• Journal of Chest Surgery
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• 제26권1호
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• pp.54-58
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• 1993

Simultaneous bilateral bleb resection was done through bilateral transaxillary thoracotomy in 10 patients with spontaneous pneumothorax during the period from May 1991 to Novemver 1992 in whom bilateral bulla or bleb was detected with using simple chest X-ray and chest CT scanning. To compare the effectiveness of bilateral transaxillary thoracotomy, we investigated 10 unilateral transaxillary thoracotomy patients with spontaneous pneumothorax and two clinical reports from other institutes which dealt the results of bilateral bleb or bulla resection through median sternotomy also. In bilateral transaxillary thoracotomy group,mean operation time was 115 minute,mean intraoperative bleeding was 329 cc, mean postoperative hospital stay was 7.5 days. Postoperative ABGA[Arterial Blood Gas Analysis] was in normal range and postoperative recovery rates of FVC[Forced Vital Capacity], FEV1[Forced Expiratory Volume at 1 second], TV[Tidal Volume] were 84.3%, 93.4%, 88.7%,respectively. In median sternotomy group,mean operation time was 129 minute,mean intraoperative bleeding was 490 cc, mean postoperative hospital stay was 12.4 days. Postoperative ABGA was in normal range and postoperative recovery rates of FVC, FEV1 were 97.3%, 97.4%, respectively. In unilateral transaxillary thoracotomy group, postoperative ABGA was in normal range also and postoperative recovery rates of FVC, FEV1, TV were 91.6%, 99.0%, 96.0%,respectively. In conclusion, simultaneous bilateral bleb resection through bilateral transaxillary thoracotomy should be considered in pneumothorax patients with bilateral bleb or bulla because of cost-effectiveness[reducing hospital days] and better cosmetic result without any impairment in recovery of respiratory function.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제11권2호
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• pp.198-203
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• 2008

저자들은 만성적인 철결핍성 빈혈을 보이는 10세 여아에서, 캡슐내시경을 비롯한 내시경적 검사로 위장관계의 다발성 정맥기형을 발견하여 blue rubber bleb nevus syndrome으로 진단하였고, 광범위한 외과적 절제술로 성공적으로 치료하였기에 이에 보고하는 바이다.

• Journal of Chest Surgery
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• 제26권1호
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• pp.44-46
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• 1993

There are several methods for managing pneumothorax through thoracoscope. Among them, electric cautery of bleb or bulla is very simple to do and can be done through the conventional thoracoscope. It is cosmetically excellent because it needs only incision. It is economically cheap comparing other methods because it does not need staplers or clips and other disposables. However, this method has been controversial for its success rate because of the ability of sealing off the air-leaking from the lung tissue. To evaluate the success rate, 29 cases of pneumothorax treated by electric cautery and instillation of oxytetracyline solution through the thoracoscope were analyzed. Among 29 patients, 18 were male and 11 female ranging 17 to 43 years old. The indications for thoracoscopy were recurrence in 20 cases and persistence in 9 cases. The underlying casuses of pneumothorax were bleb in 10 cases and bulla with bleb or not in 19 cases. Twenty one cases were successful [4%] and 8 cases were failed. The failed 8 cases were explored from 14 to 28 days after thoracoscopy.Six cases were explored through transaxillary minithoracotomy and 2 were done through limited posterolateral thoracotomy. The causes of failure were the necrotic lung tissue occured by excessive electric cautery in 6 cases and the necrotic lung tissue and residual bulla in two cases. In 10 bleb cases, 9 were successful [90.0%]. But in 19 cases of bulla, 12 were successful [63.2%]. In conclusion, the success rate of electric cautery through thoracoscope was 72. 4% and the causes of failure were lung necrosis and residual bulla. The success rate of the bleb cases was higher than that of the bulla cases.

• 약학회지
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• 제37권6호
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• pp.598-604
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• 1993

The calyx extract of Campsis grandiflora displayed inhibitory activity against protein kinase C from the bovine brain. Separation guided by protein kinase C enzyme assay and bleb forming assay led to isolation of a potent protein kinase C inhibitor that was identified as a known phenylpropanoid glycoside, verbascoside. It suppressed completely bleb-formation of K562 cell surface induced by phorbol 12,13-dibutylate at the concentration of 60 $\mu\textrm{g}$/ml and IC$_{50}$ of the protein kinase C occured at 20 $\mu{M}$. This compound was tested for cytotoxic activity against ten human tumor cell lines in vitro. it exhibited moderate cytotoxic activity against skin tumor cell line M14 (IC$_{50}$ 2.2 $\mu\textrm{g}$/ml) and very weak cytotoxicity against other cell lines (IC$_{50}$>10 $\mu\textrm{g}$/ml)

• Journal of Microbiology and Biotechnology
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• 제8권6호
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• pp.705-709
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• 1998

In the course of screening for the substances suppressing bleb formation of K562 cell induced by phorbol 12, 13-dibutyrate (PDBu), an inhibitor, chaetoglobosin A (CgA) was isolated from a cultured broth of unidentified fungus. CgA showed a strong inhibitory activity with the $IC_{50}$ value of 60 pM against bleb formation on K562 cells induced by PDBu, but it did not inhibit the activity of protein kinase C (PKC) in vitro. The inhibitory activity of CgA might be due to the modulation of actin filaments on the cell membrane. CgA exhibited strong cytotoxicity against various human cancer cell lines.

