellular microenvironment that favors premalignant and malignant transformation. Multiple lines of evidence suggest an elevated expression of cyclooxygenase-2 (COX-2) is causally linked to cancer. In response to oxidative/pro-inflammatory stimuli, turning on unusual signaling arrays mediated through diverse classes of kinases and transcription factors results in aberrant expression of COX-2. Population-based as well as laboratory studies have explored a broad spectrum of chemopreventive agents including selective COX-2 inhibitors and a wide variety of anti-inflammatory phytochemicals, which have been shown to target cellular signaling molecules as underlying mechanisms of chemoprevention. Thus, unraveling signaling pathways regulating aberrant COX-2 expression and targeted blocking of one or more components of those signal cascades may be exploited in searching chemopreventive agents in the future.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.38 no.1
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• pp.43-53
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• 2001

WT(Wavelet Transform) is used to avoid blocking effect that is the disadvantage of JPEG using DCT(Discrete Cosine Transform). Because the proposed coding scheme is the same as JPEG, the proposed algorithm is compatible with that of JPEG. To achieve the goal, WT'ed image is reconstructed into 8$\times$8 coding block. Each coding block is quantized with the proposed weighting matrix that is derived from human visual characteristic and error analysis in WT'ed domain. By experiments, the proposed algorithm is superior to JPEG, in terms of PSNR(Peak Signal to Noise Ratio) and WMSE(Weighted Mean Square Error).

• Natural Product Sciences
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• v.23 no.1
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• pp.1-4
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• 2017

Sinensetin, a pentamethoxyflavone, is known to exert various pharmacological activities including anti-angiogenesis, anti-diabetic and anti-inflammatory activities. However, its effects on the human mast cell - 1 (HMC-1) mediated inflammatory mechanism remain unknown. To explore the mediator and cellular inflammatory response of sinensetin, we examined its influence on phorbol 12-myristate 13-acetate (PMA) plus A23187 induced inflammatory mediator production in a human mast cell line. In this study, interleukin (IL)-6 production was measured using the enzyme-linked immunosorbent assay and reverse transcription polymerase chain reaction. Sinensetin inhibited PMA plus A23187 induced IL-6 production in a dose-dependent manner as well as IL-4, IL-5 and IL-8 mRNA expression. Furthermore, sinensetin inhibited signal transducer and activator of transcription 3 (STAT3) phosphorylation, suggesting that sinensetin inhibits the production of inflammatory mediators by blocking STAT3 phosphorylation. Moreover, sinensetin was found to inhibit nuclear factor kappa B activation. These findings suggest that sinensetin may be involved in the regulation of mast cell-mediated inflammatory responses.

• The KIPS Transactions:PartC
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• v.13C no.3 s.106
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• pp.323-330
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• 2006

This paper proposes a handoff time decision mechanism to utilize resource efficiently by using Differential Received Signal Strength Indicator (DRSSI). DRSSI can be used to predict the movement direction of Mobile Station (MS). In other words, DRSSI changes its sign (+ or -) when a MS changes movement direction. This mechanism maximizes resource availability of Base Station (BS) by predicting resource reservation of MS and by giving priority of resource to MS. It is possible when a BS predicts the behavior of MSs by monitoring the DRSSI of MSs in overlapped region among cells. Additionally, we show that our proposed mechanism has better handoff blocking probability than existing mechanism with numerical modeling and analysis.