• Asian Pacific Journal of Cancer Prevention
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• 제15권4호
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• pp.1831-1835
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• 2014

Background: To investigate the relationship between extracellular matrix parameters and texture of prostatic lesions evaluated by transrectal real-time tissue elastography (TRTE). Methods: 120 patients suspicious for prostate cancer underwent TRTE. Targeted biopsies were carried out after 12-core systematic biopsy. Epithelia were stained with hematoxylin-eosin, and Victoria blue and Ponceau S were used to stain elastic-collagen fibers, and picric acid-sirius red for visualization of collagen type I (Col1) and III (Col3). Smooth muscles were visualized by immunohistochemistry. All image analyses were performed in a blind manner using Image Pro Plus 6.0, and the area ratios of epithelium, elastic fibers, collagen fibers and Col1/Col3 were determined. Results: 42 patients with typical elastograms were included in the final data analysis. Significant differences were detected between the benign and malignant groups in the area ratios of epithelium (P = 0.01), smooth muscles and Col1/Col3 (P = 0.04, P = 0.02, respectively). There were no significant differences in the area ratios of epithelium, smooth muscle and elastic fibers between the stiff and soft lesion groups. The area ratio of Col1 was ($0.05{\pm}0.03$) in the stiff group, and ($0.02{\pm}0.01$) in the soft group (P= 0.00). However, the area ratio of Col3 was ($0.03{\pm}0.02$) in the stiff group, and ($0.05{\pm}0.04$) in the soft group (P = 0.16). Col1/Col3 in the stiff group ($1.99{\pm}1.59$) was greater than in the soft group ($0.71{\pm}0.64$) (P = 0.01). Conclusions: Tissue hardness of prostatic tumors was mainly dependent on the Col1 content, Col1/Col3 being higher in malignant than in benign lesions, so the prostate tissue texture can be used as a target for distinguishing between the two with TRTE.

• 한방재활의학과학회지
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• 제20권4호
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• pp.197-213
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• 2010

Objectives : The clinical trial was designed to investigate the safety and effects of Taeeumjowui-tang(Taiyintiaowei-tang) extracts on the change of the weight, body compositions, serum in obese patients. Methods : This was a 12-weeks, randomized, double blind, placebo-controlled clinical trial. Patients with a body mass index of either greater than $30kg/m^2$ or between 27 and $30kg/m^2$ with controlled hypertension, diabetes, hyperlipidemia were considered eligible. Participants of 41 obese patients were randomized either to Taeeumjowui-tang(Taiyintiaowei-tang)(23) or placebo(18). After 12 weeks of treatment, we measured anthropometric factors(weight, height, waist circumference, BMI(body mass index) etc.), abdominal fat area by CT(computed tomography)scanning, serum lipid(total cholesterol, tryglyceride, HDL-cholesterol, LDL-cholesterol), blood lever of variety(AST, ALT, BUN, creatinine etc.). Adverse events also evaluated. Results : After 12 weeks of treatment mean weight, waist-circumference, total cholesterol, LDL-cholesterol and score of KEAT-26 were significant changed in Taeeumjowui-tang(Taiyintiaowei-tang). There were no serious adverse events in either groups. Conclusions : There were limited in this study that is conducted within a short period of 12 weeks. but its weight and WC(waist circumference), WHR(waist hip ratio), total cholesterol, LDL-cholesterol and score of KEAT-26 loss effect was significant and it had few adverse events.

• 한방비만학회지
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• 제10권1호
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• pp.1-16
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• 2010

Objectives The clinical trial was designed to investigate the safety and effects of Bofu-tsusho-san extracts on the change of the weight, body compositions, serum in obese patients. Methods This study was a 4-weeks, double blind, comparative clinical trial. Eligible subjects had a body mass index(BMI) greater than $25\;kg/m^2$ and waist circumference(WC) longer than 85 cm in woman or 90 cm in man. Among 38 subjects, 36 subjects were randomized either to Bofu-tsusho-san or placebo. After 4 weeks of treatment, we measured anthropometric factors(weight, height, WC, BMI etc.), abdominal fat area by CT scanning, serum lipid(total cholesterol(TC), triglyceride(TG), HDL cholesterol, LDL cholesterol), blood level of variety(glucose, adiponectine, leptin, C-reactive protein(CRP) etc.), blood pressure(BP). Adverse events also evaluated. Results BMI, BP, TG, CRP were reduced and weight, WC, score of KOQOL(Korean version of obesity-related QOL scale), SRI(Stress response inventory) were significant changed in Bofu-tsusho-san. But there were no considerable difference between Bofu-tsusho-san and placebo. there were no serious adverse events in either group. Conclusion There were limitations in this study that it conducted within a short period of 4 weeks. but its weight and WC loss effect was significant and it had few adverse events.