• Journal of Chest Surgery
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• 제43권2호
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• pp.133-138
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• 2010

배경: 비디오 흉강경을 이용한 수술법은 자연 기흉의 효과적인 치료 방법으로 받아들여지고 있다. 수술방법은 자동봉합기를 이용한 폐쐐기 절제술, 폐기포 결찰술, 늑막유착술 등을 복합적으로 사용할 수 있다. 대상 및 방법: 2002년 2월부터 2006년 6월까지 일차 자연 기흉으로 흉강경하 폐기포결찰술을 시행한 89명의 의무기록을 후향적으로 분석하였다. 평균 65개월 동안 추적하여 재발 여부를 조사하였다. 결과: 폐기포 결찰술에 의한 일차자연기흉의 치료 후에 추적 기간 중 7명(8%)에서 기흉이 재발하였다. 결론: 일차 자연 기흉의 치료볍으로서 흉강경 폐기포 결찰술은 유용한 수술 방법으로 사료된다.

• 한국미생물·생명공학회지
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• 제21권1호
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• pp.54-58
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• 1993

미생물 대사산물로부터 phorbol ester에 의해 유도되는 K562 세포 표면의 소포형성 및 Protein kinase C(PKC)에 대한 저해제를 탐색하여 방선균 분리주 No.2007-18로 부터 용매추출 및 크로마토그래피의 기법을 이용하여 MT-2007을 분리하였다. MT-2007는 503.9MuM의 농도에서 phorbol 12,13-dibutylate에 의해 유도된 K562 세포표면의 bleb형성을 완전히 저해하였고, PKC 효소의 IC50 값은 31.4 MuM 이었다.

• Journal of Chest Surgery
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• 제32권4호
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• pp.383-387
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• 1999

배경: 일차성 자연기흉은 대개 기포가 터져서 발생하며 상당수에서 재발이 되는 것으로 알려져 있다. 그러나 단순 흉부촬영에서 기포의 발견률은 높지 않다. 이에 저자들은 고해상CT를 이용하여 치료방향 설정과 수술적 치료시 지침을 제공하고, 단순촬영에서 찾을 수 없으나 재발의 원인이 될 수 있는 숨겨진 기포를 숙지하기위해 이 연구를 시행하였다. 대상 및 방법: 외상성 기흉을 제외한 70명의 자연기흉 환자들을 대상으로 고해상 CT를 시행하여 병변측 및 반대측의 기포의 유무, 개수, 동반된 폐질환, 그리고 치료의 종류와 빈도를 후향적으로 분석하였다. 결과: 70명의 대상군중 45명은 원인질환이 분명하지 않은 일차성이었고 25명은 폐결핵에 의한 이차성으로 모두 이전에 앓은 후유증의 소견들을 보였으며 활동성 폐결핵의 소견을 보인 경우는 없었다. 일차성과 이차성 기흉의 평균 연령은 각각 25.9세와 44.1세로 일차성에서 더 젊었다. 단순촬영에서는 30.2%에서 기포를 찾을 수 있었다. 고해상 CT에서는 75.7%에서 기포를 찾을 수 있었고(병변측에 68.6%, 반대측에 55.7%) 48.6%에서는 양쪽폐에서 관찰되었다. 기포의 개수가 10개이상으로 다발성인 경우는 이차성 기흉에서 일차성 기흉에서보다 더 흔히 관찰되었다. 대부분의 환자을 흉강삽관술(36명)이나 기포제거술(27명)로 치료하였다. 결론: 자연기흉환자들에서 고해상 CT가 단순촬영보다 동반된 기포를 찾는데 훨씬 더 우수하였고 동반 질환의 평가에도 유용하였다. 따라서 고해상CT가 재발의 고위험군등에서 재발을 막는 예방적 치료를 결정하는등 치료방법의 선택에 도움을 줄 수 있고, 수술적 치료시 수술의 지침을 제공할 수도 있으며 나아가 재발의 원인이 될 수 있는 잠복된 기포를 환자에 주지시킬 수 있다는 점에서 큰 도움이 될 것으로 생각한다.

• 생약학회지
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• 제23권3호
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• pp.142-145
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• 1992

MeOH extract of twenty medicinal herbs were screened for their effects against protein kinase C (PKC) using bleb-forming assay and PKC enzyme assay. Smilax china and Sanguisorba officinalis showed potent anti-PKC activity. Campsis grandiflora and Galla Halepensis showed moderate inhibitory effect on PKC.

• Journal of Chest Surgery
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• 제18권4호
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• pp.835-839
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• 1985

Spontaneous pneumothorax is the sudden collapse of a lung usually caused by air leaking from a sub-visceral pleural bleb. Response to closed thoracotomy, needle aspiration and simple observation is usually prompt and effective. But in some cases, these are unsuccessful and open thoracotomy is indicated. Author reviewed 37 cases of open thoracotomy in spontaneous pneumothorax experienced in the Dept. of Thoracic and Cardiovascular Surgery, Pusan National University Hospital, since Jan., 1980 to Dec., 1984. The results were as follows: 1. The causes of spontaneous pneumothorax: 73.0% was primary, 27.0% was secondary origin. 2. The most frequent age group of the patient: Between 11 and 30 years old. 3. All of te patient were male. 4. The side of open thoracotomy: 58.8% was right side, 8.8% was both side. 5. The most common indication of open thoracotomy; Persistent air leakage. 6. The most frequent sites of bleb or bullae: A-P segment in the L.U.L. and apical segment in the R.U.L.