• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.26 no.12
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• pp.588-593
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• 2014

To maintain a negative pressure, the supply, exhaust airvolume are adjusted by setting volume damper and the infiltration through leakage area of the door between rooms in biosafety laboratory. Multizone simulation is useful way to predict room pressure, supply and exhaust air volume. But in a particular room, local change such as airflow and contaminants concentration distribution can not be evaluated unfortunately. Through this study, a coupled multizone and CFD simulation was performed, indoor air flow and local contaminants concentration distribution in a particular room of BSL lab are predicted. The results show that all zones of BSL lab are well ventilated by unidirectional flow without local stagnation. In addition, in case that unexpected biohazard is occured in BSL lab, multizone simulation results about the spread of pollutants along movement of the occupant also show that contaminants concentration is removing totally without the spread of the outside. In conclusion, a coupled multizone and CFD simulation can be applied to interpret differential pressure in room and local change of physical quantity in a particular room such as airflow and Influenza A contaminants concentration distribution. This simulation method is useful to enhance the reliability and accuracy of biosafety laboratory design.

• Journal of The Korea Institute of Healthcare Architecture
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• v.17 no.1
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• pp.23-32
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• 2011

Recently, with the advent of high risk infectious agent such as the Ebola virus, SARS, special research facilities dealing with such dangerous pathogenic are drawing attention gradually. Especially, this kind of facilities can be called BL4(Biosafety Level 4) facility. At the moment, Korean government is going to construct BL4 institute in order to handle efficiently such kind of pathogen. However, there are no proper design guidelines for BL4 facility. This paper proposes circulation system of BL4 facility on the basis of analysis of existing BL4 guidelines of Canada, and Korean BL3 facilities. The outcomes of this study are as follows. At first, functional areas of BL4 facilities have been divided into three categories according to the hazard level ; dangerous area, transitional area, and ordinary area. Secondly, circulation system of BL4 facility has been explored as a form of diagram according to the circulating subjects. These include human, laboratory animals, hazardous pathogen, equipments and cloth. This study has some limitations in that it lacks empirical evidences and concrete SOPs(Standard Operating Procedure). Despite of some weaknesses, it is expected to give some preliminary guidelines for the design of circulation system in BL4 facilities.

• Journal of Ginseng Research
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• v.45 no.1
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• pp.41-47
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• 2021

A wide range of studies have steadily pointed out the relation of oxidative stress to the primary and secondary causes of human disease and aging. As such, there have been multiple misconceptions about oxidative stress. Most of reactive oxygen species (ROS) generated from chronic diseases cause oxidative damage to cell membrane lipids and proteins. ROS production is increased by abnormal stimulation inside and outside in the body, and even though ROS are generated in cells in response to abnormal metabolic processes such as disease, it does not mean that they directly contribute to the pathogenesis of a disease. Therefore, the focus of treatment should not be on ROS production itself but on the prevention and treatment of diseases linked to ROS production, including types 1 and 2 diabetes, cancer, heart disease, schizophrenia, Parkinson's disease, and Alzheimer's disease. In this regard, Korean Red Ginseng (KRG) has been traditionally utilized to help prevent and treat diseases such as diabetes, cancer, inflammation, nervous system diseases, cardiovascular disease, and hyperlipidemia. Therefore, this review was intended to summarize in vivo animal and human clinical studies on the antioxidant activities of KRG and its components, ginsenosides.

• International conference on construction engineering and project management
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• 2005.10a
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• pp.627-632
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• 2005

The severe acute respiratory syndrome -SARS virus spreaded rapidly in Asia in 2003 caused a lethal and serious epidemic. Establishing special isolation wards of high-level epidemic prevention has becomes one of the most important tasks of epidemic prevention. Taking the biosafety level of US CDC biology laboratory as an example, the laboratory of the highest level, BL4 and that of the second high level, BL3 are only allowed to handle and research this kind of highly dangerous viruses safely, to ensure the safety of researchers and the surrounding environment.This research aims to study the functions and the design requirements of "special isolation wards", which is equivalent to the high-level biotechnology laboratory, and have an integrated discussion about the design and construction techniques of this kind of wards, expecting to provide a reference for constructing special isolation wards and maintaining operation safely in Taiwan.

• Safety and Health at Work
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• v.6 no.4
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• pp.353-356
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• 2015

Background: In 2012, the Alaska Section of Epidemiology investigated personnel potentially exposed to a Brucella suis isolate as it transited through three laboratories. Methods: We summarize the first implementation of the United States Centers for Disease Control and Prevention 2013 revised recommendations for monitoring such exposures: (1) risk classification; (2) antimicrobial postexposure prophylaxis; (3) serologic monitoring; and (4) symptom surveillance. Results: Over 30 people were assessed for exposure and subsequently monitored for development of illness. No cases of laboratory-associated brucellosis occurred. Changes were made to gaps in laboratory biosafety practices that had been identified in the investigation. Conclusion: Achieving full compliance for the precise schedule of serologic monitoring was challenging and resource intensive for the laboratory performing testing. More refined exposure assessments could inform decision making for follow-up to maximize likelihood of detecting persons at risk while not overtaxing resources.

• Proceedings of the SAREK Conference
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• 2009.06a
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• pp.874-879
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• 2009

• Air Cleaning Technology
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• v.29 no.2
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• pp.11-20
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• 2016

• Korean Journal of Clinical Laboratory Science
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• v.53 no.2
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• pp.199-200
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• 2021

• Proceedings of the SAREK Conference
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• 2009.06a
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• pp.1014-1019
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• 2009

The optimal control system for heat source and HVAC system has been developed for minimizing energy consumption while maintaining the comfort of indoor thermal environment in terms of the environmental variables such as time varying indoor load and outdoor temperatures. The optimal set-points of control parameters are supply air temperature and chilled or hot water temperatures. The optimal control study has been implemented for biosafety laboratory by using TRNSYS simulation program in order to investigate energy performance for heat source and HVAC system.

• Proceedings of the SAREK Conference
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• 2009.06a
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• pp.745-750
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• 2009

In Korea, since the implementation of the GMO Law, the intrest of biosafety level 3(BL3) lab. is increasing. In this study, using CONTAM which is applying multizone modelling, the multizone simulation for design verification of BL3 lab. was performed. In BL3 lab., because required air change rate is greater than general estimated air-conditioning load and it is difficult to maintain room pressure difference efficiently, to maintain pressure difference between laboratory rooms is important through sealing condition of doors and proper airflow control of laboratory rooms. In this study, about BL3 lab.(M. tuberculosis research lab.), the multizone simulation for four kind of biohazard scenarios was performed in the case of unexpected spread of contaminants in the laboratory room, anteroom, corridor and inside of BSC. Multizone simulation results show that these approach methods are used as a tool for the design and verification of BL3 lab.