• 한국컴퓨터정보학회논문지
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• 제16권12호
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• pp.93-102
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• 2011

본 논문은 야외 환경에서 하나의 카메라를 이용한 시각 장애인을 위한 보행 안내 시스템을 제안한다. 기존의 스테레오 비전을 이용한 보행 지원 시스템과는 다르게 제안된 시스템은 사용자의 허리에 고정된 하나의 카메라를 이용하여 꼭 필요한 정보만을 얻는 것을 목표로 하는 시스템이다. 제안하는 시스템은 먼저 탑-뷰 영상을 생성하고, 생성된 탑-뷰 영상 내 지역적인 코너 극점을 검출한다. 검출된 극점에서 방사형의 히스토그램을 분석하여 장애물을 검출한다. 그리고 사용자 움직임은 사용자에 가까운 지역 안에서 옵티컬 플로우를 사용하여 추정한다. 이렇게 영상으로부터 추출된 정보들을 기반으로 음성 메시지 생성 모듈은 보행 지시 정보를 합성된 음성을 통해 시각 장애인에게 전달한다. 다양한실험 영상들을 사용하여 제안한 보행 안내 시스템이 일반 인도에서 유용한 안내 지시를 제공하는 것이 가능함을 보인다.

• Journal of Ginseng Research
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• 제42권1호
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• pp.90-97
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• 2018

Background: Antihyperglycemic effects of Panax ginseng berry have never been explored in humans. The aims of this study were to assess the efficacy and safety of a 12-wk treatment with ginseng berry extract in participants with a fasting glucose level between 100 mg/dL and 140 mg/dL. Methods: This study was a 12-wk, randomized, double-blind, placebo-controlled clinical trial. A total of 72 participants were randomly allocated to two groups of either ginseng berry extract or placebo, and 63 participants completed the study. The parameters related to glucose metabolism were assessed. Results: Although the present study failed to show significant antihyperglycemic effects of ginseng berry extract on the parameters related to blood glucose and lipid metabolism in the total study population, it demonstrated that ginseng berry extract could significantly decrease serum concentration of fasting glucose by 3.7% (p = 0.035), postprandial glucose at 60 min during 75 g oral glucose tolerance test by 10.7% (p = 0.006), and the area under the curve for glucose by 7.7% (p = 0.024) in those with fasting glucose level of 110 mg/dL or higher, while the placebo group did not exhibit a statistically significant decrease. Safety profiles were not different between the two groups. Conclusion: The present study suggests that ginseng berry extract has the potential to improve glucose metabolism in human, especially in those with fasting glucose level of 110 mg/dL or higher. For a more meaningful benefit, further research in people with higher blood glucose levels is required.

• Journal of Acupuncture Research
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• 제36권2호
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• pp.100-106
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• 2019

Background: In Korean medicine, carpal tunnel syndrome is treated by stimulating the acupoints around the wrist. Although a deep understanding of anatomy and guidance is needed to stimulate these acupoints to avoid undesirable side-effects, currently there are no published guidelines for acupotomy treatment. The aim of this study is to evaluate the effectiveness and safety of fluoroscopy-guided acupotomy compared with conventional acupotomy treatment. Methods: This is a randomized, patient-assessor, patient blind, parallel clinical trial. A total of 30 patients will be enrolled at Wonkwang University Gwangju Hospital, and will be allocated to either an experimental group or a control group. The experimental group will be treated using fluoroscopy-guided acupotomy and the control group will be treated using the conventional acupotomy method. Results: The primary outcome measure will be identification of a cross-section area of the median nerve measured by ultrasonography, and the secondary outcome measure will be the alleviation of pain measured by the Visual Analogue Scale, improvement in the Nerve Conduction Study, Tinel test, Phalen's test, EuroQol 5-dimension scale, and Boston Carpal Tunnel Questionnaire score. Safety components will be measured by monitoring vital signs, electrocardiographs, blood tests, general chemical tests, urine tests and pregnancy tests. In addition, observations for adverse effects will be performed during the trial. Conclusion: This study will provide a more effective, and less harmful way of treating carpal tunnel syndrome compared with conventional acupotomy. Fluoroscopy-guided acupotomy will help practitioners to be accurate in direction and depth of the needle for treating carpal tunnel syndrome.

