• Proceedings of the Ginseng society Conference
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• 2007.05a
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• pp.18-18
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• 2007

• Proceedings of the Korean Magnestics Society Conference
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• 2008.12a
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• pp.95-95
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• 2008

• Journal of Ginseng Research
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• v.47 no.6
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• pp.686-686
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• 2023

• Korean Circulation Journal
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• v.53 no.11
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• pp.793-793
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• 2023

• The Korean journal of internal medicine
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• v.39 no.3
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• pp.371-372
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• 2024

• Korean Circulation Journal
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• v.54 no.6
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• pp.336-338
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• 2024

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.13
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• pp.5111-5116
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• 2014

Computed Tomography Colonography (CTC) is a medical imaging technology used in identifying polyps and colon cancer masses in the large intestine. The technique has evolved a great deal since its invention and has become a routine diagnostic procedure in Western countries due to its non invasiveness and ease of use. The objective of our study was to explore the possibility of CTC application in Indian hospitals. This paper gives an overview of the procedure and its commercial viability. The explanation begins with the domain aspects from gastroenterologist perspective, the new way of thinking in polyp classification, the technical components of CTC procedure, and how engineering solutions have helped clinicians in solving the complexities involved in colon diagnosis. The colon cancer statistics in India and the results of single institution study we carried out with retrospective data is explained. By considering the increasing number of patients developing colon malignancies, the practicality of CTC in Indian hospitals is discussed. This paper does not reveal any technical aspects (algorithms) of engineering solutions implemented in CTC.

• Biomedical Science Letters
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• v.27 no.3
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• pp.134-141
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• 2021

c-Jun N-terminal kinases (JNKs) have a Janus face, regulating both cell apoptosis and survival. The present study focused on understanding the function of JNK in tumor development and the chemoresistance underlying JNK-mediated cancer cell survival. We identified an inhibitor of JNK1, an important regulator of cancer cell survival. Kinase assay data showed that JNK1-dependent c-Jun phosphorylation was inhibited by indirubin derivatives. In particular, indirubin-3-monoxime (I3M) directly inhibited the phosphorylation of c-Jun in vitro, with a half inhibition dose (IC₅₀) of 10 nM. I3M had a significant inhibitory effect on JNK1 activity. Furthermore, we carried out assays to determine the viability, migration, and proliferation of breast cancer cells. Our results demonstrated that cell growth, scratched wound healing, and colony forming abilities were inhibited by the JNK inhibitor SP600125 and I3M. The combination of SP600125 and I3M significantly decreased cancer cell proliferation, compared with either SP600125 or I3M alone. Our studies may provide further support for JNK1-targeting cancer therapy using the indirubin derivative I3M in breast cancer.

• Biomedical Science Letters
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• v.25 no.2
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• pp.139-148
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• 2019

The role of electroencephalography (EEG) in the development of brain-computer interface (BCI) technology is increasing. In particular, the importance of the analysis of event related potential (ERP) in various situations is becoming more significant in BCI technology. Studies on past maze and fire situations have been difficult due to risks and realistic problems. Nowadays, according to the development of virtual reality (VR) technology, realistic maze and fire situation can be realized. In this study, ERPs (P300, and evented related negativity) were analyzed to collect objective data on case determination in an emergency situation. In order to overcome the limitations of previous methods that evaluating the EEG frequency change, ERPs were derived by setting epochs for stimulation and standardizing them, and evaluated for ERPs in this study. P3a and P3b, which are subcomponents of P300, were analyzed and the evented related negativity (ERN) was analyzed together with error positivity (Pe). As a result of the study, statistically significant changes of ERPs were observed, this result, which has little related research, is considered to be meaningful as medical basic statistics.

• Journal of Korea Multimedia Society
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• v.22 no.2
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• pp.157-166
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• 2019

With the development of medical technology, interest in rehabilitation devices is increasing and various devices are being studied. In particular, devices for speech disorders such as hearing impairment and cleft palate are attracting attention. In general, the nasometer is used for patients with flaccid dysarthria and velopharyngeal incompetence(VPI). However, in the case of the conventional separator type nasometer, that has an acoustic feedback problem between the oral and nasal sounds. In recent, the mask type nasometer has been developed which is insensitive to acoustic feedback. But, still not popularized. In this paper, the nasometer characteristics of the conventional separation type and mask type are analyzed. Also, We were obtained clinical acoustic data from the 6 subjects and examined the significant differences in the structure of the separation type and mask type nasometer. Through experiments, it was confirmed that the measurement was about 3~15% higher in the mask type nasometer than the conventional nasometer having a separator type. Also, We was considered the necessity of nasometer signal processing for acoustic feedback reduction and nasalance calculation optimization.