• 한국정보통신학회논문지
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• 제26권8호
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• pp.1248-1254
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• 2022

스쿨존에서 교통사고를 사전에 예방하려고 노력하고 있다. 하지만, 스쿨존 내 교통사고는 계속 발생하고 있다. 운전자가 어린이보호구역 내 상황 정보를 미리 알 수 있으면, 사고를 줄일 수 있다. 본 논문에서는 스쿨존 내 사각지대를 없애는 카메라, 사전 교통정보를 수집할 수 있는 번호인식 카메라 시스템을 설계한다. 차량속도 및 보행자를 인식하는 LIDAR 시스템을 개선하여 설계한다. 카메라 및 LIDAR에서 인식된 보행자 및 차량 영상 정보를 수집하고 가공하여, 인공지능 시계열 분석 및 인공지능 알고리즘을 적용한다. 본 논문에서 제안한 딥러닝으로 학습된 인공지능 교통사고 예방 시스템은, 스쿨존 진입 전 차량 내 모바일 장치에 스쿨존의 정보를 운전자에게 전달하는 강제 푸시서비스를 한다. 그리고 LED 안내판에 스쿨존 교통정보를 알람으로 제공한다.

• 한국농촌건축학회논문집
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• 제15권4호
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• pp.43-50
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• 2013

This study is to clarify the characteristics and its change of spatial elements for community focused on the existing 22 old settlements in urban area of Cheongju. These community spaces are mainly divided into three parts, that is central space, inner road, and blind alley(cul-de-sac). The transitional characteristics of them are as follows. Firstly, the characteristics of central spaces is lasting, but the function is influenced by changing times. The function of central spaces located at the entrance to the village had been reduced to adjustments to modern lifestyle, and currently changed into senior citizen community center, supermarket, and public area. Secondly, as the width of the existing inner roads passed through old settlements had been extended, they are changed into pedestrian and traffic road, but the shape and function of them have been maintained. When new roads passed through old settlements had been established, the shape of old inner roads is disappeared, and the function of them is changed into byway and alley. Thirdly, cul-de-sacs of old settlements have tended to create a sense of community, but new cul-de-sacs formed by lot division have been only changed to passage. When new roads are established and cul-de-sacs are changed into alleys, the community between individual households is lost.

• 재활복지공학회논문지
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• 제11권2호
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• pp.99-105
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• 2017

본 논문에서는 국내의 효과적인 AAC 서비스 전달체계 수립방안 논의를 위해 미국과 한국의 AAC 서비스 전달체계 현황을 비교 분석하였다. 비교 분석을 통해 본문에서 제안한 'AAC 서비스 전달체계 모델'은 현재 정부나 각 기관에서 운영하고 있는 AAC 서비스 전달체계 관련 공적급여의 방식을 최대한 유지하면서 AAC 지원체계의 사각지대가 발생하지 않도록 현재의 방식에서 부족한 부분을 추가 보완하는 형태로 구성하였다. 제언 및 시사점으로는 현재 공적급여에서 제한적으로 지원하고 있는 AAC 보조기기 품목을 대폭 확대하고 전국에 설치되어 있는 보조기기센터, 특수교육 지원센터, 발달장애인 지원센터, 언어치료실 등을 활용한 인프라 구축을 통해 사각지대가 없는 보편적인 AAC 서비스의 제공이 필요하며. 관련 협회 및 학회 차원에서 AAC 서비스를 제공할 수 있는 전문가 연수 및 보수교육과 같은 인력 관리에도 많은 노력이 필요하다.

• Transactions on Electrical and Electronic Materials
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• 제7권5호
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• pp.252-256
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• 2006

When a partial discharge takes place at the stator of a generator, the electrical pulse will propagate along the stator bars and the capacitor chains formed by the end part of the stator winds. On the first path, the pulse propagates as a travel wave at slow speed. On the second path, the pulse propagates at quick speed. Based on the data of the experiments on a real 50 MW steam generator, the author has found the pulses can propagate by magnetic field of the stator winding. It was studied that how to locating the partial discharge by signals coming from the different paths, including the features of signals on the two paths at time domain and frequency domain, the measurement frequency rang of the signals, the blind area, the advantage and disadvantage of this method.